DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and RLP24

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_180861.1	Gene:	RLP24 / 817864	AraportID:	AT2G33020	Length:	864	Species:	Arabidopsis thaliana

Alignment Length:	850	Identity:	195/850 - (22%)
Similarity:	322/850 - (37%)	Gaps:	212/850 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 LDSCKLLQLPNNAFEGLATLKSLRLSTH----NSEW-----GPTRTLEL---------FPDSLGG 187
            |.:|:|.|  :.||.........|...|    |..|     |....|:|         ...||.|
plant    37 LVACRLRQ--SQAFMQFKDEFDTRHCNHSDDFNGVWCDNSTGAVTVLQLRDCLSGTLKSNSSLFG 99

  Fly   188 LKQLTDLDLGDNNL--RQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFADMNCGAGSGSAG---- 246
            ..||..|.|..||.  ..|||.| |.:..|::|:|..|        ||.|::.....||..
plant   100 FHQLRYLALNRNNFTSASLPSEF-CNLNKLKLLSLFSN--------GFIDLSHNDLMGSFPLVRN 155

  Fly   247 -SELQVLDASHNELR-SISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLE 309
             .:|.|||.|.|... :::.:..:..|..|::||||:||:|.........|..|.:::||.|...
plant   156 LGKLAVLDLSDNHFSGTLNPNNSLFELHSLRYLNLAFNNISSSLPSKFGNLNKLEVLSLSFNGFS 220

  Fly   310 TLPEGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLI---- 370
            .......:....:.:::|..|||    .|.|..::.|..:...|       :.:..|:|.|
plant   221 GQCFPTISNLTRITQLYLHNNEL----TGSFPLVQNLTKLSFLG-------LSDNLFSGTIPSYL 274

  Fly   371 ----RLIVLNLAHNALT-RIDYRTFKELYFLQILNLRNNSIGHIEDNAFLP---LYNLHTLNLA- 426
                .|..|:|..|.|: .|:.........|:|:.|..|   |:|.....|   |.||..|:|:
plant   275 FTFPSLSTLDLRENDLSGSIEVPNSSTSSKLEIMYLGFN---HLEGKILEPISKLINLKRLDLSF 336

  Fly   427 ENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCS----DLKELDLSSNQLNEVPRALQD 487
            .|..:.:|..|.:.|..||.|..:.|.:|   ||...:.|    .::.:.||...:.|.|..|:.
plant   337 LNTSYPIDLNLLSPLKSLSYLDFSGNSLS---PASLSSSSYIPLSMESIVLSLCGIREFPNILKH 398

  Fly   488 LAMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSI 552
            |..|..:|:..|||:                       |.|...:: .||:||.::::.|.....
plant   399 LQNLIHIDITSNQIK-----------------------GKIPEWLW-TLPQLSFVDISNNSFNGF 439

  Fly   553 ERGSFD--KNFELEAIRLDRNFLADINGVFATL-VSLLWLNLSENHLVWFDYAFIPSNLKWLDIH 614
            : ||.:  .|..:..:.||.|   :..|...|| :|::..:.                     ||
plant   440 Q-GSAEVFVNLSVRILMLDAN---NFEGALPTLPLSIIGFSA---------------------IH 479

  Fly   615 GNYIEALGNYYKLQEEIRVKTLDASHNRITEIGPMSIPNTI-ELLFIN---NNLIGNVQPNAFVD 675
            .::...:.  ..:.....:..:|.|:|..|  ||  ||..: ..:|:|   |:|.|:: |:.|..
plant   480 NSFTGEIP--LSICNRTSLTMVDLSYNNFT--GP--IPQCLSNFMFVNLRKNDLEGSI-PDTFYT 537

  Fly   676 KANLARVDLYANQL------SKLQLQQLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQRINNLT 734
            .::|..:|:..|:|      |.|....||...|...:....|     ||       ||:.:.||
plant   538 DSSLKSLDVGYNRLTGKLPRSLLNCSSLRFLSVDNNRVKDTF-----PF-------WLKALPNL- 589

  Fly   735 TRQHPRVMDMANIEC---VMPHARGAAVRP-----------LSGLRPQDFLCRYESHCF------ 779
                 ||:.:.:.:.   :.|..:|....|           .:|..|..|...:::...
plant   590 -----RVLTLRSNKFYGPISPPHQGPLGFPELRIFEIADNMFTGSLPPSFFVNWKASALTKNEDG 649

  Fly   780 ALCHCCDFDACDCEMTCPSNCTCYHDQI---------------WSTNVVDCGGQQTT-ELPRRVP 828
            .|....::|..   ...|...| |.|.|               .|...:|..|.:.. ::|..:.
plant   650 GLYMVYEYDKA---ANSPVRYT-YTDTIDLQYKGLHMEQERVLTSYAAIDFSGNRLQGQIPESIG 710

  Fly   829 MDSSVVYLDGNNFPVLKNHAFIGR--------KNLRALYVNGSQVAAIQNRTFASLASLQLLHLA 885
            :..:::.|:      |.|:||.|.        .||.:|.::|:|::........||:.|..:.:|
plant   711 LLKALIALN------LSNNAFTGHIPLSFANLMNLESLDMSGNQLSGTIPNGLGSLSFLVYISVA 769

  Fly   886 DNKLR 890
            .|||:
plant   770 HNKLK 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	21/77 (27%)
		leucine-rich repeat	136..159	CDD:275380	6/17 (35%)
		leucine-rich repeat	160..190	CDD:275380	10/47 (21%)
		LRR_8	189..259	CDD:290566	26/76 (34%)
		leucine-rich repeat	191..214	CDD:275380	10/24 (42%)
		leucine-rich repeat	215..248	CDD:275380	9/37 (24%)
		LRR_RI	247..501	CDD:238064	70/271 (26%)
		LRR_8	247..308	CDD:290566	20/61 (33%)
		leucine-rich repeat	249..273	CDD:275380	7/24 (29%)
		leucine-rich repeat	274..297	CDD:275380	9/22 (41%)
		LRR_8	297..356	CDD:290566	12/58 (21%)
		leucine-rich repeat	298..321	CDD:275380	4/22 (18%)
		leucine-rich repeat	322..345	CDD:275380	6/22 (27%)
		LRR_8	345..406	CDD:290566	15/69 (22%)
		leucine-rich repeat	346..371	CDD:275380	5/32 (16%)
		leucine-rich repeat	372..395	CDD:275380	6/23 (26%)
		leucine-rich repeat	396..419	CDD:275380	8/25 (32%)
		LRR_8	419..478	CDD:290566	18/63 (29%)
		leucine-rich repeat	420..443	CDD:275380	7/23 (30%)
		leucine-rich repeat	444..467	CDD:275380	8/26 (31%)
		LRR_RI	466..622	CDD:238064	31/162 (19%)
		leucine-rich repeat	468..488	CDD:275380	5/19 (26%)
		LRR_8	491..549	CDD:290566	12/57 (21%)
		leucine-rich repeat	491..514	CDD:275380	5/22 (23%)
		leucine-rich repeat	515..536	CDD:275380	2/20 (10%)
		leucine-rich repeat	539..562	CDD:275380	6/24 (25%)
		leucine-rich repeat	563..585	CDD:275380	6/22 (27%)
		leucine-rich repeat	586..626	CDD:275380	2/39 (5%)
		leucine-rich repeat	627..653	CDD:275380	7/25 (28%)
		LRRCT	716..772	CDD:214507	14/69 (20%)
		LRRNT	796..830	CDD:214470	9/49 (18%)
		leucine-rich repeat	812..829	CDD:275380	3/17 (18%)
		leucine-rich repeat	833..854	CDD:275380	6/28 (21%)
		LRR_8	853..913	CDD:290566	12/37 (32%)
		leucine-rich repeat	855..878	CDD:275380	6/22 (27%)
		LRR_4	878..918	CDD:289563	5/12 (42%)
		leucine-rich repeat	879..902	CDD:275380	5/11 (45%)
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
RLP24	NP_180861.1	leucine-rich repeat	103..137	CDD:275380	14/42 (33%)
		PLN00113	139..>799	CDD:331614	162/736 (22%)
		leucine-rich repeat	159..184	CDD:275380	7/24 (29%)
		leucine-rich repeat	185..208	CDD:275380	9/22 (41%)
		leucine-rich repeat	209..232	CDD:275380	4/22 (18%)
		leucine-rich repeat	233..255	CDD:275380	7/25 (28%)
		leucine-rich repeat	256..279	CDD:275380	4/29 (14%)
		leucine-rich repeat	280..304	CDD:275380	6/23 (26%)
		leucine-rich repeat	305..328	CDD:275380	8/25 (32%)
		leucine-rich repeat	329..353	CDD:275380	7/23 (30%)
		leucine-rich repeat	402..423	CDD:275380	7/44 (16%)
		leucine-rich repeat	426..450	CDD:275380	6/24 (25%)
		leucine-rich repeat	472..495	CDD:275380	2/45 (4%)
		leucine-rich repeat	496..516	CDD:275380	8/23 (35%)
		leucine-rich repeat	517..540	CDD:275380	7/23 (30%)
		leucine-rich repeat	541..564	CDD:275380	6/22 (27%)
		leucine-rich repeat	565..588	CDD:275380	8/34 (24%)
		leucine-rich repeat	616..690	CDD:275380	10/77 (13%)
		leucine-rich repeat	691..714	CDD:275380	3/22 (14%)
		leucine-rich repeat	715..738	CDD:275380	6/28 (21%)
		leucine-rich repeat	739..762	CDD:275380	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000