DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-7 and Lrrc17

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001020326.1	Gene:	Lrrc17 / 502715	RGDID:	1560165	Length:	446	Species:	Rattus norvegicus

Alignment Length:	279	Identity:	70/279 - (25%)
Similarity:	125/279 - (44%)	Gaps:	45/279 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 SHNELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLPEGLFAGS 319
            :.|::|.:..:. .|:.:||:.|:|..|.:|::..||..||..|..:.|.:|.::.|.|.:|..:
  Rat    94 ARNKIRVLKNNM-FSKFKRLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYT 157

  Fly   320 KELREIHLQQNELYELPKGLFHRLEQLL-VVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNAL- 382
            ..|..:     .||:.|......||.|: ::.:..|:...|:....:...|....:|.|....|
  Rat   158 PLLSYL-----RLYDNPWHCACELETLVSMLQIPRNRNLGNYAKCGSPPALRNKKLLQLKPQELC 217

  Fly   383 -----TRID-----------------------YRTFKELYFLQILNLRNNSIGHIEDNAFLPLYN 419
                 .|:|                       |     ::.:|.|:.:...:..:.:|  :| .|
  Rat   218 DEEEKERLDPIPQVSGVPAVIRPEADSTLCHNY-----VFPIQTLDCKRKELKKVPNN--IP-PN 274

  Fly   420 LHTLNLAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVP-R 483
            :..|:|:.|::..|..|.|..::.|.||.|::|.:..::||.|.....|:|||||:|.|.... .
  Rat   275 IVKLDLSYNKISQLRPKEFEDVHELKKLNLSSNGLEFIDPAAFLGLIHLEELDLSNNSLQSFDYG 339

  Fly   484 ALQDLAMLRTLDLGENQIR 502
            .|:||..|:.|.|.:|..|
  Rat   340 VLEDLYFLKLLWLRDNPWR 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566	1/3 (33%)
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380
		LRR_RI	247..501	CDD:238064	69/276 (25%)
		LRR_8	247..308	CDD:290566	16/52 (31%)
		leucine-rich repeat	249..273	CDD:275380	3/17 (18%)
		leucine-rich repeat	274..297	CDD:275380	9/22 (41%)
		LRR_8	297..356	CDD:290566	14/59 (24%)
		leucine-rich repeat	298..321	CDD:275380	6/22 (27%)
		leucine-rich repeat	322..345	CDD:275380	5/22 (23%)
		LRR_8	345..406	CDD:290566	12/90 (13%)
		leucine-rich repeat	346..371	CDD:275380	4/25 (16%)
		leucine-rich repeat	372..395	CDD:275380	6/51 (12%)
		leucine-rich repeat	396..419	CDD:275380	4/22 (18%)
		LRR_8	419..478	CDD:290566	22/58 (38%)
		leucine-rich repeat	420..443	CDD:275380	6/22 (27%)
		leucine-rich repeat	444..467	CDD:275380	8/22 (36%)
		LRR_RI	466..622	CDD:238064	16/38 (42%)
		leucine-rich repeat	468..488	CDD:275380	9/20 (45%)
		LRR_8	491..549	CDD:290566	5/12 (42%)
		leucine-rich repeat	491..514	CDD:275380	5/12 (42%)
		leucine-rich repeat	515..536	CDD:275380
		leucine-rich repeat	539..562	CDD:275380
		leucine-rich repeat	563..585	CDD:275380
		leucine-rich repeat	586..626	CDD:275380
		leucine-rich repeat	627..653	CDD:275380
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
Lrrc17	NP_001020326.1	leucine-rich repeat	68..86	CDD:275380
		LRR_8	89..146	CDD:290566	16/52 (31%)
		leucine-rich repeat	89..111	CDD:275380	3/17 (18%)
		LRR_4	110..151	CDD:289563	14/40 (35%)
		leucine-rich repeat	112..135	CDD:275380	9/22 (41%)
		leucine-rich repeat	136..159	CDD:275380	6/22 (27%)
		leucine-rich repeat	160..210	CDD:275380	10/54 (19%)
		TPKR_C2	168..>204	CDD:301599	6/35 (17%)
		leucine-rich repeat	211..274	CDD:275380	9/70 (13%)
		LRR_8	273..333	CDD:290566	22/59 (37%)
		LRR_4	273..314	CDD:289563	12/40 (30%)
		leucine-rich repeat	275..298	CDD:275380	6/22 (27%)
		LRR_4	299..337	CDD:289563	16/37 (43%)
		leucine-rich repeat	299..322	CDD:275380	8/22 (36%)
		leucine-rich repeat	323..346	CDD:275380	11/22 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010