DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-7 and Tril

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_080093.1	Gene:	Tril / 66873	MGIID:	1914123	Length:	809	Species:	Mus musculus

Alignment Length:	296	Identity:	94/296 - (31%)
Similarity:	149/296 - (50%)	Gaps:	15/296 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   270 RLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLPEGLFAGSKELREIHLQQNELYE 334
            ||.:|:.|:|.||.:..|..:....|:.|..:.|.||.|:.|..|..|..::||.::...||:..
Mouse    81 RLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALVPGTLAPLRKLRILYANGNEIGR 145

  Fly   335 LPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQIL 399
            |.:|.|..||.|:.:.|.||.|.:  :.:..||.|..|:.|:|..|.:..:....|.:|..|:.|
Mouse   146 LSRGSFEGLESLVKLRLDGNVLGA--LPDAVFAPLGNLLYLHLESNRIRFLGKNAFSQLGKLRFL 208

  Fly   400 NLRNN----SIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPA 460
            ||..|    |:.|..  .|:||.:|.||.|:.|.|..|..::|..|..|..|:|:.|.::.:.|.
Mouse   209 NLSANELQPSLRHAA--TFVPLRSLSTLILSANSLQHLGPRVFQHLPRLGLLSLSGNQLTHLAPE 271

  Fly   461 VFKNCSDLKELDLSSNQLNEVP-RALQDLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQ 524
            .|.....|:||.|..|:||::| ..|:.|..|..|||..|::......:|.:..:|..|.|.||.
Mouse   272 AFWGLEALRELRLEGNRLNQLPLTLLEPLHSLEALDLSGNELSALHPATFGHQGRLRELSLRDNA 336

  Fly   525 IGNITVGMFQDLPRLSVLNLAKN------RIQSIER 554
            :..::..:|...|.|..|:|..|      |::.::|
Mouse   337 LSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKR 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380
		LRR_RI	247..501	CDD:238064	80/235 (34%)
		LRR_8	247..308	CDD:290566	13/37 (35%)
		leucine-rich repeat	249..273	CDD:275380	2/2 (100%)
		leucine-rich repeat	274..297	CDD:275380	7/22 (32%)
		LRR_8	297..356	CDD:290566	21/58 (36%)
		leucine-rich repeat	298..321	CDD:275380	8/22 (36%)
		leucine-rich repeat	322..345	CDD:275380	8/22 (36%)
		LRR_8	345..406	CDD:290566	19/64 (30%)
		leucine-rich repeat	346..371	CDD:275380	8/24 (33%)
		leucine-rich repeat	372..395	CDD:275380	6/22 (27%)
		leucine-rich repeat	396..419	CDD:275380	10/26 (38%)
		LRR_8	419..478	CDD:290566	20/58 (34%)
		leucine-rich repeat	420..443	CDD:275380	9/22 (41%)
		leucine-rich repeat	444..467	CDD:275380	6/22 (27%)
		LRR_RI	466..622	CDD:238064	29/96 (30%)
		leucine-rich repeat	468..488	CDD:275380	9/20 (45%)
		LRR_8	491..549	CDD:290566	17/63 (27%)
		leucine-rich repeat	491..514	CDD:275380	6/22 (27%)
		leucine-rich repeat	515..536	CDD:275380	6/20 (30%)
		leucine-rich repeat	539..562	CDD:275380	6/22 (27%)
		leucine-rich repeat	563..585	CDD:275380
		leucine-rich repeat	586..626	CDD:275380
		leucine-rich repeat	627..653	CDD:275380
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
Tril	NP_080093.1	LRR_RI	<11..194	CDD:238064	38/114 (33%)
		leucine-rich repeat	37..57	CDD:275378
		LRR 1	61..81		94/296 (32%)
		LRR_8	84..143	CDD:290566	18/58 (31%)
		LRR 2	84..105		6/20 (30%)
		leucine-rich repeat	85..108	CDD:275380	7/22 (32%)
		LRR 3	108..129		7/20 (35%)
		leucine-rich repeat	109..132	CDD:275380	8/22 (36%)
		LRR 4	132..153		7/20 (35%)
		leucine-rich repeat	133..156	CDD:275380	8/22 (36%)
		LRR_8	156..215	CDD:290566	19/60 (32%)
		LRR 5	156..177		6/22 (27%)
		leucine-rich repeat	157..180	CDD:275380	8/24 (33%)
		LRR 6	180..201		5/20 (25%)
		leucine-rich repeat	181..204	CDD:275380	6/22 (27%)
		LRR 7	204..223		7/18 (39%)
		leucine-rich repeat	205..230	CDD:275380	10/26 (38%)
		LRR_RI	229..>364	CDD:238064	42/134 (31%)
		LRR_8	229..289	CDD:290566	20/59 (34%)
		LRR 8	230..251		8/20 (40%)
		leucine-rich repeat	231..254	CDD:275380	9/22 (41%)
		LRR 9	254..275		6/20 (30%)
		leucine-rich repeat	255..278	CDD:275380	6/22 (27%)
		LRR 10	278..298		8/19 (42%)
		leucine-rich repeat	279..302	CDD:275380	10/22 (45%)
		LRR_8	302..359	CDD:290566	16/56 (29%)
		LRR 11	302..323		6/20 (30%)
		leucine-rich repeat	303..323	CDD:275380	6/19 (32%)
		LRR 12	326..347		6/20 (30%)
		leucine-rich repeat	327..350	CDD:275380	6/22 (27%)
		TPKR_C2	359..406	CDD:301599	3/14 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..462
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	483..563
		FN3	587..659	CDD:214495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100