DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and CG18249

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001163549.1	Gene:	CG18249 / 40964	FlyBaseID:	FBgn0037553	Length:	559	Species:	Drosophila melanogaster

Alignment Length:	622	Identity:	149/622 - (23%)
Similarity:	242/622 - (38%)	Gaps:	185/622 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 CALRLIERQPGLDLQGADGSSQLTIQCSELYLFESTLPVAVFA--RLQTLEALRLDSCK------ 145
            |.|.:.:   .|.:..|.|...|:..|.:.:...|..|||..|  .|| |..|.|.:|.
  Fly    12 CGLTVSD---ALAVYDASGRFNLSASCPDSFCSLSDRPVAYSATPALQ-LRELHLRNCSRQSITW 72

  Fly   146 -LLQLPNNAFEGLATLKSLRLSTHNSEWGPTRTLELFPDSLGGLKQLTDLDLGDNNLRQLPSGFL 209
             :|||.    .||.||.....:|::          :..:||..::.||.|.:...:|..|.....
  Fly    73 LVLQLT----PGLRTLVIRNCATYH----------ISKESLRPVENLTSLQMQGTSLGVLRDQIF 123

  Fly   210 CPVGNLQVLNLTRNRIRTAEQMGFADMNCGAGSGSAGSELQVLDASHNELRSISESWGISRLRRL 274
            ..|..|::|.|::|.|.|.....|.                                |:|:||.
  Fly   124 NAVPRLEILQLSQNFIHTVHVAAFQ--------------------------------GLSKLRL- 155

  Fly   275 QHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLPEGLFAGSKELREIHLQQNELYELPKGL 339
              |.|..|.::|:....|..|..|..::||.|.|.|||:.:||.:|:|:.:.|..|.|
  Fly   156 --LGLQGNAIAEILSSTLDPLMELVHLDLSRNELTTLPQNIFAKNKKLQTLLLNGNPL------- 211

  Fly   340 FHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNN 404
                 ::|:.|:.|:              |..|.:|:|.|.|             .|:::.|.
  Fly   212 -----RILMPDVLGS--------------LPNLRLLDLGHAA-------------ELEVMTLN-- 242

  Fly   405 SIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLK 469
                        |.|:..|.|..:.|.:|   :.||.::  ||...||.::.::..   |.|.:.
  Fly   243 ------------LTNVQNLVLEGSSLSSL---VINGGFI--KLQAGNNELNHLQVG---NKSSVI 287

  Fly   470 ELDLSSNQL--NEVPRALQDLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGM 532
            |:||..|.|  |:....|:.:..|:.|||.:|:|.......       :||.....|  .:.:
  Fly   288 EMDLHGNLLNGNDTAALLRGMWNLQRLDLSKNRIEALPQHG-------SGLDASGTQ--ELLI-- 341

  Fly   533 FQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRNFLADINGVFATLVS--LLWLNLSENH 595
               ||.|..||||.|::                :||...         :.::|  |.:|:||.|.
  Fly   342 ---LPSLKFLNLANNQL----------------VRLPPE---------SPILSSRLSYLDLSHNL 378

  Fly   596 LVWFDYAFIP--SNLKWLDIHGNYIEALGNYYKLQEEIRVKTLDASHNRITEIG----PMS--IP 652
            ::..|.|.:.  |.||.|.:.||.:..: ||.||.||         |..::|:|    |.|  :.
  Fly   379 MLTLDVAILRSLSVLKGLYVEGNRLNTI-NYQKLHEE---------HPDLSELGLHDNPWSSGLY 433

  Fly   653 NTIELLFINNNLIGNVQP-NAFVDKANLARVDLYANQ 688
            ..:.|.|.:..:....:| |..::|::...:|...|:
  Fly   434 RKMFLYFTDRGVHLQARPQNRVLNKSSRVDIDWPPNE 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	17/72 (24%)
		leucine-rich repeat	136..159	CDD:275380	9/29 (31%)
		leucine-rich repeat	160..190	CDD:275380	4/29 (14%)
		LRR_8	189..259	CDD:290566	13/69 (19%)
		leucine-rich repeat	191..214	CDD:275380	6/22 (27%)
		leucine-rich repeat	215..248	CDD:275380	7/32 (22%)
		LRR_RI	247..501	CDD:238064	62/255 (24%)
		LRR_8	247..308	CDD:290566	14/60 (23%)
		leucine-rich repeat	249..273	CDD:275380	3/23 (13%)
		leucine-rich repeat	274..297	CDD:275380	6/22 (27%)
		LRR_8	297..356	CDD:290566	18/58 (31%)
		leucine-rich repeat	298..321	CDD:275380	10/22 (45%)
		leucine-rich repeat	322..345	CDD:275380	4/22 (18%)
		LRR_8	345..406	CDD:290566	11/60 (18%)
		leucine-rich repeat	346..371	CDD:275380	4/24 (17%)
		leucine-rich repeat	372..395	CDD:275380	5/22 (23%)
		leucine-rich repeat	396..419	CDD:275380	3/22 (14%)
		LRR_8	419..478	CDD:290566	17/58 (29%)
		leucine-rich repeat	420..443	CDD:275380	6/22 (27%)
		leucine-rich repeat	444..467	CDD:275380	5/22 (23%)
		LRR_RI	466..622	CDD:238064	41/161 (25%)
		leucine-rich repeat	468..488	CDD:275380	7/21 (33%)
		LRR_8	491..549	CDD:290566	17/57 (30%)
		leucine-rich repeat	491..514	CDD:275380	6/22 (27%)
		leucine-rich repeat	515..536	CDD:275380	3/20 (15%)
		leucine-rich repeat	539..562	CDD:275380	6/22 (27%)
		leucine-rich repeat	563..585	CDD:275380	2/21 (10%)
		leucine-rich repeat	586..626	CDD:275380	15/41 (37%)
		leucine-rich repeat	627..653	CDD:275380	8/31 (26%)
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
CG18249	NP_001163549.1	leucine-rich repeat	57..80	CDD:275380	7/26 (27%)
		LRR_8	104..163	CDD:290566	20/93 (22%)
		leucine-rich repeat	105..128	CDD:275380	6/22 (27%)
		LRR_RI	107..438	CDD:238064	112/475 (24%)
		leucine-rich repeat	129..152	CDD:275380	8/54 (15%)
		leucine-rich repeat	153..176	CDD:275380	8/25 (32%)
		LRR_8	176..232	CDD:290566	22/81 (27%)
		leucine-rich repeat	177..200	CDD:275380	10/22 (45%)
		leucine-rich repeat	201..224	CDD:275380	8/48 (17%)
		leucine-rich repeat	225..258	CDD:275380	12/59 (20%)
		leucine-rich repeat	259..310	CDD:275380	16/58 (28%)
		leucine-rich repeat	311..344	CDD:275380	10/46 (22%)
		LRR_8	343..403	CDD:290566	23/84 (27%)
		leucine-rich repeat	345..368	CDD:275380	9/47 (19%)
		leucine-rich repeat	369..390	CDD:275380	7/20 (35%)
		leucine-rich repeat	393..417	CDD:275380	12/33 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453789
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840