DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and RLP45

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001325565.1	Gene:	RLP45 / 824491	AraportID:	AT3G53240	Length:	927	Species:	Arabidopsis thaliana

Alignment Length:	895	Identity:	205/895 - (22%)
Similarity:	322/895 - (35%)	Gaps:	317/895 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 LFESTLPVAVFARLQTLEALRLDSCKLLQLPNNAFEGLATLKSLRLSTHNSEWGPTRTLELFPDS 184
            ||:...||.        |.:.|.|.::|.|..|.|.|                      :|....
plant   150 LFKGGFPVQ--------ELINLTSLEVLDLKFNKFSG----------------------QLPTQE 184

  Fly   185 LGGLKQLTDLDLGDNNLR-QLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFADMNCGAGSGSAGSE 248
            |..|:.|..|||.:|... .|....:|.:..||.|.|:|||......:.|          |..|:
plant   185 LTNLRNLRALDLSNNKFSGSLQKQGICRLEQLQELRLSRNRFEGEIPLCF----------SRFSK 239

  Fly   249 LQVLDASHNELRSISESWGISRLRRLQHLNLAYNN------------LSEL-------------- 287
            |:|||.|.|.| |....:.||..:.:::|:|..|:            |:||
plant   240 LRVLDLSSNHL-SGKIPYFISDFKSMEYLSLLDNDFEGLFSLGLITELTELKVFKLSSRSGMLQI 303

  Fly   288 -----SGEALAGLAS--------------------LRIVNLSNNHLE-TLPEGLFAGSKELREIH 326
                 ||...:.|:|                    ||:::||||.|. ..|..|...:.||:.:.
plant   304 VETNVSGGLQSQLSSIMLSHCNLGKIPGFLWYQQELRVIDLSNNILSGVFPTWLLENNTELQALL 368

  Fly   327 LQQNELYELPKGLFHRLEQLLVVDLS----GNQLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDY 387
            ||.|....|.  |...:.:|.::|||    .|||..:          :.||:.:|.|
plant   369 LQNNSFKTLT--LPRTMRRLQILDLSVNNFNNQLPKD----------VGLILASLRH-------- 413

  Fly   388 RTFKELYFLQILNLRNN--------SIGHIEDNAFLPL-YNLHTLNLAENRLHTLDDKLFNGLYV 443
                       |||.||        |:..:|:..|:.| ||..:..|..|        ||.|.|.
plant   414 -----------LNLSNNEFLGNMPSSMARMENIEFMDLSYNNFSGKLPRN--------LFTGCYS 459

  Fly   444 LSKLTLNNNLISVVEPAVFKNCSD--LKELDLSSNQL-NEVPRALQDLAMLRTLDLGENQIRTFD 505
            ||.|.|::|..|  .|.:.|:..:  |..|.:.:|.. .::||.|.:|.||..:||..|
plant   460 LSWLKLSHNRFS--GPIIRKSSDETSLITLIMDNNMFTGKIPRTLLNLRMLSVIDLSNN------ 516

  Fly   506 NQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDR 570
                    .|||  .|...:||..         |.||.::.||:|.....|.   |.:..:
plant   517 --------LLTG--TIPRWLGNFF---------LEVLRISNNRLQGAIPPSL---FNIPYL---- 555

  Fly   571 NFLADINGVFATLVSLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYI-----EALGNYYKLQEE 630
             :|.|::|.|  |...|.|..|.      ||.:|      ||:|.|.:     :.|  :|.|
plant   556 -WLLDLSGNF--LSGSLPLRSSS------DYGYI------LDLHNNNLTGSIPDTL--WYGL--- 600

  Fly   631 IRVKTLDASHNRITEIGPM--SIPNTIELLFINNNLIGNVQPNAFVDKANLARVDLYANQLSKLQ 693
               :.||..:|:::...|:  |.|:...:|...|||.|.: |......:|:..:|...|:|:
plant   601 ---RLLDLRNNKLSGNIPLFRSTPSISVVLLRENNLTGKI-PVELCGLSNVRMLDFAHNRLN--- 658

  Fly   694 LQQLRVAPVVAPKPLP------EFYLGGNPFECDCTMDW-----LQRINNLTTRQHPRVMDMANI 747
                        :.:|      .|..||:   .:...||     |.....:.|..:
plant   659 ------------ESIPSCVTNLSFGSGGH---SNADSDWYPASLLSNFMEIYTEVY--------- 699

  Fly   748 ECVMPHARGAAVRPLSGLRPQDFLCRYE----SHCFALCHCCDFDACDCEMTCPSNCTCYH---- 804
                                      ||    |..|:|.:..||:. ..|.........|.
plant   700 --------------------------YESLIVSDRFSLDYSVDFNV-QVEFAVKQRYDLYMRGTL 737

  Fly   805 DQIWSTNVVDCGGQQTTELPRRVPMDSSVVYLDGNNFPVLKNHAFIGRKNLRALYVNGSQVAAIQ 869
            :|::..::      .:.||...:|.:...:                  |.:|:|.::.:.::...
plant   738 NQMFGLDL------SSNELSGNIPEELGDL------------------KRVRSLNLSRNSLSGSI 778

  Fly   870 NRTFASLASLQLLHLADNKLRTLHGYEFEQLSALRELYLQN---NQLTTI 916
            ..:|::|.|::.|.|:.||   |||....||:.|:.|.:.|   |.|:.:
plant   779 PGSFSNLRSIESLDLSFNK---LHGTIPSQLTLLQSLVVFNVSYNNLSGV 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	16/65 (25%)
		leucine-rich repeat	136..159	CDD:275380	8/22 (36%)
		leucine-rich repeat	160..190	CDD:275380	3/29 (10%)
		LRR_8	189..259	CDD:290566	23/70 (33%)
		leucine-rich repeat	191..214	CDD:275380	7/23 (30%)
		leucine-rich repeat	215..248	CDD:275380	9/32 (28%)
		LRR_RI	247..501	CDD:238064	85/321 (26%)
		LRR_8	247..308	CDD:290566	27/111 (24%)
		leucine-rich repeat	249..273	CDD:275380	10/23 (43%)
		leucine-rich repeat	274..297	CDD:275380	9/53 (17%)
		LRR_8	297..356	CDD:290566	22/83 (27%)
		leucine-rich repeat	298..321	CDD:275380	9/23 (39%)
		leucine-rich repeat	322..345	CDD:275380	6/22 (27%)
		LRR_8	345..406	CDD:290566	16/72 (22%)
		leucine-rich repeat	346..371	CDD:275380	7/28 (25%)
		leucine-rich repeat	372..395	CDD:275380	4/22 (18%)
		leucine-rich repeat	396..419	CDD:275380	9/31 (29%)
		LRR_8	419..478	CDD:290566	18/60 (30%)
		leucine-rich repeat	420..443	CDD:275380	5/22 (23%)
		leucine-rich repeat	444..467	CDD:275380	8/22 (36%)
		LRR_RI	466..622	CDD:238064	41/163 (25%)
		leucine-rich repeat	468..488	CDD:275380	6/20 (30%)
		LRR_8	491..549	CDD:290566	14/57 (25%)
		leucine-rich repeat	491..514	CDD:275380	4/22 (18%)
		leucine-rich repeat	515..536	CDD:275380	6/20 (30%)
		leucine-rich repeat	539..562	CDD:275380	7/22 (32%)
		leucine-rich repeat	563..585	CDD:275380	5/21 (24%)
		leucine-rich repeat	586..626	CDD:275380	11/44 (25%)
		leucine-rich repeat	627..653	CDD:275380	6/27 (22%)
		LRRCT	716..772	CDD:214507	4/60 (7%)
		LRRNT	796..830	CDD:214470	5/37 (14%)
		leucine-rich repeat	812..829	CDD:275380	2/16 (13%)
		leucine-rich repeat	833..854	CDD:275380	0/20 (0%)
		LRR_8	853..913	CDD:290566	19/62 (31%)
		leucine-rich repeat	855..878	CDD:275380	4/22 (18%)
		LRR_4	878..918	CDD:289563	15/42 (36%)
		leucine-rich repeat	879..902	CDD:275380	9/22 (41%)
		leucine-rich repeat	903..926	CDD:275380	5/17 (29%)
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
RLP45	NP_001325565.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	126	1.000	Inparanoid score	I1925
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960