DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-7 and Lrrc24

DIOPT Version :9

Sequence 1:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster
Sequence 2:NP_932787.1 Gene:Lrrc24 / 378937 MGIID:3605040 Length:521 Species:Mus musculus


Alignment Length:561 Identity:132/561 - (23%)
Similarity:203/561 - (36%) Gaps:172/561 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   796 CPSNCTCYHDQIWSTNVVDCGGQQTTELPRRVP--------MDSSV----------------VYL 836
            ||:.|.||      :..|:||..:...:|..:|        .|:|:                :||
Mouse    31 CPAACRCY------SATVECGALRLRVVPPGIPPGTQTLFLQDNSIAHLEQGSLAPLAALRHLYL 89

  Fly   837 DGNNFPVLKNHAFIGRKNLRALYVNGSQVAAIQNRTFASLASLQLLHLADNKLRTLHGYEFEQLS 901
            ..|....|::.||..:..|..|.:.|:::..::...|..|..|::|:||.|:|..|..:.|..|.
Mouse    90 HNNTLRALESGAFRAQPRLLELALTGNRLRGLRGGAFVGLVQLRVLYLAGNQLAKLLDFTFLHLP 154

  Fly   902 ALRELYLQNNQLTTIENATLAPLAALELIRIDGNRLVTLPIWQMHATHFGTRLKSISLGRNQWSC 966
            .|:||:||.|.:..:|:..||.|::|.|:.:..|:|.|:   ...|....:.|:.:.|..|.|.|
Mouse   155 RLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTI---SKEALQPLSSLQVLRLTENPWRC 216

  Fly   967 RCQFLQALTSYVADNALIVQDAQD--IYCMAASSGTGSAALEDSSSNSGSLEKRELDFNATGAAC 1029
            .|. |..|.|::.:....:..::|  |.|.........:.||                       
Mouse   217 DCA-LHWLGSWIKEGGRRLLSSRDKKITCAEPPRLALQSLLE----------------------- 257

  Fly  1030 TDYYSGGSMLQHGIPESY---IPLLAAALALLFLLVVIAMVFAFRESLRIWLFAHYGVRVFGPRC 1091
               .||||::  .||.|.   .|...|.|.  ..|.|......:.:.|.:|.      :|..|| 
Mouse   258 ---VSGGSLI--CIPPSVNVEPPEFTANLG--EDLQVACQASGYPQPLVVWR------KVPQPR- 308

  Fly  1092 EESEKLYDAVLLHSAKDSEFVCQHLAAQLETGRPPL-----------RVCLQHRDLAHDATHYQL 1145
                            |.:...|   ||||.|.|.|           .:.|.:..||| |..|: 
Mouse   309 ----------------DGKPQAQ---AQLEGGAPGLGGHGTRDTGSGMLFLTNITLAH-AGKYE- 352

  Fly  1146 LEATRVSRRVVILLTRNFLQTEWARCELRRSVHDALRGRPQKL---------VIIEEPE-----V 1196
            .||.....:              ||......| :|.|.:.|:|         .:..||:     :
Mouse   353 CEAANAGGK--------------ARVPFHLLV-NASRQQSQQLPDPQAPATRPVGHEPQHEAGSM 402

  Fly  1197 AFEA---------ESDIELL---PYLKTSAVHRIRRSDRHFWEKLRYALPVDYPTFRGNNYT--- 1246
            ||.|         .:.|.||   ..|..:.:.|.||      .:.:...|....|...|:|:   
Mouse   403 AFRALGLATQTAITAAIALLALTALLLAAMICRRRR------RRKKVPAPSGEGTLFVNDYSDGP 461

  Fly  1247 -----LE--LDHHNHERV----KQPASPGLLYRQAP---PP 1273
                 ||  .|.|.||..    .:|..|.:|..:||   ||
Mouse   462 CTFAQLEELRDDHGHEMFVIDRSKPLFPEVLPEEAPEHNPP 502

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-7NP_523797.1 LRR_8 135..201 CDD:290566
leucine-rich repeat 136..159 CDD:275380
leucine-rich repeat 160..190 CDD:275380
LRR_8 189..259 CDD:290566
leucine-rich repeat 191..214 CDD:275380
leucine-rich repeat 215..248 CDD:275380
LRR_RI 247..501 CDD:238064
LRR_8 247..308 CDD:290566
leucine-rich repeat 249..273 CDD:275380
leucine-rich repeat 274..297 CDD:275380
LRR_8 297..356 CDD:290566
leucine-rich repeat 298..321 CDD:275380
leucine-rich repeat 322..345 CDD:275380
LRR_8 345..406 CDD:290566
leucine-rich repeat 346..371 CDD:275380
leucine-rich repeat 372..395 CDD:275380
leucine-rich repeat 396..419 CDD:275380
LRR_8 419..478 CDD:290566
leucine-rich repeat 420..443 CDD:275380
leucine-rich repeat 444..467 CDD:275380
LRR_RI 466..622 CDD:238064
leucine-rich repeat 468..488 CDD:275380
LRR_8 491..549 CDD:290566
leucine-rich repeat 491..514 CDD:275380
leucine-rich repeat 515..536 CDD:275380
leucine-rich repeat 539..562 CDD:275380
leucine-rich repeat 563..585 CDD:275380
leucine-rich repeat 586..626 CDD:275380
leucine-rich repeat 627..653 CDD:275380
LRRCT 716..772 CDD:214507
LRRNT 796..830 CDD:214470 10/41 (24%)
leucine-rich repeat 812..829 CDD:275380 5/24 (21%)
leucine-rich repeat 833..854 CDD:275380 6/36 (17%)
LRR_8 853..913 CDD:290566 20/59 (34%)
leucine-rich repeat 855..878 CDD:275380 5/22 (23%)
LRR_4 878..918 CDD:289563 15/39 (38%)
leucine-rich repeat 879..902 CDD:275380 9/22 (41%)
leucine-rich repeat 903..926 CDD:275380 10/22 (45%)
leucine-rich repeat 927..953 CDD:275380 6/25 (24%)
TIR 1098..1235 CDD:214587 36/173 (21%)
Lrrc24NP_932787.1 LRR_8 48..92 CDD:290566 6/43 (14%)
LRR 1 59..80 2/20 (10%)
LRR_RI <60..>166 CDD:238064 28/105 (27%)
leucine-rich repeat 61..83 CDD:275380 2/21 (10%)
LRR 2 83..104 6/20 (30%)
LRR_8 84..142 CDD:290566 16/57 (28%)
leucine-rich repeat 84..107 CDD:275380 6/22 (27%)
LRR 3 107..128 4/20 (20%)
leucine-rich repeat 108..131 CDD:275380 5/22 (23%)
LRR_8 131..213 CDD:290566 27/84 (32%)
LRR_4 131..171 CDD:289563 15/39 (38%)
LRR 4 131..152 8/20 (40%)
leucine-rich repeat 132..155 CDD:275380 9/22 (41%)
LRR 5 155..176 8/20 (40%)
leucine-rich repeat 156..179 CDD:275380 10/22 (45%)
LRR 6 179..200 6/23 (26%)
leucine-rich repeat 180..203 CDD:275380 6/25 (24%)
LRRCT 212..265 CDD:214507 16/81 (20%)
Ig 267..361 CDD:299845 29/123 (24%)
IG_like 274..370 CDD:214653 29/139 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 306..330 11/43 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 374..395 3/20 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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