DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and Lingo4

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_796224.1	Gene:	Lingo4 / 320747	MGIID:	2444651	Length:	618	Species:	Mus musculus

Alignment Length:	627	Identity:	157/627 - (25%)
Similarity:	244/627 - (38%)	Gaps:	116/627 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 LLQLPNNAFEGLATLKSLRLSTHNSEWGPTRTLELFPDSLGGLKQLTD-LDLGDNNLRQLPSGFL 209
            ||.||..:.....|:......| .:.:...|.|:..|   |||...|: |||..|.|..|..|.|
Mouse    45 LLLLPGGSISSCPTVCDCTSQT-RAVFCAHRRLDTIP---GGLPLDTELLDLSGNRLWGLQRGML 105

  Fly   210 CPVGNLQVLNLTRNRIRTAEQMGFADMN--------------CGAGSGSAGSELQVLDASHNELR 260
            ..:|.||.|:|:.|::.|.|...|..:.              .|.|..|..:.|.:||...|::.
Mouse   106 SRLGQLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIVGPGIFSGLTALTLLDLRLNQIV 170

  Fly   261 SISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLPEGLFAGSKELREI 325
            ...:. ..|.|..||.|.:..|:|..::..|.||||.|..:.|...:|.|:|....|....|..:
Mouse   171 LFLDG-AFSELGSLQQLEVGDNHLVFVAPGAFAGLAKLSTITLERCNLSTVPGLALAQLPALVAL 234

  Fly   326 HLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNALTR-----I 385
            .|::.::..||.|....|.||       .:|..:|..:........|:.|||:..|:||     :
Mouse   235 RLRELDIERLPAGALRGLGQL-------KELEIHHWPSLEALDPGSLVGLNLSSLAITRCNLSSV 292

  Fly   386 DYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKLFNGLYVLSKLTLN 450
            .::....|.||:||:|..|.|..|......||..|..|.|:...|.::....|:||.....|.:.
Mouse   293 PFQALHHLSFLRILDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVA 357

  Fly   451 NNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRALQDLAMLRTLDLGEN-------------QIR 502
            :|.:..:|...|.:...|..|.||.|.|....|.|..|.:.|.||.|.:             .:|
Mouse   358 DNALQTLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLLRLRRRLDFGTSPPACAGPQHVQGKSLR 422

  Fly   503 TFDN-------QSFKNLHQLTGLRLIDNQIGNITV----GMFQDLPRLSVLN-----LAK-NRIQ 550
            .|.:       .....|.:.:|.|.:..:.|...|    |.....|.:|.:.     |.: .|::
Mouse   423 EFSDILPPGHFTCKPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPQGAWLGRVGRVR 487

  Fly   551 SIERGSFDKNFELEAIRL-DRNFLADINGVFATLVSLLWLNLSENHLVWFDYAFIPSNLKWLDIH 614
            .:|.|:    .|:.:::| ||       |.:..:||    |::.|          .|...||::
Mouse   488 VLEDGT----LEIRSVQLRDR-------GAYVCVVS----NVAGN----------DSLRTWLEV- 526

  Fly   615 GNYIEALGNYYKLQEEIRVKTLDASHNRITEIGPMSIPNTIELLFINNNLIGNVQPNAFVDKANL 679
                        :|.|....||  |...||..|   ||..   .|:::..:..|....|:  ..|
Mouse   527 ------------IQVEPPNGTL--SDPNITMPG---IPGP---FFLDSRGVAMVLAVGFL--PFL 569

  Fly   680 ARVDLYANQLS-----KLQLQQLRVAPVVAPKPLPEFYLGGN 716
            ..|.|....::     |.:::.......|||:|..:...|||
Mouse   570 TSVTLCFGLIALWSKGKGRVKHHMTFDFVAPRPSGDKNSGGN 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	17/55 (31%)
		leucine-rich repeat	136..159	CDD:275380	4/12 (33%)
		leucine-rich repeat	160..190	CDD:275380	7/29 (24%)
		LRR_8	189..259	CDD:290566	25/84 (30%)
		leucine-rich repeat	191..214	CDD:275380	9/23 (39%)
		leucine-rich repeat	215..248	CDD:275380	11/46 (24%)
		LRR_RI	247..501	CDD:238064	74/271 (27%)
		LRR_8	247..308	CDD:290566	18/60 (30%)
		leucine-rich repeat	249..273	CDD:275380	6/23 (26%)
		leucine-rich repeat	274..297	CDD:275380	9/22 (41%)
		LRR_8	297..356	CDD:290566	14/58 (24%)
		leucine-rich repeat	298..321	CDD:275380	6/22 (27%)
		leucine-rich repeat	322..345	CDD:275380	6/22 (27%)
		LRR_8	345..406	CDD:290566	18/65 (28%)
		leucine-rich repeat	346..371	CDD:275380	3/24 (13%)
		leucine-rich repeat	372..395	CDD:275380	8/27 (30%)
		leucine-rich repeat	396..419	CDD:275380	9/22 (41%)
		LRR_8	419..478	CDD:290566	16/58 (28%)
		leucine-rich repeat	420..443	CDD:275380	7/22 (32%)
		leucine-rich repeat	444..467	CDD:275380	4/22 (18%)
		LRR_RI	466..622	CDD:238064	39/186 (21%)
		leucine-rich repeat	468..488	CDD:275380	8/19 (42%)
		LRR_8	491..549	CDD:290566	15/87 (17%)
		leucine-rich repeat	491..514	CDD:275380	7/42 (17%)
		leucine-rich repeat	515..536	CDD:275380	5/24 (21%)
		leucine-rich repeat	539..562	CDD:275380	5/28 (18%)
		leucine-rich repeat	563..585	CDD:275380	4/22 (18%)
		leucine-rich repeat	586..626	CDD:275380	5/39 (13%)
		leucine-rich repeat	627..653	CDD:275380	9/25 (36%)
		LRRCT	716..772	CDD:214507	1/1 (100%)
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
Lingo4	NP_796224.1	LRRNT	56..89	CDD:214470	9/36 (25%)
		leucine-rich repeat	69..86	CDD:275380	6/19 (32%)
		leucine-rich repeat	87..110	CDD:275380	9/22 (41%)
		LRR_8	90..145	CDD:290566	17/54 (31%)
		leucine-rich repeat	111..134	CDD:275380	8/22 (36%)
		LRR_RI	112..345	CDD:238064	64/240 (27%)
		LRR_8	134..193	CDD:290566	13/59 (22%)
		leucine-rich repeat	135..158	CDD:275380	3/22 (14%)
		leucine-rich repeat	159..182	CDD:275380	6/23 (26%)
		LRR_8	182..237	CDD:290566	17/54 (31%)
		leucine-rich repeat	183..206	CDD:275380	9/22 (41%)
		leucine-rich repeat	207..230	CDD:275380	6/22 (27%)
		leucine-rich repeat	231..254	CDD:275380	6/22 (27%)
		leucine-rich repeat	255..302	CDD:275380	11/53 (21%)
		LRR_8	278..334	CDD:290566	19/55 (35%)
		leucine-rich repeat	303..326	CDD:275380	9/22 (41%)
		LRR_8	326..385	CDD:290566	16/58 (28%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		leucine-rich repeat	351..369	CDD:275380	3/17 (18%)
		leucine-rich repeat	375..387	CDD:275378	6/11 (55%)
		IG_like	445..526	CDD:214653	22/105 (21%)
		Ig	456..526	CDD:299845	20/94 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010