DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-7 and Hmcn2

DIOPT Version :9

Sequence 1:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster
Sequence 2:XP_006498564.1 Gene:Hmcn2 / 665700 MGIID:2677838 Length:5092 Species:Mus musculus


Alignment Length:1866 Identity:344/1866 - (18%)
Similarity:536/1866 - (28%) Gaps:733/1866 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 AVESALAPKESESSASAMLGAGTG-AAATVSLSGDYSSLLSNVPAASPVPANPSQPSG-PANQCS 78
            :||..:.|:       .::..|.| ..|||..|.|.                |.|.|| |.....
Mouse  1723 SVEMQVPPQ-------LLVAEGMGQVTATVGQSLDL----------------PCQASGSPVPTIQ 1764

  Fly    79 WSYNGTSSVHCALRLIERQPGLDLQGADGSSQLTI-QCSELYLFES------------TLPVAVF 130
            |..||             :|..:|.|...:||.|| ..|.:.|..|            |....|.
Mouse  1765 WLQNG-------------RPAEELAGVQLASQGTILHISHVELNHSGLFACQATNEAGTAGAEVE 1816

  Fly   131 ARLQTLEALRLDSCKLLQLPNNAFEGLATLKSLRLSTHNSEWGPTRTLELFPDSL-----GGLKQ 190
            ..:..|.::.:...:.|..|   |....||:.:.:..      ||.:|..:.|.:     ||..|
Mouse  1817 VSVHELPSVHIIGGENLTAP---FLQPVTLQCVGIGV------PTPSLRWWKDGVAVATSGGNLQ 1872

  Fly   191 LTDLDLGDNNLRQLPSGFLCPVGN----------LQVL---NL---------TRNRIRTAEQMGF 233
            :...||.|..:      :.|...|          |:||   |:         ..|...|.|.:..
Mouse  1873 IEKADLRDEGV------YTCSATNLAGESKKDVTLKVLVPPNIEPGPVNKVVLENASVTLECLAS 1931

  Fly   234 A----DMNCGAGSGSAGSELQVLDAS-----HNELRSISES-----------------WGISRLR 272
            .    |::...|.....::.:|:.::     |.|...:|::                 :|: |:.
Mouse  1932 GVPPPDVSWFKGRQPISTQRRVIVSADGRVLHIERVQLSDAGSYRCVATNVAGSAGLKYGL-RVN 1995

  Fly   273 RLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETL----------PEGL-----FAGSKEL 322
            ....:.|..|    |.|..|.|.......|.:.....||          |||:     |.|.:.|
Mouse  1996 VPPRITLPPN----LPGPVLLGTPFRLTCNATGTPRPTLIWLKDGNPVSPEGIPGLKVFPGGQVL 2056

  Fly   323 -------------------------REIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHV- 361
                                     |::.||   ::..|..|...|...:||:.|......:|. 
Mouse  2057 TVASARASDSGSYSCVAVSAVGEDRRDVILQ---VHMPPSILGEELNMSVVVNESVTLECQSHAV 2118

  Fly   362 ---------DNTTF---AGLIRLIVLNLAHNALTRIDYRTFKEL--YFLQILNLRNNSIGHIEDN 412
                     |....   .| |||    .|..||..:|.....:.  |..:.:|....|..|    
Mouse  2119 PPPVLRWQKDGRPLEPHPG-IRL----SADKALLEVDRAAVWDAGHYTCEAINQAGRSEKH---- 2174

  Fly   413 AFLPLYNLH-------------TLNLAENRLHTLD------------------------DKLFNG 440
                 :|||             ||.:.|.:...|.                        |.|...
Mouse  2175 -----FNLHVWVPPAFPSKEPYTLTVTEGQTARLSCDCQGIPFPKISWRKDGQPLPGEGDSLEQV 2234

  Fly   441 LYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLN-----EVPRALQDLAMLRTLDLGENQ 500
            |.| .:|.......|..|......||:..........|.     :|....:.|..:..:..|...
Mouse  2235 LAV-GRLLYLGQAQSAQEGTYTCECSNAAGTSSQEQSLEVLVPPQVTGLWEPLTTVSVIQDGNTT 2298

  Fly   501 IRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLN--LAKNRIQSIERGSFDKNFEL 563
            :..  |.:.|.|..:|..|  |.|..::..|:     ||...|  |...|.|:...|.:....|.
Mouse  2299 LAC--NATGKPLPVVTWQR--DGQPVSVEPGL-----RLQNQNHSLHVERAQASHAGGYSCVAEN 2354

  Fly   564 EAIRLDRNF--------------------LADINGVFATLVSLLWLNLSENHLVWFDYAFIPS-N 607
            .|.|.:|.|                    .|.::|.|..|.               :.|.:|: .
Mouse  2355 TAGRAERRFALSVLAPPHLTGDSDSLTNVTATLHGSFTLLC---------------EAAGVPAPT 2404

  Fly   608 LKWLD-------IHGNYIEALGNYYKL---QEEIR-----VKTLDASHNR----ITEIGPMSIPN 653
            ::|..       ..|.|:.|.|...|:   ||:.|     :.:.:|...|    :..:.|.||.|
Mouse  2405 VQWFQEGQPISPREGTYLLAGGWMLKMTQAQEQDRGLYSCLASNEAGEARRNFSVEVLVPPSIEN 2469

  Fly   654 -------------TIELLFINNNLIGNVQPNA------------------------FVDKANLAR 681
                         |.:|   ..|..|:..|..                        ::.:|||:.
Mouse  2470 EDLEEVIKVPEGQTAQL---ECNATGHPPPKVTWFKDGQSLTVEDPYEMSPDGAFLWIPQANLSN 2531

  Fly   682 VDLYA-------------NQLSKLQLQQLRVAP----------------------VVAPKPLPEF 711
            ...|:             .|||.|.:..:...|                      :..|.|...:
Mouse  2532 AGHYSCIASNAVGEKTKHTQLSVLVVPTILGVPEKNANEEVTVTINNPISLICEALAFPSPNITW 2596

  Fly   712 YLGGNPFECDCTMDWLQRINNLTTRQHPRVMDMANIECVMPHARGAAVR---------------- 760
            ...|:|||....:..|...:.|.. .:.:..|.....||:.:..|.|.:                
Mouse  2597 MKDGSPFEASKNIQLLPGTHGLQI-LNAQKEDAGQYTCVVTNELGEATKNYHVEVLIPPSISKDD 2660

  Fly   761 PLSGLRPQDFLCRYESHCFALCHCCDFDACDCEMTCPSNCTCYHD-------------------Q 806
            ||..:..::...:..|....        .|:|..|.|.:.:.|.|                   |
Mouse  2661 PLGEVSVKEVKTKVNSSLTL--------ECECWATPPPSISWYKDGRPVTPSHRLSVLGEGRLLQ 2717

  Fly   807 IWSTNVVDCGGQQTTELPRRVPMDSSVVYLDGNNFPVLKNHAFIGRKNLRALYVNGSQVAAIQNR 871
            |..|.|.|.|        |.:.:.::|...|..:|.||                  .||..:   
Mouse  2718 IQPTQVSDSG--------RYLCVATNVAGEDDQDFNVL------------------IQVPPM--- 2753

  Fly   872 TFASLASLQLLHLADNKLRTL-HGYEFE-QLSALRE--------LYLQNN-----QLTTIENATL 921
                   .|.:...|.....| |..|.: :::..||        ||...|     :||.....  
Mouse  2754 -------FQKMGDVDAGFEPLPHEEEAQGRVTEYREIVENNPAYLYCDTNAIPPPELTWYREG-- 2809

  Fly   922 APLAALELIRI-DGNRLVTLPIWQMHATHFGTRLKSISLGRNQWSCRC----------QFLQALT 975
            .||:|.:.:.: .|.|::.||:.|..           ..||  :||:.          ..|..||
Mouse  2810 QPLSAADGVSVLQGGRILQLPLVQAE-----------DAGR--YSCKAANEVGEDWLHYELLVLT 2861

  Fly   976 SYVADNALIVQDAQDIYCMAASSGTGSAALEDSSSNSGSLEKRELDFNATGAACTDYYSGGSMLQ 1040
            ..|     |..|.|::             :|:.:.|:.|....|.......|....::      |
Mouse  2862 PPV-----IPGDTQEL-------------VEEVTVNASSAVSLECPALGNPAPAVSWF------Q 2902

  Fly  1041 HGIPESYIPLLAAALALLFLLVVIAMVFAFRESLRIWLFAHYGVRVFGPRCEESEKLYDAVLLHS 1105
            :|:|.|..|.|........|.|..|.|..         .|.| :.|...:...:|||:...:...
Mouse  2903 NGLPVSPSPRLQVLEEGQVLKVATAEVAD---------AASY-MCVAENQAGSAEKLFTLKVQVP 2957

  Fly  1106 AKDSEFVCQHLAAQLETGRPPLRVCLQHRDLAH---DATHYQLLEATRVSRRVVILLTRNFLQTE 1167
            .:.|::....|.|.|.:.     |.|.....||   :.|.|:                       
Mouse  2958 PQISDWTTSQLTATLNSS-----VSLPCEVYAHPNPEVTWYK----------------------- 2994

  Fly  1168 WARCELRRSVHDALRGRPQKLVIIEEPEVAFEAESDIELLPYLKTSAVHRIRRSDRHFWEKLRYA 1232
                          .|:|..|     .:.||       |||     ..|.:|         |..|
Mouse  2995 --------------DGQPLSL-----GQEAF-------LLP-----GTHTLR---------LARA 3019

  Fly  1233 LPVDYPTF-------RGNNYTL-ELDHHNHERVKQPASPGLLYRQAPPPAYCGPADAVGIGAVPQ 1289
            .|.|..|:       .|.:..: :|:      |..|.|    ::|||.    ||.:|:.:.|..:
Mouse  3020 QPADSGTYLCEALNAAGRDQKMVQLN------VLVPPS----FKQAPG----GPQEAIQVRAGDK 3070

  Fly  1290 VVPVNASVPAEQNYSTATTATPSP--------RPQRRGEQPGSGSGGNHHLHAQYYQHHGMRPPS 1346
            .:           .|..|.:.|.|        :|...|::.....||      |..:....:...
Mouse  3071 AI-----------LSCETDSLPEPAVTWFKDQQPLALGQRIQGLQGG------QTLEILDSQASD 3118

  Fly  1347 EHIYSSIDSDYSTLDNEQHMLMMPGAPGGLAMEAAQR-----------------------AQTW- 1387
            :.:||...|:.:.......:|.:...|   ..|..:|                       ..|| 
Mouse  3119 KGVYSCKVSNTAGEAIRTFVLAIQVPP---TFEKPERETVNQVAGRTLVLACDVSGIPAPTVTWL 3180

  Fly  1388 ----------------RPKREQL-HLQQAQAGTLGSKASQA------------------------ 1411
                            |..|.|| |||.|||||....|..|                        
Mouse  3181 KDRLPVESSVVHGVVSRGGRLQLSHLQPAQAGTYTCVAENAQAEARKDFVVSVLVPPQIQDSGMA 3245

  Fly  1412 -AHQQQQQQQ----QQQQQQPNPT-------AVSGQQQGPHVQAYL 1445
             .|...::|:    .:.:.||.|.       .:..|..|||::.||
Mouse  3246 QEHNVLEKQEIRLHCEAEGQPPPDITWLKDGGLLDQHVGPHLRFYL 3291

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-7NP_523797.1 LRR_8 135..201 CDD:290566 16/70 (23%)
leucine-rich repeat 136..159 CDD:275380 4/22 (18%)
leucine-rich repeat 160..190 CDD:275380 7/34 (21%)
LRR_8 189..259 CDD:290566 17/100 (17%)
leucine-rich repeat 191..214 CDD:275380 4/22 (18%)
leucine-rich repeat 215..248 CDD:275380 9/48 (19%)
LRR_RI 247..501 CDD:238064 64/372 (17%)
LRR_8 247..308 CDD:290566 13/82 (16%)
leucine-rich repeat 249..273 CDD:275380 6/45 (13%)
leucine-rich repeat 274..297 CDD:275380 6/22 (27%)
LRR_8 297..356 CDD:290566 18/98 (18%)
leucine-rich repeat 298..321 CDD:275380 8/37 (22%)
leucine-rich repeat 322..345 CDD:275380 7/47 (15%)
LRR_8 345..406 CDD:290566 15/75 (20%)
leucine-rich repeat 346..371 CDD:275380 6/37 (16%)
leucine-rich repeat 372..395 CDD:275380 5/24 (21%)
leucine-rich repeat 396..419 CDD:275380 3/22 (14%)
LRR_8 419..478 CDD:290566 16/95 (17%)
leucine-rich repeat 420..443 CDD:275380 9/59 (15%)
leucine-rich repeat 444..467 CDD:275380 4/22 (18%)
LRR_RI 466..622 CDD:238064 35/190 (18%)
leucine-rich repeat 468..488 CDD:275380 2/24 (8%)
LRR_8 491..549 CDD:290566 13/59 (22%)
leucine-rich repeat 491..514 CDD:275380 4/22 (18%)
leucine-rich repeat 515..536 CDD:275380 5/20 (25%)
leucine-rich repeat 539..562 CDD:275380 6/24 (25%)
leucine-rich repeat 563..585 CDD:275380 8/41 (20%)
leucine-rich repeat 586..626 CDD:275380 7/47 (15%)
leucine-rich repeat 627..653 CDD:275380 8/37 (22%)
LRRCT 716..772 CDD:214507 12/71 (17%)
LRRNT 796..830 CDD:214470 10/52 (19%)
leucine-rich repeat 812..829 CDD:275380 4/16 (25%)
leucine-rich repeat 833..854 CDD:275380 5/20 (25%)
LRR_8 853..913 CDD:290566 12/74 (16%)
leucine-rich repeat 855..878 CDD:275380 2/22 (9%)
LRR_4 878..918 CDD:289563 12/54 (22%)
leucine-rich repeat 879..902 CDD:275380 5/24 (21%)
leucine-rich repeat 903..926 CDD:275380 9/35 (26%)
leucine-rich repeat 927..953 CDD:275380 5/26 (19%)
TIR 1098..1235 CDD:214587 22/139 (16%)
Hmcn2XP_006498564.1 vWFA 38..196 CDD:238119
Ig 445..511 CDD:319273
IG 525..605 CDD:214652
I-set 609..693 CDD:369462
IG 707..783 CDD:214652
IG_like 793..876 CDD:214653
I-set 889..969 CDD:369462
Ig 992..1058 CDD:386229
IG 1076..1157 CDD:214652
Ig 1161..1242 CDD:386229
Ig 1262..1336 CDD:386229
I-set 1345..1429 CDD:369462
I-set 1449..1523 CDD:369462
IG 1553..1633 CDD:214652
IGc2 1654..1716 CDD:197706
Ig 1741..1819 CDD:386229 25/106 (24%)
Ig 1839..1903 CDD:386229 15/75 (20%)
I-set 1907..1986 CDD:369462 10/78 (13%)
Ig_3 1998..2073 CDD:372822 15/78 (19%)
Ig 2092..2179 CDD:386229 22/100 (22%)
Ig 2183..2273 CDD:386229 14/90 (16%)
Ig 2291..2367 CDD:386229 21/84 (25%)
IGc2 2389..2451 CDD:197706 14/76 (18%)
I-set 2476..2554 CDD:369462 11/80 (14%)
I-set 2558..2650 CDD:369462 14/92 (15%)
I-set 2668..2740 CDD:369462 15/87 (17%)
Ig 2782..2859 CDD:386229 19/91 (21%)
I-set 2876..2954 CDD:369462 20/93 (22%)
I-set 2966..3046 CDD:369462 26/153 (17%)
I-set 3050..3141 CDD:369462 21/115 (18%)
Ig 3145..3233 CDD:386229 19/90 (21%)
Ig 3256..3320 CDD:319273 9/36 (25%)
Ig 3347..3422 CDD:386229
IG_like 3436..3511 CDD:214653
IGc2 3530..3592 CDD:197706
Ig 3614..3695 CDD:386229
I-set 3699..3786 CDD:369462
Ig 3789..3874 CDD:386229
Ig 3900..3967 CDD:319273
I-set 3974..4060 CDD:369462
Ig 4064..4151 CDD:386229
I-set 4155..4240 CDD:369462
IGc2 4259..4321 CDD:197706
I-set 4335..4421 CDD:369462
G2F 4423..4605 CDD:369383
FXa_inhibition 4664..4699 CDD:373209
EGF_CA 4701..4744 CDD:311536
EGF_CA 4746..4783 CDD:214542
EGF_CA 4789..4829 CDD:214542
EGF_CA 4896..4935 CDD:214542
EGF_CA 4936..4974 CDD:214542
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

Return to query results.
Submit another query.