DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and lgr4

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001340791.1	Gene:	lgr4 / 558825	ZFINID:	ZDB-GENE-111013-1	Length:	971	Species:	Danio rerio

Alignment Length:	873	Identity:	210/873 - (24%)
Similarity:	326/873 - (37%)	Gaps:	227/873 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 CGAGSGSAGSELQVLDASHNELRSISESWGISRLRR------------LQHLNLAYNNLSELSGE 290
            |..|..:|..|.|...|:.:.|....|..|.....|            ..:|:::.||::||...
Zfish    14 CVGGQAAAAGEGQSTPATCSPLCRCDEDGGADCSGRGLTSVPTGLSAFTYYLDISMNNITELPAN 78

  Fly   291 ALAGLASLRIVNLSNNHLETL-PEGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGN 354
            ....|..|..:.|:.|.|..: ||.| :|..:|:.:.||.|:|..:|......|..|..:.|..|
Zfish    79 VFRNLPYLEELRLAGNDLAFIHPEAL-SGLHQLKVLMLQNNQLKTVPSAALKNLNALQSLRLDAN 142

  Fly   355 QLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYN 419
            .:||  |...:|.||.:|..|.|..|:||.:.....:....||.|.|..|.|.||.||||..|.:
Zfish   143 HITS--VPEDSFEGLQQLRHLWLDDNSLTEVPISPLQHQSNLQALTLALNRITHIPDNAFANLSS 205

  Fly   420 LHTLNLAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPR- 483
            |..|:|..||:..:....||||..|..|.||.|.:.:. |...:....||||...||.:..:|.
Zfish   206 LVVLHLHNNRIQEIGKNCFNGLDNLETLDLNFNNLKIF-PEAIQMLPKLKELGFHSNNIASIPEG 269

  Fly   484 ALQDLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNR 548
            |....::|||:.|.:|.:......:|:||..|..|.|..       ..|.||.|.|:
Zfish   270 AFCRNSLLRTIHLFDNPLSFVGTTAFQNLSDLHSLMLRG-------ASMMQDFPSLT-------- 319

  Fly   549 IQSIERGSFDKNFELEAIRLDRNFLADINGVFATLVSLLWLNLSENHLVWFDYAFIPSNLKWLDI 613
                  |:.:    ||::.|.           .|.:..:..:|.|:..|          |:.:|:
Zfish   320 ------GTIN----LESLTLT-----------GTKIRSIPADLCEDLTV----------LRTVDL 353

  Fly   614 HGNYIEALGNYYKLQEEIRVKTLDASHNRITEI--GPMSIPNTIELLFINNNLIGNVQPNAFVDK 676
            ..|.||.|.::   |..:|::.::..||:|.:|  |......::.:|.::.|.|..:..:||:..
Zfish   354 SYNDIEDLPSF---QGCVRLQDINLQHNQIKQIDRGTFQGMTSLRVLDLSRNQIKFIHRDAFLSL 415

  Fly   677 ANLARVDLYANQLSKLQLQQLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQRINNLTTRQHPRV 741
            :.|..:||..|.|:.:        |......|.:..|.||          ::..|.|.::..|::
Zfish   416 SALTNLDLSLNSLASV--------PTAGLSALNQLKLTGN----------MELRNGLMSKTLPKL 462

  Fly   742 MDMANIECVMPHARGAAVRPLSGLRPQDFLCRYESHCFALCHCCDFDACDCEMTCPSNCTCYHDQ 806
            ..:     .:|:|                   |:        ||.|.|.|..:. |:.    .|:
Zfish   463 RSI-----TVPYA-------------------YQ--------CCAFVAYDSAVN-PAE----DDE 490

  Fly   807 IWSTNVVDCGGQQTTELPRRVPMDSSVVYLDGNNFPVLKNHAFIGRKNLR---------ALYVNG 862
              ..|..  ||::..|   |:||......|.|...|.  .| .:|...:|         ||..|.
Zfish   491 --RRNAF--GGEEDME---RIPMVMHCSPLPGAFKPC--EH-LLGSWMIRLTVWFICLVALLFNC 545

  Fly   863 SQVAAIQNRTFASLASLQLLHLADNKLRTLHGYEFEQLSALRELYLQNNQLTTIENATLAPLAAL 927
            ..:||    ||:...|            :|....|     |..|....|.||.:.      :|||
Zfish   546 LVLAA----TFSPRTS------------SLSPSRF-----LVALLASANLLTGVY------VAAL 583

  Fly   928 ELI-RIDGNRLVTLPIWQMHATHFGTRLKSISLGRNQW--SCRCQFLQALTSYVADNA-LIVQDA 988
            .|: .:.........:|                    |  ...||.:..|..:.::.| |::..|
Zfish   584 TLLDTVTWGSFAEYGVW--------------------WETGAGCQVVGFLAVFSSEWAVLLLALA 628

  Fly   989 QDIYCMAASSGTGSAALEDSSSNSGSL----EKRE-----------LDFNATGAACTDYYSGGSM 1038
            ....|:|..:..|.|         |:|    |:||           |...:..|||...|.|.:|
Zfish   629 AVERCLAVRALMGKA---------GALRSRGERRERRRRFAIAALLLGLVSVAAACLSLYHGSAM 684

  Fly  1039 LQHGIP------ESYIPLLAAALALLFL 1060
               |.|      |...|.|...:||:.:
Zfish   685 ---GSPLCLPFSEGSSPGLGFTVALVLM 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566	6/20 (30%)
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380	3/9 (33%)
		LRR_RI	247..501	CDD:238064	84/267 (31%)
		LRR_8	247..308	CDD:290566	16/72 (22%)
		leucine-rich repeat	249..273	CDD:275380	5/23 (22%)
		leucine-rich repeat	274..297	CDD:275380	6/22 (27%)
		LRR_8	297..356	CDD:290566	18/59 (31%)
		leucine-rich repeat	298..321	CDD:275380	8/23 (35%)
		leucine-rich repeat	322..345	CDD:275380	7/22 (32%)
		LRR_8	345..406	CDD:290566	20/60 (33%)
		leucine-rich repeat	346..371	CDD:275380	9/24 (38%)
		leucine-rich repeat	372..395	CDD:275380	6/22 (27%)
		leucine-rich repeat	396..419	CDD:275380	13/22 (59%)
		LRR_8	419..478	CDD:290566	21/58 (36%)
		leucine-rich repeat	420..443	CDD:275380	9/22 (41%)
		leucine-rich repeat	444..467	CDD:275380	6/22 (27%)
		LRR_RI	466..622	CDD:238064	37/156 (24%)
		leucine-rich repeat	468..488	CDD:275380	8/20 (40%)
		LRR_8	491..549	CDD:290566	16/57 (28%)
		leucine-rich repeat	491..514	CDD:275380	8/22 (36%)
		leucine-rich repeat	515..536	CDD:275380	5/20 (25%)
		leucine-rich repeat	539..562	CDD:275380	2/22 (9%)
		leucine-rich repeat	563..585	CDD:275380	4/21 (19%)
		leucine-rich repeat	586..626	CDD:275380	9/39 (23%)
		leucine-rich repeat	627..653	CDD:275380	7/27 (26%)
		LRRCT	716..772	CDD:214507	6/55 (11%)
		LRRNT	796..830	CDD:214470	8/33 (24%)
		leucine-rich repeat	812..829	CDD:275380	4/16 (25%)
		leucine-rich repeat	833..854	CDD:275380	5/20 (25%)
		LRR_8	853..913	CDD:290566	14/68 (21%)
		leucine-rich repeat	855..878	CDD:275380	8/31 (26%)
		LRR_4	878..918	CDD:289563	8/39 (21%)
		leucine-rich repeat	879..902	CDD:275380	2/22 (9%)
		leucine-rich repeat	903..926	CDD:275380	5/22 (23%)
		leucine-rich repeat	927..953	CDD:275380	3/26 (12%)
		TIR	1098..1235	CDD:214587
lgr4	NP_001340791.1	LRR 1	58..82		5/23 (22%)
		leucine-rich repeat	64..85	CDD:275380	6/20 (30%)
		LRR_8	84..144	CDD:316378	18/60 (30%)
		LRR 2	84..106		7/22 (32%)
		leucine-rich repeat	86..109	CDD:275380	8/23 (35%)
		LRR 3	107..130		6/22 (27%)
		leucine-rich repeat	110..133	CDD:275380	7/22 (32%)
		LRR 4	131..154		8/24 (33%)
		leucine-rich repeat	134..157	CDD:275380	9/24 (38%)
		LRR	137..>452	CDD:227223	102/384 (27%)
		LRR 5	156..178		6/21 (29%)
		leucine-rich repeat	158..181	CDD:275380	6/22 (27%)
		LRR 6	179..202		12/22 (55%)
		leucine-rich repeat	182..205	CDD:275380	13/22 (59%)
		LRR 7	204..226		6/21 (29%)
		leucine-rich repeat	206..229	CDD:275380	9/22 (41%)
		LRR 8	227..250		7/23 (30%)
		leucine-rich repeat	230..252	CDD:275380	6/22 (27%)
		LRR_8	251..308	CDD:316378	19/56 (34%)
		LRR 9	251..273		8/21 (38%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		LRR 10	275..297		6/21 (29%)
		leucine-rich repeat	277..298	CDD:275380	6/20 (30%)
		LRR 11	299..321		8/42 (19%)
		LRR 12	322..344		5/36 (14%)
		LRR 13	345..366		7/33 (21%)
		leucine-rich repeat	348..369	CDD:275380	7/23 (30%)
		LRR 14	367..390		6/22 (27%)
		leucine-rich repeat	370..393	CDD:275380	5/22 (23%)
		LRR 15	391..414		5/22 (23%)
		leucine-rich repeat	394..415	CDD:275380	5/20 (25%)
		LRR 16	416..438		6/29 (21%)
		leucine-rich repeat	418..438	CDD:275380	6/27 (22%)
		7tmA_LGR4	527..811	CDD:320483	51/242 (21%)
		TM helix 1	528..554	CDD:320483	8/29 (28%)
		TM helix 2	562..587	CDD:320483	10/35 (29%)
		TM helix 3	607..637	CDD:320483	8/29 (28%)
		TM helix 4	649..679	CDD:320483	7/29 (24%)
		TM helix 5	698..727	CDD:320483	4/12 (33%)
		TM helix 6	736..766	CDD:320483
		TM helix 7	779..804	CDD:320483
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010