DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-7 and lingo4b

DIOPT Version :9

Sequence 1:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster
Sequence 2:NP_001082850.1 Gene:lingo4b / 559074 ZFINID:ZDB-GENE-091214-3 Length:604 Species:Danio rerio


Alignment Length:362 Identity:106/362 - (29%)
Similarity:173/362 - (47%) Gaps:42/362 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   235 DMNCGAGSGSAGSE-----LQVLDASHNELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAG 294
            ::||.:...:|..|     .:.||.|.|:|::::.. ..|.|.:|:.|:|:.|.:|.:..|...|
Zfish    41 EVNCSSRHLTAVPEGLPTNAKRLDLSGNQLKTLARR-QFSSLSKLEDLDLSENIISMIEVETFQG 104

  Fly   295 LASLRIVNLSNNHLETLPEGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSN 359
            |.:||.:.:.||.|:.||.|:|:|...||.:.:.:||:.......|..:..|..:|...|.|.  
Zfish   105 LKNLRYLRIKNNRLKILPVGVFSGLSNLRRLDISENEILVFLDYTFRDMINLQQLDAGENDLV-- 167

  Fly   360 HVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLN 424
            .:....|.||..|..||:..:.||.|......:|..|..|.||..:|..:.:|||..|:.|.||.
Zfish   168 FISQRAFVGLQALKELNVDRSNLTSIPTEALSQLQSLTKLRLRKLTISVLPNNAFRRLHQLRTLQ 232

  Fly   425 LAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRA-LQDL 488
            :    ||....::.|          :|:|:.:          :|..|.|::..|:.:|.: |:.|
Zfish   233 I----LHWSSLEMLN----------SNSLVGL----------NLTTLVLTNCNLSAIPYSPLRHL 273

  Fly   489 AMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIE 553
            |.|:.|||..|.|.:.......:|.:|..|.|:...:..|..|.|:.|.|..:||::.||:.::|
Zfish   274 AYLQYLDLSYNPITSIQGNLLGDLLRLQELHLVGGNLLRIEPGAFRGLSRFRLLNVSSNRLSTLE 338

  Fly   554 RGSFDKNFELEAIRLDRNFLA-DINGVFATLVSLLWL 589
            ..:|.....|:.:|||||.|| |..        |||:
Zfish   339 ESAFHSVGNLQTLRLDRNPLACDCR--------LLWV 367

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-7NP_523797.1 LRR_8 135..201 CDD:290566
leucine-rich repeat 136..159 CDD:275380
leucine-rich repeat 160..190 CDD:275380
LRR_8 189..259 CDD:290566 8/28 (29%)
leucine-rich repeat 191..214 CDD:275380
leucine-rich repeat 215..248 CDD:275380 3/12 (25%)
LRR_RI 247..501 CDD:238064 75/259 (29%)
LRR_8 247..308 CDD:290566 20/65 (31%)
leucine-rich repeat 249..273 CDD:275380 7/23 (30%)
leucine-rich repeat 274..297 CDD:275380 8/22 (36%)
LRR_8 297..356 CDD:290566 18/58 (31%)
leucine-rich repeat 298..321 CDD:275380 10/22 (45%)
leucine-rich repeat 322..345 CDD:275380 5/22 (23%)
LRR_8 345..406 CDD:290566 18/60 (30%)
leucine-rich repeat 346..371 CDD:275380 7/24 (29%)
leucine-rich repeat 372..395 CDD:275380 7/22 (32%)
leucine-rich repeat 396..419 CDD:275380 9/22 (41%)
LRR_8 419..478 CDD:290566 11/58 (19%)
leucine-rich repeat 420..443 CDD:275380 6/22 (27%)
leucine-rich repeat 444..467 CDD:275380 2/22 (9%)
LRR_RI 466..622 CDD:238064 41/126 (33%)
leucine-rich repeat 468..488 CDD:275380 6/20 (30%)
LRR_8 491..549 CDD:290566 18/57 (32%)
leucine-rich repeat 491..514 CDD:275380 7/22 (32%)
leucine-rich repeat 515..536 CDD:275380 6/20 (30%)
leucine-rich repeat 539..562 CDD:275380 6/22 (27%)
leucine-rich repeat 563..585 CDD:275380 9/22 (41%)
leucine-rich repeat 586..626 CDD:275380 3/4 (75%)
leucine-rich repeat 627..653 CDD:275380
LRRCT 716..772 CDD:214507
LRRNT 796..830 CDD:214470
leucine-rich repeat 812..829 CDD:275380
leucine-rich repeat 833..854 CDD:275380
LRR_8 853..913 CDD:290566
leucine-rich repeat 855..878 CDD:275380
LRR_4 878..918 CDD:289563
leucine-rich repeat 879..902 CDD:275380
leucine-rich repeat 903..926 CDD:275380
leucine-rich repeat 927..953 CDD:275380
TIR 1098..1235 CDD:214587
lingo4bNP_001082850.1 LRRNT 28..61 CDD:214470 4/19 (21%)
leucine-rich repeat 41..62 CDD:275380 4/20 (20%)
LRR <56..304 CDD:227223 77/274 (28%)
leucine-rich repeat 63..83 CDD:275380 7/20 (35%)
leucine-rich repeat 84..107 CDD:275380 8/22 (36%)
leucine-rich repeat 108..131 CDD:275380 10/22 (45%)
leucine-rich repeat 132..155 CDD:275380 5/22 (23%)
leucine-rich repeat 156..179 CDD:275380 7/24 (29%)
leucine-rich repeat 180..203 CDD:275380 7/22 (32%)
leucine-rich repeat 204..251 CDD:275380 17/70 (24%)
leucine-rich repeat 228..250 CDD:275380 8/35 (23%)
leucine-rich repeat 252..275 CDD:275380 7/22 (32%)
leucine-rich repeat 276..297 CDD:275380 6/20 (30%)
LRR_8 299..358 CDD:316378 20/58 (34%)
leucine-rich repeat 300..321 CDD:275380 6/20 (30%)
leucine-rich repeat 324..344 CDD:275380 6/19 (32%)
I-set 415..498 CDD:254352
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
22.010

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