DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and CG4950

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001261934.1	Gene:	CG4950 / 39783	FlyBaseID:	FBgn0036587	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	440	Identity:	118/440 - (26%)
Similarity:	184/440 - (41%)	Gaps:	86/440 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 LQVLDASHNELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLPE 313
            |:.||.|:..:..::.: ..|....|.:||||||||:.:......|...|..::||.|.:.:|..
  Fly    96 LKTLDVSNTNILELTRN-AFSAASNLTYLNLAYNNLTSIQTSVFIGANVLMRLDLSYNEISSLSV 159

  Fly   314 GLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLA 378
            ..|.|...:.:|:|..|.|.||...:|...|.|..|...||.|||  :....|..:.|:..:||:
  Fly   160 NAFCGLHTISQIYLTGNLLKELHNDIFKDNEYLEKVSFEGNLLTS--IQPEVFRNMRRIKEVNLS 222

  Fly   379 HNALTRIDYRTFKELYFLQILNLRNNSIGHI---EDNAFLPLYNLHTLNLAENRLHTLDDKLFNG 440
            :|.|..|...||.:...|:.|.|..|.:.:.   |.|.      :|.|:|..|
  Fly   223 NNRLIFIHPDTFADAASLENLVLSYNELKNFQLTEKNI------VHQLHLDNN------------ 269

  Fly   441 LYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRALQDLAMLRTLDLGENQIRTFD 505
              .|:.||:|..                :.:..|.||::|:  .|.....:.||||..|::.:..
  Fly   270 --YLTNLTINAT----------------RFVRASHNQISEL--FLHQSLHIETLDLSANKLSSIS 314

  Fly   506 NQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDR 570
            |  ..|:..:..|.:.||.||.:.:..|..|.||..|||....|:.::.|.|.|...||.:.|..
  Fly   315 N--ITNITHMLYLDVSDNPIGPLNISTFSQLKRLRGLNLRGTGIRELKFGMFSKQKYLEELDLSF 377

  Fly   571 NFLADINGVFATLVSLLWLNLSENHLVWFDYAFIP--SNLKWLDIHGNYI-EALGNYYKLQEEIR 632
            |             :|..|||.         .|:|  :|||...|.||.: |..||....:...:
  Fly   378 N-------------NLTILNLD---------MFVPYLTNLKKFLIDGNGLTELQGNRTFSEAFPQ 420

  Fly   633 VKTLDASHNRIT------EIGPMSIPNTIELLFINNNLIGNVQPNAFVDK 676
            ::.|..|.||..      .:.|.|:|.::.|         |::|:..:|:
  Fly   421 LQKLGVSRNRFNCSYLHHLLIPPSLPESVVL---------NIEPDTNLDE 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566	4/9 (44%)
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380
		LRR_RI	247..501	CDD:238064	70/254 (28%)
		LRR_8	247..308	CDD:290566	19/58 (33%)
		leucine-rich repeat	249..273	CDD:275380	5/23 (22%)
		leucine-rich repeat	274..297	CDD:275380	10/22 (45%)
		LRR_8	297..356	CDD:290566	19/58 (33%)
		leucine-rich repeat	298..321	CDD:275380	7/22 (32%)
		leucine-rich repeat	322..345	CDD:275380	7/22 (32%)
		LRR_8	345..406	CDD:290566	20/60 (33%)
		leucine-rich repeat	346..371	CDD:275380	8/24 (33%)
		leucine-rich repeat	372..395	CDD:275380	7/22 (32%)
		leucine-rich repeat	396..419	CDD:275380	6/25 (24%)
		LRR_8	419..478	CDD:290566	10/58 (17%)
		leucine-rich repeat	420..443	CDD:275380	4/22 (18%)
		leucine-rich repeat	444..467	CDD:275380	4/22 (18%)
		LRR_RI	466..622	CDD:238064	45/158 (28%)
		leucine-rich repeat	468..488	CDD:275380	5/19 (26%)
		LRR_8	491..549	CDD:290566	19/57 (33%)
		leucine-rich repeat	491..514	CDD:275380	7/22 (32%)
		leucine-rich repeat	515..536	CDD:275380	6/20 (30%)
		leucine-rich repeat	539..562	CDD:275380	8/22 (36%)
		leucine-rich repeat	563..585	CDD:275380	4/21 (19%)
		leucine-rich repeat	586..626	CDD:275380	15/42 (36%)
		leucine-rich repeat	627..653	CDD:275380	6/31 (19%)
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
CG4950	NP_001261934.1	leucine-rich repeat	96..119	CDD:275380	5/23 (22%)
		LRR_8	118..178	CDD:290566	20/59 (34%)
		leucine-rich repeat	120..143	CDD:275380	10/22 (45%)
		leucine-rich repeat	144..167	CDD:275380	7/22 (32%)
		leucine-rich repeat	168..191	CDD:275380	7/22 (32%)
		LRR_8	192..250	CDD:290566	20/59 (34%)
		leucine-rich repeat	192..215	CDD:275380	8/24 (33%)
		LRR_RI	<207..432	CDD:238064	74/286 (26%)
		leucine-rich repeat	216..239	CDD:275380	7/22 (32%)
		leucine-rich repeat	240..299	CDD:275380	19/96 (20%)
		LRR_8	299..356	CDD:290566	19/58 (33%)
		leucine-rich repeat	300..321	CDD:275380	7/22 (32%)
		leucine-rich repeat	322..345	CDD:275380	7/22 (32%)
		LRR_8	344..405	CDD:290566	25/82 (30%)
		leucine-rich repeat	346..365	CDD:275380	6/18 (33%)
		leucine-rich repeat	370..394	CDD:275380	10/45 (22%)
		leucine-rich repeat	395..420	CDD:275380	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453766
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840