DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-7 and Tlr3

DIOPT Version :9

Sequence 1:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster
Sequence 2:NP_942086.2 Gene:Tlr3 / 364594 RGDID:735171 Length:905 Species:Rattus norvegicus


Alignment Length:1078 Identity:240/1078 - (22%)
Similarity:402/1078 - (37%) Gaps:300/1078 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   247 SELQVLDASHNELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETL 311
            |.:.||:.:||:||.:..: ..:|..:|..|:..:|::|:|..|....|..|:::||.:|.|..:
  Rat    52 SNITVLNLTHNQLRGLPPA-NFTRYSQLALLDAGFNSISKLEPELCQILPLLKVLNLQHNELSQI 115

  Fly   312 PEGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLN 376
            .:..||....|.|:||..|.:.::....|...:.|:.:|||.|.|:|..:.  |...|..|..|.
  Rat   116 SDQTFAFCTNLTELHLMSNSIRKIKSNPFKNQKSLIKLDLSRNGLSSTKLG--TGVQLENLQELL 178

  Fly   377 LAHNALTRIDYRTFKELYF-----LQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLH-TLDD 435
            ||.|.:..:   ..:||.|     ||.|:|.:|.:.......|..:..|..|.|...:|: .|.:
  Rat   179 LAKNKIFAL---RSEELDFLGNSSLQKLDLSSNPLKEFSPGCFHAIGKLFVLLLNNAQLNLNLTE 240

  Fly   436 KLFNGLYVLS-----KLTLNNNLISVVEPAVFKNC--SDLKELDLSSNQLNEVPR-ALQDLAMLR 492
            ||   .:.||     .|:|.||.:.....:.|...  ::|..||||.|.|..|.. |...|..|:
  Rat   241 KL---CWELSNTSIQNLSLANNQLLATSNSTFSGLKQTNLTSLDLSYNSLRYVGNDAFSWLPHLK 302

  Fly   493 TLDLGENQIRTFDNQSFK---NLHQLTGLRLIDNQI------GNITVGMFQDLPRLSVLNLAKNR 548
            .|.|..|.|::....||:   ||..|:..|....|.      .||....||.|..|..||:..|.
  Rat   303 YLSLEYNNIQSLTPHSFRGLSNLRYLSLKRAFTKQSVALASHPNIDDFSFQWLKCLEHLNMDDNT 367

  Fly   549 IQSIERGSFDKNFELEAIRLDRNF-----LADINGVFATLVSLLWLNLSENHL--------VWFD 600
            |..|:..:|.....|:.:.|.:.|     |.:...|..|...||.|||::||:        .|. 
  Rat   368 IPGIKSNTFTGLVSLKYLSLSKTFTGLQTLTNETFVSLTHSPLLTLNLTKNHISKIASGTFSWL- 431

  Fly   601 YAFIPSNLKWLDIHGNYIE---------ALGNYYKLQEEIRVKTLDASHNRITEIGPMS---IPN 653
                 ..|:.||:..|.||         .|||.:::.         .|:|:..::...|   :|:
  Rat   432 -----GQLRILDLGLNEIEQELTGQEWRGLGNIFEIY---------LSYNKYLQLTSKSFTLVPS 482

  Fly   654 TIELLFINNNLIG-NVQPNAFVDKANLARVDLYANQLSKLQLQQLRVAPVVAPKPLPEFYLGGNP 717
            ...|:.....|.. ::.|:.|....||..:||..|.::.|                         
  Rat   483 LQRLMLRRVALKSVDISPSPFRPLYNLTILDLSNNNIANL------------------------- 522

  Fly   718 FECDCTMDWLQRINNLTTRQHPRVMDMA--NIECVMPHAR-GAAVRPLSGLRPQDFLCRYESHCF 779
                 ..|.|:.:.||      .::|..  |:..:..||. |..|..|.||          ||  
  Rat   523 -----NEDLLEGLENL------EILDFQHNNLARLWKHANPGGPVNFLKGL----------SH-- 564

  Fly   780 ALCHCCDFDACDCEMTCPSNCTCYHDQIWSTNVVDCGGQQTTELPRRVPMDSSVVYLDGNNFPVL 844
              .|..:.:                     :|.:|       |:|.:|                 
  Rat   565 --LHILNLE---------------------SNGLD-------EIPVKV----------------- 582

  Fly   845 KNHAFIGRKNLRALYVNGSQVAAIQNRTFASLASLQLLHLADNKLRTLHGYEFEQLSALRELYLQ 909
                                        |.:|..|:.::|..|.|.||....|:..::||.|.||
  Rat   583 ----------------------------FKNLFELKSINLGLNNLNTLLPSIFDDQTSLRSLNLQ 619

  Fly   910 NNQLTTIENATLAPLAALELIRIDGNRLVTLPIWQMHATHFGTRLKSISLGRNQWSCRCQFLQAL 974
            .|.:|::|.:...|                       |.|   .|.|:.:..|.:.|.|:.:...
  Rat   620 KNLITSVEKSVFGP-----------------------AFH---NLNSLDMSFNPFDCTCESIAWF 658

  Fly   975 TSYVADNALIVQDAQDIY-CMAASSGTG-SAALEDSSSNSGSLEKRELDFNATGAACTDYYSGGS 1037
            .:::......:.:....| |.......| ...|.|:||                  |.|      
  Rat   659 VTWLNQTHTNIPELSTHYLCNTPQRYHGLPVKLFDTSS------------------CKD------ 699

  Fly  1038 MLQHGIPESYIPLLAAALALLFLLVVIAMVFAFRESLRIWLFAHYGV-RVFG-----PRCEESEK 1096
                ..|...:.::..:..|.|:|.|:.:.|   |..||..:.:..| |:.|     .:.|:.| 
  Rat   700 ----SAPFQLLFIINTSTLLTFILAVLLIHF---EGWRISFYWNVSVHRILGFKEIDAQGEQFE- 756

  Fly  1097 LYDAVLLHSAKDSEFVCQHLAAQLETGRPPLRVCLQHRDLAHDATHYQ-LLEATRVSRRVVILLT 1160
             |.|.::|:.||.::|.:|. :.:|.....|:.||:.||........: ::.:.:.||:::.::|
  Rat   757 -YTAYIIHAQKDRDWVWEHF-SPMEEQDQSLKFCLEERDFEAGVLGLEAIVNSIKRSRKIIFVIT 819

  Fly  1161 RNFLQTEWARCELRRSVHDALRGRPQKLVIIEEPEVAFEAESDIELLPYLKTSAVHRIRRSDRHF 1225
            .:.|:....|   |..||.|:             :.|.|...|..:|.:|:....:         
  Rat   820 HHLLKDPLCR---RFKVHHAV-------------QQAIEQNLDSIILIFLQNIPDY--------- 859

  Fly  1226 WEKLRYALPVDYPTFRGN---NYTLELDHHN--HERVK 1258
              ||.:||.:....|:.:   |:.::.:..|  |.:::
  Rat   860 --KLNHALCLRRGMFKSHCILNWPIQKERINAFHHKLQ 895

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Toll-7NP_523797.1 LRR_8 135..201 CDD:290566
leucine-rich repeat 136..159 CDD:275380
leucine-rich repeat 160..190 CDD:275380
LRR_8 189..259 CDD:290566 5/11 (45%)
leucine-rich repeat 191..214 CDD:275380