Protein Alignment Toll-7 and Nepn

DIOPT Version :9

• Sequence 1: NP_523797.1
• Gene: Toll-7 / 37272
• FlyBaseID: FBgn0034476
• Length: 1446
• Species: Drosophila melanogaster
• Sequence 2: XP_006512881.1
• Gene: Nepn / 66650
• MGIID: 1913900
• Length: 561
• Species: Mus musculus
• Alignment Length: 499
• Identity: 134/499 - (26%)
• Similarity: 201/499 - (40%)
• Gaps: 108/499 - (21%)

  Fly    79 WSY-------NGTSSVHCALRLIERQPGLDLQGADGSSQLTIQCSELYLFESTLPVAVFARLQTL 136
            |::       ||.|: :|        ||    .....|..::||..|....|.:|       .|.
Mouse    54 WAFLLGLSLTNGLSA-NC--------PG----RCSCDSMQSVQCYRLMELPSGIP-------STT 98

  Fly   137 EALRLDSCKLLQLPNNAFEGLATLKSLRLSTHNSEWGPTRTLELFPDSLGGLKQLTDLDLGDNNL 201
            :.|.:...::..|..:.|.||..|:...|....:|       .:..|:...|..|..|:|..|.|
Mouse    99 KRLYISHSRIQHLQLSNFTGLLALEDFILLASGTE-------SIENDTFKTLSTLKTLELWKNKL 156

  Fly   202 RQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFADMNCGAGSGSAGSELQVLDASHNELRSISESW 266
            ||:||..   ..||:||.|..|.|            |..    .|||.:
Mouse   157 RQVPSAL---PANLEVLKLNDNAI------------CAL----RGSEFE---------------- 186

  Fly   267 GISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETL--PEGLFAGSKELREIHLQQ 329
               .|:.|:.|.|..|.:|.||...|:.||||:.:.:..|::|::  |..|    ..|:.:.::.
Mouse   187 ---GLKNLKVLELKNNLISSLSPSMLSPLASLQSLMVDGNNIESVVGPLSL----PHLKYMSMEN 244

  Fly   330 NELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELY 394
            |:|:.:|..:|..|:.|..:..|||.||...::...     .|:.|.:..|.|..:.:|..|.|.
Mouse   245 NQLHLIPGNVFTSLQNLQFLSFSGNFLTKIPINLPK-----SLLSLKMERNQLKVVRFRDMKHLE 304

  Fly   395 FLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKL---------------------F 438
            .|..|.|..|.:..| |.| ..|.||.||.:::|:|..|..:|                     |
Mouse   305 NLSHLYLSENFLSSI-DGA-QQLTNLTTLEVSQNQLQMLPPRLPSRLQKLDCSSNFIQRVTAPEF 367

  Fly   439 NGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRALQDLAMLRTLDLGENQIRT 503
            ..|..|..|.|:||::|:.|....:.||.|..|.|..|.|..:|..|.  ..|..|||..|.|:.
Mouse   368 QDLRDLKHLFLDNNVVSLFEAGALQRCSQLSNLALEQNLLLSIPLRLP--KTLARLDLKGNAIQD 430

  Fly   504 FDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKN 547
            ...:..::|.||..|.|.:|:|..:.....:.||||..|.|..|
Mouse   431 MAERELRDLKQLQVLNLRNNRISALDFKALEGLPRLRHLYLDGN 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	15/65 (23%)
		leucine-rich repeat	136..159	CDD:275380	5/22 (23%)
		leucine-rich repeat	160..190	CDD:275380	5/29 (17%)
		LRR_8	189..259	CDD:290566	20/69 (29%)
		leucine-rich repeat	191..214	CDD:275380	9/22 (41%)
		leucine-rich repeat	215..248	CDD:275380	8/32 (25%)
		LRR_RI	247..501	CDD:238064	77/276 (28%)
		LRR_8	247..308	CDD:290566	16/60 (27%)
		leucine-rich repeat	249..273	CDD:275380	1/23 (4%)
		leucine-rich repeat	274..297	CDD:275380	9/22 (41%)
		LRR_8	297..356	CDD:290566	16/60 (27%)
		leucine-rich repeat	298..321	CDD:275380	5/24 (21%)
		leucine-rich repeat	322..345	CDD:275380	6/22 (27%)
		LRR_8	345..406	CDD:290566	17/60 (28%)
		leucine-rich repeat	346..371	CDD:275380	6/24 (25%)
		leucine-rich repeat	372..395	CDD:275380	7/22 (32%)
		leucine-rich repeat	396..419	CDD:275380	8/22 (36%)
		LRR_8	419..478	CDD:290566	23/79 (29%)
		leucine-rich repeat	420..443	CDD:275380	9/43 (21%)
		leucine-rich repeat	444..467	CDD:275380	8/22 (36%)
		LRR_RI	466..622	CDD:238064	28/82 (34%)
		leucine-rich repeat	468..488	CDD:275380	7/19 (37%)
		LRR_8	491..549	CDD:290566	20/57 (35%)
		leucine-rich repeat	491..514	CDD:275380	7/22 (32%)
		leucine-rich repeat	515..536	CDD:275380	5/20 (25%)
		leucine-rich repeat	539..562	CDD:275380	4/9 (44%)
		leucine-rich repeat	563..585	CDD:275380
		leucine-rich repeat	586..626	CDD:275380
		leucine-rich repeat	627..653	CDD:275380
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
Nepn	XP_006512881.1	leucine-rich repeat	101..121	CDD:275380	5/19 (26%)
		leucine-rich repeat	122..145	CDD:275380	5/29 (17%)
		leucine-rich repeat	146..166	CDD:275380	9/22 (41%)
		PRK15370	<148..>367	CDD:185268	71/267 (27%)
		leucine-rich repeat	167..190	CDD:275380	11/57 (19%)
		leucine-rich repeat	191..214	CDD:275380	9/22 (41%)
		leucine-rich repeat	215..236	CDD:275380	5/24 (21%)
		leucine-rich repeat	237..260	CDD:275380	6/22 (27%)
		leucine-rich repeat	261..305	CDD:275380	13/48 (27%)
		PRK15370	<271..>474	CDD:185268	62/211 (29%)
		leucine-rich repeat	282..297	CDD:275380	4/14 (29%)
		leucine-rich repeat	306..327	CDD:275380	8/22 (36%)
		leucine-rich repeat	328..348	CDD:275380	7/19 (37%)
		leucine-rich repeat	349..372	CDD:275380	2/22 (9%)
		leucine-rich repeat	373..396	CDD:275380	8/22 (36%)
		leucine-rich repeat	397..420	CDD:275380	8/24 (33%)
		leucine-rich repeat	421..441	CDD:275380	6/19 (32%)
		leucine-rich repeat	442..465	CDD:275380	6/22 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100