DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-7 and TLR5

DIOPT Version :9

Sequence 1:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster
Sequence 2:NP_003259.2 Gene:TLR5 / 7100 HGNCID:11851 Length:858 Species:Homo sapiens


Alignment Length:927 Identity:208/927 - (22%)
Similarity:350/927 - (37%) Gaps:255/927 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   374 VLNLAHNALTRIDY-RT-----FKELYFLQILNLRNNSIG-HIEDNAFLPLYNLHTLNLAENRLH 431
            |||.....|...:| ||     |..|..||:|.|.:.... .|:..||..|.||..|:|..::::
Human    44 VLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIY 108

  Fly   432 TLDDKLFNGLYVLSKLTLNNNLIS--VVEPAVFKNCSDLKELDLSSNQLNEVPRALQDLAMLRTL 494
            .|....|.||:.|.:|.|....:|  |::...|:|...|..||||.||             :|:|
Human   109 FLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQ-------------IRSL 160

  Fly   495 DLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDL--PRLSVLNLAKNRIQSIERGSF 557
            .|         :.||..|:.|..:....|||..:.....:.|  ..||..:||.|.:.|  |.|.
Human   161 YL---------HPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYS--RVSV 214

  Fly   558 D--------KNFELEAIRLDRN-FLADINGVFATLV--SLLWLNLSENHLVWFDYAF-------- 603
            |        :|..||.:.:..| :..||.|.|:..:  |..:..:..:|::...:.|        
Human   215 DWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQ 279

  Fly   604 ------IPSNLKWLDIHGNYIEALGNYYKLQEEIR-VKTLDASHNRITEIGPMSI--PNTIELLF 659
                  ..|:::.||:...::.:|.:  ::.|.:: :|.|:.::|:|.:|...:.  .:.:::|.
Human   280 NTFAGLARSSVRHLDLSHGFVFSLNS--RVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLN 342

  Fly   660 INNNLIGNVQPNAFVDKANLARVDLYANQ-----------LSKLQLQQLR---VAPVVAPKPLPE 710
            ::.||:|.:..:.|.....:|.:||..|.           |.|||...||   :..:.....:|:
Human   343 LSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPD 407

  Fly   711 FYLGGNPFECDCTMDWLQRINNLTTRQHPRVMDMANIECVMPHARGAAVRPLSGLRPQDFLCRYE 775
            .:|.||      .:..|.:||......|.....:.|::.:.                  ||.|..
Human   408 IFLSGN------KLVTLPKINLTANLIHLSENRLENLDILY------------------FLLRVP 448

  Fly   776 SHCFALCHCCDFDACDCEMTCPSNCTCYHDQIWSTN---VVDCGGQQTTELPRRVPMDSSVVYLD 837
                                        |.||...|   ...|.|.||       |.::      
Human   449 ----------------------------HLQILILNQNRFSSCSGDQT-------PSEN------ 472

  Fly   838 GNNFPVLKNHAFIGRKNLRALYVNGSQVAAIQNRTFASLASLQLLHLADNKLRTLHGYEFEQLSA 902
                |.|: ..|:|...|:..:     ...:....|..|:.||:|:|..|.|.:|....|..|:|
Human   473 ----PSLE-QLFLGENMLQLAW-----ETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTA 527

  Fly   903 LRELYLQNNQLTTIENATLAPLAALELIRIDGNRL--------VTLPIWQMHATHFGTRLKSISL 959
            ||.|.|.:|:||.:.:..|.  |.||::.|..|:|        |:|.:  :..||          
Human   528 LRGLSLNSNRLTVLSHNDLP--ANLEILDISRNQLLAPNPDVFVSLSV--LDITH---------- 578

  Fly   960 GRNQWSCRCQFLQALTSYVADNALIVQDAQDIYCMAASSGTGSAALEDSSSNSGSLEK---RELD 1021
              |::.|.|:....:......|..|.....||||:...|.:|.:..  |.|..|..|:   :.|.
Human   579 --NKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLF--SLSTEGCDEEEVLKSLK 639

  Fly  1022 FNATGAACTDYYSGGSMLQHGIPESYIPLLAAALALLFLLVVIAMV-------FAFRESLRIWLF 1079
            |:                        :.::......|||:.::.:.       ..::.:.|:...
Human   640 FS------------------------LFIVCTVTLTLFLMTILTVTKFRGFCFICYKTAQRLVFK 680

  Fly  1080 AHYGVRVFGPRCEESEKL-YDAVLLHSAKDSEFVCQHLAAQLET---GRPPLRVCLQHRDLAHDA 1140
            .|       |:..|.:.. |||.|..|:||..:|...|...|:|   .:....:|.:.||.....
Human   681 DH-------PQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGE 738

  Fly  1141 THY-QLLEATRVSRRVVILLTRNFLQTEW---------ARC--ELRRSV---------------H 1178
            ... .:.:|...||::|.|::|:||:..|         .||  :|..::               |
Human   739 NRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLMKH 803

  Fly  1179 DALRGRPQKLVIIEEPE 1195
            .::||..||...:..||
Human   804 QSIRGFVQKQQYLRWPE 820

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Toll-7NP_523797.1 LRR_8 135..201 CDD:290566
leucine-rich repeat 136..159 CDD:275380
leucine-rich repeat 160..190 CDD:275380
LRR_8 189..259 CDD:290566
leucine-rich repeat 191..214 CDD:275380
leucine-rich repeat 215..248 CDD:275380
LRR_RI 247..501 CDD:238064 42/135 (31%)
LRR_8 247..308 CDD:290566
leucine-rich repeat 249..273 CDD:275380
leucine-rich repeat 274..297 CDD:275380
LRR_8 297..356 CDD:290566
leucine-rich repeat 298..321 CDD:275380
leucine-rich repeat 322..345 CDD:275380
LRR_8 345..406 CDD:290566 13/37 (35%)
leucine-rich repeat 346..371 CDD:275380
leucine-rich repeat 372..395 CDD:275380 9/26 (35%)
leucine-rich repeat 396..419 CDD:275380 8/23 (35%)
LRR_8 419..478 CDD:290566 21/60 (35%)
leucine-rich repeat 420..443 CDD:275380 7/22 (32%)
leucine-rich repeat 444..467 CDD:275380 7/24 (29%)
LRR_RI 466..622 CDD:238064 41/182 (23%)
leucine-rich repeat 468..488 CDD:275380 7/19 (37%)
LRR_8 491..549 CDD:290566 16/59 (27%)
leucine-rich repeat 491..514 CDD:275380 6/22 (27%)
leucine-rich repeat 515..536 CDD:275380 4/20 (20%)
leucine-rich repeat 539..562 CDD:275380 10/30 (33%)
leucine-rich repeat 563..585 CDD:275380 7/24 (29%)
leucine-rich repeat 586..626 CDD:275380 6/53 (11%)
leucine-rich repeat 627..653 CDD:275380 6/28 (21%)
LRRCT 716..772 CDD:214507 7/55 (13%)
LRRNT 796..830 CDD:214470 9/36 (25%)
leucine-rich repeat 812..829 CDD:275380 4/16 (25%)
leucine-rich repeat 833..854 CDD:275380 4/20 (20%)
LRR_8 853..913 CDD:290566 18/59 (31%)
leucine-rich repeat 855..878 CDD:275380 3/22 (14%)
LRR_4 878..918 CDD:289563 17/39 (44%)
leucine-rich repeat 879..902 CDD:275380 9/22 (41%)
leucine-rich repeat 903..926 CDD:275380 8/22 (36%)
leucine-rich repeat 927..953 CDD:275380 9/33 (27%)
TIR 1098..1235 CDD:214587 33/128 (26%)
TLR5NP_003259.2 LRR 1. /evidence=ECO:0000269|PubMed:22173220 45..68 7/22 (32%)
leucine-rich repeat 48..83 CDD:275378 10/34 (29%)
LRR 2. /evidence=ECO:0000269|PubMed:22173220 71..93 7/21 (33%)
PLN00113 90..>581 CDD:331614 138/607 (23%)
LRR 3. /evidence=ECO:0000269|PubMed:22173220 95..117 6/21 (29%)
leucine-rich repeat 97..120 CDD:275380 7/22 (32%)
LRR 4. /evidence=ECO:0000269|PubMed:22173220 120..143 6/22 (27%)
leucine-rich repeat 121..146 CDD:275380 7/24 (29%)
LRR 5. /evidence=ECO:0000269|PubMed:22173220 146..166 10/41 (24%)
leucine-rich repeat 147..171 CDD:275380 13/45 (29%)
LRR 6. /evidence=ECO:0000269|PubMed:22173220 171..192 4/20 (20%)
leucine-rich repeat 172..205 CDD:275380 8/32 (25%)
LRR 7. /evidence=ECO:0000269|PubMed:22173220 197..211 6/15 (40%)
LRR 8. /evidence=ECO:0000269|PubMed:22173220 214..229 2/14 (14%)