DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-7 and LRRTM1

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_849161.2	Gene:	LRRTM1 / 347730	HGNCID:	19408	Length:	522	Species:	Homo sapiens

Alignment Length:	311	Identity:	88/311 - (28%)
Similarity:	143/311 - (45%)	Gaps:	48/311 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 PSGFLCP-----VGNL---QVLNLTRNRIRTAEQMG-------FADMNCGAGSGSAGSELQVLDA 254
            |||  ||     .|.|   :.||||......:..:|       .:::..|..:|.  .:|..|..
Human    36 PSG--CPQLCRCEGRLLYCEALNLTEAPHNLSGLLGLSLRYNSLSELRAGQFTGL--MQLTWLYL 96

  Fly   255 SHNELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLPEGLFAGS 319
            .||.:.|: :.....:|||::.|.|:.|.:::|.......:.:||.|:||.|.|:.|...||.|.
Human    97 DHNHICSV-QGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGL 160

  Fly   320 KELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNALTR 384
            ::|..:|::.|.:..:|..:|.....|..:|:..|||.|  :...:||||.:|..|:|.||.|.:
Human   161 RKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKS--LARNSFAGLFKLTELHLEHNDLVK 223

  Fly   385 IDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKLFNGLYVLSKLTL 449
            :::..|..|..|..|.||.|.:..:                    :.:||     .::.|.|:.|
Human   224 VNFAHFPRLISLHSLCLRRNKVAIV--------------------VSSLD-----WVWNLEKMDL 263

  Fly   450 NNNLISVVEPAVFKNCSDLKELDLSSNQLNEV-PRALQDLAMLRTLDLGEN 499
            :.|.|..:||.||:....|:.|.|.||:|..: ||.|.....|.::.|..|
Human   264 SGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGN 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566	18/68 (26%)
		leucine-rich repeat	191..214	CDD:275380	5/13 (38%)
		leucine-rich repeat	215..248	CDD:275380	8/42 (19%)
		LRR_RI	247..501	CDD:238064	74/254 (29%)
		LRR_8	247..308	CDD:290566	18/60 (30%)
		leucine-rich repeat	249..273	CDD:275380	6/23 (26%)
		leucine-rich repeat	274..297	CDD:275380	4/22 (18%)
		LRR_8	297..356	CDD:290566	19/58 (33%)
		leucine-rich repeat	298..321	CDD:275380	11/22 (50%)
		leucine-rich repeat	322..345	CDD:275380	5/22 (23%)
		LRR_8	345..406	CDD:290566	23/60 (38%)
		leucine-rich repeat	346..371	CDD:275380	10/24 (42%)
		leucine-rich repeat	372..395	CDD:275380	8/22 (36%)
		leucine-rich repeat	396..419	CDD:275380	5/22 (23%)
		LRR_8	419..478	CDD:290566	16/58 (28%)
		leucine-rich repeat	420..443	CDD:275380	2/22 (9%)
		leucine-rich repeat	444..467	CDD:275380	9/22 (41%)
		LRR_RI	466..622	CDD:238064	12/35 (34%)
		leucine-rich repeat	468..488	CDD:275380	9/20 (45%)
		LRR_8	491..549	CDD:290566	3/9 (33%)
		leucine-rich repeat	491..514	CDD:275380	3/9 (33%)
		leucine-rich repeat	515..536	CDD:275380
		leucine-rich repeat	539..562	CDD:275380
		leucine-rich repeat	563..585	CDD:275380
		leucine-rich repeat	586..626	CDD:275380
		leucine-rich repeat	627..653	CDD:275380
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
LRRTM1	NP_849161.2	LRR 1	64..87		2/22 (9%)
		LRR_8	73..125	CDD:290566	13/54 (24%)
		LRR_RI	<85..268	CDD:238064	58/212 (27%)
		LRR 2	89..111		5/22 (23%)
		leucine-rich repeat	91..114	CDD:275380	6/23 (26%)
		LRR 3	112..135		7/22 (32%)
		LRR_8	113..173	CDD:290566	20/59 (34%)
		leucine-rich repeat	115..138	CDD:275380	4/22 (18%)
		LRR 4	137..159		10/21 (48%)
		leucine-rich repeat	139..162	CDD:275380	11/22 (50%)
		LRR_8	161..221	CDD:290566	20/61 (33%)
		LRR 5	161..183		5/21 (24%)
		leucine-rich repeat	163..186	CDD:275380	5/22 (23%)
		LRR 6	184..207		7/24 (29%)
		leucine-rich repeat	187..210	CDD:275380	10/24 (42%)
		LRR 7	209..231		7/21 (33%)
		leucine-rich repeat	211..234	CDD:275380	8/22 (36%)
		LRR 8	233..255		7/46 (15%)
		leucine-rich repeat	235..257	CDD:275380	7/46 (15%)
		LRR 9	256..278		9/21 (43%)
		LRR_8	257..315	CDD:290566	21/58 (36%)
		LRR_4	257..297	CDD:289563	15/39 (38%)
		leucine-rich repeat	258..281	CDD:275380	9/22 (41%)
		LRR 10	279..302		9/22 (41%)
		leucine-rich repeat	282..300	CDD:275380	8/17 (47%)
		leucine-rich repeat	306..318	CDD:275378	3/9 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..401
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100