DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and Cpn2

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_082180.2	Gene:	Cpn2 / 71756	MGIID:	1919006	Length:	547	Species:	Mus musculus

Alignment Length:	446	Identity:	125/446 - (28%)
Similarity:	191/446 - (42%)	Gaps:	98/446 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 AFEGLATL-KSLRLSTHNSEWGPTRTLELFPDSLGGLKQLTDLDLGDNNLRQLPSGFLCPVGNLQ 216
            ||.|...| |.:.|:|.      .|.||  ||:.|||.:|.||::..:           ||.||
Mouse    68 AFSGSPNLTKVVFLNTQ------VRHLE--PDAFGGLPRLQDLEITGS-----------PVSNL- 112

  Fly   217 VLNLTRNRIRTAEQMGFADMNCGAGSGSAGSELQVLDASHNELRSISESWGISRLRRLQHLNLAY 281
                                                 ::|.          .|.|..|:.|.|.:
Mouse   113 -------------------------------------SAHI----------FSNLSSLEKLTLDF 130

  Fly   282 NNLSELSGEALAGLASLRIVNLSNNHLETLPEGLFAGSKELREIHLQQNELYELPKGLFHRLEQL 346
            :.|:.|..:....:..|..:.|..|.|.|||..||...::||.::|.||.|.:||||.|..|..|
Mouse   131 DRLAGLPEDLFCHMDILESLQLQGNQLRTLPGRLFQSLRDLRTLNLAQNLLTQLPKGAFQSLTGL 195

  Fly   347 LVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIED 411
            .::.||.|.|.  .:.......|..|..|.|..||:|.:....|.:|:.|::|.|::|:|.|:..
Mouse   196 QMLKLSNNMLA--RLPEGALGSLSSLQELFLDGNAITELSPHLFSQLFSLEMLWLQHNAICHLPV 258

  Fly   412 NAFLPLYNLHTLNLAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSN 476
            :.|..|:||..|:|.:|.|.||.:.||.....|..|:|:.|.:..:....|.|.|.|..|.||.|
Mouse   259 SLFSSLHNLTFLSLKDNALRTLPEGLFAHNQGLLHLSLSYNQLETIPEGAFTNLSRLVSLTLSHN 323

  Fly   477 QLNEVPRALQDLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSV 541
            .:.::|..:                       |:||.||..|.|..|.:..:...:|.:|.||.:
Mouse   324 AITDLPEHV-----------------------FRNLEQLVKLSLDSNNLTALHPALFHNLSRLQL 365

  Fly   542 LNLAKNRIQSIERGSFDKNFELEAIRLDRN-FLADINGVFATLVSLLWLNLSENHL 596
            |||::|::.::..|.||.|::|..:.|..| :..|.:..:.|    .||.|..|.:
Mouse   366 LNLSRNQLTTLPGGIFDTNYDLFNLALLGNPWQCDCHLSYLT----SWLRLYNNQI 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	18/48 (38%)
		leucine-rich repeat	136..159	CDD:275380	3/5 (60%)
		leucine-rich repeat	160..190	CDD:275380	12/30 (40%)
		LRR_8	189..259	CDD:290566	8/69 (12%)
		leucine-rich repeat	191..214	CDD:275380	5/22 (23%)
		leucine-rich repeat	215..248	CDD:275380	1/32 (3%)
		LRR_RI	247..501	CDD:238064	74/253 (29%)
		LRR_8	247..308	CDD:290566	11/60 (18%)
		leucine-rich repeat	249..273	CDD:275380	3/23 (13%)
		leucine-rich repeat	274..297	CDD:275380	5/22 (23%)
		LRR_8	297..356	CDD:290566	25/58 (43%)
		leucine-rich repeat	298..321	CDD:275380	9/22 (41%)
		leucine-rich repeat	322..345	CDD:275380	12/22 (55%)
		LRR_8	345..406	CDD:290566	18/60 (30%)
		leucine-rich repeat	346..371	CDD:275380	6/24 (25%)
		leucine-rich repeat	372..395	CDD:275380	8/22 (36%)
		leucine-rich repeat	396..419	CDD:275380	8/22 (36%)
		LRR_8	419..478	CDD:290566	22/58 (38%)
		leucine-rich repeat	420..443	CDD:275380	9/22 (41%)
		leucine-rich repeat	444..467	CDD:275380	6/22 (27%)
		LRR_RI	466..622	CDD:238064	36/132 (27%)
		leucine-rich repeat	468..488	CDD:275380	6/19 (32%)
		LRR_8	491..549	CDD:290566	16/57 (28%)
		leucine-rich repeat	491..514	CDD:275380	3/22 (14%)
		leucine-rich repeat	515..536	CDD:275380	5/20 (25%)
		leucine-rich repeat	539..562	CDD:275380	9/22 (41%)
		leucine-rich repeat	563..585	CDD:275380	5/22 (23%)
		leucine-rich repeat	586..626	CDD:275380	4/11 (36%)
		leucine-rich repeat	627..653	CDD:275380
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
Cpn2	NP_082180.2	LRRNT	21..52	CDD:214470
		LRR_8	73..133	CDD:290566	25/126 (20%)
		leucine-rich repeat	75..98	CDD:275380	12/30 (40%)
		LRR 1	98..119		8/79 (10%)
		leucine-rich repeat	99..122	CDD:275380	10/81 (12%)
		LRR_8	121..181	CDD:290566	19/59 (32%)
		LRR 2	122..143		5/20 (25%)
		leucine-rich repeat	123..146	CDD:275380	5/22 (23%)
		LRR 3	146..167		9/20 (45%)
		leucine-rich repeat	147..170	CDD:275380	9/22 (41%)
		LRR_RI	149..374	CDD:238064	81/249 (33%)
		LRR 4	170..191		11/20 (55%)
		LRR_8	171..229	CDD:290566	22/59 (37%)
		leucine-rich repeat	171..194	CDD:275380	12/22 (55%)
		LRR 5	194..215		5/22 (23%)
		leucine-rich repeat	195..218	CDD:275380	6/24 (25%)
		LRR_8	217..277	CDD:290566	21/59 (36%)
		LRR 6	218..239		7/20 (35%)
		leucine-rich repeat	219..242	CDD:275380	8/22 (36%)
		LRR 7	242..263		7/20 (35%)
		leucine-rich repeat	243..266	CDD:275380	8/22 (36%)
		LRR_8	266..325	CDD:290566	22/58 (38%)
		LRR 8	266..287		10/20 (50%)
		leucine-rich repeat	267..290	CDD:275380	9/22 (41%)
		LRR 9	290..311		5/20 (25%)
		leucine-rich repeat	291..314	CDD:275380	6/22 (27%)
		LRR_8	313..373	CDD:290566	23/82 (28%)
		LRR 10	314..335		7/43 (16%)
		leucine-rich repeat	315..338	CDD:275380	9/45 (20%)
		LRR 11	338..359		6/20 (30%)
		leucine-rich repeat	339..360	CDD:275380	5/20 (25%)
		LRR 12	362..383		8/20 (40%)
		leucine-rich repeat	363..382	CDD:275380	6/18 (33%)
		LRRCT	395..436	CDD:214507	7/27 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010