DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-7 and lgi1a

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_955921.2	Gene:	lgi1a / 323011	ZFINID:	ZDB-GENE-030131-1731	Length:	537	Species:	Danio rerio

Alignment Length:	285	Identity:	62/285 - (21%)
Similarity:	95/285 - (33%)	Gaps:	79/285 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   796 CPSNCTCYHDQIWSTNVVDCGGQQTTELPRRVPMDSSVVYLDGNNFPVLKNHAFIGRKNLRALYV 860
            ||:.|||..|.....|        |..:||..|.|...:....:.|..:...:||....|..|..
Zfish    28 CPAPCTCSKDNALCAN--------TGAIPRSFPQDVISLSFVKSGFTEIPKESFIHTPALHLLLF 84

  Fly   861 NGSQVAAIQNRTFASLASLQLLHLADNKLRTLHGYEFEQLSALRELYLQNNQLTTIENATLAPLA 925
            ..:...:|....|..|..|:.|.:.:|:::::..:.|..|.:|..|.|..|.|.|:.......:.
Zfish    85 TANSFDSINEDAFLGLPHLEYLFIENNQIKSISPFAFRGLKSLIHLSLAYNNLETLPKDLFKGME 149

  Fly   926 ALELIRIDGN------RLVTLPIWQMH--------------------------------ATHFGT 952
            ||..:.:.||      :|..|..|..|                                .|.| |
Zfish   150 ALTKVDLRGNLFSCDCKLKWLVDWMFHTNATVDQIFCNGPEGYQGKKINDLEAQTFDCITTDF-T 213

  Fly   953 RLKSI----------SLGRNQ-------WSCRCQFLQ--------------ALTSYVADNALIVQ 986
            .|||:          |...:|       :|.||.|::              ..||.|....|::
Zfish   214 LLKSLEFQSISVEAFSFAGDQFVVFAQPFSGRCSFMEWDHVQMEFRNFDNITSTSTVICKPLVI- 277

  Fly   987 DAQDIYCMAASSGTGSAALEDSSSN 1011
            |:|....:|...|.......|.|:|
Zfish   278 DSQLFIIVAQLFGGSHIFKRDVSAN 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380
		LRR_RI	247..501	CDD:238064
		LRR_8	247..308	CDD:290566
		leucine-rich repeat	249..273	CDD:275380
		leucine-rich repeat	274..297	CDD:275380
		LRR_8	297..356	CDD:290566
		leucine-rich repeat	298..321	CDD:275380
		leucine-rich repeat	322..345	CDD:275380
		LRR_8	345..406	CDD:290566
		leucine-rich repeat	346..371	CDD:275380
		leucine-rich repeat	372..395	CDD:275380
		leucine-rich repeat	396..419	CDD:275380
		LRR_8	419..478	CDD:290566
		leucine-rich repeat	420..443	CDD:275380
		leucine-rich repeat	444..467	CDD:275380
		LRR_RI	466..622	CDD:238064
		leucine-rich repeat	468..488	CDD:275380
		LRR_8	491..549	CDD:290566
		leucine-rich repeat	491..514	CDD:275380
		leucine-rich repeat	515..536	CDD:275380
		leucine-rich repeat	539..562	CDD:275380
		leucine-rich repeat	563..585	CDD:275380
		leucine-rich repeat	586..626	CDD:275380
		leucine-rich repeat	627..653	CDD:275380
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470	11/33 (33%)
		leucine-rich repeat	812..829	CDD:275380	3/16 (19%)
		leucine-rich repeat	833..854	CDD:275380	3/20 (15%)
		LRR_8	853..913	CDD:290566	14/59 (24%)
		leucine-rich repeat	855..878	CDD:275380	5/22 (23%)
		LRR_4	878..918	CDD:289563	11/39 (28%)
		leucine-rich repeat	879..902	CDD:275380	5/22 (23%)
		leucine-rich repeat	903..926	CDD:275380	6/22 (27%)
		leucine-rich repeat	927..953	CDD:275380	9/63 (14%)
		TIR	1098..1235	CDD:214587
lgi1a	NP_955921.2	LRR_8	57..113	CDD:290566	11/55 (20%)
		LRR_4	77..120	CDD:289563	8/42 (19%)
		leucine-rich repeat	79..102	CDD:275378	5/22 (23%)
		LRR_8	101..161	CDD:290566	15/59 (25%)
		LRR_4	101..141	CDD:289563	11/39 (28%)
		leucine-rich repeat	103..126	CDD:275378	5/22 (23%)
		leucine-rich repeat	127..150	CDD:275378	6/22 (27%)
		leucine-rich repeat	151..163	CDD:275378	3/11 (27%)
		TPKR_C2	159..207	CDD:301599	5/47 (11%)
		EPTP	211..252	CDD:281697	11/41 (27%)
		EPTP	257..298	CDD:281697	8/41 (20%)
		EPTP	303..349	CDD:281697	62/285 (22%)
		EPTP	352..394	CDD:281697
		EPTP	399..441	CDD:281697
		EPTP	444..485	CDD:281697
		EPTP	490..530	CDD:281697
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000