Protein Alignment Toll-7 and LRFN3

DIOPT Version :10

• Sequence 1: NP_523797.1
• Gene: Toll-7 / 37272
• FlyBaseID: FBgn0034476
• Length: 1446
• Species: Drosophila melanogaster
• Sequence 2: NP_078785.1
• Gene: LRFN3 / 79414
• HGNCID: 28370
• Length: 628
• Species: Homo sapiens
• Alignment Length: 267
• Identity: 74/267 - (27%)
• Similarity: 120/267 - (44%)
• Gaps: 49/267 - (18%)

  Fly   518 LRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRNFLADI-NGVFA 581
            |||.||.|.::......::..|..|:|::|.|:.:..|:|.....|.|:.||.|.|..: .|...
Human    64 LRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLR 128

  Fly   582 TLVSLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVKTLDASHNRITE- 645
            .||:|..|.||.|.|     |.:.:.            ||.:..:..|:     ||.|:|.:.:
Human   129 GLVNLRHLILSNNQL-----AALAAG------------ALDDCAETLED-----LDLSYNNLEQL 171

  Fly   646 ----IGPMSIPNTIELLFINNNLIGNVQPNAFVDKANLARVDLYANQLSKLQLQQL--RVAPVVA 704
                :|.:...||:.|   ::||:.:|...||.....|||:|:.:|:|:.:....|  |:..:..
Human   172 PWEALGRLGNVNTLGL---DHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLLAR 233

  Fly   705 PKPLPEFYL----GGNPFECDCTMDWLQRINNLTTRQHPRVMDMANIECVMPHARGAAVRPLSGL 765
            |:..|...|    ||||..|:|.:.||:|:        .|..|:.  .|..|.|.|.  |....:
Human   234 PRGSPASALVLAFGGNPLHCNCELVWLRRL--------AREDDLE--ACASPPALGG--RYFWAV 286

  Fly   766 RPQDFLC 772
            ..::|:|
Human   287 GEEEFVC 293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR	45..473	CDD:443914
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380
		leucine-rich repeat	249..273	CDD:275380
		leucine-rich repeat	274..297	CDD:275380
		leucine-rich repeat	298..321	CDD:275380
		leucine-rich repeat	322..345	CDD:275380
		leucine-rich repeat	346..371	CDD:275380
		LRR	369..>675	CDD:443914	45/162 (28%)
		leucine-rich repeat	372..395	CDD:275380
		leucine-rich repeat	396..419	CDD:275380
		leucine-rich repeat	420..443	CDD:275380
		leucine-rich repeat	444..467	CDD:275380
		leucine-rich repeat	468..488	CDD:275380
		leucine-rich repeat	491..514	CDD:275380
		leucine-rich repeat	515..536	CDD:275380	6/17 (35%)
		leucine-rich repeat	539..562	CDD:275380	7/22 (32%)
		leucine-rich repeat	563..585	CDD:275380	8/22 (36%)
		leucine-rich repeat	586..626	CDD:275380	9/39 (23%)
		leucine-rich repeat	627..653	CDD:275380	6/30 (20%)
		LRRCT	716..772	CDD:214507	15/55 (27%)
		LRR	<812..>963	CDD:443914
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		leucine-rich repeat	855..878	CDD:275380
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
LRFN3	NP_078785.1	LRR 1	60..83		6/18 (33%)
		LRR	<63..>228	CDD:443914	52/188 (28%)
		leucine-rich repeat	63..84	CDD:275380	6/19 (32%)
		LRR 2	84..105		7/20 (35%)
		leucine-rich repeat	85..108	CDD:275380	7/22 (32%)
		LRR 3	108..129		7/20 (35%)
		leucine-rich repeat	109..132	CDD:275380	8/22 (36%)
		LRR 4	132..153		9/37 (24%)
		leucine-rich repeat	133..157	CDD:275380	9/40 (23%)
		LRR 5	157..178		5/25 (20%)
		leucine-rich repeat	158..181	CDD:275380	6/27 (22%)
		LRR 6	181..202		8/23 (35%)
		leucine-rich repeat	182..205	CDD:275380	8/25 (32%)
		LRR 7	205..226		7/20 (35%)
		leucine-rich repeat	206..230	CDD:275380	8/23 (35%)
		leucine-rich repeat	242..253	CDD:275378	5/10 (50%)
		LRRCT	249..>281	CDD:214507	13/43 (30%)
		Ig	296..383	CDD:472250
		Ig strand B	313..317	CDD:409353
		Ig strand C	326..330	CDD:409353
		Ig strand E	349..353	CDD:409353
		Ig strand F	363..368	CDD:409353
		Ig strand G	376..379	CDD:409353
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	382..430
		fn3	424..502	CDD:394996