DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and Toll-9

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster

Alignment Length:	1095	Identity:	197/1095 - (17%)
Similarity:	352/1095 - (32%)	Gaps:	412/1095 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   312 PEGLFAGSKELREIHLQQNEL--------------------------YELPKGLFH----RLEQL 346
            |:.....|:|..|:..::.:|                          ::.|.|...    :....
  Fly    37 PDSATTSSEEAEEVSKERTDLKSLMLKYESDDGNSCLLDLIKDEVIWWQFPNGTLRDSTKKYAHK 101

  Fly   347 LVVDLSGNQLTSNHVDNTTF--AGLIRLI------VLNLAHNALTRIDYRTFKELY----FLQIL 399
            |.:|||...|..   |:..|  |.|.|.:      |.:.|.|.||...:||   ||    .|::|
  Fly   102 LYLDLSHGNLKD---DSDLFREAKLSRKVTIWRTEVFSAAFNTLTAAPFRT---LYSMRESLKLL 160

  Fly   400 NLRNNSIGHI----EDNA-FLPLYNLHTLNLAENR-----LHTLDDKLFNGLYVLSKLTLNN--- 451
            :||.|:...:    ||.| |:....|...|...:.     ||...|......|    |..||
  Fly   161 SLRGNNFAELIPDAEDFARFVNESRLEASNSVPHHCELLLLHNTTDLYDRECY----LYFNNNTN 221

  Fly   452 ------------NLISVVEP--------------AVFKNCSDLKELDLSSNQLNEVPR-ALQDLA 489
                        |.|.|::.              |.|.....|.|||:|:..:..|.: |.::::
  Fly   222 MGQSITTGRNYTNFIKVLKDRFDQHGSSSQSIAWATFPKMPRLVELDISNCSIEYVSKEAFRNVS 286

  Fly   490 MLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQ-DLPRLSV-LNLAKNRIQSI 552
            .||.|.:.:|:|.|..:.:|   :.:.|::.:|....|.....:| .||.|.: |:|
  Fly   287 NLRRLFMSDNKIMTISHDTF---YYVQGVQYLDLSFTNFLTYSYQLQLPTLEMALSL-------- 340

  Fly   553 ERGSFDKNFELEAIRLDRNFLADINGVFATLVSLLWLNLS-----ENHLVWFDYAFIPSNLKWLD 612
                      :..:::.:|       ||..|..|::|:||     .|..|.|.:
  Fly   341 ----------IYGLKIQQN-------VFKYLPELIYLDLSHSKMTRNSAVAFAH----------- 377

  Fly   613 IHGNYIEALGNYYKLQEEIRVKTLDASHNRITEIGPMSIPNTI-ELLFINNN--LIGNVQPNAFV 674
                    ||:        ::|.|...:..|..:......||: |.|.::.|  |..|:..:||
  Fly   378 --------LGD--------KLKFLSLCYTAIPMVSSTIFKNTVLEGLDLSGNPYLSYNIIDDAF- 425

  Fly   675 DKANLARVDLYANQLSKLQLQQLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQRINNLTTRQHP 739
                    |..||.|..|..::
  Fly   426 --------DGIANTLKYLYFER------------------------------------------- 439

  Fly   740 RVMDMANIECVMPHARGAAVRPLSGLRPQDFLCRYESHCFALCHCCDFDACDCEMTCPSNCTCYH 804
                 :||:
  Fly   440 -----SNIK-------------------------------------------------------- 443

  Fly   805 DQIWSTNVVDCGGQQTTELPRRVPMDSSVVYLDGNNFPVLKNHAFIGRKNLRALYVNGSQVAAIQ 869
            |..||.::                                        |||:.|.:.|:.:.|:.
  Fly   444 DLEWSKSL----------------------------------------KNLQVLGLAGNNINALT 468

  Fly   870 NRTFASLASLQLLHLADNKLRTLHGYEFEQLSALRELYLQNNQLTTIENATLAPLAALELIRIDG 934
            ...|.||.||::|.|:.|.:...:...|...||||.|.|::|.:..:.|..|.....|:.:.:..
  Fly   469 PAMFQSLESLEILDLSSNHVGNWYRSAFHNNSALRVLNLRSNTINMLSNEMLKDFERLDYLSLGD 533

  Fly   935 NRLV-----------------------TLPIWQMHATHFGTRL----KSISLGRNQWSCR-CQFL 971
            |..:                       .|..:..:|.  |..:    :|:.:.|..|..| ..:|
  Fly   534 NDFICDCHLRAVVEVAAANNKDADCSYRLLNYSQNAV--GEEVISLAESLIIDRKLWQSRYIPWL 596

  Fly   972 QALTSYV-----ADNALIVQDAQDIYCMAASSGTGSAALEDSSSNSGSLEKRELDFNATGAACTD 1031
            |...|.:     |::.:.::.:.:.|.:|..|......|.|...:. :|:.:.||:.|:...|
  Fly   597 QRSYSNIREFNRANHIIKLRFSSEDYMVAKCSAAQPYHLGDLDGDL-TLKFQLLDYEASQYYC-- 658

  Fly  1032 YYSGGSMLQ------------------HGIPESYIPLLAAALALLFLLVVIAMVFAFRESLRIWL 1078
             ::....||                  |.:..:.|.::.:        :|.|.:..|...|:.|.
  Fly   659 -FNNTDQLQVDELNCQIRSMSDLAEELHHVTNTVIAVMGS--------LVGACILGFIIYLKRWH 714

  Fly  1079 FAHY-----GVRVFGPRCEES------------EKLYDAVLLHSAKDSEFVCQHLAAQL-ETGRP 1125
            ..:|     ...:.....:||            ..:||..:.:...|..:|...|...: |||
  Fly   715 IHYYYSSLKSAALLSSASKESVNKFTNISQRDPSAVYDIFISYCQNDRTWVLNELLPNVEETG-- 777

  Fly  1126 PLRVCLQHRDLAHDATHY-QLLEATRVSRRVVILLTRNFLQTEWARCELRRSVHDALRGRPQKLV 1189
            .:.:||..||.....|.. .::.....|..::::::..||.:.|.:.|:..:.|.......:.|:
  Fly   778 DVSICLHERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLI 842

  Fly  1190 II--------EEPEVAFEAESDIELLPYLKTSAVHRIRRSDRH-FWEKLRYALPV 1235
            ::        :.|:.       ::.|..:||.......:.||. ||::|:.:|.|
  Fly   843 LVFLEDIPRRKRPKT-------LQYLMDVKTYIKWPTAKEDRKLFWKRLKRSLEV 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380
		LRR_RI	247..501	CDD:238064	60/270 (22%)
		LRR_8	247..308	CDD:290566
		leucine-rich repeat	249..273	CDD:275380
		leucine-rich repeat	274..297	CDD:275380
		LRR_8	297..356	CDD:290566	11/73 (15%)
		leucine-rich repeat	298..321	CDD:275380	2/8 (25%)
		leucine-rich repeat	322..345	CDD:275380	4/52 (8%)
		LRR_8	345..406	CDD:290566	24/72 (33%)
		leucine-rich repeat	346..371	CDD:275380	9/26 (35%)
		leucine-rich repeat	372..395	CDD:275380	9/32 (28%)
		leucine-rich repeat	396..419	CDD:275380	9/27 (33%)
		LRR_8	419..478	CDD:290566	19/92 (21%)
		leucine-rich repeat	420..443	CDD:275380	5/27 (19%)
		leucine-rich repeat	444..467	CDD:275380	8/51 (16%)
		LRR_RI	466..622	CDD:238064	34/163 (21%)
		leucine-rich repeat	468..488	CDD:275380	7/20 (35%)
		LRR_8	491..549	CDD:290566	16/59 (27%)
		leucine-rich repeat	491..514	CDD:275380	7/22 (32%)
		leucine-rich repeat	515..536	CDD:275380	4/21 (19%)
		leucine-rich repeat	539..562	CDD:275380	3/23 (13%)
		leucine-rich repeat	563..585	CDD:275380	4/21 (19%)
		leucine-rich repeat	586..626	CDD:275380	9/44 (20%)
		leucine-rich repeat	627..653	CDD:275380	3/25 (12%)
		LRRCT	716..772	CDD:214507	2/55 (4%)
		LRRNT	796..830	CDD:214470	3/33 (9%)
		leucine-rich repeat	812..829	CDD:275380	0/16 (0%)
		leucine-rich repeat	833..854	CDD:275380	0/20 (0%)
		LRR_8	853..913	CDD:290566	22/59 (37%)
		leucine-rich repeat	855..878	CDD:275380	7/22 (32%)
		LRR_4	878..918	CDD:289563	13/39 (33%)
		leucine-rich repeat	879..902	CDD:275380	5/22 (23%)
		leucine-rich repeat	903..926	CDD:275380	7/22 (32%)
		leucine-rich repeat	927..953	CDD:275380	5/48 (10%)
		TIR	1098..1235	CDD:214587	30/147 (20%)
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	9/27 (33%)
		LRR_8	262..322	CDD:290566	16/62 (26%)
		leucine-rich repeat	264..287	CDD:275380	7/22 (32%)
		leucine-rich repeat	288..311	CDD:275380	7/25 (28%)
		leucine-rich repeat	312..356	CDD:275380	12/68 (18%)
		LRR_8	<344..387	CDD:290566	15/76 (20%)
		leucine-rich repeat	357..381	CDD:275380	9/50 (18%)
		leucine-rich repeat	382..397	CDD:275380	3/14 (21%)
		leucine-rich repeat	405..430	CDD:275380	8/33 (24%)
		LRR_8	431..488	CDD:290566	21/200 (11%)
		leucine-rich repeat	432..453	CDD:275380	7/164 (4%)
		LRR_RI	<449..536	CDD:238064	26/126 (21%)
		leucine-rich repeat	454..477	CDD:275380	7/22 (32%)
		LRR_8	477..536	CDD:290566	17/58 (29%)
		leucine-rich repeat	478..501	CDD:275380	5/22 (23%)
		leucine-rich repeat	502..525	CDD:275380	7/22 (32%)
		TIR	751..891	CDD:214587	31/149 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453680
Domainoid	1	1.000	44	1.000	Domainoid score	I4673
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24216
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
	6	5.850