DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-7 and TLR7

DIOPT Version :9

Sequence 1:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster
Sequence 2:NP_057646.1 Gene:TLR7 / 51284 HGNCID:15631 Length:1049 Species:Homo sapiens


Alignment Length:1298 Identity:251/1298 - (19%)
Similarity:428/1298 - (32%) Gaps:476/1298 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   109 SQLTIQCSELYLFE-----------STLPV--------AVFARLQTLEALRLD-SCKLLQLPNNA 153
            :.:.:.|::.:|.|           .||.:        |.|.||..|  :.:| .|..:.:|   
Human    45 NHVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHL--VEIDFRCNCVPIP--- 104

  Fly   154 FEGLATLKSLRLSTHNSEWGPTRTLELFPDSLGGLKQLTDLDLGDNNLRQLPSGFLCPVGNLQVL 218
                       |.:.|:..  .:.|::.|.|..||..|..|.|..|.|.::|.| |.|  :||:|
Human   105 -----------LGSKNNMC--IKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQG-LPP--SLQLL 153

  Fly   219 NLTRNRIRTAEQMGFADMNCGAGSGSAGSELQVLDASHNELRSISESWGISRLRRLQHLNLAYNN 283
            :|..|.|.:..:....::          :.:::|....|                ..:.|..|.:
Human   154 SLEANNIFSIRKENLTEL----------ANIEILYLGQN----------------CYYRNPCYVS 192

  Fly   284 LSELSGEALAGLASLRIVNLSNNHLETLPEGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLV 348
            .| :..:|...|..|::::|.:|::..:|..|   ...|.|::|..|.:.::.:..|:.|.||.:
Human   193 YS-IEKDAFLNLTKLKVLSLKDNNVTAVPTVL---PSTLTELYLYNNMIAKIQEDDFNNLNQLQI 253

  Fly   349 VDLSGN--------------------QLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKEL 393
            :|||||                    |:..|     .|..|..|.||.|..|:|..:..|.||.:
Human   254 LDLSGNCPRCYNAPFPCAPCKNNSPLQIPVN-----AFDALTELKVLRLHSNSLQHVPPRWFKNI 313

  Fly   394 YFLQILNLRNN----SIGHIEDNAFLP-------LYNLH------TLNLAE--NRLHTL------ 433
            ..||.|:|..|    .||..:...|||       .:|..      ::||::  :.|.:|      
Human   314 NKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIR 378

  Fly   434 -----DDKLFN-----GLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQL------NEV- 481
                 :.|.||     .|..|..|.|..|.|.:...::||....||.:|||.|::      :|| 
Human   379 GYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVG 443

  Fly   482 -------------PRALQDLAMLR-----------------------------TLDLGENQIRTF 504
                         |:.|:.|...|                             ||||.:|.|...
Human   444 FCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFV 508

  Fly   505 DNQSFKNLHQLTGLRLIDNQIGNITVGM-FQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRL 568
            .:..|::|..|..|.|..|.|.....|. ||.|..|..|:.:.||:..:...:|::..:||.:.:
Human   509 KSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDI 573

  Fly   569 DRN------------------------FLADINGVFATL------VSLLWLNLSENHLVWFDYAF 603
            ..|                        .:.:.|.:.::.      .||..|....|||       
Human   574 SSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTLEFRGNHL------- 631

  Fly   604 IPSNLKWLDIHGNYIEALGNYYKLQEEIRVKTLDASHNRITEIGPMSIPNTIELLFINNNLIGNV 668
               ::.|.:....|::...|..||:|      ||.|.|              .|.|:.:.:...:
Human   632 ---DVLWREGDNRYLQLFKNLLKLEE------LDISKN--------------SLSFLPSGVFDGM 673

  Fly   669 QPNAFVDKANLARVDLYANQLSKLQLQQLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQRINNL 733
            .|       ||..:.|..|.|.....::|                                    
Human   674 PP-------NLKNLSLAKNGLKSFSWKKL------------------------------------ 695

  Fly   734 TTRQHPRVMDMANIECVMPHARGAAVRPLSGLRPQDFLCRYESHCFALCHCCDFDACDCEMTCPS 798
                          :|:                                                
Human   696 --------------QCL------------------------------------------------ 698

  Fly   799 NCTCYHDQIWSTNVVDCGGQQTTELPRRVPMDSSVVYLDGNNFPVLKNHAFIGRKNLRALYVNGS 863
                                                                  |||..|.::.:
Human   699 ------------------------------------------------------KNLETLDLSHN 709

  Fly   864 QVAAIQNRTFASLASLQLLHLADNKLRTLHGYEFEQLSALRELYLQNNQLTTIENATLAPLAALE 928
            |:..:..|......||:.|.|.:|::|:|..|..:....||.|.|.:|::..|:. |..|...| 
Human   710 QLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQK-TSFPENVL- 772

  Fly   929 LIRIDGNRLVTLPIWQMHATHFGTRLKSISLGRNQWSCRCQFLQALTSYVADNALIVQDAQDIYC 993
                                   ..||.:.|..|::.|.|..:..:.........|...|.|:.|
Human   773 -----------------------NNLKMLLLHHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTC 814

  Fly   994 MAASSGTGSAALEDSSSNSGSLEKRELDFNATGAACTDYYSGGSMLQHGIPESYIPLLAAALALL 1058
            :...:..|.:.:      |..|...|||                     :....:..|:.:::|.
Human   815 VGPGAHKGQSVI------SLDLYTCELD---------------------LTNLILFSLSISVSLF 852

  Fly  1059 FLLVVIAMVFAFRESLRIWLFAHY------GV-RVFGPRCEESEKLYDAVLLHSAKD---SEFVC 1113
            .::::.|....|.:   :|...|:      |. |:..|.|     .|||.:::..||   :|:|.
Human   853 LMVMMTASHLYFWD---VWYIYHFCKAKIKGYQRLISPDC-----CYDAFIVYDTKDPAVTEWVL 909

  Fly  1114 QHLAAQLETGRPP-LRVCLQHRD-LAHDATHYQLLEATRVSRRVVILLTRNFLQTEWARCELRRS 1176
            ..|.|:||..|.. ..:||:.|| |........|.::.::|::.|.::|..:.:||..:.....|
Human   910 AELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKIAFYLS 974

  Fly  1177 VHDALRGRPQKLVIIEEPEVAFEAESDIELLPYLKTSAVHRIRRSDR---HFWEKLRYALPVD 1236
             |..|......::|:...|..|:....::|...|..|:|.....:.:   :||:.|:.||..|
Human   975 -HQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQAHPYFWQCLKNALATD 1036

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-7NP_523797.1 LRR_8 135..201 CDD:290566 15/66 (23%)
leucine-rich repeat 136..159 CDD:275380 4/23 (17%)
leucine-rich repeat 160..190 CDD:275380 7/29 (24%)
LRR_8 189..259 CDD:290566 17/69 (25%)
leucine-rich repeat 191..214 CDD:275380 9/22 (41%)
leucine-rich repeat 215..248 CDD:275380 6/32 (19%)
LRR_RI 247..501 CDD:238064 81/357 (23%)
LRR_8 247..308 CDD:290566 10/60 (17%)
leucine-rich repeat 249..273 CDD:275380 2/23 (9%)
leucine-rich repeat 274..297 CDD:275380 5/22 (23%)
LRR_8 297..356 CDD:290566 18/78 (23%)
leucine-rich repeat 298..321 CDD:275380 5/22 (23%)
leucine-rich repeat 322..345 CDD:275380 6/22 (27%)
LRR_8 345..406 CDD:290566 25/84 (30%)
leucine-rich repeat 346..371 CDD:275380 10/44 (23%)
leucine-rich repeat 372..395 CDD:275380 9/22 (41%)
leucine-rich repeat 396..419 CDD:275380 10/33 (30%)
LRR_8 419..478 CDD:290566 22/82 (27%)
leucine-rich repeat 420..443 CDD:275380 8/46 (17%)
leucine-rich repeat 444..467 CDD:275380 7/22 (32%)
LRR_RI 466..622 CDD:238064 46/235 (20%)
leucine-rich repeat 468..488 CDD:275380 10/39 (26%)
LRR_8 491..549 CDD:290566 21/87 (24%)
leucine-rich repeat 491..514 CDD:275380 9/51 (18%)
leucine-rich repeat 515..536 CDD:275380 8/21 (38%)
leucine-rich repeat 539..562 CDD:275380 5/22 (23%)
leucine-rich repeat 563..585 CDD:275380 4/51 (8%)
leucine-rich repeat 586..626 CDD:275380 8/39 (21%)
leucine-rich repeat 627..653 CDD:275380 6/25 (24%)
LRRCT 716..772 CDD:214507 1/55 (2%)
LRRNT 796..830 CDD:214470 0/33 (0%)
leucine-rich repeat 812..829 CDD:275380 0/16 (0%)
leucine-rich repeat 833..854 CDD:275380 0/20 (0%)
LRR_8 853..913 CDD:290566 19/59 (32%)
leucine-rich repeat 855..878 CDD:275380 4/22 (18%)
LRR_4 878..918 CDD:289563 14/39 (36%)
leucine-rich repeat 879..902 CDD:275380 7/22 (32%)
leucine-rich repeat 903..926 CDD:275380 8/22 (36%)
leucine-rich repeat 927..953 CDD:275380 1/25 (4%)
TIR 1098..1235 CDD:214587 38/144 (26%)
TLR7NP_057646.1 leucine-rich repeat 598..651 CDD:275380 10/62 (16%)
LRR 21 619..644 8/34 (24%)
leucine-rich repeat 621..643 CDD:275380 6/31 (19%)
LRR 22 649..672 9/42 (21%)
leucine-rich repeat 652..676 CDD:275380 9/50 (18%)
LRR 23 674..697 7/79 (9%)
leucine-rich repeat 677..700 CDD:275380 6/174 (3%)
LRR 24 698..721 6/124 (5%)
leucine-rich repeat 701..724 CDD:275380 4/22 (18%)
LRR 25 723..745 8/21 (38%)
leucine-rich repeat 725..748 CDD:275380 7/22 (32%)
LRR 26 746..769 7/23 (30%)
leucine-rich repeat 749..767 CDD:275380 7/18 (39%)
PCC 753..>837 CDD:188093 22/135 (16%)
LRR 27 772..795 7/46 (15%)
TIR 890..>993 CDD:214587 27/103 (26%)
LRR 1 43..64 3/18 (17%)
leucine-rich repeat 48..69 CDD:275380 3/20 (15%)
LRR 2 65..87 4/21 (19%)
LRR_8 75..139 CDD:404697 19/81 (23%)
leucine-rich repeat 91..128 CDD:275380 11/54 (20%)
LRR 3 110..126 3/17 (18%)
LRR 4 127..149 9/24 (38%)
leucine-rich repeat 129..173 CDD:275380 15/56 (27%)
LRR 5 151..170 5/18 (28%)
LRR 6 171..195 5/50 (10%)
PLN00113 191..>711 CDD:215061 128/717 (18%)
LRR 7 203..226 6/25 (24%)
leucine-rich repeat 206..225 CDD:275380 5/21 (24%)
leucine-rich repeat 227..250 CDD:275380 6/22 (27%)
LRR 8 228..247 4/18 (22%)
LRR 9 248..275 8/26 (31%)
leucine-rich repeat 251..291 CDD:275380 10/44 (23%)
LRR 10 289..312 9/22 (41%)
leucine-rich repeat 292..315 CDD:275380 9/22 (41%)
LRR 11 314..337 7/22 (32%)
leucine-rich repeat 316..341 CDD:275380 9/24 (38%)
LRR 12 339..368 5/28 (18%)
leucine-rich repeat 342..371 CDD:275380 4/28 (14%)
LRR 13 369..392 5/22 (23%)
leucine-rich repeat 372..398 CDD:275380 5/25 (20%)
LRR 14 396..419 7/22 (32%)
leucine-rich repeat 399..422 CDD:275380 7/22 (32%)
LRR 15 421..443 7/21 (33%)
LRR <488..775 CDD:227223 75/500 (15%)
LRR 16 492..515 7/22 (32%)
leucine-rich repeat 496..518 CDD:275380 8/21 (38%)
LRR 17 516..540 8/23 (35%)
leucine-rich repeat 519..543 CDD:275380 9/23 (39%)
LRR 18 541..564 6/22 (27%)
leucine-rich repeat 544..567 CDD:275380 5/22 (23%)
LRR 19 566..588 3/21 (14%)
leucine-rich repeat 568..597 CDD:275380 3/28 (11%)
LRR 20 595..618 1/22 (5%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
54.780

Return to query results.
Submit another query.