DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and CG6749

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster

Alignment Length:	638	Identity:	166/638 - (26%)
Similarity:	250/638 - (39%)	Gaps:	167/638 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 LQGADGSSQL---TIQCSELYLFESTLPVAVFARLQTLEALRLDSCKLLQLPNNAFEGLATLKSL 163
            |.|||....:   ..||||:            |.||.|..|..::...|.:.|...|
  Fly    23 LHGADLCQPIGWRNFQCSEV------------ASLQDLVDLGAENWHTLAIRNVQTE-------- 67

  Fly   164 RLSTHNSEWGPTRTLELFPDSLGGLKQLTDLDL-GDNNLRQLPSGF-LCPVGNLQVLNLTRNRIR 226
             |...:.|            :...|..|.|||| |...:....:|| :.|  ||:.|||:
  Fly    68 -LEVGSGE------------NADHLANLLDLDLTGAAPINVHTNGFSILP--NLRQLNLS----- 112

  Fly   227 TAEQMGFADMNCG----AGSGSA-GSELQVLDASHNELRSISESWGISRLRRLQHLNLAYNNLSE 286
                      .||    .|:..| .|.||.:|.|||::..:...: ...||:|.:.|.::|.|.:
  Fly   113 ----------GCGLVDIRGNHFAPESALQRIDFSHNQMELLDRDF-FGNLRKLIYANFSHNALKQ 166

  Fly   287 LSGEALAGLASLRIVNLSNNHLETLPEGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDL 351
            ..   |..:..|..:.|.:|.   |....|....:|:|:.|..|:|.:|....|..|..||.:.|
  Fly   167 CD---LPHMPLLNRLELGHNR---LVNATFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQL 225

  Fly   352 SGNQLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDYRTF----KELYFLQILNLRNNSIGHIEDN 412
            |||:|:|  :...||..|.:|..|||:.|||..:....|    ..:..||.|:|..|.|..:.||
  Fly   226 SGNRLSS--IGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDN 288

  Fly   413 AFLPLYNLHTLNLAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQ 477
            .|..|..|..|:::.|.:.:|....|.||..|.||.|..|.|..::||.|....:|..||||.|.
  Fly   289 QFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNN 353

  Fly   478 L----------NEVPRALQDLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGM 532
            |          |.:||       :|.|:|..|:::.....:|.:|..|..|:|..|::.::.|.|
  Fly   354 LEFLEEQIFGGNTLPR-------MRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRM 411

  Fly   533 FQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRN---FLADINGVFATLVSLLWLNLSEN 594
            |..:.||..|:|..|.::.|.....:....::.|.:|.|   |||.:|..|
  Fly   412 FAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFLAKVNVSF-------------- 462

  Fly   595 HLVWFDYAFIPSNLKWLDIHGN--------------------YIEALGNYYKLQEEIRVKTLDAS 639
                       .|||.:.|.||                    |:.....|||.:.
  Fly   463 -----------PNLKRVAIEGNPWQCPCFVKLQHWLATRDVVYLRDNTGYYKGER---------- 506

  Fly   640 HNRITEIGPMSIPNTIELLFIN------NNLIGN-----VQPNAFVDKANLAR 681
                    |:.|...::....|      ..::|:     |:.:||.|.|:.|:
  Fly   507 --------PLCIVTNVDYCIQNLQAVRRLGILGDFQGEQVEADAFDDDASAAQ 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	14/66 (21%)
		leucine-rich repeat	136..159	CDD:275380	5/22 (23%)
		leucine-rich repeat	160..190	CDD:275380	3/29 (10%)
		LRR_8	189..259	CDD:290566	25/76 (33%)
		leucine-rich repeat	191..214	CDD:275380	9/24 (38%)
		leucine-rich repeat	215..248	CDD:275380	8/37 (22%)
		LRR_RI	247..501	CDD:238064	86/267 (32%)
		LRR_8	247..308	CDD:290566	17/60 (28%)
		leucine-rich repeat	249..273	CDD:275380	7/23 (30%)
		leucine-rich repeat	274..297	CDD:275380	5/22 (23%)
		LRR_8	297..356	CDD:290566	19/58 (33%)
		leucine-rich repeat	298..321	CDD:275380	5/22 (23%)
		leucine-rich repeat	322..345	CDD:275380	8/22 (36%)
		LRR_8	345..406	CDD:290566	24/64 (38%)
		leucine-rich repeat	346..371	CDD:275380	11/24 (46%)
		leucine-rich repeat	372..395	CDD:275380	8/26 (31%)
		leucine-rich repeat	396..419	CDD:275380	10/22 (45%)
		LRR_8	419..478	CDD:290566	22/58 (38%)
		leucine-rich repeat	420..443	CDD:275380	7/22 (32%)
		leucine-rich repeat	444..467	CDD:275380	9/22 (41%)
		LRR_RI	466..622	CDD:238064	44/188 (23%)
		leucine-rich repeat	468..488	CDD:275380	10/29 (34%)
		LRR_8	491..549	CDD:290566	18/57 (32%)
		leucine-rich repeat	491..514	CDD:275380	6/22 (27%)
		leucine-rich repeat	515..536	CDD:275380	7/20 (35%)
		leucine-rich repeat	539..562	CDD:275380	5/22 (23%)
		leucine-rich repeat	563..585	CDD:275380	8/24 (33%)
		leucine-rich repeat	586..626	CDD:275380	8/59 (14%)
		leucine-rich repeat	627..653	CDD:275380	2/25 (8%)
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	55/178 (31%)
		LRR_8	104..164	CDD:290566	22/77 (29%)
		leucine-rich repeat	106..129	CDD:275380	8/37 (22%)
		leucine-rich repeat	130..153	CDD:275380	7/23 (30%)
		leucine-rich repeat	154..195	CDD:275380	10/46 (22%)
		LRR_RI	194..455	CDD:238064	85/269 (32%)
		LRR_8	194..254	CDD:290566	24/61 (39%)
		leucine-rich repeat	196..219	CDD:275380	8/22 (36%)
		leucine-rich repeat	220..243	CDD:275380	11/24 (46%)
		leucine-rich repeat	244..267	CDD:275380	8/22 (36%)
		LRR_8	271..330	CDD:290566	22/58 (38%)
		leucine-rich repeat	272..295	CDD:275380	10/22 (45%)
		leucine-rich repeat	296..319	CDD:275380	7/22 (32%)
		LRR_8	319..380	CDD:290566	23/67 (34%)
		leucine-rich repeat	320..343	CDD:275380	9/22 (41%)
		leucine-rich repeat	344..369	CDD:275380	8/24 (33%)
		LRR_8	368..428	CDD:290566	20/66 (30%)
		leucine-rich repeat	370..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..417	CDD:275380	7/22 (32%)
		leucine-rich repeat	418..441	CDD:275380	5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453547
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840