DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-7 and lgi3

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001034768.1	Gene:	lgi3 / 654830	ZFINID:	ZDB-GENE-060217-4	Length:	551	Species:	Danio rerio

Alignment Length:	426	Identity:	96/426 - (22%)
Similarity:	153/426 - (35%)	Gaps:	107/426 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   368 GLIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHT 432
            |:|.|.::|.   |.|.|....|..::.||.|.|.:|:...|.|:||..|.:|..|.:..|.:..
Zfish    67 GIISLTMVNA---AFTEIPEGAFSHMHLLQFLLLNSNTFSVISDDAFSGLGHLQYLFIENNDIQA 128

  Fly   433 LDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRALQDLAMLRTLDLG 497
            |....|.||..|:.|:|:||.:.|:...:||:...|.:|||..|...      .|..:...:|..
Zfish   129 LSKHTFRGLKSLTHLSLSNNNLQVLPRELFKHLDILTDLDLRGNSFR------CDCKIKWLVDWM 187

  Fly   498 ENQ---------IRTFDNQSFKNLHQLT--GLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQS 551
            |..         ...|:.|. :.:|:||  ....|...........||.|              |
Zfish   188 EKTNTSVPPIYCASPFEFQG-RRIHELTPRDFNCISADFAVYETYSFQSL--------------S 237

  Fly   552 IERGSFDKN----FELEAIRLDRNFLAD-INGVFATLVSLLWLNLSENHLVWFDYAFIPSNLKWL 611
            :|...|..:    |......:...|:.| :|.:|.|     ..|::....|:.....|.:.|..:
Zfish   238 VESYEFQDDQYVVFAQPNTGICTVFIWDHVNMLFKT-----HYNITSRSAVYCKPVVINNTLYMV 297

  Fly   612 DIH---GNYIEALGNYYKLQE-EIR-VKTLDASHNRITEIGPMSIPNTIELLFINNNLIGNVQPN 671
            ...   |::|      ||.:: .:| ||..|....|:.:      ||.||...|..:..     .
Zfish   298 VAQLFGGSHI------YKWEDGPLRFVKIQDIDTTRVRK------PNFIETFQIEGDWY-----F 345

  Fly   672 AFVDKANLARVDLYA-NQLSKLQLQQLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQ-----RI 730
            |.||.:......||. |.......|.|                  :|:..|..:|:|:     |:
Zfish   346 AVVDSSKAGSTSLYRWNSNGFYSHQSL------------------HPWHRDTHIDFLEVDGKPRL 392

  Fly   731 N-------------NLTTRQ---HPRVMDMANIECV 750
            .             |.:.||   |.::.|..:::.|
Zfish   393 ILSSASQPPVVYQWNRSQRQFVFHSQITDSGDVQMV 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380
		LRR_RI	247..501	CDD:238064	41/141 (29%)
		LRR_8	247..308	CDD:290566
		leucine-rich repeat	249..273	CDD:275380
		leucine-rich repeat	274..297	CDD:275380
		LRR_8	297..356	CDD:290566
		leucine-rich repeat	298..321	CDD:275380
		leucine-rich repeat	322..345	CDD:275380
		LRR_8	345..406	CDD:290566	13/37 (35%)
		leucine-rich repeat	346..371	CDD:275380	1/2 (50%)
		leucine-rich repeat	372..395	CDD:275380	6/22 (27%)
		leucine-rich repeat	396..419	CDD:275380	10/22 (45%)
		LRR_8	419..478	CDD:290566	20/58 (34%)
		leucine-rich repeat	420..443	CDD:275380	7/22 (32%)
		leucine-rich repeat	444..467	CDD:275380	8/22 (36%)
		LRR_RI	466..622	CDD:238064	32/174 (18%)
		leucine-rich repeat	468..488	CDD:275380	5/19 (26%)
		LRR_8	491..549	CDD:290566	11/68 (16%)
		leucine-rich repeat	491..514	CDD:275380	4/31 (13%)
		leucine-rich repeat	515..536	CDD:275380	5/22 (23%)
		leucine-rich repeat	539..562	CDD:275380	3/26 (12%)
		leucine-rich repeat	563..585	CDD:275380	5/22 (23%)
		leucine-rich repeat	586..626	CDD:275380	6/42 (14%)
		leucine-rich repeat	627..653	CDD:275380	5/27 (19%)
		LRRCT	716..772	CDD:214507	11/56 (20%)
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
lgi3	NP_001034768.1	LRR_8	92..150	CDD:290566	22/57 (39%)
		leucine-rich repeat	92..115	CDD:275378	10/22 (45%)
		LRR_4	115..>150	CDD:289563	12/34 (35%)
		leucine-rich repeat	116..139	CDD:275378	7/22 (32%)
		LRR	137..160	CDD:197688	8/22 (36%)
		leucine-rich repeat	140..163	CDD:275378	8/22 (36%)
		leucine-rich repeat	164..176	CDD:275378	5/17 (29%)
		LRRCT	172..220	CDD:214507	9/54 (17%)
		EPTP	224..265	CDD:281697	8/54 (15%)
		EPTP	271..311	CDD:281697	10/50 (20%)
		EPTP	316..362	CDD:281697	15/56 (27%)
		EPTP	365..407	CDD:281697	7/59 (12%)
		EPTP	412..454	CDD:281697	4/17 (24%)
		EPTP	457..498	CDD:281697
		EPTP	503..543	CDD:281697
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000