DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-7 and LRRN1

DIOPT Version :9

Sequence 1:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster
Sequence 2:NP_001311117.1 Gene:LRRN1 / 57633 HGNCID:20980 Length:716 Species:Homo sapiens


Alignment Length:859 Identity:184/859 - (21%)
Similarity:303/859 - (35%) Gaps:281/859 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   143 SCKLLQLPNNAFEGLATLKSLRLSTHNSEWGPTRTLELFP--DSLGGLKQLTDLDLGDNNLRQLP 205
            :|:|:.       ||........|..|||.......|:.|  ......::.|.:|..|..|.::|
Human    10 ACQLVL-------GLLMTSLTESSIQNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIP 67

  Fly   206 SGFLCPVGNLQVLNLTRNRI-RTAEQMGFADMNCGAGSGSAGSELQVLDASHNELRSISESWGIS 269
            |..   ..:.|||.|..|.| :|.:::            .....|..||.|.|...:|.|. |::
Human    68 SNL---SSDTQVLLLQSNNIAKTVDEL------------QQLFNLTELDFSQNNFTNIKEV-GLA 116

  Fly   270 RLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLPEGLFAGSKELREIHLQQNELYE 334
            .|.:|..|:|..|.::|::...|..|::|:.:.:::|.:.|:....|||.|.|..:||..|:   
Human   117 NLTQLTTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNK--- 178

  Fly   335 LPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQIL 399
                                                           |..||.|.|.....|:||
Human   179 -----------------------------------------------LKVIDSRWFDSTPNLEIL 196

  Fly   400 NLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKN 464
            .:..|.:..|.|..|.||.||.:|.||             |:|:..  ...|.|:.:        
Human   197 MIGENPVIGILDMNFKPLANLRSLVLA-------------GMYLTD--IPGNALVGL-------- 238

  Fly   465 CSDLKELDLSSNQLNEVPR-ALQDLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGN- 527
             ..|:.|....|:|.:||: |||.:..|:.|||.:|.|.......|||:.:|..|.:  |.:|. 
Human   239 -DSLESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGI--NNMGEL 300

  Fly   528 ITVGMF--QDLPRLSVLNLAKN-RIQSIERGSFDKNFELEAIRLDRNFLADINGVFATLVSLLWL 589
            ::|..:  .:||.|:.|....| ::..|.|.:|.....||::.|:.|.|   |.::...|..|  
Human   301 VSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNAL---NAIYQKTVESL-- 360

  Fly   590 NLSENHLVWFDYAFIPSNLKWLDIHGN-------------------YIEALGNY------YKLQE 629
                            .||:.:.||.|                   ::|.|..:      ||..:
Human   361 ----------------PNLREISIHSNPLRCDCVIHWINSNKTNIRFMEPLSMFCAMPPEYKGHQ 409

  Fly   630 EIRVKTLDASHNRITEIGPMSIPNTIELLFINNNLIGNVQPNAFVDKANLARVDLYANQLSKLQL 694
            ...|...|:|...:..|...|.||.:.:         ::....|:|...:|              
Human   410 VKEVLIQDSSEQCLPMISHDSFPNRLNV---------DIGTTVFLDCRAMA-------------- 451

  Fly   695 QQLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQRINNLTTRQ---------HPRVMDMANIE-- 748
                       :|.||.|             |:..|.|..|.:         ....::::||:  
Human   452 -----------EPEPEIY-------------WVTPIGNKITVETLSDKYKLSSEGTLEISNIQIE 492

  Fly   749 ------CVMPHARGAAVRP---------LSGLRP-QDFLCRYESHCFALCHCCDFDACDCEMTCP 797
                  ||..:.:||..|.         |.|.:. :.::.:.|||...:....:.:.    ||  
Human   493 DSGRYTCVAQNVQGADTRVATIKVNGTLLDGTQVLKIYVKQTESHSILVSWKVNSNV----MT-- 551

  Fly   798 SNCTCYHDQIWSTNVVDCGGQQTTELPRRVPMD---SSVVYLD-GNNFPV--------------- 843
            ||..      ||:..:.......| ...|||:|   .::.:|. ..::.|               
Human   552 SNLK------WSSATMKIDNPHIT-YTARVPVDVHEYNLTHLQPSTDYEVCLTVSNIHQQTQKSC 609

  Fly   844 ----LKNHAFIGRKNLRALYVNGSQ----VAAIQNRTFA--SLASLQLLHLADNKLRTLHG--YE 896
                .||.||       |:.::..:    :||:....||  ||||:.:......|.:..|.  .:
Human   610 VNVTTKNAAF-------AVDISDQETSTALAAVMGSMFAVISLASIAVYFAKRFKRKNYHHSLKK 667

  Fly   897 FEQLSA---LRELY 907
            :.|.::   |.|||
Human   668 YMQKTSSIPLNELY 681

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-7NP_523797.1 LRR_8 135..201 CDD:290566 13/59 (22%)
leucine-rich repeat 136..159 CDD:275380 4/15 (27%)
leucine-rich repeat 160..190 CDD:275380 6/31 (19%)
LRR_8 189..259 CDD:290566 18/70 (26%)
leucine-rich repeat 191..214 CDD:275380 6/22 (27%)
leucine-rich repeat 215..248 CDD:275380 7/33 (21%)
LRR_RI 247..501 CDD:238064 64/254 (25%)
LRR_8 247..308 CDD:290566 18/60 (30%)
leucine-rich repeat 249..273 CDD:275380 9/23 (39%)
leucine-rich repeat 274..297 CDD:275380 7/22 (32%)
LRR_8 297..356 CDD:290566 11/58 (19%)
leucine-rich repeat 298..321 CDD:275380 6/22 (27%)
leucine-rich repeat 322..345 CDD:275380 4/22 (18%)
LRR_8 345..406 CDD:290566 9/60 (15%)
leucine-rich repeat 346..371 CDD:275380 0/24 (0%)
leucine-rich repeat 372..395 CDD:275380 5/22 (23%)
leucine-rich repeat 396..419 CDD:275380 9/22 (41%)
LRR_8 419..478 CDD:290566 12/58 (21%)
leucine-rich repeat 420..443 CDD:275380 5/22 (23%)
leucine-rich repeat 444..467 CDD:275380 2/22 (9%)
LRR_RI 466..622 CDD:238064 45/179 (25%)
leucine-rich repeat 468..488 CDD:275380 9/20 (45%)
LRR_8 491..549 CDD:290566 19/61 (31%)
leucine-rich repeat 491..514 CDD:275380 9/22 (41%)
leucine-rich repeat 515..536 CDD:275380 5/23 (22%)
leucine-rich repeat 539..562 CDD:275380 6/23 (26%)
leucine-rich repeat 563..585 CDD:275380 6/21 (29%)
leucine-rich repeat 586..626 CDD:275380 8/64 (13%)
leucine-rich repeat 627..653 CDD:275380 5/25 (20%)
LRRCT 716..772 CDD:214507 13/82 (16%)
LRRNT 796..830 CDD:214470 8/33 (24%)
leucine-rich repeat 812..829 CDD:275380 3/16 (19%)
leucine-rich repeat 833..854 CDD:275380 6/40 (15%)
LRR_8 853..913 CDD:290566 16/66 (24%)
leucine-rich repeat 855..878 CDD:275380 7/28 (25%)
LRR_4 878..918 CDD:289563 8/35 (23%)
leucine-rich repeat 879..902 CDD:275380 3/24 (13%)
leucine-rich repeat 903..926 CDD:275380 4/5 (80%)
leucine-rich repeat 927..953 CDD:275380
TIR 1098..1235 CDD:214587
LRRN1NP_001311117.1 LRR_RI 13..273 CDD:238064 85/356 (24%)
leucine-rich repeat 54..73 CDD:275380 6/21 (29%)
LRR 1 73..95 7/33 (21%)
leucine-rich repeat 74..96 CDD:275380 7/33 (21%)
LRR 2 96..117 8/21 (38%)
leucine-rich repeat 97..120 CDD:275380 9/23 (39%)
LRR_8 119..179 CDD:290566 18/109 (17%)
LRR 3 120..141 6/20 (30%)
leucine-rich repeat 121..144 CDD:275380 7/22 (32%)
LRR 4 144..165 4/20 (20%)
leucine-rich repeat 145..168 CDD:275380 6/22 (27%)
LRR 5 168..189 9/70 (13%)
leucine-rich repeat 169..192 CDD:275380 9/72 (13%)
LRR 6 192..213 7/20 (35%)
leucine-rich repeat 193..216 CDD:275380 9/22 (41%)
LRR_8 216..275 CDD:290566 23/82 (28%)
LRR 7 216..237 9/35 (26%)
leucine-rich repeat 217..240 CDD:275380 8/46 (17%)
LRR_RI 240..>376 CDD:238064 44/158 (28%)
LRR 8 240..261 8/20 (40%)
leucine-rich repeat 241..264 CDD:275380 9/22 (41%)
LRR_8 263..323 CDD:290566 18/61 (30%)
LRR 9 264..285 7/20 (35%)
leucine-rich repeat 265..288 CDD:275380 9/22 (41%)
leucine-rich repeat 289..313 CDD:275380 6/25 (24%)
LRR_8 312..373 CDD:290566 20/81 (25%)
LRR 10 313..335 6/21 (29%)
leucine-rich repeat 314..335 CDD:275380 6/20 (30%)
LRR 11 338..359 7/23 (30%)
leucine-rich repeat 339..362 CDD:275378 8/43 (19%)
leucine-rich repeat 363..375 CDD:275378 4/11 (36%)
LRRCT 371..419 CDD:214507 7/47 (15%)
I-set 429..516 CDD:254352 21/133 (16%)
Ig 431..516 CDD:299845 20/131 (15%)
fn3 531..600 CDD:278470 16/81 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 691..716
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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