DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-7 and lingo1b

DIOPT Version :9

Sequence 1:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster
Sequence 2:NP_001004576.1 Gene:lingo1b / 447837 ZFINID:ZDB-GENE-040912-136 Length:622 Species:Danio rerio


Alignment Length:344 Identity:94/344 - (27%)
Similarity:153/344 - (44%) Gaps:37/344 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   248 ELQVLDASHNELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLP 312
            :.::||.|.|.|::|:....:: ..:|:.|.|..|.:|.:...|.:.|..||.:.|.||:|:.:.
Zfish    74 DTRLLDLSKNRLKAINPEEFLN-YPQLEDLQLNENIISVIEPGAFSNLLGLRTLGLRNNNLKLIQ 137

  Fly   313 EGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNL 377
            .|:|.|...|..:.:.:|::..|...:|..|..|..:::..|.|.  .:.:..|.||..|..|.:
Zfish   138 LGVFTGLSNLTRLDISENKIVILLDYMFQELYNLKELEVGDNDLV--FISHRAFHGLSSLEQLTM 200

  Fly   378 AHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAE-NRLHTLDDKLFNGL 441
            ....||.:....|..|:.|..|.||:.::..|.|.:|..||.|..|.:|. ..|.:|..|..:||
Zfish   201 ERCNLTSVPTEAFSHLHNLLTLKLRHLNVNVIRDFSFRRLYRLKILEIANWPLLESLTAKSLHGL 265

  Fly   442 YVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRALQDLAMLRTLDLGENQIRTFDN 506
            .:.:....|.||.:|  |.|                      |:|.|..||..:|..|.|...:.
Zfish   266 NITTLSITNCNLTAV--PYV----------------------AIQHLVYLRFFNLSFNPIEVVEG 306

  Fly   507 QSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRN 571
            ....||.:|....|:..::.:|....|:.|..|.|||::.|.:.::|..:|.....||.:.|..|
Zfish   307 NKMHNLLRLQAFHLVGGRLVSIEPYSFKGLNYLRVLNVSSNSLSTLEESAFHSVGNLETLALHDN 371

  Fly   572 FLA-DINGVFATLVSLLWL 589
            .|| |..        |||:
Zfish   372 PLACDCR--------LLWV 382

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-7NP_523797.1 LRR_8 135..201 CDD:290566
leucine-rich repeat 136..159 CDD:275380
leucine-rich repeat 160..190 CDD:275380
LRR_8 189..259 CDD:290566 4/10 (40%)
leucine-rich repeat 191..214 CDD:275380
leucine-rich repeat 215..248 CDD:275380 94/344 (27%)
LRR_RI 247..501 CDD:238064 69/253 (27%)
LRR_8 247..308 CDD:290566 18/59 (31%)
leucine-rich repeat 249..273 CDD:275380 6/23 (26%)
leucine-rich repeat 274..297 CDD:275380 7/22 (32%)
LRR_8 297..356 CDD:290566 16/58 (28%)
leucine-rich repeat 298..321 CDD:275380 9/22 (41%)
leucine-rich repeat 322..345 CDD:275380 5/22 (23%)
LRR_8 345..406 CDD:290566 16/60 (27%)
leucine-rich repeat 346..371 CDD:275380 6/24 (25%)
leucine-rich repeat 372..395 CDD:275380 6/22 (27%)
leucine-rich repeat 396..419 CDD:275380 8/22 (36%)
LRR_8 419..478 CDD:290566 14/59 (24%)
leucine-rich repeat 420..443 CDD:275380 8/23 (35%)
leucine-rich repeat 444..467 CDD:275380 6/22 (27%)
LRR_RI 466..622 CDD:238064 32/125 (26%)
leucine-rich repeat 468..488 CDD:275380 2/19 (11%)
LRR_8 491..549 CDD:290566 17/57 (30%)
leucine-rich repeat 491..514 CDD:275380 7/22 (32%)
leucine-rich repeat 515..536 CDD:275380 4/20 (20%)
leucine-rich repeat 539..562 CDD:275380 7/22 (32%)
leucine-rich repeat 563..585 CDD:275380 7/22 (32%)
leucine-rich repeat 586..626 CDD:275380 3/4 (75%)
leucine-rich repeat 627..653 CDD:275380
LRRCT 716..772 CDD:214507
LRRNT 796..830 CDD:214470
leucine-rich repeat 812..829 CDD:275380
leucine-rich repeat 833..854 CDD:275380
LRR_8 853..913 CDD:290566
leucine-rich repeat 855..878 CDD:275380
LRR_4 878..918 CDD:289563
leucine-rich repeat 879..902 CDD:275380
leucine-rich repeat 903..926 CDD:275380
leucine-rich repeat 927..953 CDD:275380
TIR 1098..1235 CDD:214587
lingo1bNP_001004576.1 LRRNT 43..77 CDD:214470 0/2 (0%)
LRR 1 74..95 6/20 (30%)
leucine-rich repeat 75..98 CDD:275380 6/23 (26%)
LRR_8 76..133 CDD:290566 18/57 (32%)
LRR_RI 78..>315 CDD:238064 72/263 (27%)
LRR 2 98..119 6/20 (30%)
leucine-rich repeat 99..146 CDD:275380 16/46 (35%)
LRR 3 122..143 8/20 (40%)
LRR_8 130..181 CDD:290566 13/50 (26%)
LRR 4 146..167 4/20 (20%)
leucine-rich repeat 147..170 CDD:275380 5/22 (23%)
LRR_8 170..226 CDD:290566 15/57 (26%)
LRR 5 170..191 4/22 (18%)
leucine-rich repeat 171..194 CDD:275380 6/24 (25%)
LRR 6 194..215 5/20 (25%)
leucine-rich repeat 195..218 CDD:275380 6/22 (27%)
LRR 7 218..239 7/20 (35%)
leucine-rich repeat 219..242 CDD:275380 8/22 (36%)
leucine-rich repeat 243..290 CDD:275380 17/70 (24%)
LRR_8 266..325 CDD:290566 18/82 (22%)
LRR 8 266..287 7/44 (16%)
LRR 9 290..311 5/20 (25%)
leucine-rich repeat 291..338 CDD:275380 12/46 (26%)
LRR_8 314..373 CDD:290566 16/58 (28%)
LRR 10 314..335 4/20 (20%)
LRR 11 338..359 7/20 (35%)
leucine-rich repeat 339..362 CDD:275380 7/22 (32%)
TPKR_C2 371..424 CDD:301599 7/20 (35%)
IG_like 438..516 CDD:214653
Ig 441..516 CDD:299845
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.100

Return to query results.
Submit another query.