DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-7 and LRRC24

DIOPT Version :9

Sequence 1:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster
Sequence 2:NP_001019849.2 Gene:LRRC24 / 441381 HGNCID:28947 Length:513 Species:Homo sapiens


Alignment Length:247 Identity:83/247 - (33%)
Similarity:114/247 - (46%) Gaps:21/247 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly   267 GISRLRRL--------QHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLPEGLFAGSKELR 323
            |..|||.:        |.|.|..||::.|...|||.||:||.:.|.||.|..|..|.|.....|.
Human    37 GALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLL 101

  Fly   324 EIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDYR 388
            |:.|..|.|..|..|.|..|.||.|:.|:||||.  .:.:.||..|.||..|:|..|::..::.:
Human   102 ELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLA--RLLDFTFLHLPRLQELHLQENSIELLEDQ 164

  Fly   389 TFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAEN------RLHTLDDKLFNGLYVLSKL 447
            ....|..|.:|:|..|.:|.|...|..||.:|..|.|.||      .||.|...:..|...|  |
Human   165 ALAGLSSLALLDLSRNQLGTISREALQPLASLQVLRLTENPWRCDCALHWLGAWIKEGGQRL--L 227

  Fly   448 TLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRALQDLAMLRTLDLGEN 499
            |..:..|...||   ...:....||:|.:.|..:|.::....:..|.:|||:
Human   228 TSRDRKIMCAEP---PRLALQSLLDVSHSSLICIPPSVHVQPLELTANLGED 276

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-7NP_523797.1 LRR_8 135..201 CDD:290566
leucine-rich repeat 136..159 CDD:275380
leucine-rich repeat 160..190 CDD:275380
LRR_8 189..259 CDD:290566
leucine-rich repeat 191..214 CDD:275380
leucine-rich repeat 215..248 CDD:275380
LRR_RI 247..501 CDD:238064 83/247 (34%)
LRR_8 247..308 CDD:290566 20/48 (42%)
leucine-rich repeat 249..273 CDD:275380 3/5 (60%)
leucine-rich repeat 274..297 CDD:275380 10/30 (33%)
LRR_8 297..356 CDD:290566 24/58 (41%)
leucine-rich repeat 298..321 CDD:275380 9/22 (41%)
leucine-rich repeat 322..345 CDD:275380 9/22 (41%)
LRR_8 345..406 CDD:290566 21/60 (35%)
leucine-rich repeat 346..371 CDD:275380 10/24 (42%)
leucine-rich repeat 372..395 CDD:275380 5/22 (23%)
leucine-rich repeat 396..419 CDD:275380 9/22 (41%)
LRR_8 419..478 CDD:290566 18/64 (28%)
leucine-rich repeat 420..443 CDD:275380 9/28 (32%)
leucine-rich repeat 444..467 CDD:275380 6/22 (27%)
LRR_RI 466..622 CDD:238064 9/34 (26%)
leucine-rich repeat 468..488 CDD:275380 5/19 (26%)
LRR_8 491..549 CDD:290566 4/9 (44%)
leucine-rich repeat 491..514 CDD:275380 4/9 (44%)
leucine-rich repeat 515..536 CDD:275380
leucine-rich repeat 539..562 CDD:275380
leucine-rich repeat 563..585 CDD:275380
leucine-rich repeat 586..626 CDD:275380
leucine-rich repeat 627..653 CDD:275380
LRRCT 716..772 CDD:214507
LRRNT 796..830 CDD:214470
leucine-rich repeat 812..829 CDD:275380
leucine-rich repeat 833..854 CDD:275380
LRR_8 853..913 CDD:290566
leucine-rich repeat 855..878 CDD:275380
LRR_4 878..918 CDD:289563
leucine-rich repeat 879..902 CDD:275380
leucine-rich repeat 903..926 CDD:275380
leucine-rich repeat 927..953 CDD:275380
TIR 1098..1235 CDD:214587
LRRC24NP_001019849.2 LRR_RI 49..>158 CDD:238064 45/110 (41%)
LRR_8 <50..86 CDD:290566 16/35 (46%)
LRR 1 51..72 8/20 (40%)
leucine-rich repeat 53..75 CDD:275380 10/21 (48%)
LRR 2 75..96 9/20 (45%)
LRR_8 76..134 CDD:290566 24/57 (42%)
leucine-rich repeat 76..99 CDD:275380 9/22 (41%)
LRR 3 99..120 8/20 (40%)
leucine-rich repeat 100..123 CDD:275380 9/22 (41%)
LRR_8 123..205 CDD:290566 30/83 (36%)
LRR 4 123..144 10/22 (45%)
leucine-rich repeat 124..147 CDD:275380 10/24 (42%)
LRR 5 147..168 5/20 (25%)
leucine-rich repeat 148..171 CDD:275380 5/22 (23%)
LRR 6 171..192 7/20 (35%)
leucine-rich repeat 172..195 CDD:275380 9/22 (41%)
LRRCT 204..257 CDD:214507 15/57 (26%)
Ig 259..364 CDD:299845 5/18 (28%)
IG_like 266..362 CDD:214653 4/11 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 365..391
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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