DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and tlr19.1

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001352353.1	Gene:	tlr19.1 / 403134	ZFINID:	ZDB-GENE-040220-3	Length:	958	Species:	Danio rerio

Alignment Length:	1200	Identity:	261/1200 - (21%)
Similarity:	437/1200 - (36%)	Gaps:	391/1200 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 SQLTIQCSELYLFE--STLPVAVFARLQTLEALRLDSCKLLQLPNNAFEGLATLKSLRLSTHNSE 171
            ||:..:...|.:|.  :::|...|:.|.:||.|.:|..:|.::...|||||..||.|.:...:..
Zfish    74 SQVGFEVRTLCVFGDITSIPAKAFSHLPSLEVLHIDGIRLERVQAGAFEGLPNLKYLSMLFSDEL 138

  Fly   172 WGPTRTLELFPDSLGGLKQLTDLDLGDNNLRQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFADM 236
            :   |.:.:...|..||..|.:|.|....|....||...|:.:|..|::.|.   .|:.:|  ::
Zfish   139 Y---RLVRIDNRSFAGLNNLEELSLTGLMLLNGSSGIFDPLVSLIRLDIVRT---CAQDLG--EI 195

  Fly   237 NCGAGSGSAGSELQVLDASHNELRSI--------SESWGISRLRRLQHLNLAYNNLSELSGEALA 293
            .|...:|.  :.|:.|:...:|:.:|        |.:|.::.|..:|:|.|..||:..:...:|
Zfish   196 FCCISNGM--TRLRHLNVEDSEISTIENKGCPGGSMTWPLTALSGVQNLYLIGNNIKYIQANSL- 257

  Fly   294 GLASLRIVNLSNNHLETLPEGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTS 358
                :...|||:..||.  ||...||            ::|...|..:.|      .|.|..|..
Zfish   258 ----IIFQNLSSLFLEF--EGKSLGS------------IWESGVGKVNDL------TLKGKVLKK 298

  Fly   359 NHVDNTTFAGLIRLI------VLNLAHNALTRIDYRTFKEL-YFLQILNLRNNSIGHIEDNAFLP 416
            .   :|.|..|..|:      .|:|.:.::.|:.....|:. ..|..|.::|:.|.:::...:..
Zfish   299 Y---STNFKDLCHLVSSLYSQSLSLVYTSIDRLTAEDLKDCGTKLTKLLIQNSKIDNLDFRFWTS 360

  Fly   417 LYNLHTLNLAENRLHTLDDKLF-----NGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSN 476
            ...:..|.:|..:   |.|..|     :.::.|:.|.|..|.|:.:|...|. |
Zfish   361 KLEMQALQMAYMK---LTDAPFCFVANSTMWSLTSLDLTGNSITNIEGDQFA-C----------- 410

  Fly   477 QLNEVPRALQDLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSV 541
                       :..|..|.|.:|.|:|....:|:.|.:|..|:|..|:|..::...|::|..|.|
Zfish   411 -----------MPFLEQLYLSQNAIKTLQLHAFRGLPRLKILQLDSNKIWQLSANDFKNLRALEV 464

  Fly   542 LNLAKNRIQSIERGSFDKNFELEAIRLDRNFLADINGVFATLVSLLWLNLSENHLVWFDYAFIPS 606
            |.:..|.|::||.|:|          .|:..|.:::  |..|..:..|:| ||  ::|::   |.
Zfish   465 LLINDNIIETIETGTF----------WDQRELCELS--FGRLEYVYELHL-EN--IFFEF---PP 511

  Fly   607 NLKWLDIHGNYIEALG-NYYKLQEEIRVKTLDASHNRITEIGPMSIPNTIELLFINNNLIGNVQP 670
            .|:.|.|..:|    | |.|                    ||..|.||....|.:|...:|
Zfish   512 KLQRLSIDAHY----GTNIY--------------------IGNASPPNGTFALELNGERLG---- 548

  Fly   671 NAFVDKANLARVDLYANQLSKLQLQQLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQRINNLTT 735
                                                     ::|       |..|.|..:..|
Zfish   549 -----------------------------------------FVG-------CDSDVLMAVREL-- 563

  Fly   736 RQHPRVMDMANIECVMPHARGAAVRPLSGLRPQDFLCRYESHCFALCHCCDFDACDCEMTCPSNC 800
                      .:.|..                  |||:                       .|..
Zfish   564 ----------KVNCTY------------------FLCK-----------------------DSFM 577

  Fly   801 TCYHDQIWSTNVVDCGGQQTTELPRRVPMDSSVVYLDGNNFPVLKNHAFIGRKNLRALYVNGSQV 865
            ..|...:.|..:  .||.:      |.|::.:.:    ||...|| |..:.|.|
Zfish   578 APYFLNLESLEI--SGGAE------RAPLNYATI----NNLHHLK-HLKLARLN----------- 618

  Fly   866 AAIQNRTFASLASLQLLHLADNKLRTLHGYEFEQLSALRELYLQNNQLTTIENATLAPLAALELI 930
              ..|.|.:..|                   |..|:.|:.|.:.|..|:.:..:....|.:|:|:
Zfish   619 --FPNYTESRSA-------------------FWNLTQLQTLVVVNCHLSFLTKSMFRDLTSLQLL 662

  Fly   931 RI--DGNRLVT------LPIWQMHATHFGTRLKSISLGRNQWSCRCQFLQALTSYVADNALIVQD 987
            |:  |...::|      ||:           ||:..|.|..:.|.|:     ..::.|.|...:.
Zfish   663 RLYSDSPLILTDGVFGVLPV-----------LKAFILDRVDFQCSCE-----NGWLLDWADSTEK 711

  Fly   988 AQDIYCMAASSGTGSAALEDSSSNSGSLEKRE-------LDFNAT-GAAC-TDYYSGGSMLQHGI 1043
            .|.||                      |:|::       |:|.|| ...| ||
Zfish   712 VQVIY----------------------LQKQQCVWHYQKLNFLATMEKLCQTD------------ 742

  Fly  1044 PESYIPLLAAALAL-LFLLVVIAMVFAFRESLRIWL-FAHYGVRVFGPRC------------EES 1094
             ..||..:|.|.:: |.|...:...||...||.::| ...:..|.||.|.            |..
Zfish   743 -AQYICYVATASSISLLLSAAVGYQFARWPSLVLFLRLKGWMERRFGRRWNRRRRRMEDDYGEIE 806

  Fly  1095 EKLYDAVLLHSAKDSEFVCQHLAAQL-ETGRPPLRVCLQHRD--LAHDATHYQLLEATRVSRRVV 1156
            |..|||.:...::|..:|...:|::| |.|.|.||:||.:||  :..|... .:.::...|:..|
Zfish   807 EMQYDAFVSFCSQDEAWVLGEMASRLEEQGNPRLRLCLHNRDFEVGKDIMD-NITDSIHNSQCTV 870

  Fly  1157 ILLTRNFLQTEWARCELRRSVHDALRGRPQKLVIIEEPEVAFEAESDIELLPYLKTSAVHRIRR- 1220
            .|::|.:|:::|...|:|.:.|..|..:..:|::|....:     |..||      ||.||:.:
Zfish   871 CLISRRYLRSDWCGLEMRVATHRQLEEQKHRLILIFLQHI-----SPFEL------SAFHRLAKL 924

  Fly  1221 -------------SDR-HFWEKLRYALPVD 1236
                         .|| |||::||..:..|
Zfish   925 VRSRTYLDWPEEEGDREHFWDRLRRNIAED 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	20/65 (31%)
		leucine-rich repeat	136..159	CDD:275380	10/22 (45%)
		leucine-rich repeat	160..190	CDD:275380	7/29 (24%)
		LRR_8	189..259	CDD:290566	16/69 (23%)
		leucine-rich repeat	191..214	CDD:275380	7/22 (32%)
		leucine-rich repeat	215..248	CDD:275380	7/32 (22%)
		LRR_RI	247..501	CDD:238064	57/273 (21%)
		LRR_8	247..308	CDD:290566	16/68 (24%)
		leucine-rich repeat	249..273	CDD:275380	7/31 (23%)
		leucine-rich repeat	274..297	CDD:275380	6/22 (27%)
		LRR_8	297..356	CDD:290566	14/58 (24%)
		leucine-rich repeat	298..321	CDD:275380	9/22 (41%)
		leucine-rich repeat	322..345	CDD:275380	3/22 (14%)
		LRR_8	345..406	CDD:290566	14/67 (21%)
		leucine-rich repeat	346..371	CDD:275380	6/24 (25%)
		leucine-rich repeat	372..395	CDD:275380	5/29 (17%)
		leucine-rich repeat	396..419	CDD:275380	4/22 (18%)
		LRR_8	419..478	CDD:290566	13/63 (21%)
		leucine-rich repeat	420..443	CDD:275380	5/27 (19%)
		leucine-rich repeat	444..467	CDD:275380	8/22 (36%)
		LRR_RI	466..622	CDD:238064	38/155 (25%)
		leucine-rich repeat	468..488	CDD:275380	0/19 (0%)
		LRR_8	491..549	CDD:290566	19/57 (33%)
		leucine-rich repeat	491..514	CDD:275380	8/22 (36%)
		leucine-rich repeat	515..536	CDD:275380	6/20 (30%)
		leucine-rich repeat	539..562	CDD:275380	9/22 (41%)
		leucine-rich repeat	563..585	CDD:275380	4/21 (19%)
		leucine-rich repeat	586..626	CDD:275380	12/40 (30%)
		leucine-rich repeat	627..653	CDD:275380	3/25 (12%)
		LRRCT	716..772	CDD:214507	6/55 (11%)
		LRRNT	796..830	CDD:214470	7/33 (21%)
		leucine-rich repeat	812..829	CDD:275380	3/16 (19%)
		leucine-rich repeat	833..854	CDD:275380	6/20 (30%)
		LRR_8	853..913	CDD:290566	9/59 (15%)
		leucine-rich repeat	855..878	CDD:275380	2/22 (9%)
		LRR_4	878..918	CDD:289563	6/39 (15%)
		leucine-rich repeat	879..902	CDD:275380	2/22 (9%)
		leucine-rich repeat	903..926	CDD:275380	5/22 (23%)
		leucine-rich repeat	927..953	CDD:275380	7/33 (21%)
		TIR	1098..1235	CDD:214587	43/154 (28%)
tlr19.1	NP_001352353.1	LRR_8	101..162	CDD:316378	20/63 (32%)
		leucine-rich repeat	103..126	CDD:275380	10/22 (45%)
		leucine-rich repeat	127..154	CDD:275380	7/29 (24%)
		leucine-rich repeat	155..178	CDD:275380	7/22 (32%)
		leucine-rich repeat	179..238	CDD:275380	14/65 (22%)
		leucine-rich repeat	207..219	CDD:275378	2/11 (18%)
		leucine-rich repeat	239..265	CDD:275380	8/30 (27%)
		leucine-rich repeat	340..363	CDD:275380	4/22 (18%)
		leucine-rich repeat	364..389	CDD:275380	5/27 (19%)
		LRR_8	389..448	CDD:316378	20/81 (25%)
		leucine-rich repeat	390..413	CDD:275378	8/45 (18%)
		leucine-rich repeat	414..437	CDD:275378	8/22 (36%)
		LRR_8	436..>482	CDD:316378	16/55 (29%)
		leucine-rich repeat	438..461	CDD:275378	7/22 (32%)
		leucine-rich repeat	462..485	CDD:275378	10/32 (31%)
		leucine-rich repeat	540..562	CDD:275380	7/73 (10%)
		leucine-rich repeat	563..608	CDD:275380	14/109 (13%)
		leucine-rich repeat	609..634	CDD:275380	10/57 (18%)
		leucine-rich repeat	635..658	CDD:275380	5/22 (23%)
		TIR	809..952	CDD:214587	43/154 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910