DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-7 and TLR10

DIOPT Version :9

Sequence 1:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster
Sequence 2:NP_001017388.1 Gene:TLR10 / 81793 HGNCID:15634 Length:811 Species:Homo sapiens


Alignment Length:914 Identity:181/914 - (19%)
Similarity:320/914 - (35%) Gaps:286/914 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   422 TLNLAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRALQ 486
            ||:|:.|.|..|....|:.:..|..|.|.:|.|..::...|:...:|:.||||:|:|..|...| 
Human    52 TLDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSVTWYL- 115

  Fly   487 DLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQS 551
             ||.||.|||..|...|..               |..:.||::        .|.:|.|:..:|| 
Human   116 -LAGLRYLDLSFNDFDTMP---------------ICEEAGNMS--------HLEILGLSGAKIQ- 155

  Fly   552 IERGSFDKNFELEAIRLDRNFLADINGVFATLV-----SLLWLNLSENHLVWFDYAFIPSNLKWL 611
              :..|.|   :..:.|:..||.     |.||.     ||..||.::.|:|             |
Human   156 --KSDFQK---IAHLHLNTVFLG-----FRTLPHYEEGSLPILNTTKLHIV-------------L 197

  Fly   612 DIHGNYIEALGNYYKLQEEIRVKTLDASHNRITEIGPMSIPNTIELLFINNNLIGNVQ-PNAFVD 675
            .:..|:...|.:..|..:.:.:..:|....                 |::..:..|:. .||...
Human   198 PMDTNFWVLLRDGIKTSKILEMTNIDGKSQ-----------------FVSYEMQRNLSLENAKTS 245

  Fly   676 KANLARVDLYANQLSKL-------QLQQLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQRINNL 733
            ...|.:|||..:.|..:       .::..::..|...   .:.||..|.|:...|:....::.::
Human   246 VLLLNKVDLLWDDLFLILQFVWHTSVEHFQIRNVTFG---GKAYLDHNSFDYSNTVMRTIKLEHV 307

  Fly   734 TTR----QHPRV------MDMANI---ECVMPHARGAAVRPLSGLRPQDFLCRYESHCFALCHCC 785
            ..|    |..::      ||:.|:   ...|||                                
Human   308 HFRVFYIQQDKIYLLLTKMDIENLTISNAQMPH-------------------------------- 340

  Fly   786 DFDACDCEMTCPSNCTCYHDQIWSTNVVDCGGQQTTELPRRVPMDSSVVYLDGNNFPVLKNHAFI 850
                    |..|:..|.:....::.|::      |.||.:|.                      |
Human   341 --------MLFPNYPTKFQYLNFANNIL------TDELFKRT----------------------I 369

  Fly   851 GRKNLRALYVNGSQVAAIQ-NRTFASLASLQLLHLADNKLRTLH-------------GYEFEQLS 901
            ...:|:.|.:||:::..:. ...||:...|:.|.|:.|.|:..:             ...:.:||
Human   370 QLPHLKTLILNGNKLETLSLVSCFANNTPLEHLDLSQNLLQHKNDENCSWPETVVNMNLSYNKLS 434

  Fly   902 ---------ALRELYLQNNQLTTIENATLAPLAALELIRIDGNRLVTLPIWQMHATHFG------ 951
                     :::.|.|.|||:.|:...|: .|.||..:.|..|.|..||    ..:||.      
Human   435 DSVFRCLPKSIQILDLNNNQIQTVPKETI-HLMALRELNIAFNFLTDLP----GCSHFSRLSVLN 494

  Fly   952 -----------------TRLKSISLGRNQWSCRCQ---FLQALTSYVADNALIVQDAQDIYCMAA 996
                             ..:|:::.|||.:.|.|:   |:| |.:|   :.:::....|.|....
Human   495 IEMNFILSPSLDFVQSCQEVKTLNAGRNPFRCTCELKNFIQ-LETY---SEVMMVGWSDSYTCEY 555

  Fly   997 SSGTGSAALEDSSSNSGSLEKRELDFNATGAACTDYYSGGSMLQHGIPESYIPLLAAALALLFLL 1061
            ........|:|       :...||..|..                        ||...:.::.|:
Human   556 PLNLRGTRLKD-------VHLHELSCNTA------------------------LLIVTIVVIMLV 589

  Fly  1062 VVIAMVFAFRESLRIWLFAHYGVRVFGPRCEES---------EKL-----YDAVLLHSAKDSEFV 1112
            :.:|:.|........|.     :|:.| :|.::         |:|     :.|.:.:|..||.:|
Human   590 LGLAVAFCCLHFDLPWY-----LRMLG-QCTQTWHRVRKTTQEQLKRNVRFHAFISYSEHDSLWV 648

  Fly  1113 CQHLAAQLETGRPPLRVCL--QHRDLAHDATHYQLLEATRVSRRVVILLTRNFLQTEWARCELRR 1175
            ...|...||.....:.:||  .:.|.....:. .::.....|.:.:.:|:.||:|.||...|...
Human   649 KNELIPNLEKEDGSILICLYESYFDPGKSISE-NIVSFIEKSYKSIFVLSPNFVQNEWCHYEFYF 712

  Fly  1176 SVHDALRGRPQKLVIIEEPEVAF--------EAESDIELLPYLKTSAVHRIRRSDRHFWEKLRYA 1232
            :.|:........:::|....:.|        :.::.:|...||:..   :.||....||..||.|
Human   713 AHHNLFHENSDHIILILLEPIPFYCIPTRYHKLKALLEKKAYLEWP---KDRRKCGLFWANLRAA 774

  Fly  1233 LPVD 1236
            :.|:
Human   775 INVN 778

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-7NP_523797.1 LRR_8 135..201 CDD:290566
leucine-rich repeat 136..159 CDD:275380
leucine-rich repeat 160..190 CDD:275380
LRR_8 189..259 CDD:290566
leucine-rich repeat 191..214 CDD:275380
leucine-rich repeat 215..248 CDD:275380
LRR_RI 247..501 CDD:238064 30/78 (38%)
LRR_8 247..308 CDD:290566
leucine-rich repeat 249..273 CDD:275380
leucine-rich repeat 274..297 CDD:275380
LRR_8 297..356 CDD:290566
leucine-rich repeat 298..321 CDD:275380
leucine-rich repeat 322..345 CDD:275380
LRR_8 345..406 CDD:290566
leucine-rich repeat 346..371 CDD:275380
leucine-rich repeat 372..395 CDD:275380
leucine-rich repeat 396..419 CDD:275380
LRR_8 419..478 CDD:290566 19/55 (35%)
leucine-rich repeat 420..443 CDD:275380 7/20 (35%)
leucine-rich repeat 444..467 CDD:275380 6/22 (27%)
LRR_RI 466..622 CDD:238064 42/160 (26%)
leucine-rich repeat 468..488 CDD:275380 9/19 (47%)
LRR_8 491..549 CDD:290566 13/57 (23%)
leucine-rich repeat 491..514 CDD:275380 7/22 (32%)
leucine-rich repeat 515..536 CDD:275380 3/20 (15%)
leucine-rich repeat 539..562 CDD:275380 7/22 (32%)
leucine-rich repeat 563..585 CDD:275380 6/26 (23%)
leucine-rich repeat 586..626 CDD:275380 8/39 (21%)
leucine-rich repeat 627..653 CDD:275380 1/25 (4%)
LRRCT 716..772 CDD:214507 11/68 (16%)
LRRNT 796..830 CDD:214470 7/33 (21%)
leucine-rich repeat 812..829 CDD:275380 4/16 (25%)
leucine-rich repeat 833..854 CDD:275380 1/20 (5%)
LRR_8 853..913 CDD:290566 17/82 (21%)
leucine-rich repeat 855..878 CDD:275380 6/23 (26%)
LRR_4 878..918 CDD:289563 13/61 (21%)
leucine-rich repeat 879..902 CDD:275380 7/44 (16%)
leucine-rich repeat 903..926 CDD:275380 8/22 (36%)
leucine-rich repeat 927..953 CDD:275380 8/48 (17%)
TIR 1098..1235 CDD:214587 32/146 (22%)
TLR10NP_001017388.1 LRR 1 24..46
LRR 2 49..70 7/17 (41%)
leucine-rich repeat 50..73 CDD:275378 7/20 (35%)
LRR_8 72..129 CDD:316378 23/58 (40%)
LRR 3 73..94 6/20 (30%)
leucine-rich repeat 74..97 CDD:275378 6/22 (27%)
LRR 4 97..118 10/22 (45%)
leucine-rich repeat 98..112 CDD:275378 7/13 (54%)
leucine-rich repeat 119..143 CDD:275378 10/46 (22%)
LRR 5 119..139 8/34 (24%)
LRR 6 143..166 7/28 (25%)
leucine-rich repeat 144..155 CDD:275378 3/10 (30%)
LRR 289..>522 CDD:227223 52/305 (17%)
LRR 7 296..321 3/24 (13%)
LRR 8 325..348 8/62 (13%)
LRR 9 349..368 4/24 (17%)
leucine-rich repeat 350..373 CDD:275380 6/50 (12%)
LRR 10 373..394 4/20 (20%)
leucine-rich repeat 374..398 CDD:275380 6/23 (26%)
LRR 11 398..419 5/20 (25%)
leucine-rich repeat 399..422 CDD:275380 5/22 (23%)
LRR 12 422..442 2/19 (11%)
leucine-rich repeat 423..444 CDD:275380 2/20 (10%)
LRR 13 444..465 7/21 (33%)
leucine-rich repeat 445..467 CDD:275380 8/22 (36%)
LRR 14 467..488 8/24 (33%)
leucine-rich repeat 468..490 CDD:275380 8/25 (32%)
LRR 15 489..509 0/19 (0%)
leucine-rich repeat 491..513 CDD:275380 0/21 (0%)
LRRCT 522..574 CDD:214507 13/62 (21%)
TIR 633..775 CDD:214587 31/145 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X221
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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