DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and Tehao

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster

Alignment Length:	964	Identity:	213/964 - (22%)
Similarity:	363/964 - (37%)	Gaps:	287/964 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   340 FH---RLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLA---------------HNALTRID 386
            ||   ....||.|...|..|..::..:|....|.|..:.:|.               .:.|..:.
  Fly    49 FHCPDEYAMLLEVSEPGASLYMSYYASTELQWLPRFNISSLVKIEFDAYIFWPEKFLSDLLKTLG 113

  Fly   387 YRTFKELYF----LQILNLR---NNSIGHIEDNAFLPLYNLHTLNLAE----------NRLHTLD 434
            .:|.|.:.|    |:.:..|   |:..|::|.:.  | .|:.|.:...          :.:..|.
  Fly   114 VQTVKTIIFRDRTLETVVTRDVLNSGNGYMETSQ--P-ENITTWHFGSVPGLKKFKFFSHVPELQ 175

  Fly   435 DKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRALQDLAMLRTLDLGEN 499
            :.:|:|...|..|.|:.|:.:                 |..|.|:.|.      ..|:||.:...
  Fly   176 ESIFHGFDTLRDLHLSVNVTT-----------------LPGNMLSTVN------GTLKTLTIESP 217

  Fly   500 QIRTFDNQSFKNLHQLTGLRLI--------DNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGS 556
            .|.:|.|...:.|.||..|.|.        |.|   :....|..:..|..:.|| :...|:.|..
  Fly   218 GIVSFGNPLLRELQQLRNLSLALIHPFHERDKQ---LQPHFFGSMTNLEEVRLA-SATSSVNRSM 278

  Fly   557 FDKNFELEAIRLDRN-FLADING-VFATLVSLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIE 619
            |....:|:.|:::.| .|.::.| :|...|:|..|:||.|.:|              .:|.:..:
  Fly   279 FKGTNKLQLIKMNGNDDLMELPGEIFLDQVNLKTLDLSCNAIV--------------TLHEDVFK 329

  Fly   620 ALGNYYKLQEEIRVKTLDASHNRITEI-----GPMSIPNTIELLFINNNLIGNVQPNAFVDKANL 679
            .|||         :..||.|.||:|.:     .|::   ::.:|.:|.|.:..:.|:.|.|..:|
  Fly   330 GLGN---------LTLLDLSKNRLTNLSSTIFAPLT---SLNVLRLNKNSLTAMSPSVFQDVVSL 382

  Fly   680 ARVDLYANQLSKLQLQQLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQRINNLTTRQHPRVMDM 744
            ..:::...|                      ||        ..|:                :|:.
  Fly   383 NYIEMVNTQ----------------------FY--------GATL----------------LMNY 401

  Fly   745 ANIECVMPHARGAAVRPLSGLRPQDFLCRYESHCFALCHCCDFDACDCEMTCPSNCTCYHDQIWS 809
            ..:.|.                 .|..|:|:|               .|..|...|.|:..:...
  Fly   402 EAVVCT-----------------NDEACQYKS---------------AEWQCDPRCICWVQRSVG 434

  Fly   810 TNVVDCGGQQTTELP--RRVPMDSSVVYLDGNN----FPVLKNHAFIGRKNLRALYVNGSQVAAI 868
            :.:|||.|....|||  .|..:.|:|:.: |||    .|.:..|:  |..|:..|:
  Fly   435 SLIVDCRGTSLEELPDLPRTTLLSTVLKV-GNNSLTSLPTVSEHS--GYANVSGLF--------- 487

  Fly   869 QNRTFASLASLQLLHLADNKLRTLHGYEFEQLSALRELYLQNNQLTTIENATLAPLAALELIRID 933
                           |:||.|.:| |...:....|..|.::.||:.::.:..|       |...:
  Fly   488 ---------------LSDNNLTSL-GSGDQLPDNLTHLDVRGNQIQSLSDEFL-------LFLQE 529

  Fly   934 GNRLVTLPIWQMHATHFGTRLKSISLGRNQWSCRCQFLQALTSYVADNALIVQDAQDIYCMAASS 998
            .|..:||                 ||..|..:|.|:.| :|..:|..|...|:|..||.|
  Fly   530 PNNTMTL-----------------SLSGNPITCGCESL-SLLFFVRTNPQRVRDIADIVC----- 571

  Fly   999 GTGSAALEDSSSNSGSLEKRELDFNATGAACTDYYSGGSMLQHGIPESYIPLLAAALALLFLLVV 1063
                             .|::..|.             .|....:..||:.|::..:..|.:::.
  Fly   572 -----------------TKQKKSFQ-------------QMEAFELCPSYVLLISCVVGGLVIVIC 606

  Fly  1064 IAMVF--AFRESLRIWLFAHYGVRVFGPRCEE--SEKLYDAVLLHSAKDSEFVCQHLAAQLETGR 1124
            :..||  .|::.|:|||: :..:.::....||  .:|.|||.:.:|.||.|.:.: |..:||:|.
  Fly   607 LLTVFYLMFQQELKIWLY-NNNLCLWWVSEEELDKDKTYDAFISYSHKDEELISK-LLPKLESGP 669

  Fly  1125 PPLRVCLQHRD-LAHDATHYQLLEATRVSRRVVILLTRNFLQTEWARCELRRSVHDALRGRPQKL 1188
            .|.|:||..|| |..|....|::.....|:||:|:|:::|:.:.|||.|.|.:....|:.:.:::
  Fly   670 HPFRLCLHDRDWLVGDCIPEQIVRTVDDSKRVIIVLSQHFIDSVWARMEFRIAYQATLQDKRKRI 734

  Fly  1189 VIIEEPEVAFEAESDIELLPYLKTSAVHRIRRSDRHFWEKLRYALPVDYPTFRG 1242
            :||...|:......|.||..|||.:..  ::..|..||.||.||:|.:....:|
  Fly   735 IIILYRELEHMNGIDSELRAYLKLNTY--LKWGDPLFWSKLYYAMPHNRRVLKG 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380
		LRR_RI	247..501	CDD:238064	37/195 (19%)
		LRR_8	247..308	CDD:290566
		leucine-rich repeat	249..273	CDD:275380
		leucine-rich repeat	274..297	CDD:275380
		LRR_8	297..356	CDD:290566	6/18 (33%)
		leucine-rich repeat	298..321	CDD:275380
		leucine-rich repeat	322..345	CDD:275380	2/7 (29%)
		LRR_8	345..406	CDD:290566	16/82 (20%)
		leucine-rich repeat	346..371	CDD:275380	7/24 (29%)
		leucine-rich repeat	372..395	CDD:275380	4/37 (11%)
		leucine-rich repeat	396..419	CDD:275380	6/25 (24%)
		LRR_8	419..478	CDD:290566	11/68 (16%)
		leucine-rich repeat	420..443	CDD:275380	4/32 (13%)
		leucine-rich repeat	444..467	CDD:275380	4/22 (18%)
		LRR_RI	466..622	CDD:238064	38/165 (23%)
		leucine-rich repeat	468..488	CDD:275380	4/19 (21%)
		LRR_8	491..549	CDD:290566	17/65 (26%)
		leucine-rich repeat	491..514	CDD:275380	7/22 (32%)
		leucine-rich repeat	515..536	CDD:275380	6/28 (21%)
		leucine-rich repeat	539..562	CDD:275380	6/22 (27%)
		leucine-rich repeat	563..585	CDD:275380	6/23 (26%)
		leucine-rich repeat	586..626	CDD:275380	10/39 (26%)
		leucine-rich repeat	627..653	CDD:275380	7/30 (23%)
		LRRCT	716..772	CDD:214507	4/55 (7%)
		LRRNT	796..830	CDD:214470	11/35 (31%)
		leucine-rich repeat	812..829	CDD:275380	8/18 (44%)
		leucine-rich repeat	833..854	CDD:275380	7/24 (29%)
		LRR_8	853..913	CDD:290566	11/59 (19%)
		leucine-rich repeat	855..878	CDD:275380	1/22 (5%)
		LRR_4	878..918	CDD:289563	10/39 (26%)
		leucine-rich repeat	879..902	CDD:275380	6/22 (27%)
		leucine-rich repeat	903..926	CDD:275380	5/22 (23%)
		leucine-rich repeat	927..953	CDD:275380	4/25 (16%)
		TIR	1098..1235	CDD:214587	48/137 (35%)
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380	8/44 (18%)
		leucine-rich repeat	209..232	CDD:275380	7/22 (32%)
		leucine-rich repeat	233..261	CDD:275380	6/30 (20%)
		LRR_RI	<261..370	CDD:238064	33/135 (24%)
		leucine-rich repeat	262..284	CDD:275380	6/22 (27%)
		leucine-rich repeat	285..309	CDD:275380	6/23 (26%)
		LRR_8	309..368	CDD:290566	20/84 (24%)
		leucine-rich repeat	310..333	CDD:275380	8/36 (22%)
		leucine-rich repeat	334..357	CDD:275380	7/25 (28%)
		leucine-rich repeat	358..381	CDD:275380	6/22 (27%)
		leucine-rich repeat	445..482	CDD:275380	12/39 (31%)
		LRR_8	459..516	CDD:290566	18/84 (21%)
		leucine-rich repeat	483..505	CDD:275380	7/46 (15%)
		LRR_4	486..521	CDD:289563	11/59 (19%)
		TIR	643..779	CDD:214587	48/138 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I4673
eggNOG	1	0.900	-	-		E2759_KOG4641
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25481
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
	6	5.820