DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and tlr22

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001122147.2	Gene:	tlr22 / 403135	ZFINID:	ZDB-GENE-040220-5	Length:	955	Species:	Danio rerio

Alignment Length:	1230	Identity:	257/1230 - (20%)
Similarity:	424/1230 - (34%)	Gaps:	433/1230 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 DGSSQLTIQCSELYLFESTLPVAVFARLQTLEALRLDSCKLLQLPNNAF--------------EG 156
            |..:|..:.|.::..|  |:|                     ::|||.:              |.
Zfish    44 DIKTQPKVLCYKMNFF--TIP---------------------RVPNNTWILDISFNSFAQIQIED 85

  Fly   157 LATLKSLR-LSTHNSEWGPTRTLELFPDSLGGLKQLTDLDLGDNNLRQLPSGFLCPVGNLQVLNL 220
            |..|.:|: |:..|:     :..::...:.|.|..||||:|..|.|..:.:|.|..:.||.||.|
Zfish    86 LNILLNLQYLNVSNN-----KISKIQDGAFGSLFNLTDLNLASNRLNAVSNGMLRGLTNLLVLRL 145

  Fly   221 TRNRIRTAEQMGFADMNCGAGSGSAGSELQVLDASHNELRSISESWGISRLRRLQHLNLAYN--- 282
            .||.|...::..|:.::          .||||:.|.|.||.|.:...:.....|:.|.:..|
Zfish   146 DRNYISVIKESAFSTLH----------SLQVLNLSKNHLRHIDDVKPVLASLYLEELYIGSNYFN 200

  Fly   283 --NLSELSGEALAGLASLRIVNLSNNHLETLPEGLFAGSKELREIHLQQNELYELPKGLFHRLEQ 345
              |.||||.:.|    ||:.::||||.        ||.              ::|...:|.
Zfish   201 VFNSSELSTKPL----SLKRLDLSNNR--------FAA--------------FQLTNNIFP---- 235

  Fly   346 LLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNA-----LTRIDY-RTFKELYFL-------- 396
                       |.||:| .::.|          ||.     :|...| .:.|.|||:
Zfish   236 -----------TLNHLD-LSYCG----------HNGTMAWNVTEKSYLASVKTLYFMDVNMSIQT 278

  Fly   397 --QILNLRNNSIGHIEDNAFLPLYN-----------LHTLNLAENRLHTLDDKLFNGLYVLSKLT 448
              .:|...||::..|..|..:.|..           |..|.|...::..|.:.:|:....||:|.
Zfish   279 ADNVLQSFNNTLNKIRLNGNVRLNKTSLLLSVCSPMLRVLRLIATKIKHLTNHMFDPCSELSELD 343

  Fly   449 LNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRALQDLAMLRTLDLGENQIRTFDNQSFKNLH 513
            |..|.||.:..::|:....||:|.|..|:|..|..:.|.|..|..:||..|.|.......|.||.
Zfish   344 LGGNEISNLSQSMFRGFKQLKKLQLQINKLTRVTNSFQILTSLEFIDLSRNHIHKLSCNDFANLT 408

  Fly   514 QLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRNFLADING 578
            |:..|.|..|:|.:|...:|:||..|.||.|..|.:..|:....:..:.|:.::|..|.|:.|..
Zfish   409 QVKTLYLYSNKISSIRSCLFKDLKSLEVLRLGTNNLLKIDDVFSNGPYFLKELQLSYNKLSLIKS 473

  Fly   579 -VFATLVSLLWLNLSENHLVWFD-YAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVKTLDASHN 641
             .|..|..|..|:|.:|.:...: |||            ..:|.|.:.:....:|..|||
Zfish   474 HTFGNLPQLNNLSLEDNQISEIEGYAF------------GGLENLTSLFLSSNKITGKTL----- 521

  Fly   642 RITEIGPMSIPNTIELLFINNNLIGNVQPNAFVDKANLARVDLYANQLSKLQLQQLRVAPVVAPK 706
                                     ...||.|....||..:||:||.:|
Zfish   522 -------------------------TTHPNVFSGMPNLQNLDLFANSIS---------------- 545

  Fly   707 PLPEFYLGGNPFECDCTMDWLQRINNLTTRQHPRVMDMANIECVMPHARGAAVRPLSGLRPQDFL 771
                       |..|             ..::|...|:.|:            |.||
Zfish   546 -----------FAYD-------------KLKYPLFKDLKNL------------RELS-------- 566

  Fly   772 CRYESHCFALCHCCDFDACDCEMTCPSNCTCYHDQIWSTNVVDCGGQQTTELPRRVPMDSSVVYL 836
                                                                          :|.
Zfish   567 --------------------------------------------------------------LYS 569

  Fly   837 DGNNFPVLKNHAFIGRKNLRALYVNGSQVAAIQNRTFASLASLQLLHLADNKLR---TLHGYEFE 898
            .......|.::...|..:|:..|:..:.:..:....|.....|..|.|:.|.||   .:....|.
Zfish   570 QRRGIGQLPSNLLEGLSSLQMFYIGNTNLNQLNPNLFNFTPQLWFLDLSKNALREDDAIPPELFH 634

  Fly   899 QLSALRELYLQNNQLTTIENATLAPLAALELIRIDGNR--------LVTLPIWQMHATHFGTRLK 955
            .:..|.:|.:...||.::.....|.|..|..:|..||.        :.:||           ||.
Zfish   635 PIPNLTKLIISRTQLRSLNFLLGANLNKLSTLRASGNEIDSVNETLIKSLP-----------RLA 688

  Fly   956 SISLGRNQWSCRCQFLQALTSYVADNALIV-----QDAQDIYCMAASSGTGSAALEDSSSNSGSL 1015
            .:.|..|.::|.|           :||..:     .::..:|.::..:.:....|..:|.
Zfish   689 VLDLQNNTFTCDC-----------NNAFFIDWAKKNESTQVYYLSRYTCSYPRTLRGTSL----- 737

  Fly  1016 EKRELDFNATGAACTDYYSGGSMLQHGIPESYIPLLAAALALLFLLVVIAMVFAFRESLRIWLFA 1080
                .:||..  :||..:            .||..:.::     :||::.::.:|     ||.|.
Zfish   738 ----AEFNTD--SCTFNW------------DYICFVCSS-----ILVILTLLLSF-----IWNFL 774

  Fly  1081 HYGV---------RVFGPRCEESEKL--YDAVLLHSAKDSEFVCQHLAAQLETGRPPLRVCLQHR 1134
            .|.|         .::..|..:|.:.  |||.:.::..|..:|.:.|..:|| |....|:||.||
Zfish   775 RYQVVYTYYLFLAFLYDSRRNQSGQTFQYDAFISYNTLDEAWVMEELIPKLE-GEQGWRLCLHHR 838

  Fly  1135 DLAHDATHY-QLLEATRVSRRVVILLTRNFLQTEWARCELRRSVHDALRGRPQKLVIIEEPEVA- 1197
            |........ .:::....||:.:.|:|||:|::.|...|:                     :||
Zfish   839 DFEPGRPIIDNIVDGIYSSRKTICLITRNYLKSNWCSSEV---------------------QVAS 882

  Fly  1198 ---FEAESDIELLPYL------KTSAVHRIRR---------------SDRHFWEKLRYAL 1233
               |:.:.|:.:|.:|      :.|..||:|:               .::.||:||:.||
Zfish   883 FRLFDEQKDVLILVFLEDIPTHQLSPYHRLRKLVKKRTYIRWPKPGEDNKIFWQKLKMAL 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	17/80 (21%)
		leucine-rich repeat	136..159	CDD:275380	5/36 (14%)
		leucine-rich repeat	160..190	CDD:275380	6/30 (20%)
		LRR_8	189..259	CDD:290566	24/69 (35%)
		leucine-rich repeat	191..214	CDD:275380	9/22 (41%)
		leucine-rich repeat	215..248	CDD:275380	8/32 (25%)
		LRR_RI	247..501	CDD:238064	73/285 (26%)
		LRR_8	247..308	CDD:290566	24/65 (37%)
		leucine-rich repeat	249..273	CDD:275380	9/23 (39%)
		leucine-rich repeat	274..297	CDD:275380	9/27 (33%)
		LRR_8	297..356	CDD:290566	10/58 (17%)
		leucine-rich repeat	298..321	CDD:275380	7/22 (32%)
		leucine-rich repeat	322..345	CDD:275380	2/22 (9%)
		LRR_8	345..406	CDD:290566	16/76 (21%)
		leucine-rich repeat	346..371	CDD:275380	5/24 (21%)
		leucine-rich repeat	372..395	CDD:275380	6/28 (21%)
		leucine-rich repeat	396..419	CDD:275380	6/32 (19%)
		LRR_8	419..478	CDD:290566	18/69 (26%)
		leucine-rich repeat	420..443	CDD:275380	5/22 (23%)
		leucine-rich repeat	444..467	CDD:275380	8/22 (36%)
		LRR_RI	466..622	CDD:238064	47/157 (30%)
		leucine-rich repeat	468..488	CDD:275380	8/19 (42%)
		LRR_8	491..549	CDD:290566	22/57 (39%)
		leucine-rich repeat	491..514	CDD:275380	8/22 (36%)
		leucine-rich repeat	515..536	CDD:275380	6/20 (30%)
		leucine-rich repeat	539..562	CDD:275380	6/22 (27%)
		leucine-rich repeat	563..585	CDD:275380	7/22 (32%)
		leucine-rich repeat	586..626	CDD:275380	9/40 (23%)
		leucine-rich repeat	627..653	CDD:275380	4/25 (16%)
		LRRCT	716..772	CDD:214507	8/55 (15%)
		LRRNT	796..830	CDD:214470	0/33 (0%)
		leucine-rich repeat	812..829	CDD:275380	0/16 (0%)
		leucine-rich repeat	833..854	CDD:275380	3/20 (15%)
		LRR_8	853..913	CDD:290566	12/62 (19%)
		leucine-rich repeat	855..878	CDD:275380	3/22 (14%)
		LRR_4	878..918	CDD:289563	11/42 (26%)
		leucine-rich repeat	879..902	CDD:275380	7/25 (28%)
		leucine-rich repeat	903..926	CDD:275380	6/22 (27%)
		leucine-rich repeat	927..953	CDD:275380	6/33 (18%)
		TIR	1098..1235	CDD:214587	40/162 (25%)
tlr22	NP_001122147.2	leucine-rich repeat	458..481	CDD:275380	7/22 (32%)
		LRR_RI	461..700	CDD:238064	66/413 (16%)
		LRR_8	480..544	CDD:290566	22/105 (21%)
		leucine-rich repeat	482..505	CDD:275380	7/34 (21%)
		leucine-rich repeat	506..533	CDD:275380	8/56 (14%)
		leucine-rich repeat	534..561	CDD:275380	10/66 (15%)
		LRR_8	560..622	CDD:290566	14/143 (10%)
		leucine-rich repeat	562..587	CDD:275380	6/106 (6%)
		leucine-rich repeat	588..606	CDD:275380	2/17 (12%)
		leucine-rich repeat	612..638	CDD:275380	7/25 (28%)
		LRR_8	637..695	CDD:290566	15/68 (22%)
		leucine-rich repeat	639..662	CDD:275380	6/22 (27%)
		leucine-rich repeat	663..686	CDD:275380	6/33 (18%)
		leucine-rich repeat	687..705	CDD:275380	6/28 (21%)
		TIR	802..945	CDD:214587	40/163 (25%)
		leucine-rich repeat	71..91	CDD:275380	3/19 (16%)
		LRR_8	91..150	CDD:290566	21/63 (33%)
		leucine-rich repeat	92..115	CDD:275380	5/27 (19%)
		leucine-rich repeat	116..139	CDD:275380	9/22 (41%)
		LRR_8	138..199	CDD:290566	21/70 (30%)
		leucine-rich repeat	140..163	CDD:275380	8/32 (25%)
		leucine-rich repeat	164..213	CDD:275380	18/52 (35%)
		leucine-rich repeat	214..338	CDD:275380	33/171 (19%)
		LRR_8	337..396	CDD:290566	21/58 (36%)
		leucine-rich repeat	339..362	CDD:275380	8/22 (36%)
		LRR_RI	<363..494	CDD:238064	43/130 (33%)
		leucine-rich repeat	363..385	CDD:275380	9/21 (43%)
		LRR_8	384..444	CDD:290566	22/59 (37%)
		leucine-rich repeat	386..409	CDD:275380	8/22 (36%)
		leucine-rich repeat	410..433	CDD:275380	8/22 (36%)
		LRR_8	432..492	CDD:290566	17/59 (29%)
		leucine-rich repeat	434..457	CDD:275380	6/22 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3549
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24216
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.970