DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-7 and Toll-4

DIOPT Version :9

Sequence 1:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster
Sequence 2:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster


Alignment Length:1259 Identity:260/1259 - (20%)
Similarity:461/1259 - (36%) Gaps:408/1259 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   199 NNLRQLPSGFLCPVGNLQVLNL-----TRNRIRTAE-QMGFADMNCGAGSGS------------- 244
            ||....|:.......|....||     .|.|:|... :|...|:||..|.|:             
  Fly    36 NNKDDPPNSHQKSKSNNDARNLNSRVRVRARVRVVPGEMRMGDINCSNGLGNIREDYCEIYLDEL 100

  Fly   245 --------AGSE---------LQVLDASHNELRSISESWGISRL--------------------- 271
                    |.:|         |..|....|....:...|.|.::                     
  Fly   101 GENGTCSIANNEVTTEDYQMKLVFLKLEINWTSPVFHGWNIFKICNETDYELVIISVLGIRSEVD 165

  Fly   272 ----RRLQHLNLAYNNLSELSGEALAGLASLRI-----------------------VN--LSNNH 307
                ..:|:|:|.  .:.|:||..:. |.|:.|                       ||  ::||:
  Fly   166 MRISPAVQYLSLL--GIREISGYDIY-LPSVLITEMDVHHANGPKMVTFKYLYDSTVNSVITNNY 227

  Fly   308 L-ETLPEGLFAGSKELREIHLQQNELYE-----LPKGLFH---RLEQLLVVDLSGNQLTSNHVDN 363
            : :|:        ....:|.:..:..:|     :.|.:||   ::..|:...|....||:|..:|
  Fly   228 IRKTM--------NNTEKIKIYYHNTFEKTTLTMEKNIFHGKNKMSALIFNGLKIKGLTNNTFEN 284

  Fly   364 TTFAGLIRLIVLNL------------AHNALT--------RIDYRTFKELYFLQILNLRNNSIGH 408
            .|  .|..||..|:            ..::||        .:|.::|::...|:|:.:.... |.
  Fly   285 LT--SLNTLIFDNVFLKDLSFLRSSTLQSSLTYCIMKVDNMVDLKSFEKFTNLEIIEVSQYK-GF 346

  Fly   409 IEDNAFL--PLYNLH---TLNLAE-------NRLHTLD------DKLFNGLYVL----------S 445
            ....||:  | |..|   ||.:.|       |..:..|      |.....|..:          |
  Fly   347 KNFTAFICEP-YKSHCKFTLGINEVACPLKCNCSYNRDKSQLEIDCWQKNLTTIPSLPVPKKGSS 410

  Fly   446 KLTLNNNLISVVEPAVFKNCSDLKELDLSSNQL-----NEVPRALQDLAMLRTLDLGENQIRTFD 505
            .|...:||::.:.....:...:||.||:|.|||     :::|.:      |..||:..|:|.|..
  Fly   411 ALVFQSNLLAELPDNSLEGYHNLKSLDVSYNQLTSLSVSQLPES------LHYLDIRHNKITTLS 469

  Fly   506 NQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRL--------SVLNLAKNRIQSI-------ERG 555
            .|..:.|:.:.    :.||.|| ...::.|...|        .:|.:..::.|:|       .:|
  Fly   470 PQVVEYLYSVN----VFNQYGN-KWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELSSKG 529

  Fly   556 SFDKNFELEAIRLDRNFLA----DINGVFATLVSLLWLNLSE--NHLVW-----FD--------- 600
            ||.:||.::  .:|:.:|.    :|...|........|.|.|  ||.:|     ||         
  Fly   530 SFVENFFVQ--NIDQLYLEANEDEIIDAFGPSDKYFNLKLMEALNHAIWLFSGEFDEIILHHLNS 592

  Fly   601 ----------------------------YAFIPSNLKW---LDIHGNYIEALGNYYKL--QEEIR 632
                                        |..:|:::.:   |.:..|.|..|.|...|  .....
  Fly   593 PCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLPNSIPYKTTLYLDRNEIRKLTNTESLVVAGHAS 657

  Fly   633 VKTLDASHNRITEIGPMSIPNTIELLFINNNLIGNVQPNAFVDKANLARVDLYANQLSKLQLQQL 697
            :..|..|.|.:.|:....:|..|..|.:.|||:      .::|...:|.:: |...::|::    
  Fly   658 IHKLHMSQNLLRELPLHLLPENITYLDVRNNLL------KYLDDGVIAFLE-YRENITKIE---- 711

  Fly   698 RVAPVVAPKPLPEFYLGGNPFECDCT----MDWLQRINNLTTRQHPRVMDMANIECVMPHARGAA 758
                           |.|||:||:|.    :.:|:|...:......|.:::.:.:|         
  Fly   712 ---------------LSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKC--------- 752

  Fly   759 VRPLSGLRPQDFLCRYESHCFALCHCCDFDACDCEMTCPSNCTCYHDQIWSTNVVDCGGQQTTEL 823
                    |:|.:|           |.|        |..|:...|        ||||.|::.:|:
  Fly   753 --------PEDCIC-----------CVD--------TSNSDSLAY--------VVDCSGKELSEI 782

  Fly   824 PRRVPMDSSVVYLDGNNFPVLKNHAFIGRKNLRALYVNGSQVAAIQNRTFASLASLQLLHLADNK 888
            | ::|.            |.......:..:|         .:....:......:|:...:||.|:
  Fly   783 P-QLPT------------PTYGQTTLVFERN---------SLKKWPSSLLPGYSSVTRFYLAHNR 825

  Fly   889 LRTLHGYEFEQL-SALRELYLQNNQLTTIENATLAPLAALELIRIDGNRLVTLPIWQMHATHFGT 952
            |.     :.:|| ..|..|.:.||..:.:::.....|..    |::.::|               
  Fly   826 LS-----DIDQLPDKLEYLDISNNNFSALDDRVRGFLQK----RMNSSQL--------------- 866

  Fly   953 RLKSISLGRNQWSCRCQFLQALTSYVADNALIVQDAQDIYCMAASSGTGSAALEDSSSNSGSLEK 1017
               .:||..|.|:|||:....|. :|.:.|..:.:|..|.|:    .||.:.:|        :|:
  Fly   867 ---QLSLFGNPWTCRCEDKDFLV-FVKEQAKNIANASAIQCI----DTGRSLIE--------VEE 915

  Fly  1018 RELDFNATGAACTDYYSGGSMLQHGIPESYIPLLAAALALLFLLVVIAMVFAFRESLRIWLFAHY 1082
            .::        |              |...|...:.|::||.:.:.|.:...||:.:.||.:.|.
  Fly   916 TDI--------C--------------PSVLIYYTSLAVSLLIIALSINVFICFRQPIMIWFYEHE 958

  Fly  1083 GVRVFGPRCE-ESEKLYDAVLLHSAKDSEFVCQHLAAQLETGRPPLRVCLQHRD-LAHDATHYQL 1145
            .......|.| :.:|.|||.|..:.||.:.: :....:||.||...|:|...|| |..::....:
  Fly   959 ICLSLAARRELDEDKKYDAFLSFTHKDEDLI-EEFVDRLENGRHKFRLCFYLRDWLVGESIPDCI 1022

  Fly  1146 LEATRVSRRVVILLTRNFLQTEWARCELRRSVHDALRGRPQKLVIIEEPEVAFEAESDIELLPYL 1210
            .::.:.|||::||:|:|||::.|.|.|.|.::|...|.|.::|:::..|:|....:.|.||..|:
  Fly  1023 NQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVVLYPDVEHFDDLDSELRAYM 1087

  Fly  1211 KTSAVHRIRRSDRHFWEKLRYALP 1234
            ..:..  :.|::.:||.||.|::|
  Fly  1088 VLNTY--LDRNNPNFWNKLMYSMP 1109

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-7NP_523797.1 LRR_8 135..201 CDD:290566 1/1 (100%)
leucine-rich repeat 136..159 CDD:275380
leucine-rich repeat 160..190 CDD:275380
LRR_8 189..259 CDD:290566 20/95 (21%)
leucine-rich repeat 191..214 CDD:275380 3/14 (21%)
leucine-rich repeat 215..248 CDD:275380 12/59 (20%)
LRR_RI 247..501 CDD:238064 72/374 (19%)
LRR_8 247..308 CDD:290566 19/119 (16%)
leucine-rich repeat 249..273 CDD:275380 5/48 (10%)
leucine-rich repeat 274..297 CDD:275380 7/22 (32%)
LRR_8 297..356 CDD:290566 14/92 (15%)
leucine-rich repeat 298..321 CDD:275380 6/48 (13%)
leucine-rich repeat 322..345 CDD:275380 5/30 (17%)
LRR_8 345..406 CDD:290566 17/80 (21%)
leucine-rich repeat 346..371 CDD:275380 8/24 (33%)
leucine-rich repeat 372..395 CDD:275380 7/42 (17%)
leucine-rich repeat 396..419 CDD:275380 6/24 (25%)
LRR_8 419..478 CDD:290566 18/84 (21%)
leucine-rich repeat 420..443 CDD:275380 8/38 (21%)
leucine-rich repeat 444..467 CDD:275380 4/32 (13%)
LRR_RI 466..622 CDD:238064 48/226 (21%)
leucine-rich repeat 468..488 CDD:275380 9/24 (38%)
LRR_8 491..549 CDD:290566 15/65 (23%)
leucine-rich repeat 491..514 CDD:275380 8/22 (36%)
leucine-rich repeat 515..536 CDD:275380 4/20 (20%)
leucine-rich repeat 539..562 CDD:275380 8/37 (22%)
leucine-rich repeat 563..585 CDD:275380 4/25 (16%)
leucine-rich repeat 586..626 CDD:275380 15/86 (17%)
leucine-rich repeat 627..653 CDD:275380 5/27 (19%)
LRRCT 716..772 CDD:214507 11/59 (19%)
LRRNT 796..830 CDD:214470 10/33 (30%)
leucine-rich repeat 812..829 CDD:275380 7/16 (44%)
leucine-rich repeat 833..854 CDD:275380 1/20 (5%)
LRR_8 853..913 CDD:290566 12/60 (20%)
leucine-rich repeat 855..878 CDD:275380 0/22 (0%)
LRR_4 878..918 CDD:289563 11/40 (28%)
leucine-rich repeat 879..902 CDD:275380 6/23 (26%)
leucine-rich repeat 903..926 CDD:275380 5/22 (23%)
leucine-rich repeat 927..953 CDD:275380 2/25 (8%)
TIR 1098..1235 CDD:214587 45/138 (33%)
Toll-4NP_523519.2 leucine-rich repeat 264..287 CDD:275380 7/24 (29%)
leucine-rich repeat 288..308 CDD:275380 4/19 (21%)
leucine-rich repeat 309..334 CDD:275380 4/24 (17%)
leucine-rich repeat 335..386 CDD:275380 13/52 (25%)
leucine-rich repeat 388..408 CDD:275380 2/19 (11%)
LRR_8 412..465 CDD:290566 16/58 (28%)
leucine-rich repeat 412..432 CDD:275378 3/19 (16%)
LRR_4 432..470 CDD:289563 15/43 (35%)
leucine-rich repeat 433..454 CDD:275378 9/20 (45%)
leucine-rich repeat 455..478 CDD:275378 8/22 (36%)
leucine-rich repeat 479..490 CDD:275378 4/15 (27%)
leucine-rich repeat 632..657 CDD:275378 6/24 (25%)
leucine-rich repeat 658..679 CDD:275378 5/20 (25%)
leucine-rich repeat 680..706 CDD:275378 8/32 (25%)
leucine-rich repeat 707..719 CDD:275378 5/30 (17%)
leucine-rich repeat 771..791 CDD:275380 9/32 (28%)
leucine-rich repeat 793..815 CDD:275378 1/30 (3%)
leucine-rich repeat 816..835 CDD:275378 6/23 (26%)
leucine-rich repeat 836..859 CDD:275378 5/22 (23%)
TIR 974..1110 CDD:214587 45/139 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45468847
Domainoid 1 1.000 44 1.000 Domainoid score I4673
eggNOG 1 0.900 - - E2759_KOG4641
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X221
65.750

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