DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-7 and Tlr12

DIOPT Version :9

Sequence 1:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster
Sequence 2:NP_991392.1 Gene:Tlr12 / 384059 MGIID:3045221 Length:906 Species:Mus musculus


Alignment Length:1217 Identity:254/1217 - (20%)
Similarity:394/1217 - (32%) Gaps:474/1217 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   109 SQLTIQCSELYLFESTLPVAVFARLQTLEALRLDSCKLLQLPNNAFEGLATLKSLRLSTHNSEWG 173
            |:|:...:.|.:...|..:.|..|  |:|.|.|.......|| :||.....||.|.||.|     
Mouse    46 SKLSFLAACLSVSNLTQTLEVVPR--TVEGLCLGGTVSTLLP-DAFSAFPGLKVLALSLH----- 102

  Fly   174 PTRTLELFPDSLGGLKQLTDLDLGDNNLRQ---LP-----------------------SGFLCPV 212
               ..:|.|.:|.||.||..|...|:.||:   ||                       :|...|.
Mouse   103 ---LTQLLPGALRGLGQLQSLSFFDSPLRRSLFLPPDAFSDLISLQRLHISGPCLDKKAGIRLPP 164

  Fly   213 GNLQVLNLTRNRIRTAEQMG--FADMNCGAGS----------------------GS-AGSELQVL 252
            | ||.|.:|.:.|:...::.  |.|:..|:.|                      || .|.::::|
Mouse   165 G-LQWLGVTLSCIQDVGELAGMFPDLVQGSSSRVSWTLQKLDLSSNWKLKMASPGSLQGLQVEIL 228

  Fly   253 DASHNELRSISESW--GISRLRRLQHLNLAY--NNLSELSGEALAGLASLRIVNLSNNHLETLPE 313
            |.:...|.::   |  |:.    ||.|::.|  ...:||:.||:|.. .|:.:.:..:.:.::.:
Mouse   229 DLTRTPLDAV---WLKGLG----LQKLDVLYAQTATAELAAEAVAHF-ELQGLIVKESKIGSISQ 285

  Fly   314 GLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLA 378
            ...|....|:.:.|....|.:||.|....:.:|..::||||||.|              .||.: 
Mouse   286 EALASCHSLKTLGLSSTGLTKLPPGFLTAMPRLQRLELSGNQLQS--------------AVLCM- 335

  Fly   379 HNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKLFNGLYV 443
                                     |..|.:.        .|.||:|:.|||..|....|:.|..
Mouse   336 -------------------------NETGDVS--------GLTTLDLSGNRLRILPPAAFSCLPH 367

  Fly   444 LSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRA-LQDLAMLRTLDLGENQIRTFDNQ 507
            |.:|.|..|.:..:|..:|:....|:.|.|..|.|..:.:. |..|..|.||.|.:.|||.....
Mouse   368 LRELLLRYNQLLSLEGYLFQELQQLETLKLDGNPLLHLGKNWLAALPALTTLSLLDTQIRMSPEP 432

  Fly   508 SF---KNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLD 569
            .|   ||||.|: |:|             ..||..:||.|.                        
Mouse   433 GFWGAKNLHTLS-LKL-------------PALPAPAVLFLP------------------------ 459

  Fly   570 RNFLADINGVFATLVSLLWLNLSENHLV------W-FDYAFIPSNLKWLDIHGNYIEALGNYYKL 627
                             ::|...|.|:.      | ...|..|| |:.|.|.|..:         
Mouse   460 -----------------MYLTSLELHIASGTTEHWTLSPAIFPS-LETLTISGGGL--------- 497

  Fly   628 QEEIRVKTLDASHNRITEIGPMSIPNTIELLFINNNLIGNVQPNAFVDKANLARVDLYANQLSKL 692
              ::::.:.:||.         ..|...:|..:.|:|      :||..:..   .:|:..||.| 
Mouse   498 --KLKLGSQNASG---------VFPALQKLSLLKNSL------DAFCSQGT---SNLFLWQLPK- 541

  Fly   693 QLQQLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQRINNLTTRQHPRVMDMANIECVMPHARGA 757
             ||.|||                          |                           ..|.
Mouse   542 -LQSLRV--------------------------W---------------------------GAGN 552

  Fly   758 AVRPLSGLRPQDFLCRYESHCFALCHCCDFDACDCEMTCPSNCTCYHDQIWSTNVVDCGGQQTTE 822
            :.||                                        |....:.|...:.....|:..
Mouse   553 SSRP----------------------------------------CLITGLPSLRELKLASLQSIT 577

  Fly   823 LPRRVPMDSSVVYLDGNNFPVLKNHAFIGRKNLRALYVNGSQVAAIQNRTFASLASLQLLHLADN 887
            .||.|.::..|     .:.|           .|:||.::.:.:.::....|..|.|||:|.|   
Mouse   578 QPRSVQLEELV-----GDLP-----------QLQALVLSSTGLKSLSAAAFQRLHSLQVLVL--- 623

  Fly   888 KLRTLHGYEFEQ----LSALRE--------LY-LQNNQLTTIENATLAPLAALELIRIDGNRLVT 939
                    |:|:    ..:|||        :| |::|......||.:.|                
Mouse   624 --------EYEKDLMLQDSLREYSPQMPHYIYILESNLACHCANAWMEP---------------- 664

  Fly   940 LPIWQMHATHFGTRLKSISLGRNQWSCRCQFLQALTSYVADNALIVQDAQDIYCMAASSGTGSAA 1004
               |...:|.  |.:                      |:.||.|         |..         
Mouse   665 ---WVKRSTK--TYI----------------------YIRDNRL---------CPG--------- 684

  Fly  1005 LEDSSSNSGSLEKRELDFNATGAACTDYYSGGSMLQHGIPESY-IPLLAAALALLFLLVVIAMVF 1068
             :|..|..|||.                    |.|....|::. :.|..|:.||:|:|:.:.::.
Mouse   685 -QDRLSARGSLP--------------------SFLWDHCPQTLELKLFLASSALVFMLIALPLLQ 728

  Fly  1069 AFRES--------LRIWLFAHYGVRVFGPRCEESEKLYDAVLLHSAKDSEFVCQHLAAQLETGRP 1125
            ..|.|        .|:||   .|:|..|.:.:..  |:|..:.|..:|..:|.:.|...||...|
Mouse   729 EARNSWIPYLQALFRVWL---QGLRGKGDKGKRF--LFDVFVSHCRQDQGWVIEELLPALEGFLP 788

  Fly  1126 P---LRVCLQHRDL--AHDATHYQLLEATRVSRRVVILLTRNFLQTEWARCELR--RSVHDALRG 1183
            .   ||:||..||.  ..|... .::::...||..:.:|:...|.....|.|||  .|:..|...
Mouse   789 AGLGLRLCLPERDFEPGKDVVD-NVVDSMLSSRTTLCVLSGQALCNPRCRLELRLATSLLLAAPS 852

  Fly  1184 RPQKLVIIEEPEVAFEAESDIELLPYLKTSAVHR----IRRSDRHFW 1226
            .|..|::..||....:       ||     ..||    :||.|...|
Mouse   853 PPVLLLVFLEPISRHQ-------LP-----GYHRLARLLRRGDYCLW 887

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-7NP_523797.1 LRR_8 135..201 CDD:290566 23/65 (35%)
leucine-rich repeat 136..159 CDD:275380 7/22 (32%)
leucine-rich repeat 160..190 CDD:275380 11/29 (38%)
LRR_8 189..259 CDD:290566 25/120 (21%)
leucine-rich repeat 191..214 CDD:275380 9/48 (19%)
leucine-rich repeat 215..248 CDD:275380 12/57 (21%)
LRR_RI 247..501 CDD:238064 61/258 (24%)
LRR_8 247..308 CDD:290566 15/64 (23%)
leucine-rich repeat 249..273 CDD:275380 5/25 (20%)
leucine-rich repeat 274..297 CDD:275380 9/24 (38%)
LRR_8 297..356 CDD:290566 13/58 (22%)
leucine-rich repeat 298..321 CDD:275380 2/22 (9%)
leucine-rich repeat 322..345 CDD:275380 6/22 (27%)
LRR_8 345..406 CDD:290566 11/60 (18%)
leucine-rich repeat 346..371 CDD:275380 8/24 (33%)
leucine-rich repeat 372..395 CDD:275380 2/22 (9%)
leucine-rich repeat 396..419 CDD:275380 2/22 (9%)
LRR_8 419..478 CDD:290566 20/58 (34%)
leucine-rich repeat 420..443 CDD:275380 10/22 (45%)
leucine-rich repeat 444..467 CDD:275380 6/22 (27%)
LRR_RI 466..622 CDD:238064 38/166 (23%)
leucine-rich repeat 468..488 CDD:275380 6/20 (30%)
LRR_8 491..549 CDD:290566 20/60 (33%)
leucine-rich repeat 491..514 CDD:275380 11/25 (44%)
leucine-rich repeat 515..536 CDD:275380 3/20 (15%)
leucine-rich repeat 539..562 CDD:275380 3/22 (14%)
leucine-rich repeat 563..585 CDD:275380 0/21 (0%)
leucine-rich repeat 586..626 CDD:275380 11/46 (24%)
leucine-rich repeat 627..653 CDD:275380 2/25 (8%)
LRRCT 716..772 CDD:214507 4/55 (7%)
LRRNT 796..830 CDD:214470 6/33 (18%)
leucine-rich repeat 812..829 CDD:275380 4/16 (25%)
leucine-rich repeat 833..854 CDD:275380 2/20 (10%)
LRR_8 853..913 CDD:290566 18/72 (25%)
leucine-rich repeat 855..878 CDD:275380 5/22 (23%)
LRR_4 878..918 CDD:289563 13/52 (25%)
leucine-rich repeat 879..902 CDD:275380 6/26 (23%)
leucine-rich repeat 903..926 CDD:275380 9/31 (29%)
leucine-rich repeat 927..953 CDD:275380 2/25 (8%)
TIR 1098..1235 CDD:214587 37/140 (26%)
Tlr12NP_991392.1 LRR 1 91..114 9/30 (30%)
leucine-rich repeat 94..116 CDD:275380 11/29 (38%)
LRR 2 115..140 8/24 (33%)
leucine-rich repeat 117..143 CDD:275380 7/25 (28%)
LRR 3 142..170 5/28 (18%)
leucine-rich repeat 144..191 CDD:275380 10/47 (21%)
LRR 4 198..222 2/23 (9%)
leucine-rich repeat 201..224 CDD:275380 3/22 (14%)
LRR 5 224..247 6/29 (21%)
leucine-rich repeat 225..247 CDD:275380 6/28 (21%)
leucine-rich repeat 248..293 CDD:275380 9/45 (20%)
LRR 6 267..290 1/23 (4%)
LRR_8 269..328 CDD:290566 13/58 (22%)
LRR 7 291..314 6/22 (27%)
leucine-rich repeat 294..317 CDD:275380 6/22 (27%)
LRR 8 316..338 11/61 (18%)
leucine-rich repeat 318..343 CDD:275380 12/72 (17%)
LRR 9 341..364 9/30 (30%)
LRR_8 342..402 CDD:290566 20/67 (30%)
leucine-rich repeat 344..367 CDD:275380 10/22 (45%)
LRR_RI 364..625 CDD:238064 84/467 (18%)
LRR 10 366..388 6/21 (29%)
leucine-rich repeat 368..391 CDD:275380 6/22 (27%)
LRR 11 389..412 6/22 (27%)
leucine-rich repeat 392..415 CDD:275380 7/22 (32%)
LRR 12 414..436 8/21 (38%)
leucine-rich repeat 416..436 CDD:275380 8/19 (42%)
leucine-rich repeat 440..512 CDD:275380 23/147 (16%)
LRR 13 462..484 5/21 (24%)
LRR 14 485..508 7/34 (21%)
LRR 15 510..533 6/31 (19%)
leucine-rich repeat 513..564 CDD:275380 19/154 (12%)
LRR 16 562..586 5/23 (22%)
leucine-rich repeat 565..593 CDD:275380 6/43 (14%)
LRR 17 591..614 5/33 (15%)
leucine-rich repeat 594..617 CDD:275380 5/22 (23%)
TIR 761..902 CDD:214587 37/140 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

Return to query results.
Submit another query.