DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-7 and Lrrc17

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_083253.1	Gene:	Lrrc17 / 74511	MGIID:	1921761	Length:	443	Species:	Mus musculus

Alignment Length:	400	Identity:	87/400 - (21%)
Similarity:	144/400 - (36%)	Gaps:	130/400 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   588 WLNLSENHLVWF--DYAFIPSNLKWLDIHGNYIEALGN--YYKLQEEIRVKTLDASHNRITEIGP 648
            :|:..|..||:.  |:   |.:|..:.:..|.|..|.|  :.|.:   |:|:||...|.|::|..
Mouse    66 YLDCQERKLVYVLPDW---PQDLLHMLLARNKIRVLKNNMFAKFK---RLKSLDLQQNEISKIES 124

  Fly   649 MSI--PNTIELLFINNNLIGNVQPNAFVDKANLARVDLYANQLSKLQLQQLRVAPVVAPKPLPEF 711
            .:.  .|.:..|.:.:|.|..:...||:          |...||.|:|..
Mouse   125 EAFFGLNKLTTLLLQHNQIKVLTEEAFI----------YTPLLSYLRLYD--------------- 164

  Fly   712 YLGGNPFECDCTMDWLQRINNLTTRQHPRVMDMAN-IECVMPHARGAAVRPLSGLRPQDFLCRYE 775
                ||:.|.|.::.|     ::..|.||..::.| .:|..|.|  ...:.|..|:||:
Mouse   165 ----NPWHCTCELETL-----ISMLQIPRNRNLGNYAKCGSPPA--LRNKKLLQLKPQE------ 212

  Fly   776 SHCFALCHCCDFDACDCEMTCP--------------SNCTCYHDQIWSTNVVDCGGQQTTELPRR 826
                 ||     |..:.|...|              ::.|..|:.::....:||..::..::|..
Mouse   213 -----LC-----DEEEKEQLDPKPQVSGIPAVIRPEADSTLCHNYVFPIQTLDCKRKELKKVPSN 267

  Fly   827 VPMDSSVVYLDGNNFPVLKNHAFIGRKNLRALYVNGSQVAAIQNRTFASLASLQLLHLADNKLRT 891
            :|.|  :|.||                                              |:.||:|.
Mouse   268 IPPD--IVKLD----------------------------------------------LSSNKIRQ 284

  Fly   892 LHGYEFEQLSALRELYLQNNQLTTIENATLAPLAALELIRIDGNRLVTLPIWQMHATHFGTRLKS 956
            |...|||.:..|::|.|.:|.:..|:.|....|..||.:.:..|.|.......:...:|   ||.
Mouse   285 LRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLIHLEELDLSNNSLQNFDYGVLEDLYF---LKL 346

  Fly   957 ISLGRNQWSC 966
            :.|..|.|.|
Mouse   347 LWLRDNPWRC 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380
		LRR_RI	247..501	CDD:238064
		LRR_8	247..308	CDD:290566
		leucine-rich repeat	249..273	CDD:275380
		leucine-rich repeat	274..297	CDD:275380
		LRR_8	297..356	CDD:290566
		leucine-rich repeat	298..321	CDD:275380
		leucine-rich repeat	322..345	CDD:275380
		LRR_8	345..406	CDD:290566
		leucine-rich repeat	346..371	CDD:275380
		leucine-rich repeat	372..395	CDD:275380
		leucine-rich repeat	396..419	CDD:275380
		LRR_8	419..478	CDD:290566
		leucine-rich repeat	420..443	CDD:275380
		leucine-rich repeat	444..467	CDD:275380
		LRR_RI	466..622	CDD:238064	9/35 (26%)
		leucine-rich repeat	468..488	CDD:275380
		LRR_8	491..549	CDD:290566
		leucine-rich repeat	491..514	CDD:275380
		leucine-rich repeat	515..536	CDD:275380
		leucine-rich repeat	539..562	CDD:275380
		leucine-rich repeat	563..585	CDD:275380
		leucine-rich repeat	586..626	CDD:275380	11/41 (27%)
		leucine-rich repeat	627..653	CDD:275380	7/27 (26%)
		LRRCT	716..772	CDD:214507	16/56 (29%)
		LRRNT	796..830	CDD:214470	7/47 (15%)
		leucine-rich repeat	812..829	CDD:275380	3/16 (19%)
		leucine-rich repeat	833..854	CDD:275380	3/20 (15%)
		LRR_8	853..913	CDD:290566	12/59 (20%)
		leucine-rich repeat	855..878	CDD:275380	0/22 (0%)
		LRR_4	878..918	CDD:289563	13/39 (33%)
		leucine-rich repeat	879..902	CDD:275380	8/22 (36%)
		leucine-rich repeat	903..926	CDD:275380	7/22 (32%)
		leucine-rich repeat	927..953	CDD:275380	5/25 (20%)
		TIR	1098..1235	CDD:214587
Lrrc17	NP_083253.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..48
		leucine-rich repeat	65..83	CDD:275380	5/19 (26%)
		LRR 1	84..105		5/20 (25%)
		leucine-rich repeat	85..108	CDD:275380	6/25 (24%)
		LRR_8	86..143	CDD:290566	15/59 (25%)
		LRR_4	107..148	CDD:289563	11/43 (26%)
		LRR 2	108..129		7/20 (35%)
		leucine-rich repeat	109..132	CDD:275380	6/22 (27%)
		LRR 3	132..153		5/30 (17%)
		leucine-rich repeat	133..156	CDD:275380	6/32 (19%)
		leucine-rich repeat	157..207	CDD:275380	17/75 (23%)
		TPKR_C2	165..>201	CDD:301599	12/42 (29%)
		leucine-rich repeat	208..245	CDD:275380	9/52 (17%)
		leucine-rich repeat	251..271	CDD:275380	4/19 (21%)
		LRR_RI	<270..352	CDD:238064	27/132 (20%)
		LRR 4	271..292		11/68 (16%)
		leucine-rich repeat	272..295	CDD:275380	11/68 (16%)
		LRR_8	274..330	CDD:290566	20/101 (20%)
		LRR 5	295..316		6/20 (30%)
		LRR_4	296..334	CDD:289563	11/37 (30%)
		leucine-rich repeat	296..319	CDD:275380	7/22 (32%)
		LRR 6	319..342		4/22 (18%)
		leucine-rich repeat	320..343	CDD:275380	4/22 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100