DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and tlr20.2

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001170914.2	Gene:	tlr20.2 / 403140	ZFINID:	ZDB-GENE-040220-6	Length:	950	Species:	Danio rerio

Alignment Length:	1208	Identity:	251/1208 - (20%)
Similarity:	416/1208 - (34%)	Gaps:	412/1208 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 DLQGADGSSQLTIQCSELYLFESTLPVAVFARLQTLEALRLDSCKLLQLPNNAFEGLATLKSLRL 165
            ||:|...:.|..|..::|. :...|....|.|..:||.|.:..| |.::|..||.||..:.:|.|
Zfish    66 DLRGLPANLQNLIVQTDLG-YHGVLAPNSFLRFGSLENLEIVGC-LSEVPPEAFNGLTNVTTLTL 128

  Fly   166 STHNSEWGPTRTLELFPDSLGGLKQLTDLDLGDNNLRQLPSGFLCPVGNLQVLNLTRNRIRTAEQ 230
            |...      :..|:..| ...|..||.|.|.|.:|..|||.....:..|:.|:|....::
Zfish   129 SCSQ------QCTEVAFD-FSRLTSLTSLSLSDYSLSLLPSNVFEKIPQLRWLHLCSECLK---- 182

  Fly   231 MGFADMNCGAGSGSAGSELQVLDASHNELRSISE----SWGISRLRRLQHLNLAYNNLSELSGEA 291
             ..:::.|                   .|:::..    ..|.:.|.|||:.|.:..|:||:|.:
Zfish   183 -DLSEVLC-------------------RLKNVKSLKYLGLGNTMLTRLQYPNCSVFNVSEISTK- 226

  Fly   292 LAGLASLRIVNLSNNHLETLPEGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQL 356
                .::...:|....||.:.||...                     :|.:|.:|.....|
Zfish   227 ----FNIERADLLLGKLEHVDEGALK---------------------VFGKLSRLYFTVSS---- 262

  Fly   357 TSNHVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLH 421
             .|.:.:.:..|:.::.|:....:.|...|.....:||.::.:::                 :..
Zfish   263 -KNFLRDLSLIGVHQISVIIATVDVLNVDDLCVAAKLYSVKSVDV-----------------DYD 309

  Fly   422 TLNLAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRALQ 486
            |:||      :|..|:.:|...:..:.|.||        :|....:|  ||::|        ..|
Zfish   310 TINL------SLTSKISDGCKQIGYIMLENN--------IFGKTVNL--LDVNS--------LFQ 350

  Fly   487 DLAMLRTLDLGENQIRTFDNQSF--------KNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLN 543
            ..:.|.::.:.::.:|:.|.||.        |.:..:. ||:|  :|..|....|.....|..|.
Zfish   351 IFSNLTSVTIDKHVLRSNDFQSLCASFPQTVKKISDMV-LRII--RIDKIVSHQFMCFVNLKTLK 412

  Fly   544 LAKNRIQSIERGSFDKNFELEAIRLDRNFLADINGVFATLVSLLWLNLSENHLVWFDYAFIPSN- 607
            ||.::...||                                              |:|||..|
Zfish   413 LAMSKFSVIE----------------------------------------------DFAFIGLNK 431

  Fly   608 LKWLDIHGNYIEALGNY-YKLQEEIRVKTLDASHNRITEIGPMSIPNTIELLFINNNLIG--NVQ 669
            ||.|::|.|.|.::..: :....|:||  ||.:.|.:..|.|.|..:.|.|..:   |:|  |..
Zfish   432 LKELNLHSNKISSIHQHTFSGLHELRV--LDLNENPLFHIEPESFRHLINLRTL---LLGDLNFP 491

  Fly   670 PNAFVDKANLARVDLYANQLSKLQLQQLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQRINNLT 734
            ||..:.|.:|:  |::
Zfish   492 PNMSLIKLHLS--DIF------------------------------------------------- 505

  Fly   735 TRQHPRVMDMANIECVMPHARGAAVRPLSGLRPQDFLCRYESHCFALCHCCDFDACDCEMTCPSN 799
             |:.||.:....|.              |||||.                        .:...||
Zfish   506 -REIPRNLSNVFIS--------------SGLRPM------------------------HLVIGSN 531

  Fly   800 CTC-----YHDQIWSTNVVDCGGQQTTELPRRVPMDSSVVYLDGNNFPVLKNHAFIGRKNLRALY 859
            .|.     .|.:.....|.||.....|          |||.|..|...::..:.|||:
Zfish   532 TTLNNGLNLHIKGQYVIVEDCNSLLLT----------SVVTLQINAAYMICENEFIGK------- 579

  Fly   860 VNGSQVAAIQNRTFASLAS---------LQLLHLADNKLRTLH-------GYEFEQLSALRELYL 908
                .|.::.:..|.|:.|         .||:||...||..:.       |..|..|:.|..|.|
Zfish   580 ----YVPSVVSLKFESMFSDNIGDLSVINQLVHLKTLKLENIDLTNQPNTGIMFHNLTKLETLIL 640

  Fly   909 QNNQLTTIENATLAPLAALELIRIDGNRLVTLP-----IWQMHATHFGTRLKSISLGRNQWSCRC 968
            .|.:|..::.:....|.||       ..||.||     |.|..|.|. .:|:.:...|....|.|
Zfish   641 ANCRLLFLDGSLTKDLKAL-------TTLVLLPKDTVNILQTFAVHL-IQLEFVCFYRLGLYCSC 697

  Fly   969 QFLQALTSYVADNALIVQD-----AQDIYCMAASSGTGSAALEDSSSNSGSLEKRELDFNATGAA 1028
            .... |.|::.||..:..|     ..|:.|...:.      .:..:..|.:.|....|.:....|
Zfish   698 DNAW-LVSWIRDNRKVEVDMSNPSMHDLQCFFGNE------FDQLNFVSYAKENCSFDLDFVFFA 755

  Fly  1029 CTDYYSGGSMLQHGIPESYIPLLAAALALLFLLVVIAMVFA--------------FRESLRIWLF 1079
            |:..:                      ..:|::||:...|.              |||:||:
Zfish   756 CSSVF----------------------LCIFIVVVLMYKFVGQYFKPFYHIANGWFREALRM--- 795

  Fly  1080 AHYGVRVFGPRCEESEKLYDAVLLHSAKDSEFVCQHLAAQLETGRPP-LRVCLQHRD--LAHDAT 1141
                       .|:.:..|||.:.:|.||..:|.:.|...||...|| ||:||..||  |.||..
Zfish   796 -----------KEKQQYRYDAFVSYSGKDEHWVIEELLPNLEQRGPPFLRLCLHSRDFQLGHDIV 849

  Fly  1142 HYQLLEATRVSRRVVILLTRNFLQTEWARCELRRSVHDALRGRPQKLVIIEEPEVAFEAESDIEL 1206
            . .:.::...|||.:.|::||:|.:.|...|::.:.: .|:...:.::|:     .|     :|.
Zfish   850 E-NITDSIYASRRTLCLVSRNYLNSNWCSLEMQLATY-RLQVEHRDILIL-----VF-----LEN 902

  Fly  1207 LPYLKTSAVHRIRR-------------SDRH--FWEKL 1229
            :|....|:.||:.|             .:.|  ||::|
Zfish   903 IPSRLLSSHHRLARLVKTRTYLDWPQEPEMHDAFWDRL 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	21/65 (32%)
		leucine-rich repeat	136..159	CDD:275380	10/22 (45%)
		leucine-rich repeat	160..190	CDD:275380	6/29 (21%)
		LRR_8	189..259	CDD:290566	13/69 (19%)
		leucine-rich repeat	191..214	CDD:275380	9/22 (41%)
		leucine-rich repeat	215..248	CDD:275380	4/32 (13%)
		LRR_RI	247..501	CDD:238064	43/257 (17%)
		LRR_8	247..308	CDD:290566	12/64 (19%)
		leucine-rich repeat	249..273	CDD:275380	3/27 (11%)
		leucine-rich repeat	274..297	CDD:275380	7/22 (32%)
		LRR_8	297..356	CDD:290566	9/58 (16%)
		leucine-rich repeat	298..321	CDD:275380	5/22 (23%)
		leucine-rich repeat	322..345	CDD:275380	2/22 (9%)
		LRR_8	345..406	CDD:290566	9/60 (15%)
		leucine-rich repeat	346..371	CDD:275380	4/24 (17%)
		leucine-rich repeat	372..395	CDD:275380	4/22 (18%)
		leucine-rich repeat	396..419	CDD:275380	0/22 (0%)
		LRR_8	419..478	CDD:290566	14/58 (24%)
		leucine-rich repeat	420..443	CDD:275380	6/22 (27%)
		leucine-rich repeat	444..467	CDD:275380	4/22 (18%)
		LRR_RI	466..622	CDD:238064	34/164 (21%)
		leucine-rich repeat	468..488	CDD:275380	5/19 (26%)
		LRR_8	491..549	CDD:290566	16/65 (25%)
		leucine-rich repeat	491..514	CDD:275380	6/30 (20%)
		leucine-rich repeat	515..536	CDD:275380	6/20 (30%)
		leucine-rich repeat	539..562	CDD:275380	6/22 (27%)
		leucine-rich repeat	563..585	CDD:275380	0/21 (0%)
		leucine-rich repeat	586..626	CDD:275380	11/41 (27%)
		leucine-rich repeat	627..653	CDD:275380	9/25 (36%)
		LRRCT	716..772	CDD:214507	9/55 (16%)
		LRRNT	796..830	CDD:214470	8/38 (21%)
		leucine-rich repeat	812..829	CDD:275380	4/16 (25%)
		leucine-rich repeat	833..854	CDD:275380	7/20 (35%)
		LRR_8	853..913	CDD:290566	17/75 (23%)
		leucine-rich repeat	855..878	CDD:275380	3/22 (14%)
		LRR_4	878..918	CDD:289563	15/55 (27%)
		leucine-rich repeat	879..902	CDD:275380	9/29 (31%)
		leucine-rich repeat	903..926	CDD:275380	6/22 (27%)
		leucine-rich repeat	927..953	CDD:275380	9/30 (30%)
		TIR	1098..1235	CDD:214587	43/150 (29%)
tlr20.2	NP_001170914.2	leucine-rich repeat	358..383	CDD:275380	4/24 (17%)
		LRR_8	407..466	CDD:290566	23/106 (22%)
		leucine-rich repeat	408..431	CDD:275380	10/68 (15%)
		LRR_4	431..471	CDD:289563	13/41 (32%)
		leucine-rich repeat	432..455	CDD:275380	6/22 (27%)
		leucine-rich repeat	456..479	CDD:275380	8/24 (33%)
		leucine-rich repeat	496..539	CDD:275380	15/132 (11%)
		leucine-rich repeat	540..583	CDD:275380	14/63 (22%)
		leucine-rich repeat	584..608	CDD:275380	5/23 (22%)
		leucine-rich repeat	609..634	CDD:275380	6/24 (25%)
		leucine-rich repeat	635..658	CDD:275380	6/22 (27%)
		TIR	802..940	CDD:214587	42/149 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3549
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24216
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.870