DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-7 and Gp1ba

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001103124.1	Gene:	Gp1ba / 691992	RGDID:	1310239	Length:	717	Species:	Rattus norvegicus

Alignment Length:	228	Identity:	70/228 - (30%)
Similarity:	109/228 - (47%)	Gaps:	24/228 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 LTDLDLGDNNLRQLPSGFLCPVGNLQVLNLTRNRI---RTAEQMGFADM------NCGAGSGSAG 246
            |.:::..|..|::||:......|   :|:|::|::   .|:..:.|..:      .|...|..|.
  Rat    28 LLEVNCEDKKLKKLPTDLPADTG---ILHLSKNQLGTFSTSYLVHFTHLTHLYLSRCELTSLQAH 89

  Fly   247 S---ELQVLDASHNELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHL 308
            .   :|:.||.|||.|:|: .|.| ..|..|..|::::|.|..||..||.||..|..:.|.||.|
  Rat    90 EKLLKLETLDLSHNHLQSL-PSLG-RALPALTTLDVSFNKLGSLSPGALEGLGQLEELYLQNNDL 152

  Fly   309 ETLPEGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLI 373
            ::||.||...:.:|.::.|..|:|.|||.||...||.|..:.|.||.|::  :....|..|:...
  Rat   153 KSLPPGLLMPTTKLLKLSLANNKLRELPPGLLDGLEDLDTLYLQGNWLST--IPKGFFGSLLLPF 215

  Fly   374 VLNLAHNALTRIDYRTFKELYFLQILNLRNNSI 406
            |...|:..     |...:.|||...|....|.:
  Rat   216 VFLHANTW-----YCDCEILYFRNWLQENPNRV 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	2/9 (22%)
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566	20/79 (25%)
		leucine-rich repeat	191..214	CDD:275380	5/22 (23%)
		leucine-rich repeat	215..248	CDD:275380	8/44 (18%)
		LRR_RI	247..501	CDD:238064	56/163 (34%)
		LRR_8	247..308	CDD:290566	25/63 (40%)
		leucine-rich repeat	249..273	CDD:275380	11/23 (48%)
		leucine-rich repeat	274..297	CDD:275380	10/22 (45%)
		LRR_8	297..356	CDD:290566	24/58 (41%)
		leucine-rich repeat	298..321	CDD:275380	9/22 (41%)
		leucine-rich repeat	322..345	CDD:275380	10/22 (45%)
		LRR_8	345..406	CDD:290566	15/60 (25%)
		leucine-rich repeat	346..371	CDD:275380	7/24 (29%)
		leucine-rich repeat	372..395	CDD:275380	4/22 (18%)
		leucine-rich repeat	396..419	CDD:275380	2/11 (18%)
		LRR_8	419..478	CDD:290566
		leucine-rich repeat	420..443	CDD:275380
		leucine-rich repeat	444..467	CDD:275380
		LRR_RI	466..622	CDD:238064
		leucine-rich repeat	468..488	CDD:275380
		LRR_8	491..549	CDD:290566
		leucine-rich repeat	491..514	CDD:275380
		leucine-rich repeat	515..536	CDD:275380
		leucine-rich repeat	539..562	CDD:275380
		leucine-rich repeat	563..585	CDD:275380
		leucine-rich repeat	586..626	CDD:275380
		leucine-rich repeat	627..653	CDD:275380
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
Gp1ba	NP_001103124.1	LRRNT	20..49	CDD:214470	5/20 (25%)
		LRR_RI	<50..176	CDD:238064	42/130 (32%)
		LRR_8	51..105	CDD:290566	14/53 (26%)
		leucine-rich repeat	51..72	CDD:275380	5/20 (25%)
		leucine-rich repeat	73..94	CDD:275380	3/20 (15%)
		LRR_8	94..152	CDD:290566	25/59 (42%)
		leucine-rich repeat	95..117	CDD:275380	11/23 (48%)
		leucine-rich repeat	118..141	CDD:275380	10/22 (45%)
		LRR_8	141..198	CDD:290566	22/56 (39%)
		leucine-rich repeat	142..165	CDD:275380	9/22 (41%)
		LRR_4	164..204	CDD:289563	16/41 (39%)
		leucine-rich repeat	166..189	CDD:275380	10/22 (45%)
		leucine-rich repeat	190..211	CDD:275380	6/22 (27%)
		TPKR_C2	221..281	CDD:301599	6/28 (21%)
		TonB_N	404..523	CDD:292650
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100