DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-7 and CG5810

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_650952.2	Gene:	CG5810 / 42513	FlyBaseID:	FBgn0038866	Length:	428	Species:	Drosophila melanogaster

Alignment Length:	341	Identity:	94/341 - (27%)
Similarity:	160/341 - (46%)	Gaps:	41/341 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   319 SKELRE---IHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHN 380
            :|.||:   :.|..::|..||:.:|..|.||  |:....:.....:::..|.|...|..||...|
  Fly    59 TKHLRKYETLVLHSSDLANLPRKIFLNLPQL--VEFHVLECELQQIESVCFDGAKNLKRLNFGGN 121

  Fly   381 ALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKLFNGLYVLS 445
            ||..:|..||:....|:.|||.:|.:..:....|.||.||..:||:.|||.||...:|:.|..|.
  Fly   122 ALRVLDSNTFELATQLEELNLSDNQLEDLPTTIFRPLKNLQKINLSNNRLITLSQHIFSQLGSLK 186

  Fly   446 KLTLNNNLISVVEPAVFKN-CSDLKELDLSSNQLNEVP----RALQDLAM-----LRTLDL---- 496
            .:.:::|.:..:...:|:: ...|.|....||||..:|    |.:..|::     ||.|.|
  Fly   187 SINVDSNQLVELPGELFRDQRKHLSEFSAQSNQLVRIPFNIFREIDHLSLSFNPQLRRLHLSAKI 251

  Fly   497 GENQIRTFDNQSFKNLHQLTGLRLIDN-QIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKN 560
            .|.:....|.:|.:...::.|::|..| ::..:.:...|||..|.:.|....|:..:.:.|  |.
  Fly   252 NELEATNCDLESVELDGRVIGVQLEANPKLHELKISQPQDLEHLYLANTNLYRLDFLSKAS--KL 314

  Fly   561 FELEAIRLDRNFLADINGVFAT----LVSLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEAL 621
            .:|:.  .|...|||:..:.:.    .:|..:.||:.||:     ..:| :||.|    ||:|.
  Fly   315 VDLDV--TDIVNLADLPKITSAKGLERLSFTYDNLTSNHM-----DMLP-HLKDL----NYLEI- 366

  Fly   622 GNYYKLQEEIRVKTLD 637
              .::..:||.:|.||
  Fly   367 --SHEKGKEIFIKDLD 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380
		LRR_RI	247..501	CDD:238064	59/198 (30%)
		LRR_8	247..308	CDD:290566
		leucine-rich repeat	249..273	CDD:275380
		leucine-rich repeat	274..297	CDD:275380
		LRR_8	297..356	CDD:290566	12/39 (31%)
		leucine-rich repeat	298..321	CDD:275380	0/1 (0%)
		leucine-rich repeat	322..345	CDD:275380	8/25 (32%)
		LRR_8	345..406	CDD:290566	19/60 (32%)
		leucine-rich repeat	346..371	CDD:275380	4/24 (17%)
		leucine-rich repeat	372..395	CDD:275380	9/22 (41%)
		leucine-rich repeat	396..419	CDD:275380	8/22 (36%)
		LRR_8	419..478	CDD:290566	18/59 (31%)
		leucine-rich repeat	420..443	CDD:275380	10/22 (45%)
		leucine-rich repeat	444..467	CDD:275380	3/23 (13%)
		LRR_RI	466..622	CDD:238064	44/173 (25%)
		leucine-rich repeat	468..488	CDD:275380	8/23 (35%)
		LRR_8	491..549	CDD:290566	15/62 (24%)
		leucine-rich repeat	491..514	CDD:275380	7/26 (27%)
		leucine-rich repeat	515..536	CDD:275380	4/21 (19%)
		leucine-rich repeat	539..562	CDD:275380	5/22 (23%)
		leucine-rich repeat	563..585	CDD:275380	5/25 (20%)
		leucine-rich repeat	586..626	CDD:275380	11/39 (28%)
		leucine-rich repeat	627..653	CDD:275380	5/11 (45%)
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
CG5810	NP_650952.2	leucine-rich repeat	65..88	CDD:275380	6/22 (27%)
		LRR_8	87..147	CDD:290566	19/61 (31%)
		leucine-rich repeat	89..112	CDD:275380	4/24 (17%)
		leucine-rich repeat	113..136	CDD:275380	9/22 (41%)
		LRR_8	135..195	CDD:290566	21/59 (36%)
		LRR_4	135..175	CDD:289563	16/39 (41%)
		leucine-rich repeat	137..160	CDD:275380	8/22 (36%)
		leucine-rich repeat	161..184	CDD:275380	10/22 (45%)
		leucine-rich repeat	185..209	CDD:275380	3/23 (13%)
		leucine-rich repeat	210..231	CDD:275380	8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453631
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930