DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and CG32055

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_729599.1	Gene:	CG32055 / 39188	FlyBaseID:	FBgn0052055	Length:	534	Species:	Drosophila melanogaster

Alignment Length:	550	Identity:	143/550 - (26%)
Similarity:	219/550 - (39%)	Gaps:	120/550 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 ALRLIERQPGLDLQGADGSSQLTIQCSELYLFESTLPVAVFARLQTLEALRLDSCKLL------- 147
            ||.|:....|.|||..:.....:..|.|:..||         :|.........|.|::
  Fly     8 ALLLLSGVFGKDLQECEDLGNGSYLCREIESFE---------QLNRYVGKNWKSVKVVNEHTGIE 63

  Fly   148 -----QLPNNAFEGLATLKSLRLSTHN---------SEWGPTRTLELFPDSLGGLK--------Q 190
                 :||     ||:||..|.||...         .::...:.|.|....|..||        :
  Fly    64 RAEDGELP-----GLSTLLQLDLSESGGVTLGEKGLQDFKALQKLNLTHAQLDELKSEQFPNPSE 123

  Fly   191 LTDLDLGDNNLRQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFADMNCGAGSGSAGSELQVLDAS 255
            :.:.|:..|::..:.:..:...|||...|.:.|.|...|...|..|          ..|:.||.:
  Fly   124 MINFDVSYNDILAITTKLMSGFGNLVYANFSENLIAVIEPNAFRHM----------KNLRFLDLT 178

  Fly   256 HNELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNN--------HLETLP 312
            .|...:|:                            |...|:||.:::|||        ||..||
  Fly   179 TNYQENIT----------------------------LGENANLRFLSISNNNLRDFQWCHLRVLP 215

  Fly   313 EGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAG---LIRLIV 374
                    :|.|:||..|.|..|..|:|:.|..|.|:::|.|.|.  .:..|.|..   :..|.:
  Fly   216 --------KLEELHLHSNWLEHLDMGIFYALPNLRVLNVSNNNLF--EIKRTLFMAPGEIAPLEL 270

  Fly   375 LNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKLFN 439
            |:.:.|.:..:|...|..|..|:.|||..|.|..|...|||.|.:|.||:|..|::..|.|.:|.
  Fly   271 LDYSSNIVKVLDDSVFCRLKKLRTLNLWLNQINRIHPRAFLGLSSLQTLHLQGNKISILPDDVFA 335

  Fly   440 GLYVLSKLTLNNNLISVVEPAVF--KNCSDLKELDLSSNQLNEV-PRALQDLAMLRTLDLGENQI 501
            .|..|.||.|:.|.|..:...||  :....|..||||:|.:.:: |.||..:..::.|.|..|::
  Fly   336 NLTALEKLDLSKNNIQKLGLRVFGERILRKLIYLDLSNNYIADLHPLALSSMPFIKELRLRRNRL 400

  Fly   502 RTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKN-FELEA 565
            .:.|.:.|..|.||..|.:.:|::..|...:...|.||:.|.|..||:..:......:| .:|..
  Fly   401 VSLDLRMFAPLRQLQLLTINENRLEEIDGEILDTLDRLNHLELNNNRLTFLPDLKSSQNLLQLRN 465

  Fly   566 IRLDRN-----FLADINGVFATLVSLLWLN 590
            |.|:.|     .|.:|..         |||
  Fly   466 ITLEGNPWQCLCLDEITS---------WLN 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	18/94 (19%)
		leucine-rich repeat	136..159	CDD:275380	6/34 (18%)
		leucine-rich repeat	160..190	CDD:275380	9/46 (20%)
		LRR_8	189..259	CDD:290566	16/77 (21%)
		leucine-rich repeat	191..214	CDD:275380	2/22 (9%)
		leucine-rich repeat	215..248	CDD:275380	7/32 (22%)
		LRR_RI	247..501	CDD:238064	79/267 (30%)
		LRR_8	247..308	CDD:290566	12/68 (18%)
		leucine-rich repeat	249..273	CDD:275380	5/23 (22%)
		leucine-rich repeat	274..297	CDD:275380	1/22 (5%)
		LRR_8	297..356	CDD:290566	23/66 (35%)
		leucine-rich repeat	298..321	CDD:275380	9/30 (30%)
		leucine-rich repeat	322..345	CDD:275380	10/22 (45%)
		LRR_8	345..406	CDD:290566	18/63 (29%)
		leucine-rich repeat	346..371	CDD:275380	7/27 (26%)
		leucine-rich repeat	372..395	CDD:275380	6/22 (27%)
		leucine-rich repeat	396..419	CDD:275380	11/22 (50%)
		LRR_8	419..478	CDD:290566	23/60 (38%)
		leucine-rich repeat	420..443	CDD:275380	9/22 (41%)
		leucine-rich repeat	444..467	CDD:275380	8/24 (33%)
		LRR_RI	466..622	CDD:238064	36/131 (27%)
		leucine-rich repeat	468..488	CDD:275380	9/20 (45%)
		LRR_8	491..549	CDD:290566	17/57 (30%)
		leucine-rich repeat	491..514	CDD:275380	6/22 (27%)
		leucine-rich repeat	515..536	CDD:275380	4/20 (20%)
		leucine-rich repeat	539..562	CDD:275380	6/23 (26%)
		leucine-rich repeat	563..585	CDD:275380	6/26 (23%)
		leucine-rich repeat	586..626	CDD:275380	2/4 (50%)
		leucine-rich repeat	627..653	CDD:275380
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
CG32055	NP_729599.1	leucine-rich repeat	76..99	CDD:275380	4/22 (18%)
		leucine-rich repeat	100..123	CDD:275380	5/22 (23%)
		LRR_8	128..180	CDD:290566	14/61 (23%)
		leucine-rich repeat	128..147	CDD:275380	2/18 (11%)
		leucine-rich repeat	148..171	CDD:275380	7/32 (22%)
		leucine-rich repeat	172..192	CDD:275380	6/47 (13%)
		LRR_RI	<187..400	CDD:238064	74/222 (33%)
		LRR_8	192..251	CDD:290566	23/66 (35%)
		leucine-rich repeat	193..216	CDD:275380	9/30 (30%)
		leucine-rich repeat	217..240	CDD:275380	10/22 (45%)
		leucine-rich repeat	241..267	CDD:275380	7/27 (26%)
		leucine-rich repeat	268..291	CDD:275380	6/22 (27%)
		LRR_8	290..350	CDD:290566	25/59 (42%)
		leucine-rich repeat	292..315	CDD:275380	11/22 (50%)
		leucine-rich repeat	316..339	CDD:275380	9/22 (41%)
		LRR_8	340..400	CDD:290566	20/59 (34%)
		leucine-rich repeat	340..365	CDD:275380	8/24 (33%)
		leucine-rich repeat	366..389	CDD:275380	9/22 (41%)
		leucine-rich repeat	390..413	CDD:275380	6/22 (27%)
		LRR_8	391..448	CDD:290566	17/56 (30%)
		leucine-rich repeat	414..437	CDD:275380	5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453559
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940