DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and RLP41

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001327885.1	Gene:	RLP41 / 822092	AraportID:	AT3G25010	Length:	912	Species:	Arabidopsis thaliana

Alignment Length:	1038	Identity:	226/1038 - (21%)
Similarity:	360/1038 - (34%)	Gaps:	310/1038 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLLLLGFSWSLAVESALAPKESESSASAMLGAGT----GAAATVSLSGDYSSLLSNVPAASPVPA 65
            |||.|.|...|.: |.::|....:..:.::|.|.    ...|......::::...|
plant    35 LLLRLNFLLLLLL-SCVSPSSFVTFNNPVVGLGACGPHQIQAFTQFKNEFNTRACN--------- 89

  Fly    66 NPSQPSGPANQCSWSYNGTSSV------HCALRLIERQPGLDLQGADGSSQLTIQCSELYL---- 120
                .|.|.|.. |..|.|.:|      .|            |.|...|:....|..||..
plant    90 ----HSSPWNGV-WCDNSTGAVTKIQFMAC------------LSGTLKSNSSLFQFHELRSLLLI 137

  Fly   121 ---FESTLPVAVFARLQTLEALRLDSCKLLQLPNNAFEGLATLKSLRLSTHNSEWGPTRTLELFP 182
               |.|:...:.|..|..||.|.|.|        :.|.|..                       |
plant   138 HNNFTSSSISSKFGMLNKLEVLFLSS--------SGFLGQV-----------------------P 171

  Fly   183 DSLGGLKQLTDLDLGDNNLRQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFADMNCGAGSGSAGS 247
            .|...|..|:.|||.||.|    :|.|..|.||:
plant   172 FSFSNLSMLSALDLSDNEL----TGSLSFVRNLR------------------------------- 201

  Fly   248 ELQVLDASHNELRSI-SESWGISRLRRLQHLNLAYNNL--SELSGEALAGLASLRIVNLSNNHLE 309
            :|:|||.|:|....| :.:..:..|..|.:|:|..|:.  |.|..| ...|..|.::::|:|...
plant   202 KLRVLDVSYNHFSGILNPNSSLFELHHLTYLSLGSNSFTSSTLPYE-FGNLNKLELLDVSSNSFF 265

  Fly   310 TLPEGLFAGSKELREIHLQQNELY-ELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIR-- 371
            .......:...:|.|::|..|:.. .||  |...|.:|.::.|.|     ||...|..:.|..
plant   266 GQVPPTISNLTQLTELYLPLNDFTGSLP--LVQNLTKLSILALFG-----NHFSGTIPSSLFTMP 323

  Fly   372 -LIVLNLAHNALT-RIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRL---- 430
             |..|:|..|.|. .|:.........|:.|.|..|   |.|.....|:..|  :||.|..|
plant   324 FLSYLSLKGNNLNGSIEVPNSSSSSRLESLYLGKN---HFEGKILKPISKL--INLKELDLSFLS 383

  Fly   431 --HTLDDKLFNGLYVLSKLTLNNNLIS------------VVE------------PAVFKNCSDLK 469
              :.:|..||:....|..|.|..:.||            .:|            |.:.|:..:|:
plant   384 TSYPIDLSLFSSFKSLLVLDLTGDWISQAGLSSDSYISLTLEALYMKQCNISDFPNILKSLPNLE 448

  Fly   470 ELDLSSNQLN-EVPRALQDLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMF 533
            .:|:|:|::: ::|..|..|..|.::.:|:|.:..|:..|...::....:.::|:   |...|..
plant   449 CIDVSNNRVSGKIPEWLWSLPRLSSVFIGDNLLTGFEGSSEILVNSSVQILVLDS---NSLEGAL 510

  Fly   534 QDLPRLSVLNLAK--NRIQSIERGSFDKNFELEAIRLD-RNFLADINGVFATLVSLLWLNLSENH 595
            ..|| ||::..:.  ||.:.....|......|:.:.|. .||...|.   ..|.:||:|||.:|:
plant   511 PHLP-LSIIYFSARYNRFKGDIPLSICNRSSLDVLDLRYNNFTGPIP---PCLSNLLFLNLRKNN 571

  Fly   596 LVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVKTLDASHNRITEIGPMSIPN--TIELL 658
            |    ...||.                .|:   .:..:::||..:||:|...|.|:.|  .::.|
plant   572 L----EGSIPD----------------TYF---ADAPLRSLDVGYNRLTGKLPRSLLNCSALQFL 613

  Fly   659 FINNNLIGNVQPNAFVDKANLARVDLYANQLSKLQLQQLRVAPVVAPKPLPEFYLGGNPFECDCT 723
            .:::|.|.:..|             .|...|.|||:..|.......|...|.....|.|
plant   614 SVDHNGIEDTFP-------------FYLKVLPKLQVLLLSSNKFYGPLSPPNQGSLGFP------ 659

  Fly   724 MDWLQRINNLTTRQHPRVMDMANIECVMPHARGAAVRPLSGLRPQDFLCR--------------- 773
                          ..|::::|.             ..|:|..||||...
plant   660 --------------ELRILEIAG-------------NKLTGSLPQDFFVNWKASSLTMNEDQGLY 697

  Fly   774 --YESHCFALCHCCDFDACDCEMTCPSNCTCYHDQIW---STNVVDCGGQQTT-ELPRRVPMDSS 832
              |....:.:.:.......|.:....|     .:|.|   |:..:|..|.:.. |:|..:.:..:
plant   698 MVYSKVVYGIYYLSYLATIDLQYKGLS-----MEQKWVLTSSATIDLSGNRLEGEIPESIGLLKA 757

  Fly   833 VVYLDGNNFPVLKNHAFIGRKNLRALYVNGSQVAAIQNRTFASLASLQLLHLADNKLRTLHGYEF 897
            ::.|:      |.|:||.|...|                :.|:|..::.|.|:.|:|........
plant   758 LIALN------LSNNAFTGHIPL----------------SLANLVKIESLDLSSNQLSGTIPNGL 800

  Fly   898 EQLSALRELYLQNNQL-------TTIENATLAPLAALELIRIDGNR-LVTLPIWQMHATHFGT 952
            ..||.|..:.:.:|||       |.|   |..|.::.|     ||. |..||:.|   ..|||
plant   801 GTLSFLAYVNVSHNQLNGEIPQGTQI---TGQPKSSFE-----GNAGLCGLPLQQ---RCFGT 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	16/65 (25%)
		leucine-rich repeat	136..159	CDD:275380	7/22 (32%)
		leucine-rich repeat	160..190	CDD:275380	3/29 (10%)
		LRR_8	189..259	CDD:290566	18/69 (26%)
		leucine-rich repeat	191..214	CDD:275380	10/22 (45%)
		leucine-rich repeat	215..248	CDD:275380	1/32 (3%)
		LRR_RI	247..501	CDD:238064	73/292 (25%)
		LRR_8	247..308	CDD:290566	19/63 (30%)
		leucine-rich repeat	249..273	CDD:275380	8/24 (33%)
		leucine-rich repeat	274..297	CDD:275380	8/24 (33%)
		LRR_8	297..356	CDD:290566	14/59 (24%)
		leucine-rich repeat	298..321	CDD:275380	3/22 (14%)
		leucine-rich repeat	322..345	CDD:275380	8/23 (35%)
		LRR_8	345..406	CDD:290566	17/64 (27%)
		leucine-rich repeat	346..371	CDD:275380	7/24 (29%)
		leucine-rich repeat	372..395	CDD:275380	6/23 (26%)
		leucine-rich repeat	396..419	CDD:275380	7/22 (32%)
		LRR_8	419..478	CDD:290566	20/88 (23%)
		leucine-rich repeat	420..443	CDD:275380	8/28 (29%)
		leucine-rich repeat	444..467	CDD:275380	8/46 (17%)
		LRR_RI	466..622	CDD:238064	37/159 (23%)
		leucine-rich repeat	468..488	CDD:275380	6/20 (30%)
		LRR_8	491..549	CDD:290566	13/59 (22%)
		leucine-rich repeat	491..514	CDD:275380	5/22 (23%)
		leucine-rich repeat	515..536	CDD:275380	3/20 (15%)
		leucine-rich repeat	539..562	CDD:275380	5/24 (21%)
		leucine-rich repeat	563..585	CDD:275380	6/22 (27%)
		leucine-rich repeat	586..626	CDD:275380	10/39 (26%)
		leucine-rich repeat	627..653	CDD:275380	7/25 (28%)
		LRRCT	716..772	CDD:214507	9/55 (16%)
		LRRNT	796..830	CDD:214470	8/37 (22%)
		leucine-rich repeat	812..829	CDD:275380	4/17 (24%)
		leucine-rich repeat	833..854	CDD:275380	6/20 (30%)
		LRR_8	853..913	CDD:290566	11/59 (19%)
		leucine-rich repeat	855..878	CDD:275380	3/22 (14%)
		LRR_4	878..918	CDD:289563	12/46 (26%)
		leucine-rich repeat	879..902	CDD:275380	5/22 (23%)
		leucine-rich repeat	903..926	CDD:275380	8/29 (28%)
		leucine-rich repeat	927..953	CDD:275380	10/27 (37%)
		TIR	1098..1235	CDD:214587
RLP41	NP_001327885.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000