DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-7 and tlr8a

DIOPT Version :9

Sequence 1:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster
Sequence 2:XP_001920594.5 Gene:tlr8a / 403137 ZFINID:ZDB-GENE-040219-13 Length:1019 Species:Danio rerio


Alignment Length:1185 Identity:261/1185 - (22%)
Similarity:420/1185 - (35%) Gaps:355/1185 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   176 RTLELFPDSLGGLKQLTDLDLGDNNLRQLPSGFLCPVGNLQVLN---LTRNRIRTAEQMGFADMN 237
            |.|::.|..|.   ..|.:||.:|.::.|.......:.||.:||   |.:||          ::.
Zfish    50 RKLKVLPQFLA---NTTYIDLSENYIKNLTVQSFHGLENLTLLNLNWLNQNR----------EVV 101

  Fly   238 CGAGSGSAGSELQVLDASHNELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVN 302
            ...|..|..::|:|||.:..:|:.|.:...    :.|:.|:|..|.::.::......:.:|.::.
Zfish   102 IAKGVFSNLTKLRVLDLNGIKLKYIPKDIP----KNLEKLSLVENKITWINLTTFEHVKNLSVLY 162

  Fly   303 LSNN--------HLETLPEGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSN 359
            ||||        ....:.:|..:....|:.:.|..|.|.::|.||...||:|   :|..|.||  
Zfish   163 LSNNCYYWNPCSRRYRIEKGSLSYLVNLKRLTLSFNNLTQVPIGLPVSLERL---ELGSNSLT-- 222

  Fly   360 HVDNTTFAGLIRLIVLNL----------------AHNALTRIDYRTFKELYFLQILNLRNNSIGH 408
            ::....|.||..|.||.:                ..|....|..:.|.:|..|.||:|..|||..
Zfish   223 YIGEHDFRGLFNLTVLKIQGNCPRCHTAPYPCIPCKNTSIEIHPQAFSDLRNLHILHLAGNSIKS 287

  Fly   409 IEDNAFLPLYNLHTLNLAENRLHTL----DDKLFNG-LYVLSKLTLNNNL------ISVVEPAVF 462
            |....|..|.||..|.|:.|.|.:.    .|.:|.| |.:|:||.|:.|.      ::||....|
Zfish   288 INPAWFANLSNLQQLFLSFNLLFSAITDPADTVFLGNLPLLTKLDLSYNFAFKTYPLTVVLSPGF 352

  Fly   463 KNCSDLKELDLSSNQLNEVP----RALQDLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDN 523
            .|.:.|:.|.|......::.    ::|.||..|..||:|.|.|....:..|:::..   |.|.:|
Zfish   353 ANLTSLRSLHLRGLVFRKIQKDTFKSLFDLQHLNVLDVGVNFIVFATSYIFQHVRL---LYLAEN 414

  Fly   524 QIGNITVG-------------------MFQDLPRLS---------------VLNLAKNRIQSIER 554
            ::..:||.                   |.:.|....               ||:|::|.:..|..
Zfish   415 RLYPVTVNGELSKATFVGSNHRSIMPLMAEPLDTFDAPKNLVKSECYNAGRVLDLSRNNLFLISP 479

  Fly   555 GSFDKNFELEAIRLDRN-FLADING-VFATLVSLLWLNLSENHL-VWFDYAFIP-SNLKWLDI-- 613
            ..||....:..:.|.|| |....|| .|.:|.:|.:|:||.|.: :.:|.||.. .:|:.|||  
Zfish   480 EQFDTYGNISCLNLSRNGFSTAPNGSEFTSLPNLKYLDLSFNKVDLAYDNAFRELQSLEVLDISY 544

  Fly   614 HGNYIEALG---NYYKLQEEIRVKTLDASHNRITEI--GPMSIPNTIELLFINNNL------IGN 667
            :.:|....|   |...||....:|.|:.|.|.|..:  ..||..:..||.|..|.|      ..|
Zfish   545 NSHYFTVAGVTHNMMFLQYLPSLKVLNMSFNSINTLTTKTMSSKSLRELQFRGNKLGRMWRDKDN 609

  Fly   668 VQPNAFVDKANLARVDLYANQLSKLQLQQLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQRINN 732
            .....|.:..||..:|:..|.:.|:        |......||            .|:..||..:|
Zfish   610 TYVMIFKNFTNLIHLDISNNSIGKI--------PYTVYTQLP------------ITIQRLQMSHN 654

  Fly   733 LTTRQHPRVMDMANIECVMPHARGAAVRPLSGLRPQDFLCRYESHCFALCHCCDFDACDCEMTCP 797
                      .:|||...|                   |.|::                      
Zfish   655 ----------QLANINWTM-------------------LRRFQ---------------------- 668

  Fly   798 SNCTCYHDQIWSTNVVDCGGQQTTELPRRVPMDSSVVYLDGNNFPVLKNHAFIGRKNLRALYVNG 862
                                                                    |||.|.::.
Zfish   669 --------------------------------------------------------NLRELILHD 677

  Fly   863 SQVAAIQNRTFASLASLQLLHLADNKLRTLHGYEFEQLSALRELYLQNNQLTTIENATLAPLAAL 927
            :.:..|.:.....:.||:||:|..|::..|.....:.:..|:||.|..|.|.|:..:|....:.|
Zfish   678 NNIIEIASNLSVDVPSLELLNLQHNRISKLAIGFLQGVVNLKELDLSYNYLITVNQSTFPTESDL 742

  Fly   928 ELIRIDGNRLVTLPIWQMHATHFGTRLKSISLGRNQWSCRCQFLQALTSYVADNALIVQDAQDIY 992
            :::.:.|                           |.:.|.|..|:.:...:..|..|.:      
Zfish   743 KMLWLHG---------------------------NPFHCTCNLLEFVLWILDTNVKIPR------ 774

  Fly   993 CMAASSGTGSAALEDSSSNSGSLEKRELDFNATGAACT--DYYSGGSMLQHGIPESYIPLLAAAL 1055
                                          ..||..||  :...|.::::..|.|.....||...
Zfish   775 ------------------------------LVTGVTCTMPEERKGLAVIKFDIQECIDDQLAFVA 809

  Fly  1056 ALLFLLVVIAMVF-AFRESLRIW----LFAHYGVRVFGPRCEESEK-LYDAVLLHSAKD---SEF 1111
            ..:....:|...| |....|..|    |:.:...|..|.:...||. :|||.:.:..||   |::
Zfish   810 YFISAACIICTTFAAITMHLFYWDVSYLYYYLKARFTGYQQLSSESCIYDAFITYDTKDPQVSDW 874

  Fly  1112 VCQHLAAQL-ETGRPPLRVCLQHRD-LAHDATHYQLLEATRVSRRVVILLTRNFLQTEWARCELR 1174
            |..||..|| |.....|.:||:.|| :........|.::.:.||:.|.:||..::.:        
Zfish   875 VLNHLRVQLEERSELFLPICLEERDWIPGSPVLDSLTQSIQNSRKTVFVLTEGYVNS-------- 931

  Fly  1175 RSVHDALRGRPQKLVIIEEPEVAFEAESDIELL---PYLKTSAVHRIRR---------------S 1221
                    |..:..|.:....:..|.|..|.||   |.|:.|...|:||               :
Zfish   932 --------GSFKLAVFLAHQRLLEENEDVIVLLLLEPVLQHSHFVRLRRRLCARSILEWPHSSSA 988

  Fly  1222 DRHFWEKLRYALPVD 1236
            :..||:.||.|:.||
Zfish   989 EAWFWQSLRNAIRVD 1003

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-7NP_523797.1 LRR_8 135..201 CDD:290566 8/24 (33%)
leucine-rich repeat 136..159 CDD:275380
leucine-rich repeat 160..190 CDD:275380 4/13 (31%)
LRR_8 189..259 CDD:290566 18/72 (25%)
leucine-rich repeat 191..214 CDD:275380 5/22 (23%)
leucine-rich repeat 215..248 CDD:275380 8/35 (23%)
LRR_RI 247..501 CDD:238064 80/292 (27%)
LRR_8 247..308 CDD:290566 15/68 (22%)
leucine-rich repeat 249..273 CDD:275380 6/23 (26%)
leucine-rich repeat 274..297 CDD:275380 4/22 (18%)
LRR_8 297..356 CDD:290566 18/66 (27%)
leucine-rich repeat 298..321 CDD:275380 6/30 (20%)
leucine-rich repeat 322..345 CDD:275380 8/22 (36%)
LRR_8 345..406 CDD:290566 20/76 (26%)
leucine-rich repeat 346..371 CDD:275380 8/24 (33%)
leucine-rich repeat 372..395 CDD:275380 7/38 (18%)
leucine-rich repeat 396..419 CDD:275380 10/22 (45%)
LRR_8 419..478 CDD:290566 22/69 (32%)
leucine-rich repeat 420..443 CDD:275380 9/27 (33%)
leucine-rich repeat 444..467 CDD:275380 9/28 (32%)
LRR_RI 466..622 CDD:238064 48/199 (24%)
leucine-rich repeat 468..488 CDD:275380 4/23 (17%)
LRR_8 491..549 CDD:290566 18/91 (20%)
leucine-rich repeat 491..514 CDD:275380 7/22 (32%)
leucine-rich repeat 515..536 CDD:275380 6/39 (15%)
leucine-rich repeat 539..562 CDD:275380 7/37 (19%)
leucine-rich repeat 563..585 CDD:275380 8/23 (35%)
leucine-rich repeat 586..626 CDD:275380 15/46 (33%)
leucine-rich repeat 627..653 CDD:275380 9/27 (33%)
LRRCT 716..772 CDD:214507 8/55 (15%)
LRRNT 796..830 CDD:214470 0/33 (0%)
leucine-rich repeat 812..829 CDD:275380 0/16 (0%)
leucine-rich repeat 833..854 CDD:275380 0/20 (0%)
LRR_8 853..913 CDD:290566 17/59 (29%)
leucine-rich repeat 855..878 CDD:275380 4/22 (18%)
LRR_4 878..918 CDD:289563 14/39 (36%)
leucine-rich repeat 879..902 CDD:275380 6/22 (27%)
leucine-rich repeat 903..926 CDD:275380 8/22 (36%)
leucine-rich repeat 927..953 CDD:275380 2/25 (8%)
TIR 1098..1235 CDD:214587 41/159 (26%)
tlr8aXP_001920594.5 NEL <15..>226 CDD:330839 48/197 (24%)
leucine-rich repeat 62..112 CDD:275380 14/59 (24%)
leucine-rich repeat 113..133 CDD:275380 6/23 (26%)
LRR_8 133..200 CDD:316378 13/66 (20%)
leucine-rich repeat 134..157 CDD:275380 4/22 (18%)
leucine-rich repeat 158..189 CDD:275380 6/30 (20%)
PLN00113 189..>702 CDD:331614 147/647 (23%)
leucine-rich repeat 190..234 CDD:275380 17/48 (35%)
leucine-rich repeat 235..274 CDD:275380 7/38 (18%)
leucine-rich repeat 275..298 CDD:275380 10/22 (45%)
leucine-rich repeat 299..327 CDD:275380 9/27 (33%)
leucine-rich repeat 328..357 CDD:275380 9/28 (32%)
leucine-rich repeat 358..381 CDD:275380 4/22 (18%)
leucine-rich repeat 465..487 CDD:275380 7/21 (33%)
leucine-rich repeat 488..512 CDD:275380 8/23 (35%)
leucine-rich repeat 513..536 CDD:275380 8/22 (36%)
leucine-rich repeat 537..566 CDD:275380 9/28 (32%)
leucine-rich repeat 567..620 CDD:275380 14/52 (27%)
leucine-rich repeat 621..645 CDD:275380 7/43 (16%)
leucine-rich repeat 646..669 CDD:275380 9/129 (7%)
leucine-rich repeat 670..693 CDD:275380 4/22 (18%)
LRR_8 692..752 CDD:316378 18/86 (21%)
leucine-rich repeat 694..717 CDD:275380 6/22 (27%)
leucine-rich repeat 718..736 CDD:275380 7/17 (41%)
TPKR_C2 750..>789 CDD:326558 10/74 (14%)
TIR 858..1000 CDD:214587 40/157 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.820

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