DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-7 and Tlr9

DIOPT Version :10

Sequence 1:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster
Sequence 2:NP_112455.2 Gene:Tlr9 / 81897 MGIID:1932389 Length:1032 Species:Mus musculus


Alignment Length:1269 Identity:268/1269 - (21%)
Similarity:425/1269 - (33%) Gaps:422/1269 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   113 IQCSELYLFESTLPVAVFARLQTLEALRLDSCKLLQLPNNAFEGLATLKSLRLSTHNSEWGPTRT 177
            :.|:.|:| :|....:..|....:..|.|.|.::..|.|:.|..|:.|:.|     |.:|.    
Mouse    43 VDCNWLFL-KSVPRFSAAASCSNITRLSLISNRIHHLHNSDFVHLSNLRQL-----NLKWN---- 97

  Fly   178 LELFPDSLGGLKQLTDLDLGDNNLRQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFADMNCGAGS 242
                                            ||...|..|:.:.:  .|.|...|..|.     
Mouse    98 --------------------------------CPPTGLSPLHFSCH--MTIEPRTFLAMR----- 123

  Fly   243 GSAGSELQVLDASHNELRSISESWGISRLRRLQ----HLNLAYNNLSELSGEALAGLASLRIVNL 303
                 .|:.|:.|:|         ||:.:.||.    :|:|::.|:..|...:||||.|||::.:
Mouse   124 -----TLEELNLSYN---------GITTVPRLPSSLVNLSLSHTNILVLDANSLAGLYSLRVLFM 174

  Fly   304 SNNHLETLP--------EGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNH 360
            ..|.....|        .|...|...|..:.|:.|.|.::|:.|...||.|||            
Mouse   175 DGNCYYKNPCTGAVKVTPGALLGLSNLTHLSLKYNNLTKVPRQLPPSLEYLLV------------ 227

  Fly   361 VDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNN------------SIG----HI 409
                             ::|.:.::.......|..|::|::..|            ..|    |:
Mouse   228 -----------------SYNLIVKLGPEDLANLTSLRVLDVGGNCRRCDHAPNPCIECGQKSLHL 275

  Fly   410 EDNAFLPLYNLHTLNLAENRLHTLDDKLFNGLYVLSKLTLNNNLI--SVVEPAVFKNCSDLKELD 472
            ....|..|.:|..|.|.::.||||:...|.||..||.|.|:.|.:  |:.....|:|.:.|::|:
Mouse   276 HPETFHHLSHLEGLVLKDSSLHTLNSSWFQGLVNLSVLDLSENFLYESITHTNAFQNLTRLRKLN 340

  Fly   473 LSSNQLNEVPRALQDLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLR---LIDNQIGNITVGMFQ 534
            ||.|...:|..|...||                 .|||||..|..|.   :....:...|:....
Mouse   341 LSFNYRKKVSFARLHLA-----------------SSFKNLVSLQELNMNGIFFRLLNKYTLRWLA 388

  Fly   535 DLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRNFLADINGVFATLVSLLWLNLSENHLVWF 599
            |||:|..|:|..|.|...:.                       .:|.|..:|.:::||:|.:.. 
Mouse   389 DLPKLHTLHLQMNFINQAQL-----------------------SIFGTFRALRFVDLSDNRISG- 429

  Fly   600 DYAFIPSNLK----------------WLDIH---------GNYIEALGNYYKLQEEIRVKTLDAS 639
                 ||.|.                ..|.|         .|:::...| :|.       |:|.|
Mouse   430 -----PSTLSEATPEEADDAEQEELLSADPHPAPLSTPASKNFMDRCKN-FKF-------TMDLS 481

  Fly   640 HNRITEIGPMSIPN--TIELLFINNNLIGN-VQPNAFVDKANLARVDLYANQL--------SKL- 692
            .|.:..|.|....|  .::.|.:::|.|.. |..:.|:...||..:||..|:|        |:| 
Mouse   482 RNNLVTIKPEMFVNLSRLQCLSLSHNSIAQAVNGSQFLPLTNLQVLDLSHNKLDLYHWKSFSELP 546

  Fly   693 QLQQLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQRI----NNLTTRQHPRVMDMANIECVMPH 753
            |||.|.::....|..:...   |:.|.....:..||.:    |::.||             |..|
Mouse   547 QLQALDLSYNSQPFSMKGI---GHNFSFVTHLSMLQSLSLAHNDIHTR-------------VSSH 595

  Fly   754 ARGAAVRPLSGLRPQDFLCRYESHCFALCHCCDFDACDCEMTCPSNCTCYHDQIWSTNVVDCGGQ 818
            ....:||         ||              ||.....            .::|     |.|| 
Mouse   596 LNSNSVR---------FL--------------DFSGNGM------------GRMW-----DEGG- 619

  Fly   819 QTTELPRRVPMDSSVVYLDGNNFPVLKNHAFIGRKNLRALYVNGSQVAAIQNRTFASL-ASLQLL 882
                           :||          |.|.|...|..|.::.:.:..::.:...:| .||:||
Mouse   620 ---------------LYL----------HFFQGLSGLLKLDLSQNNLHILRPQNLDNLPKSLKLL 659

  Fly   883 HLADNKLRTLHGYEFEQLSALRELYLQNNQLTTIENATLAPLAALELIRIDGNRLVT-------- 939
            .|.||.|...:......|..|..|.|..|||..:.|.||.....|:.:.:..|.:|:        
Mouse   660 SLRDNYLSFFNWTSLSFLPNLEVLDLAGNQLKALTNGTLPNGTLLQKLDVSSNSIVSVVPAFFAL 724

  Fly   940 -LPIWQMHATH----------FG---TRLKSISLGRNQWSCRCQFLQALTSYVADNALIVQD--- 987
             :.:.:::.:|          ||   ..|..:.:..|...|.|.     .::| |..|.||.   
Mouse   725 AVELKEVNLSHNILKTVDRSWFGPIVMNLTVLDVRSNPLHCACG-----AAFV-DLLLEVQTKVP 783

  Fly   988 --AQDIYCMAASSGTGSAALEDSSSNSGSLEKRELDFNATGAACTDYYSGGSMLQHGIPESYIPL 1050
              |..:.|                .:.|.|:.|.: |......|.|..                |
Mouse   784 GLANGVKC----------------GSPGQLQGRSI-FAQDLRLCLDEV----------------L 815

  Fly  1051 LAAALALLFLLVVIAMVFAFRESL---RIWLFAHYGVRVFGPRCEESEKL-----YDAVLLHSAK 1107
            ......|..|.|.:.||......|   .:|...|..: .:.|....|.:.     |||.::....
Mouse   816 SWDCFGLSLLAVAVGMVVPILHHLCGWDVWYCFHLCL-AWLPLLARSRRSAQTLPYDAFVVFDKA 879

  Fly  1108 DS---EFVCQHLAAQLE--TGRPPLRVCLQHRDLAHDATHYQLLEATRV-SRRVVILLTRNFLQT 1166
            .|   ::|...|..:||  .||..||:||:.||.....|.::.|.|:.. ||:.:.:|...    
Mouse   880 QSAVADWVYNELRVRLEERRGRRALRLCLEDRDWLPGQTLFENLWASIYGSRKTLFVLAHT---- 940

  Fly  1167 EWARCELRRSVHDALRGRPQKLVIIEEPEVAFEAESDIELLPYLKTSAVHRIR------------ 1219
                        |.:.|..:...::.:..: .|...|:.:|..|:..| ||.|            
Mouse   941 ------------DRVSGLLRTSFLLAQQRL-LEDRKDVVVLVILRPDA-HRSRYVRLRQRLCRQS 991

  Fly  1220 --------RSDRHFWEKLRYALPVDYPTFRGNNY 1245
                    .....||.:|..||..|...|...|:
Mouse   992 VLFWPQQPNGQGGFWAQLSTALTRDNRHFYNQNF 1025

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-7NP_523797.1 LRR 45..473 CDD:443914 87/389 (22%)
leucine-rich repeat 136..159 CDD:275380 7/22 (32%)
leucine-rich repeat 160..190 CDD:275380 4/29 (14%)
leucine-rich repeat 191..214 CDD:275380 2/22 (9%)
leucine-rich repeat 215..248 CDD:275380 6/32 (19%)
leucine-rich repeat 249..273 CDD:275380 6/23 (26%)
leucine-rich repeat 274..297 CDD:275380 9/26 (35%)
leucine-rich repeat 298..321 CDD:275380 6/30 (20%)
leucine-rich repeat 322..345 CDD:275380 7/22 (32%)
leucine-rich repeat 346..371 CDD:275380 3/24 (13%)
LRR 369..>675 CDD:443914 78/354 (22%)
leucine-rich repeat 372..395 CDD:275380 2/22 (9%)
leucine-rich repeat 396..419 CDD:275380 7/38 (18%)
leucine-rich repeat 420..443 CDD:275380 10/22 (45%)
leucine-rich repeat 444..467 CDD:275380 8/24 (33%)
leucine-rich repeat 468..488 CDD:275380 7/19 (37%)
leucine-rich repeat 491..514 CDD:275380 5/22 (23%)
leucine-rich repeat 515..536 CDD:275380 3/23 (13%)
leucine-rich repeat 539..562 CDD:275380 5/22 (23%)
leucine-rich repeat 563..585 CDD:275380 2/21 (10%)
leucine-rich repeat 586..626 CDD:275380 11/64 (17%)
leucine-rich repeat 627..653 CDD:275380 6/25 (24%)
LRRCT 716..772 CDD:214507 11/59 (19%)
LRR <812..>963 CDD:443914 36/173 (21%)
leucine-rich repeat 812..829 CDD:275380 3/16 (19%)
leucine-rich repeat 833..854 CDD:275380 5/20 (25%)
leucine-rich repeat 855..878 CDD:275380 3/23 (13%)
leucine-rich repeat 879..902 CDD:275380 8/22 (36%)
leucine-rich repeat 903..926 CDD:275380 9/22 (41%)
leucine-rich repeat 927..953 CDD:275380 6/47 (13%)
TIR 1098..1235 CDD:214587 37/162 (23%)
Tlr9NP_112455.2 leucine-rich repeat 43..64 CDD:275380 5/21 (24%)
LRR 46..453 CDD:443914 118/544 (22%)
LRR 1 62..85 6/22 (27%)
leucine-rich repeat 65..88 CDD:275380 7/22 (32%)
LRR 2 87..110 8/63 (13%)
LRR 3 122..147 9/43 (21%)
leucine-rich repeat 125..168 CDD:275380 16/51 (31%)
LRR 4 150..166 5/15 (33%)
LRR 5 167..190 5/22 (23%)
leucine-rich repeat 169..200 CDD:275380 6/30 (20%)
LRR 6 198..221 6/22 (27%)
leucine-rich repeat 201..221 CDD:275380 6/19 (32%)
leucine-rich repeat 222..245 CDD:275380 7/51 (14%)
LRR 7 223..242 5/47 (11%)
LRR 8 243..268 4/24 (17%)
leucine-rich repeat 246..285 CDD:275380 7/38 (18%)
LRR 9 283..306 9/22 (41%)
leucine-rich repeat 286..309 CDD:275380 10/22 (45%)
LRR 10 308..332 7/23 (30%)
leucine-rich repeat 310..335 CDD:275380 8/24 (33%)
LRR 11 333..356 7/22 (32%)
leucine-rich repeat 336..365 CDD:275380 14/45 (31%)
LRR 12 363..386 4/22 (18%)
LRR 13 390..413 8/45 (18%)
leucine-rich repeat 393..411 CDD:275380 5/40 (13%)
LRR 14 415..440 7/30 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 430..462 5/31 (16%)
LRR 15 471..495 8/31 (26%)
LRR <477..756 CDD:443914 77/360 (21%)
leucine-rich repeat 477..498 CDD:275380 7/20 (35%)
LRR 16 497..520 5/22 (23%)
leucine-rich repeat 499..523 CDD:275380 5/23 (22%)
LRR 17 521..544 6/22 (27%)
leucine-rich repeat 524..547 CDD:275380 7/22 (32%)
LRR 18 546..573 7/29 (24%)
leucine-rich repeat 548..577 CDD:275380 6/31 (19%)
LRR 19 575..599 7/36 (19%)
leucine-rich repeat 578..600 CDD:275380 7/34 (21%)
leucine-rich repeat 601..630 CDD:275380 15/94 (16%)
LRR 20 601..623 12/87 (14%)
LRR 21 628..651 2/22 (9%)
leucine-rich repeat 631..679 CDD:275380 12/47 (26%)
LRR 22 653..676 8/22 (36%)
LRR 23 677..700 10/22 (45%)
leucine-rich repeat 680..703 CDD:275380 9/22 (41%)
LRR 24 702..724 3/21 (14%)
leucine-rich repeat 704..752 CDD:275380 6/47 (13%)
LRR 25 725..748 2/22 (9%)
LRR 26 750..773 5/28 (18%)
leucine-rich repeat 753..774 CDD:275380 5/26 (19%)
SEFIR 870..>974 CDD:474043 28/120 (23%)

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