DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-7 and Tlr8

DIOPT Version :9

Sequence 1:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster
Sequence 2:NP_001094479.1 Gene:Tlr8 / 684440 RGDID:1590327 Length:1029 Species:Rattus norvegicus


Alignment Length:1149 Identity:252/1149 - (21%)
Similarity:420/1149 - (36%) Gaps:349/1149 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   249 LQVLDASHNELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLP- 312
            |...:.:|.:|..:.::.|    :.:..::|:.|.:..::.|:.....:|..:||::|..:..| 
  Rat    41 LVTAECNHRQLHEVPQTIG----KYVTDVDLSDNTIMHITNESFQKFRNLTKINLNHNAKQQHPN 101

  Fly   313 ---------EGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAG 368
                     ||.|...:.|.|:.|:.|:||.:|.||...|::|.::..:..|:|.|:    || |
  Rat   102 ENKNGMNITEGAFLSLRNLTELLLEDNQLYTIPAGLPESLKELSLIQNNIFQVTKNN----TF-G 161

  Fly   369 LIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTL 433
            |..|..|.|..|.            ||      :.|.|..:||.||..|.||..|:|:.|.|.::
  Rat   162 LRNLERLYLGWNC------------YF------KCNQIFKVEDGAFNNLINLKLLSLSFNNLFSV 208

  Fly   434 DDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRALQDLAMLRTLDLGE 498
            ..||.:.   ||||.|:|..||.:....||....|..||||.|    .||.........:.:|..
  Rat   209 PPKLPSS---LSKLFLSNAKISTITQEDFKGLEHLILLDLSGN----CPRCFNAPFPCESCNLSA 266

  Fly   499 NQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFEL 563
            : ||         :|.|.                ||:|.:|..|||:...:::|....||....|
  Rat   267 S-IR---------IHPLA----------------FQNLTQLRFLNLSSTSLRTIPSTWFDNLTNL 305

  Fly   564 EAIRLDRNFLAD--INGVFAT-LVSLLWLNLSEN--HLVWFDYAFIPSN------LKWLDIHGNY 617
            :.:.|:.|:|..  .:|.|.| |.||..|:||.|  |..:..|..|..|      |:.|.:.| |
  Rat   306 KELHLEFNYLVQEIASGAFLTKLPSLQTLDLSFNFIHKEYLQYITISPNFSMLRSLRKLHLKG-Y 369

  Fly   618 IEALGNYYKLQEEIRVKTLDASHNRITEIGPMSIPN--TIELLFINNNLIGNVQPNAFVDKANLA 680
            :     :.:|::| ..|.|            .::||  ||.|   ..|.|..:...||.|..||.
  Rat   370 V-----FRELKKE-HFKPL------------QNLPNLTTINL---GINFIEKIDFKAFQDFPNLK 413

  Fly   681 RVDLYANQLSKLQLQQLRVAPVVAPKPLPEFYLGGNPFECDCT--MDWLQRINNLTTRQHPRVMD 743
            .:.|..|          |:|.|:                 |.|  ..|..|:.            
  Rat   414 VIYLSGN----------RIASVI-----------------DGTDHSSWRNRLR------------ 439

  Fly   744 MANIECVMPHARGAAVRPLSGLRPQDFLCRYESHCFALCHCCDFDACDCEM-----TCP---SNC 800
                            :|||                     .|:|..|..|     |.|   ..|
  Rat   440 ----------------KPLS---------------------TDYDEFDPHMNFYHSTEPLIKPQC 467

  Fly   801 TCYHD--QIWSTNVVDCGGQQTTELPRRVPMDSSVVYLDGN-NFPVLKNHAFIGRKNLRALYVNG 862
            |.|..  .:...|:...|..|....     .|.:.:.|..| |..||....|....:::.|.:..
  Rat   468 TTYGKALDLSLNNIFVIGKSQFEGF-----QDIACLNLSFNANGQVLNGTEFSSMPHIKYLDLTN 527

  Fly   863 SQVAAIQNRTFASLASLQLLHLADN--------------------KLRTLH-----------GYE 896
            :::....|:||:.|..|::|.|:.|                    ||:.|:           .|:
  Rat   528 NRLDFDDNQTFSDLHDLEVLDLSHNAHYFSIAGVTHRLGFIQNLIKLKVLNLSHNGIYTLTDEYK 592

  Fly   897 FEQLSALRELYLQNNQL---------------TTIENATLAPLAALELIRIDGNRLVTLP--IWQ 944
            . |..:|:||....|:|               |::|..|...|:...|.:|.....:.||  :.:
  Rat   593 L-QSKSLKELVFSGNRLDRLWNANDGKYWSIFTSLETLTRLDLSYNNLQQIPNEAFLNLPQSLQE 656

  Fly   945 MHAT------------HFGTRLKSISLGRNQ----WSCRCQFLQALTSYVADN-------ALIVQ 986
            :|..            .:...|..:.||||:    .:|..:|..:|.:.:.::       |..:.
  Rat   657 LHINDNRLRFFNWTLLQYFPHLHVLDLGRNELYFLTNCLSKFTHSLKTLLLNHNHFSHLPAGFLS 721

  Fly   987 DAQDIYCMAASSGT----GSAALEDSSSNSGSLEKRELDFNATGAACT-DYYSGGSMLQHGIPES 1046
            :|:::..:..|..|    ..::|:..:..:.|:    ||.......|| |.....|.|:.. |..
  Rat   722 EARNLVYLDLSFNTIKMINKSSLQTETKTNLSV----LDLQGNHFDCTCDISDFRSWLEEN-PHV 781

  Fly  1047 YIPLLAAAL--------------------------ALLFLL-------VVIAMVFAFRESLRIWL 1078
            .||.|...:                          |:||..       |::|.:........:|.
  Rat   782 RIPRLVDVICSNPGDQRWKSVMSLDLTTCVSDTTAAILFFFTFLTTSTVLLAALVHHLFYWDVWF 846

  Fly  1079 FAHY-GVRVFGPRCEE-SEKLYDAVLLHSAKD---SEFVCQHLAAQLETGR-PPLRVCLQHRDLA 1137
            ..|. ..::.|.|... |:..|||.:.:..||   :::|...|...||... ..:.:||:.||..
  Rat   847 IYHMCSAKLRGYRSSSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESEDKSVLLCLEERDWD 911

  Fly  1138 HDATHY-QLLEATRVSRRVVILLTRNFLQTEWARCELRRSVHDALRGRPQKLVIIEEPEVAFEAE 1201
            ...... .|:::...|::.:.:||:.:.:: |   ..:.:.:.||    |:|:......:.|   
  Rat   912 PGLPIIDNLMQSINQSKKTIFVLTKKYAKS-W---NFKTAFYLAL----QRLMDENMDVIIF--- 965

  Fly  1202 SDIELLPYLKTSAVHRIR---------------RSDRHFWEKLR 1230
              |.|.|.|:.|...|:|               :::..||:.|:
  Rat   966 --ILLEPVLQYSQYLRLRQRICKSSILQWPNNPKAENLFWQSLK 1007

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-7NP_523797.1 LRR_8 135..201 CDD:290566
leucine-rich repeat 136..159 CDD:275380
leucine-rich repeat 160..190 CDD:275380
LRR_8 189..259 CDD:290566 2/9 (22%)
leucine-rich repeat 191..214 CDD:275380
leucine-rich repeat 215..248 CDD:275380
LRR_RI 247..501 CDD:238064 73/261 (28%)
LRR_8 247..308 CDD:290566 11/58 (19%)
leucine-rich repeat 249..273 CDD:275380 4/23 (17%)
leucine-rich repeat 274..297 CDD:275380 3/22 (14%)
LRR_8 297..356 CDD:290566 19/68 (28%)
leucine-rich repeat 298..321 CDD:275380 8/32 (25%)
leucine-rich repeat 322..345 CDD:275380 10/22 (45%)
LRR_8 345..406 CDD:290566 15/60 (25%)
leucine-rich repeat 346..371 CDD:275380 8/24 (33%)
leucine-rich repeat 372..395 CDD:275380 4/22 (18%)
leucine-rich repeat 396..419 CDD:275380 7/22 (32%)
LRR_8 419..478 CDD:290566 24/58 (41%)
leucine-rich repeat 420..443 CDD:275380 7/22 (32%)
leucine-rich repeat 444..467 CDD:275380 10/22 (45%)
LRR_RI 466..622 CDD:238064 45/166 (27%)
leucine-rich repeat 468..488 CDD:275380 8/19 (42%)
LRR_8 491..549 CDD:290566 12/57 (21%)
leucine-rich repeat 491..514 CDD:275380 3/22 (14%)
leucine-rich repeat 515..536 CDD:275380 3/20 (15%)
leucine-rich repeat 539..562 CDD:275380 7/22 (32%)
leucine-rich repeat 563..585 CDD:275380 8/24 (33%)
leucine-rich repeat 586..626 CDD:275380 13/47 (28%)
leucine-rich repeat 627..653 CDD:275380 4/25 (16%)
LRRCT 716..772 CDD:214507 7/57 (12%)
LRRNT 796..830 CDD:214470 7/38 (18%)
leucine-rich repeat 812..829 CDD:275380 2/16 (13%)
leucine-rich repeat 833..854 CDD:275380 6/21 (29%)
LRR_8 853..913 CDD:290566 18/90 (20%)
leucine-rich repeat 855..878 CDD:275380 5/22 (23%)
LRR_4 878..918 CDD:289563 15/85 (18%)
leucine-rich repeat 879..902 CDD:275380 9/53 (17%)
leucine-rich repeat 903..926 CDD:275380 9/37 (24%)
leucine-rich repeat 927..953 CDD:275380 5/39 (13%)
TIR 1098..1235 CDD:214587 33/153 (22%)
Tlr8NP_001094479.1 PRK15370 <21..>218 CDD:185268 55/206 (27%)
leucine-rich repeat 62..85 CDD:275380 3/22 (14%)
leucine-rich repeat 86..119 CDD:275380 8/32 (25%)
leucine-rich repeat 120..140 CDD:275380 9/19 (47%)
PLN00113 141..>664 CDD:215061 160/682 (23%)
leucine-rich repeat 141..164 CDD:275380 9/27 (33%)
leucine-rich repeat 165..194 CDD:275380 13/46 (28%)
leucine-rich repeat 195..215 CDD:275380 7/19 (37%)
leucine-rich repeat 216..239 CDD:275380 10/22 (45%)
leucine-rich repeat 240..280 CDD:275380 16/69 (23%)
leucine-rich repeat 281..304 CDD:275380 7/22 (32%)
leucine-rich repeat 305..324 CDD:275380 5/18 (28%)
leucine-rich repeat 331..387 CDD:275380 17/74 (23%)
leucine-rich repeat 388..411 CDD:275380 8/25 (32%)
leucine-rich repeat 467..494 CDD:275380 6/31 (19%)
leucine-rich repeat 495..510 CDD:275380 4/14 (29%)
leucine-rich repeat 520..543 CDD:275380 5/22 (23%)
leucine-rich repeat 544..573 CDD:275380 4/28 (14%)
leucine-rich repeat 574..597 CDD:275380 4/23 (17%)
leucine-rich repeat 598..628 CDD:275380 6/29 (21%)
PRK15370 <629..>739 CDD:185268 19/109 (17%)
leucine-rich repeat 629..653 CDD:275380 6/23 (26%)
leucine-rich repeat 654..677 CDD:275380 1/22 (5%)
leucine-rich repeat 678..701 CDD:275380 7/22 (32%)
leucine-rich repeat 702..725 CDD:275380 3/22 (14%)
leucine-rich repeat 726..745 CDD:275380 2/18 (11%)
PCC 730..>813 CDD:188093 15/87 (17%)
TIR 868..1004 CDD:214587 31/148 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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