Protein Alignment Toll-7 and CG16974

DIOPT Version :10

• Sequence 1: NP_523797.1
• Gene: Toll-7 / 37272
• FlyBaseID: FBgn0034476
• Length: 1446
• Species: Drosophila melanogaster
• Sequence 2: NP_609610.2
• Gene: CG16974 / 34713
• FlyBaseID: FBgn0032479
• Length: 1257
• Species: Drosophila melanogaster
• Alignment Length: 1536
• Identity: 306/1536 - (19%)
• Similarity: 496/1536 - (32%)
• Gaps: 576/1536 - (37%)

  Fly   123 STLPVAVFARLQTLEALRLDSCKLLQLPNNAFEGLATLKSLRLSTHNSEWGP-TRTLELFPDSLG 186
            |.:..|:|..|:...|:..||...|...::|...||.:.    ..|..:..| .||.:....||.
  Fly     8 SLILCALFVGLKAAAAISGDSTHCLATYSSAEAYLAQIP----QQHRPQIRPRIRTWQEHEFSLL 68

  Fly   187 GLK-------QLTDLDLGDNNL--------------------RQLPS-GFLCPVGNLQVLNLTRN 223
            |.|       ...|.||.|::.                    .:||| |.:.|.||:..||....
  Fly    69 GYKFHLPFVGHAVDSDLDDSDSDEGLWLDAADAGSESVEVEEHELPSVGHVDPTGNVFKLNCEHV 133

  Fly   224 RIRTAEQMGFADMNCGAGSGSAGSELQVLDASH---------------------NELRSISE-SW 266
            .:|...|                 ||....:||                     .:|.|:.| ||
  Fly   134 DLRRVNQ-----------------ELLSQRSSHINYNQLMLAHVPADRSNPLKLPQLESLREFSW 181

  Fly   267 GISRLR----------------RLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLPEGL 315
            ..|.|:                .::.||||.|.|..|.......:..::::.:|.|.|.......
  Fly   182 QSSELKDETLMELFTRQPRSFEYMERLNLAENRLECLHWAIPLAVRRVKVLEMSGNRLSNCSLLN 246

  Fly   316 FAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHN 380
            ....|:|:|:||.::||..||:.....|.:|.:::||.|.||  .:....|.|.::|..|.|:.|
  Fly   247 LQYMKQLQELHLDRSELTYLPQRFLGELSELRMLNLSQNLLT--ELPRDIFVGALKLERLYLSGN 309

  Fly   381 ALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKLF--NGLYV 443
            .|:.:.:..|:....||:                        |:|::|||.:..|..|  ||
  Fly   310 RLSVLPFMLFQTAADLQV------------------------LDLSDNRLLSFPDNFFARNG--- 347

  Fly   444 LSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPR-ALQDLAMLRTLDLGENQIRTFDNQ 507
                                   .|::|.|..|||..:.: :|..|..||.|||.:|.:...|.:
  Fly   348 -----------------------QLRQLHLQRNQLKSIGKHSLYSLRELRQLDLSQNSLSVIDRK 389

  Fly   508 SFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRNF 572
            :|::|..|..|.:..|.:..::..:||.|..|..|:|::|:.:.:..|.|.:...|..:|:|...
  Fly   390 AFESLDHLLALNVSGNNLTLLSSIIFQSLHALRQLDLSRNQFKQLPSGLFQRQRSLVLLRIDETP 454

  Fly   573 LADINGVFATLVSLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVKTLD 637
            :...:.         |::                         .|.|:|.:...|.   |::.|.
  Fly   455 IEQFSN---------WIS-------------------------RYDESLVDPQVLH---RLRYLS 482

  Fly   638 ASHNRITEIGPMSI----PNTIELLFINNNLIGNVQPNAFVDKANLARVDLYANQLSKL-----Q 693
            ...||.....|.::    ||..|||...|.|:  ..|......:.|.|:.:..|.|..|     :
  Fly   483 VQQNRKLTYLPATLFANTPNIRELLLAENGLL--QLPTQISGLSRLQRLSVRGNSLGSLPENIKE 545

  Fly   694 LQQLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQR--INNLTTRQHPRVMDMANIECVMPHARG 756
            |:||....::           ||.::|||:|.||..  .|..|:.:|.           ||.|:.
  Fly   546 LRQLHYLNIL-----------GNEYQCDCSMYWLTAWLANTSTSLRHQ-----------MPQAQN 588

  Fly   757 AAVRPLSGLRPQDFLCRYESHCFALCHCCDFDACDCE---------MTCPSNCTC---------- 802
            .:    :|...|..|..|||    :.|  ..||..|:         :....||:.
  Fly   589 HS----NGSTNQTPLDSYES----IDH--QIDALKCQYGYRGDMLRVLSKLNCSVPTVVQFSEPK 643

  Fly   803 YHDQIWSTNVVDCGGQQTTELPRRVPMDSSVVYLDGNNFPVLKNHAFIGRKNLRALYVNGSQVAA 867
            .| ::.||..::|   |.:..|  ||   .::::...| .:|::||...::.:    :..|:..|
  Fly   644 MH-KLLSTAKLEC---QISGSP--VP---DIIWVTPRN-KILRHHADPDKRPI----IIDSKEDA 694

  Fly   868 IQNRTFASLASLQLLHLADNKLRTLHGYEFEQLSALRELYLQNNQLTTIENATLAPLAALELIRI 932
            .|..:...||:|                       :.|.|:|:...|. :|:.:
  Fly   695 HQPPSAQELAAL-----------------------MDESYIQSLNWTR-QNSLV----------- 724

  Fly   933 DGNRLVTLPIWQMHATHFGTRLKSISLGRNQWSCRCQFLQALTSYVADNALIVQDAQDI-----Y 992
             |.|:|                                      .|.:.:|:|.:...|     .
  Fly   725 -GRRVV--------------------------------------LVENGSLLVHNISRIDSGLYT 750

  Fly   993 CMAASSGTGSAALEDSSSNSGSLEKRELDFNATGAACTDYYSGGSMLQHGIPESYIP-------- 1049
            |.|                          ||..|.|     |.|..|       ||.
  Fly   751 CYA--------------------------FNVMGKA-----SAGLRL-------YIDPIVFYRVK 777

  Fly  1050 ----LLAAALALLFLLVVIAMVFAFRESLRIW-----LFAHYGVRVFGPRCEESEKLYDAVLLHS 1105
                |...|||..|||:.: :|...|..|..|     .:.....:...||..:...:.|::..:.
  Fly   778 IGSILFGTALATAFLLLTL-IVQGLRSCLSRWGICNRFYCCVNRKKKSPRKHQIYAMLDSIETYK 841

  Fly  1106 AKDSEFVCQHLAAQLETGRPPLRVCLQH------------------RDLA-------HDATHYQL 1145
            ::..|.:.::...|:...|   ..|.|.                  ||:.       .|..:.|:
  Fly   842 SQQLERLRENYTQQVHRIR---ENCAQQVEWIQSSYTSQAKHIREFRDIGSNHLTTLKDQYYDQV 903

  Fly  1146 LEATRVSRRVVILLTRNFLQTEWARCELRR-SVHDALRGR------PQKL--VIIEEPEVAFE-- 1199
            .:....|...:..:..|::   :.|.::|: |.|..||.|      .|.|  |:...|...||
  Fly   904 KKVRDYSTGQLSWVRENYV---FQRNKIRKFSAHQVLRLREGYKYQQQTLNKVLENLPSFYFENC 965

  Fly  1200 ---AESDI--ELLPYLK-------TSAVH----RIRRSDRHFWEKLR-YALPVDYPTFRGNNYTL 1247
               .|.||  ::..|.|       :..:|    :.|.|..:...|.. |..|.|......:...|
  Fly   966 RGRCEEDIAEDIDCYFKGQMDFGDSKELHIQKIKARLSANYSASKASLYYTPPDDDLLHSSQLNL 1030

  Fly  1248 E------------LDHH---NHERVKQPA----SPGLLYRQAPPPAYCGPADAV-GIGAVPQVVP 1292
            :            ||..   .|:...:|.    :..:||......:..|.|.|: ..||:.|.:.
  Fly  1031 QNSPIHINYIDENLDQQKQLEHDFKMEPQLLLYNASMLYMNPEGASSSGQAAALAAAGALSQFIS 1095

  Fly  1293 V---------------------------------NASVPA--------------------EQNY- 1303
            |                                 :.|.||                    |..|
  Fly  1096 VEDNNQEQEMQPLRKISGKPLGMPELKDLNDVKTSKSCPAIYKVSKQRDGSTLHELQKEGEAPYQ 1160

  Fly  1304 --------STATTATPSPRPQRRGEQ----------------PGSGSGGNHHLHAQYYQHHGMRP 1344
                    :|:.|:|.:|..|.|.|:                ...|..||..           .|
  Fly  1161 MLRINPVETTSLTSTVAPVMQARTEKLNIILDECGTASLCKAEQEGDAGNSE-----------TP 1214

  Fly  1345 PSEHIYSSIDSD------------YSTLDNEQHMLMMPGAP 1373
            |||   ||.:|:            .|.|.|:..:...|..|
  Fly  1215 PSE---SSCESNSLAASCGDVCQVSSKLANDASLPSTPPKP 1252

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR	45..473	CDD:443914	92/418 (22%)
		leucine-rich repeat	136..159	CDD:275380	6/22 (27%)
		leucine-rich repeat	160..190	CDD:275380	8/37 (22%)
		leucine-rich repeat	191..214	CDD:275380	9/43 (21%)
		leucine-rich repeat	215..248	CDD:275380	4/32 (13%)
		leucine-rich repeat	249..273	CDD:275380	10/61 (16%)
		leucine-rich repeat	274..297	CDD:275380	7/22 (32%)
		leucine-rich repeat	298..321	CDD:275380	3/22 (14%)
		leucine-rich repeat	322..345	CDD:275380	9/22 (41%)
		leucine-rich repeat	346..371	CDD:275380	8/24 (33%)
		LRR	369..>675	CDD:443914	67/312 (21%)
		leucine-rich repeat	372..395	CDD:275380	6/22 (27%)
		leucine-rich repeat	396..419	CDD:275380	2/22 (9%)
		leucine-rich repeat	420..443	CDD:275380	9/24 (38%)
		leucine-rich repeat	444..467	CDD:275380	0/22 (0%)
		leucine-rich repeat	468..488	CDD:275380	7/20 (35%)
		leucine-rich repeat	491..514	CDD:275380	9/22 (41%)
		leucine-rich repeat	515..536	CDD:275380	5/20 (25%)
		leucine-rich repeat	539..562	CDD:275380	6/22 (27%)
		leucine-rich repeat	563..585	CDD:275380	3/21 (14%)
		leucine-rich repeat	586..626	CDD:275380	4/39 (10%)
		leucine-rich repeat	627..653	CDD:275380	6/29 (21%)
		LRRCT	716..772	CDD:214507	15/57 (26%)
		LRR	<812..>963	CDD:443914	23/150 (15%)
		leucine-rich repeat	812..829	CDD:275380	4/16 (25%)
		leucine-rich repeat	833..854	CDD:275380	4/20 (20%)
		leucine-rich repeat	855..878	CDD:275380	4/22 (18%)
		leucine-rich repeat	879..902	CDD:275380	1/22 (5%)
		leucine-rich repeat	903..926	CDD:275380	5/22 (23%)
		leucine-rich repeat	927..953	CDD:275380	3/25 (12%)
		TIR	1098..1235	CDD:214587	35/189 (19%)
CG16974	NP_609610.2	leucine-rich repeat	206..228	CDD:275380	7/21 (33%)
		leucine-rich repeat	229..252	CDD:275380	3/22 (14%)
		LRR	<230..531	CDD:443914	90/391 (23%)
		leucine-rich repeat	253..276	CDD:275380	9/22 (41%)
		leucine-rich repeat	277..300	CDD:275380	8/24 (33%)
		leucine-rich repeat	301..324	CDD:275380	6/22 (27%)
		leucine-rich repeat	325..348	CDD:275380	11/72 (15%)
		leucine-rich repeat	349..372	CDD:275380	8/22 (36%)
		leucine-rich repeat	373..396	CDD:275380	9/22 (41%)
		leucine-rich repeat	397..420	CDD:275380	6/22 (27%)
		leucine-rich repeat	421..444	CDD:275380	6/22 (27%)
		leucine-rich repeat	478..502	CDD:275380	4/23 (17%)
		leucine-rich repeat	503..526	CDD:275380	6/24 (25%)
		Ig	<714..761	CDD:472250	15/128 (12%)
		Ig strand C	714..718	CDD:409358	0/3 (0%)
		Ig strand E	734..738	CDD:409358	1/3 (33%)
		Ig strand F	748..753	CDD:409358	1/4 (25%)