DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-7 and TLR4

DIOPT Version :9

Sequence 1:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster
Sequence 2:NP_612564.1 Gene:TLR4 / 7099 HGNCID:11850 Length:839 Species:Homo sapiens


Alignment Length:1154 Identity:241/1154 - (20%)
Similarity:403/1154 - (34%) Gaps:412/1154 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   148 QLPNNAFEGLATLKSLRLSTHNSEWGPTRTLELFPDSLGGLKQLTDLDLGDNNLRQLPSGFLCPV 212
            :|.......:|.|..:|    ...|.|  .:|:.|:......:|....:.||    ||.      
Human     6 RLAGTLIPAMAFLSCVR----PESWEP--CVEVVPNITYQCMELNFYKIPDN----LPF------ 54

  Fly   213 GNLQVLNLTRNRIRTAEQMGFADMNCGAGSGSAGSELQVLDASHNELRSISESWGISRLRRLQHL 277
             :.:.|:|:.|.:|          :.|:.|..:..||||||.|..|:::| |......|..|..|
Human    55 -STKNLDLSFNPLR----------HLGSYSFFSFPELQVLDLSRCEIQTI-EDGAYQSLSHLSTL 107

  Fly   278 NLAYNNLSELSGEALAGLASL-RIVNLSNN--HLETLPEGLFAGSKELREIHLQQN--ELYELPK 337
            .|..|.:..|:..|.:||:|| ::|.:..|  .||..|.|..   |.|:|:::..|  :.::||:
Human   108 ILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHL---KTLKELNVAHNLIQSFKLPE 169

  Fly   338 GLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILNLR 402
             .|..|..|..:|||.|::.|.:.  |....|.::.:|||:                    |:|.
Human   170 -YFSNLTNLEHLDLSSNKIQSIYC--TDLRVLHQMPLLNLS--------------------LDLS 211

  Fly   403 NNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSD 467
            .|.:..|:..||           .|.|||              ||||.||..|:   .|.|.|  
Human   212 LNPMNFIQPGAF-----------KEIRLH--------------KLTLRNNFDSL---NVMKTC-- 246

  Fly   468 LKELDLSSNQLNEVPRALQDLAMLRT--LDLG----ENQIRTFDNQSFKNLHQLT----GLRLID 522
                             :|.||.|..  |.||    |..:..||..:.:.|..||    .|..:|
Human   247 -----------------IQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLD 294

  Fly   523 NQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRNFLADIN---GVFAT-- 582
            ..:.:| :.:|..|..:|..:|....|:.::  .|..||..:.:.|       :|   |.|.|  
Human   295 YYLDDI-IDLFNCLTNVSSFSLVSVTIERVK--DFSYNFGWQHLEL-------VNCKFGQFPTLK 349

  Fly   583 ----------------------LVSLLWLNLSENHLVW----FDYAFIPSNLKWLDIHGN-YIEA 620
                                  |.||.:|:||.|.|.:    ....|..::||:||:..| .|..
Human   350 LKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITM 414

  Fly   621 LGNYYKLQEEIRVKTLDASHNRITEIGPMSIPNTIELLFINNNLIGNVQPNAFVDKANLARVDL- 684
            ..|:..|::   ::.||..|:.:.::...|:                     |:...||..:|: 
Human   415 SSNFLGLEQ---LEHLDFQHSNLKQMSEFSV---------------------FLSLRNLIYLDIS 455

  Fly   685 ----------YANQLSKLQLQQLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQRINNLTTRQHP 739
                      ..|.||.|::  |::|              ||.|:.:...|....:.|||     
Human   456 HTHTRVAFNGIFNGLSSLEV--LKMA--------------GNSFQENFLPDIFTELRNLT----- 499

  Fly   740 RVMDMANIECVMPHARGAAVRPLSGLRPQDFLCRYESHCFALCHCCDFDACDCEMTCPSNCTCYH 804
                                          ||              |...|..|...|:      
Human   500 ------------------------------FL--------------DLSQCQLEQLSPT------ 514

  Fly   805 DQIWSTNVVDCGGQQTTELPRRVPMDSSVVYLDGNNFPVLKNHAFIGRKNLRALYVNGSQVAAIQ 869
                                                                             
Human   515 ----------------------------------------------------------------- 514

  Fly   870 NRTFASLASLQLLHLADNKLRTLHGYEFEQLSALRELYLQNNQLTTIENATLAPLAALELIRIDG 934
              .|.||:|||:|:::.|...:|..:.::.|::|:.|....|.:.|.:...|             
Human   515 --AFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQEL------------- 564

  Fly   935 NRLVTLPIWQMHATHFGTRLKSISLGRNQWSCRCQFLQALTSYVADNALIVQDAQDIYCMAASSG 999
                         .||.:.|..::|.:|.::|.|:. |:...::.|...::.:.:.:.|...|..
Human   565 -------------QHFPSSLAFLNLTQNDFACTCEH-QSFLQWIKDQRQLLVEVERMECATPSDK 615

  Fly  1000 TGSAALEDSSSNSGSLEKRELDFNATGAACTDYYSGGSMLQHGIPESYIPLLAAALALLFLLVVI 1064
            .|...|  |.:.:..:.|..:                     |:         :.|::|.:.||.
Human   616 QGMPVL--SLNITCQMNKTII---------------------GV---------SVLSVLVVSVVA 648

  Fly  1065 AMVFAFRESLRIWLFAHYGVRVFGPRCEESEKLYDAVLLHSAKDSEFVCQHLAAQLETGRPPLRV 1129
            .:|:.|  ...:.|.|  |...:|    ..|.:|||.:::|::|.::|...|...||.|.||.::
Human   649 VLVYKF--YFHLMLLA--GCIKYG----RGENIYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQL 705

  Fly  1130 CLQHRD------LAHDATHYQLLEATRVSRRVVILLTRNFLQTEWARCELR-RSVHDALRGRPQK 1187
            ||.:||      :|.:..|    |....||:|:::::::|:|:.|...|.. ......|..|...
Human   706 CLHYRDFIPGVAIAANIIH----EGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGI 766

  Fly  1188 LVIIEEPEVAFEAESDIELLPYLKTSAVHRIRRS--DRH-FWEKLRYAL 1233
            :.|:.:..........:||...|..:.......|  .|| ||.:||.||
Human   767 IFIVLQKVEKTLLRQQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKAL 815

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-7NP_523797.1 LRR_8 135..201 CDD:290566 11/52 (21%)
leucine-rich repeat 136..159 CDD:275380 1/10 (10%)
leucine-rich repeat 160..190 CDD:275380 6/29 (21%)
LRR_8 189..259 CDD:290566 18/69 (26%)
leucine-rich repeat 191..214 CDD:275380 5/22 (23%)
leucine-rich repeat 215..248 CDD:275380 6/32 (19%)
LRR_RI 247..501 CDD:238064 74/264 (28%)
LRR_8 247..308 CDD:290566 23/63 (37%)
leucine-rich repeat 249..273 CDD:275380 10/23 (43%)
leucine-rich repeat 274..297 CDD:275380 8/22 (36%)
LRR_8 297..356 CDD:290566 21/63 (33%)
leucine-rich repeat 298..321 CDD:275380 7/25 (28%)
leucine-rich repeat 322..345 CDD:275380 7/24 (29%)
LRR_8 345..406 CDD:290566 14/60 (23%)
leucine-rich repeat 346..371 CDD:275380 8/24 (33%)
leucine-rich repeat 372..395 CDD:275380 3/22 (14%)
leucine-rich repeat 396..419 CDD:275380 6/22 (27%)
LRR_8 419..478 CDD:290566 14/58 (24%)
leucine-rich repeat 420..443 CDD:275380 4/22 (18%)
leucine-rich repeat 444..467 CDD:275380 10/22 (45%)
LRR_RI 466..622 CDD:238064 44/197 (22%)
leucine-rich repeat 468..488 CDD:275380 1/19 (5%)
LRR_8 491..549 CDD:290566 17/67 (25%)
leucine-rich repeat 491..514 CDD:275380 8/28 (29%)
leucine-rich repeat 515..536 CDD:275380 6/24 (25%)
leucine-rich repeat 539..562 CDD:275380 5/22 (23%)
leucine-rich repeat 563..585 CDD:275380 6/48 (13%)
leucine-rich repeat 586..626 CDD:275380 14/44 (32%)
leucine-rich repeat 627..653 CDD:275380 5/25 (20%)
LRRCT 716..772 CDD:214507 7/55 (13%)
LRRNT 796..830 CDD:214470 1/33 (3%)
leucine-rich repeat 812..829 CDD:275380 0/16 (0%)
leucine-rich repeat 833..854 CDD:275380 0/20 (0%)
LRR_8 853..913 CDD:290566 13/59 (22%)
leucine-rich repeat 855..878 CDD:275380 3/22 (14%)
LRR_4 878..918 CDD:289563 11/39 (28%)
leucine-rich repeat 879..902 CDD:275380 6/22 (27%)
leucine-rich repeat 903..926 CDD:275380 5/22 (23%)
leucine-rich repeat 927..953 CDD:275380 2/25 (8%)
TIR 1098..1235 CDD:214587 41/146 (28%)
TLR4NP_612564.1 LRR_RI 55..>195 CDD:238064 48/156 (31%)
LRR 1 55..76 6/30 (20%)
leucine-rich repeat 56..79 CDD:275378 6/32 (19%)
LRR_8 57..114 CDD:290566 21/67 (31%)
LRR 2 79..100 10/21 (48%)
leucine-rich repeat 80..103 CDD:275378 10/23 (43%)
LRR_8 102..187 CDD:290566 29/88 (33%)
LRR 3 103..124 6/20 (30%)
leucine-rich repeat 104..127 CDD:275378 8/22 (36%)
LRR 4 127..148 7/20 (35%)
leucine-rich repeat 128..176 CDD:275378 15/51 (29%)
leucine-rich repeat 130..151 CDD:275380 6/23 (26%)
LRR 5 151..172 5/21 (24%)
LRR_RI 152..456 CDD:238064 92/407 (23%)
LRR 6 176..199 7/24 (29%)
leucine-rich repeat 177..190 CDD:275378 5/12 (42%)
leucine-rich repeat 195..224 CDD:275380 10/59 (17%)
LRR 7 205..225 8/50 (16%)
LRR 8 227..247 13/55 (24%)
LRR 9 331..351 5/26 (19%)
LRR 10 352..373 0/20 (0%)
leucine-rich repeat 353..374 CDD:275380 1/20 (5%)
LRR_RI <372..581 CDD:238064 64/396 (16%)
LRR 11 374..394 7/19 (37%)
LRR_8 399..458 CDD:290566 16/82 (20%)
LRR 12 400..422 7/21 (33%)
leucine-rich repeat 401..423 CDD:275380 8/21 (38%)
LRR 13 423..444 4/44 (9%)
leucine-rich repeat 424..448 CDD:275380 5/44 (11%)
LRR_8 447..508 CDD:290566 20/125 (16%)
LRR 14 448..456 3/7 (43%)
leucine-rich repeat 449..472 CDD:275380 4/22 (18%)
LRR 15 472..495 7/38 (18%)
leucine-rich repeat 473..497 CDD:275380 7/39 (18%)
LRR 16 497..518 10/142 (7%)
leucine-rich repeat 498..521 CDD:275380 11/144 (8%)
LRR_8 520..581 CDD:290566 17/86 (20%)
LRR 17 521..542 6/20 (30%)
LRR 18 545..565 5/45 (11%)
leucine-rich repeat 546..570 CDD:275380 7/49 (14%)
LRRCT 579..625 CDD:214507 10/48 (21%)
TIR 674..815 CDD:214587 39/144 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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