DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and Slitrk3

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001101153.1	Gene:	Slitrk3 / 310519	RGDID:	1310506	Length:	979	Species:	Rattus norvegicus

Alignment Length:	1139	Identity:	235/1139 - (20%)
Similarity:	367/1139 - (32%)	Gaps:	390/1139 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   310 TLPEGLFAGSKELREIHLQQNELY-ELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLI 373
            |.|..|...|:|:.|...  :..| |:.:.|||                 .|.|:..|..:
  Rat    28 TTPIPLIEDSEEIDEPCF--DPCYCEVKESLFH-----------------IHCDSKGFTNI---- 69

  Fly   374 VLNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKLF 438
                  :.:|....|.||       |.|:.||:..:..|:||.|.|..::||..|.|..:....|
  Rat    70 ------SQITEFWSRPFK-------LYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAF 121

  Fly   439 NGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRALQDLAMLRTLDLGENQIRT 503
            |||.:|.:|.|:.|.:.     ||:|.:.|                  .|..|..|....|.|:.
  Rat   122 NGLKILKRLYLHENKLD-----VFRNDTFL------------------GLESLEYLQADYNVIKR 163

  Fly   504 FDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSI-ERGSFDKNFELEAIR 567
            .::.:|:||.:|..|.|.||.|..:...:|:.: .|:.|:|..||::.: .||..|        .
  Rat   164 IESGAFRNLSKLRVLILNDNLIPVLPTNLFKAV-SLTHLDLRGNRLKVLFYRGMLD--------H 219

  Fly   568 LDRNFLADINGVFATLVSLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIR 632
            :.|              ||:.|.|.||  .|.....|.....||       |.: .|..|..:|.
  Rat   220 IGR--------------SLMELQLEEN--PWNCTCEIVQLKSWL-------ERI-PYTALVGDIT 260

  Fly   633 VKT------LDASHNRITEIGPMSIPNTIEL-LFINNNLIGNVQPNAFVDKAN--LARVDLYANQ 688
            .:|      .|....:.||:.|:...:.:|. |.|.:  :.:.:.||:..|.:  |:.|...|:.
  Rat   261 CETPFHFHGKDLREIKKTELCPLLSDSEVEASLGIPH--LSSSKENAWPTKPSSMLSSVHFTASS 323

  Fly   689 LS-KLQLQQLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQRINNLTTRQHPRVMDMANIECVMP 752
            :. |...:|        |||                           |:|.......:..:.:.|
  Rat   324 VEYKSSNKQ--------PKP---------------------------TKQPRTPRPPSTSQALYP 353

  Fly   753 HARGAAVRPLSGLRPQDFLCRYESHCFALCHCCDFDACDCEMTCPSNCTC---YHDQIWSTNVVD 814
            ......:.|.....|                        ..:.||:.|||   .:|...:.|..:
  Rat   354 GPNQPPIAPYQTRPP------------------------IPIICPTGCTCNLHINDLGLTVNCKE 394

  Fly   815 CGGQQTTE-LPRRVPMDSSVVYLDGN-----------NFPVL-------------KNHAFIGRKN 854
            .|....:| |||  |:::..:||..|           ||..|             ::.|||...|
  Rat   395 RGFNNISELLPR--PLNAKKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPN 457

  Fly   855 LRALYVNGSQVAAIQNRTFASLASLQLLHLADNKLRTLHGYEFEQLSALRELYLQNNQLTTIENA 919
            |::|::||:.:..:....|..|.||..|:...|.:|.:....|..:..|:.|:|.||.|.|:...
  Rat   458 LKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTD 522

  Fly   920 TLA--PLAALELIRIDGNRLVTLPIWQMHATHFGTRLKSISLGRNQWSCRC------QFLQALTS 976
            ..|  .||.|.|.:   |..:.||:..: ..|... :..|.|..|.|.|.|      |:::.::|
  Rat   523 AFAGTSLARLNLRK---NYFLYLPVAGV-LEHLNA-IVQIDLNENPWDCTCDLVPFKQWIETISS 582

  Fly   977 YVADNALIVQDAQDIYCMA------------------------ASSGTGSAALEDSSSNSGSLEK 1017
                    |....|:.|..                        |..|.......|...|.|....
  Rat   583 --------VSVVGDVLCRTPENLTHRDVRTIELEVLCPEMLHIAQPGPSPPQSGDYHPNGGPTSA 639

  Fly  1018 RELDFNATGAACTDYYSGGSMLQHGIPESYIPLLAAALALLFL----LVVIAMVFAF-----RES 1073
            ...||:..|..                   :||....|:||.|    :.|.|.:||:     |:.
  Rat   640 SPYDFSPPGGP-------------------VPLSVLILSLLVLFFSAVFVAAGLFAYVLRRRRKK 685

  Fly  1074 LRIWLFAHYGVRVFGPRCEESEKLYDAVLLHSAKDSEFVCQHL--------AAQLETGRPPLRVC 1130
            |........||.:.|.:.:                    |..|        ......|||.|...
  Rat   686 LPFRSKRQEGVDLTGIQMQ--------------------CHRLFEDSGGSGGGSGSGGRPTLSSP 730

  Fly  1131 LQHRDLAHDATHYQLLEATRVSRRVVILLTRNFLQTEWARCELRRSVHDALRGRPQKLVIIEEPE 1195
            .:...:.| ...|.....|::....:.                          :|:     ||.|
  Rat   731 EKAPPVGH-VYEYIPHPVTQMCNNPIY--------------------------KPR-----EEEE 763

  Fly  1196 VAFEAESDIELL----PYLKTSAVHRIRRSDRHFWE---------------KLRYALPVDYPTFR 1241
            ||..|..|....    |..:...:..:......|.|               :..:||.|.....
  Rat   764 VAASAAQDTGATDRGGPGTQPPGMGEVLLGSEQFAETPKENHSNYRTLLEKEKEWALAVSNSQL- 827

  Fly  1242 GNNYTLELDHH---------------------------NHER----VKQPASPG------LLYRQ 1269
              |..:.::||                           :||:    |..|...|      ||.|:
  Rat   828 --NTIVTVNHHHPHPHHSAVGGVSGVGGGTGGDLAGFRHHEKNGGVVLFPPGGGCGGGSLLLERE 890

  Fly  1270 APPPAYC--GPADAVGIGAVPQVVPVNASVPAEQ 1301
            .|.||.|  |..|.: .|.||::..::...|..|
  Rat   891 RPQPAPCTVGFVDCL-YGTVPKLKELHVHPPGMQ 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380
		LRR_RI	247..501	CDD:238064	47/191 (25%)
		LRR_8	247..308	CDD:290566
		leucine-rich repeat	249..273	CDD:275380
		leucine-rich repeat	274..297	CDD:275380
		LRR_8	297..356	CDD:290566	11/46 (24%)
		leucine-rich repeat	298..321	CDD:275380	4/10 (40%)
		leucine-rich repeat	322..345	CDD:275380	6/23 (26%)
		LRR_8	345..406	CDD:290566	10/60 (17%)
		leucine-rich repeat	346..371	CDD:275380	3/24 (13%)
		leucine-rich repeat	372..395	CDD:275380	4/22 (18%)
		leucine-rich repeat	396..419	CDD:275380	8/22 (36%)
		LRR_8	419..478	CDD:290566	17/58 (29%)
		leucine-rich repeat	420..443	CDD:275380	8/22 (36%)
		leucine-rich repeat	444..467	CDD:275380	7/22 (32%)
		LRR_RI	466..622	CDD:238064	36/156 (23%)
		leucine-rich repeat	468..488	CDD:275380	1/19 (5%)
		LRR_8	491..549	CDD:290566	18/57 (32%)
		leucine-rich repeat	491..514	CDD:275380	7/22 (32%)
		leucine-rich repeat	515..536	CDD:275380	7/20 (35%)
		leucine-rich repeat	539..562	CDD:275380	8/23 (35%)
		leucine-rich repeat	563..585	CDD:275380	1/21 (5%)
		leucine-rich repeat	586..626	CDD:275380	11/39 (28%)
		leucine-rich repeat	627..653	CDD:275380	7/31 (23%)
		LRRCT	716..772	CDD:214507	5/55 (9%)
		LRRNT	796..830	CDD:214470	13/37 (35%)
		leucine-rich repeat	812..829	CDD:275380	5/17 (29%)
		leucine-rich repeat	833..854	CDD:275380	9/44 (20%)
		LRR_8	853..913	CDD:290566	18/59 (31%)
		leucine-rich repeat	855..878	CDD:275380	6/22 (27%)
		LRR_4	878..918	CDD:289563	13/39 (33%)
		leucine-rich repeat	879..902	CDD:275380	5/22 (23%)
		leucine-rich repeat	903..926	CDD:275380	9/24 (38%)
		leucine-rich repeat	927..953	CDD:275380	6/25 (24%)
		TIR	1098..1235	CDD:214587	22/163 (13%)
Slitrk3	NP_001101153.1	leucine-rich repeat	81..102	CDD:275380	9/27 (33%)
		leucine-rich repeat	103..126	CDD:275380	8/22 (36%)
		LRR_8	105..161	CDD:290566	20/78 (26%)
		leucine-rich repeat	127..150	CDD:275380	9/45 (20%)
		LRR_8	150..208	CDD:290566	18/58 (31%)
		leucine-rich repeat	151..174	CDD:275380	7/22 (32%)
		leucine-rich repeat	175..197	CDD:275380	7/22 (32%)
		leucine-rich repeat	198..402	CDD:275380	55/296 (19%)
		LRRCT	232..>270	CDD:214507	10/47 (21%)
		leucine-rich repeat	403..433	CDD:275380	9/31 (29%)
		LRR_8	432..492	CDD:290566	15/59 (25%)
		LRR_4	433..473	CDD:289563	9/39 (23%)
		leucine-rich repeat	434..457	CDD:275380	4/22 (18%)
		LRR_4	456..497	CDD:289563	12/40 (30%)
		leucine-rich repeat	458..481	CDD:275380	6/22 (27%)
		leucine-rich repeat	482..501	CDD:275380	4/18 (22%)
		leucine-rich repeat	506..528	CDD:275380	8/21 (38%)
		leucine-rich repeat	529..553	CDD:275380	8/27 (30%)
		LRRCT	562..>597	CDD:214507	9/42 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3875
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050