DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and LINGO4

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001004432.1	Gene:	LINGO4 / 339398	HGNCID:	31814	Length:	593	Species:	Homo sapiens

Alignment Length:	443	Identity:	122/443 - (27%)
Similarity:	168/443 - (37%)	Gaps:	83/443 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 WGPTRTLELFPDSLGG-LKQLTDLDLGDNNLRQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFAD 235
            |.|...|.|.|...|| ...:.|       ....|...||  |:.|:
Human    14 WPPLLFLLLLPGGSGGSCPAVCD-------CTSQPQAVLC--GHRQL------------------ 51

  Fly   236 MNCGAGSGSAGSELQVLDASHNELRSISESWG-----ISRLRRLQHLNLAYNNLSELSGEALAGL 295
               .|..|....:.::||.|.|.|      ||     :|||..||.|:|:||.||.|...|..||
Human    52 ---EAVPGGLPLDTELLDLSGNRL------WGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGL 107

  Fly   296 ASLRIVNLSNNHLETLPEGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNH 360
            .||..:.|..|.|..:..|:|:|...|..:.|:.|::.....|.|..|..|..:::..|.|.  .
Human   108 QSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLV--F 170

  Fly   361 VDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNL 425
            |....||||.:|..|.|....|:.:.......|..|..|.||...||.:...|...|..|..|.:
Human   171 VAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEI 235

  Fly   426 -AENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVP-RALQDL 488
             ....|..||.....||                         :|..|.::...|:.|| :||..|
Human   236 HLWPSLEALDPGSLVGL-------------------------NLSSLAITRCNLSSVPFQALYHL 275

  Fly   489 AMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIE 553
            :.||.|||.:|.|.....:....|.:|..|||....:.:|....|..|....:|::|.|.:|::|
Human   276 SFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLE 340

  Fly   554 RGSFDKNFELEAIRLDRNFL-ADINGVFATLVSLLWLNLSENHLVWFDYAFIP 605
            ..:|....:|..:||..|.| .|..        ||||.....||   |:...|
Human   341 ETAFPSPDKLVTLRLSGNPLTCDCR--------LLWLLRLRRHL---DFGMSP 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	8/29 (28%)
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380	7/18 (39%)
		LRR_8	189..259	CDD:290566	12/69 (17%)
		leucine-rich repeat	191..214	CDD:275380	4/22 (18%)
		leucine-rich repeat	215..248	CDD:275380	3/32 (9%)
		LRR_RI	247..501	CDD:238064	78/260 (30%)
		LRR_8	247..308	CDD:290566	26/65 (40%)
		leucine-rich repeat	249..273	CDD:275380	10/28 (36%)
		leucine-rich repeat	274..297	CDD:275380	12/22 (55%)
		LRR_8	297..356	CDD:290566	16/58 (28%)
		leucine-rich repeat	298..321	CDD:275380	7/22 (32%)
		leucine-rich repeat	322..345	CDD:275380	6/22 (27%)
		LRR_8	345..406	CDD:290566	17/60 (28%)
		leucine-rich repeat	346..371	CDD:275380	8/24 (33%)
		leucine-rich repeat	372..395	CDD:275380	5/22 (23%)
		leucine-rich repeat	396..419	CDD:275380	8/22 (36%)
		LRR_8	419..478	CDD:290566	9/59 (15%)
		leucine-rich repeat	420..443	CDD:275380	7/23 (30%)
		leucine-rich repeat	444..467	CDD:275380	0/22 (0%)
		LRR_RI	466..622	CDD:238064	43/142 (30%)
		leucine-rich repeat	468..488	CDD:275380	7/20 (35%)
		LRR_8	491..549	CDD:290566	18/57 (32%)
		leucine-rich repeat	491..514	CDD:275380	8/22 (36%)
		leucine-rich repeat	515..536	CDD:275380	6/20 (30%)
		leucine-rich repeat	539..562	CDD:275380	6/22 (27%)
		leucine-rich repeat	563..585	CDD:275380	6/22 (27%)
		leucine-rich repeat	586..626	CDD:275380	8/20 (40%)
		leucine-rich repeat	627..653	CDD:275380
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
LINGO4	NP_001004432.1	LRRNT	31..64	CDD:214470	8/62 (13%)
		leucine-rich repeat	62..85	CDD:275380	10/28 (36%)
		LRR_8	65..120	CDD:290566	26/60 (43%)
		leucine-rich repeat	86..109	CDD:275380	12/22 (55%)
		LRR_RI	87..320	CDD:238064	74/259 (29%)
		LRR_8	109..168	CDD:290566	16/58 (28%)
		leucine-rich repeat	110..133	CDD:275380	7/22 (32%)
		leucine-rich repeat	134..157	CDD:275380	6/22 (27%)
		LRR_8	157..212	CDD:290566	15/56 (27%)
		leucine-rich repeat	158..181	CDD:275380	8/24 (33%)
		leucine-rich repeat	182..205	CDD:275380	5/22 (23%)
		leucine-rich repeat	206..229	CDD:275380	8/22 (36%)
		leucine-rich repeat	230..277	CDD:275380	15/71 (21%)
		LRR_8	253..309	CDD:290566	20/55 (36%)
		leucine-rich repeat	278..301	CDD:275380	8/22 (36%)
		LRR_8	301..360	CDD:290566	17/58 (29%)
		leucine-rich repeat	302..325	CDD:275380	7/22 (32%)
		leucine-rich repeat	326..344	CDD:275380	5/17 (29%)
		leucine-rich repeat	350..362	CDD:275378	5/11 (45%)
		IG_like	420..501	CDD:214653
		Ig	431..501	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100