DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and lingo3a

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001076323.1	Gene:	lingo3a / 567293	ZFINID:	ZDB-GENE-060503-54	Length:	605	Species:	Danio rerio

Alignment Length:	565	Identity:	144/565 - (25%)
Similarity:	215/565 - (38%)	Gaps:	141/565 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 GAGSGSAGSELQVLDASHNELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNL 303
            |:..|...::.::||.|.|.||.: |...:|.|.||:.|:|:.|.:|.|...|.:.|.:||::.|
Zfish    48 GSIPGGIPADTRLLDLSCNSLRWV-EYNDLSTLLRLEELDLSENLISVLEPNAFSSLLNLRVLRL 111

  Fly   304 SNNHLETLPEGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAG 368
            ..|.|:.:|.|.|:....|..:.|..|:|..|....|..|..|..:::..|.|.  ::.|..|.|
Zfish   112 RANQLKLVPMGAFSRLTNLTTLDLSGNKLVILLDFTFQDLRNLRNLEVGDNDLV--YISNKAFLG 174

  Fly   369 LIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAE-NRLHT 432
            |:.|..|.:....||.|..::...|..|..|.||..||..:|:..|..|..|..|.:.. ..|..
Zfish   175 LVGLRELTIERCNLTSISGQSLSYLRGLVTLRLRYLSIASLEEQNFRKLGGLRGLEIDHWPFLEY 239

  Fly   433 LDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPR-ALQDLAMLRTLDL 496
            :....|.||. ||.|::.|..||.|.....:|...|..|:||.|.::.:.. ||:||..|
Zfish   240 ISPHSFQGLN-LSWLSITNTNISTVPTGALRNLIHLASLNLSYNPISVLESWALRDLVRL----- 298

  Fly   497 GENQIRTFDNQSFKNLHQLTGLRLIDNQ---IGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFD 558
                         |.|| |.|..||..|   :|.        |.::.:|||:.|.:.::|.|||.
Zfish   299 -------------KELH-LVGTNLISVQPYGLGG--------LQQIRLLNLSNNGLVTLEEGSFH 341

  Fly   559 KNFELEAIRLDRNFLADINGVFATLVSLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGN 623
            ....||.:|:|.|.|:                 .:..|:|     |....|.|:..|.     ..
Zfish   342 SVNTLETLRVDGNPLS-----------------CDCRLLW-----ILQRRKTLNFDGK-----SP 379

  Fly   624 YYKLQEEIRVKTLDASHNRITEIGPMSIPNTIELLFINNNLIGNVQPNAFVDKANLARVDLYANQ 688
            ......|:|.|:|                                  :.|.|.|..........:
Zfish   380 VCTAPVEVRGKSL----------------------------------STFTDSALFDHFTCQRPK 410

  Fly   689 LSKLQLQQL--RVAPVVAPKPLPEFYLGGNPFECDCTMD------WL--QRINNLTTR------- 736
            :...:||||  |...||:             |.|....|      |:  || ..:||:
Zfish   411 IRNRKLQQLTAREGQVVS-------------FVCRAEGDPTPVIFWISPQR-RRITTKSTGRVIV 461

  Fly   737 --------QHPRVMDMANIECVMPHARG----AAVRPLSGLRPQD 769
                    ::.:|.|.....|:..:|.|    .|...:||| |.|
Zfish   462 LPEGTLEIRYAQVTDTGTYICIASNAGGNDTYFATLTVSGL-PLD 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566	6/19 (32%)
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380	2/8 (25%)
		LRR_RI	247..501	CDD:238064	79/255 (31%)
		LRR_8	247..308	CDD:290566	22/60 (37%)
		leucine-rich repeat	249..273	CDD:275380	9/23 (39%)
		leucine-rich repeat	274..297	CDD:275380	8/22 (36%)
		LRR_8	297..356	CDD:290566	17/58 (29%)
		leucine-rich repeat	298..321	CDD:275380	8/22 (36%)
		leucine-rich repeat	322..345	CDD:275380	7/22 (32%)
		LRR_8	345..406	CDD:290566	17/60 (28%)
		leucine-rich repeat	346..371	CDD:275380	7/24 (29%)
		leucine-rich repeat	372..395	CDD:275380	6/22 (27%)
		leucine-rich repeat	396..419	CDD:275380	9/22 (41%)
		LRR_8	419..478	CDD:290566	19/59 (32%)
		leucine-rich repeat	420..443	CDD:275380	6/23 (26%)
		leucine-rich repeat	444..467	CDD:275380	8/22 (36%)
		LRR_RI	466..622	CDD:238064	40/159 (25%)
		leucine-rich repeat	468..488	CDD:275380	7/20 (35%)
		LRR_8	491..549	CDD:290566	15/60 (25%)
		leucine-rich repeat	491..514	CDD:275380	3/22 (14%)
		leucine-rich repeat	515..536	CDD:275380	6/23 (26%)
		leucine-rich repeat	539..562	CDD:275380	8/22 (36%)
		leucine-rich repeat	563..585	CDD:275380	6/21 (29%)
		leucine-rich repeat	586..626	CDD:275380	6/39 (15%)
		leucine-rich repeat	627..653	CDD:275380	4/25 (16%)
		LRRCT	716..772	CDD:214507	19/81 (23%)
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
lingo3a	NP_001076323.1	LRRNT	27..60	CDD:214470	2/11 (18%)
		LRR	<49..357	CDD:227223	103/338 (30%)
		leucine-rich repeat	58..81	CDD:275380	9/23 (39%)
		leucine-rich repeat	82..105	CDD:275380	8/22 (36%)
		leucine-rich repeat	130..153	CDD:275380	7/22 (32%)
		leucine-rich repeat	154..177	CDD:275380	7/24 (29%)
		leucine-rich repeat	178..201	CDD:275380	6/22 (27%)
		leucine-rich repeat	202..225	CDD:275380	9/22 (41%)
		leucine-rich repeat	226..249	CDD:275380	5/22 (23%)
		leucine-rich repeat	250..273	CDD:275380	8/22 (36%)
		leucine-rich repeat	274..297	CDD:275380	9/22 (41%)
		leucine-rich repeat	298..321	CDD:275380	11/49 (22%)
		leucine-rich repeat	322..342	CDD:275380	8/19 (42%)
		PCC	326..>392	CDD:188093	22/92 (24%)
		Ig	424..492	CDD:325142	15/81 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.100