DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and Slitrk2

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001101057.1	Gene:	Slitrk2 / 309349	RGDID:	1561361	Length:	846	Species:	Rattus norvegicus

Alignment Length:	719	Identity:	166/719 - (23%)
Similarity:	269/719 - (37%)	Gaps:	175/719 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   421 HTLNL-AENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEV-PR 483
            :.||: .||:..|....|....|.:.:|.||.||::.:.|..|.|.|:...|.|.:|.|.|: |.
  Rat    40 NVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRPG 104

  Fly   484 ALQDLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNR 548
            |...|..|:.|.|..|::......:|..|..|..|:...|.|..|..|.|..|.:|.||.|..|.
  Rat   105 AFSGLKTLKRLHLNNNKLEVLREDTFLGLESLEYLQADYNYISTIEAGAFSKLNKLKVLILNDNL 169

  Fly   549 IQSIERGSFDKNFELEA---IRLDRNFLADINGVFATLVSLLWLNLSENHLVWFDYAFIPSN--- 607
            :.|:....|  .|.|..   :|.:|..:....||...:..::.:.|.||          |.|
  Rat   170 LLSLPSNVF--RFVLLTHLDLRGNRLKVMPFAGVLEHIGGIMEIQLEEN----------PWNCTC 222

  Fly   608 ----LK-WLDIHGNYIEALGNYYKLQEEIRVKTLDASHNR-ITEIGPMSIPNTIELLFINNNLIG 666
                || |||....::          .||..:|....|.: :|::       |.:.|....:..|
  Rat   223 DLLPLKAWLDTITVFV----------GEIVCETPFRLHGKDVTQL-------TRQDLCPRKSASG 270

  Fly   667 NVQPNAFVDKANLARVDLYANQLSKLQLQQLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQRIN 731
            :....:       :..|.:..:||......|.  |..|||                    ..|..
  Rat   271 DSSQRS-------SHSDTHVQRLSPTMNPALN--PTRAPK--------------------ASRPP 306

  Fly   732 NLTTRQHPRV---MDMANIECVMPHARGAAVRPLSGLRPQDFLCRYESHCFALCHCCDFDACDCE 793
            .:..|..|||   .|..:...:|.:...:.|                                 .
  Rat   307 KMRNRPTPRVTVSKDRQSFGPIMVYQTKSPV---------------------------------A 338

  Fly   794 MTCPSNCTCYHDQIWSTNVVDCGGQQTTELPRRVPMDSS--VVYLDGNNFPVLKNHAFIGRKNLR 856
            :||||:|.|......:...|:|..::.|.:....|..:|  .:||.||....:..:..:...:|.
  Rat   339 LTCPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYTSLD 403

  Fly   857 ALYVNGSQVAAIQNRTFASLASLQLLHLADNKLRTLHGYEFEQLSALRELYLQNNQLTTIENATL 921
            .|::..:::|.||...|.:|.||:.|:|..|.|..|:...|:.|.:|:.|||:.|.:..|:..|.
  Rat   404 LLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTF 468

  Fly   922 APLAALELIRIDGNRLVTLP-------------IWQMHATHFGTR--------LKSISLGRNQWS 965
            ..|..|:|:.::.|.|.:||             :...|.:|...:        ...|.|..|.|.
  Rat   469 DALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWD 533

  Fly   966 CRCQF--LQALTSYVADNALIVQDAQDIYCMAASSGTGSAALEDSSSNSGSLEKRELDFNATGAA 1028
            |.|..  |:..|.: |::.:|:   .::.|            |..:.::|.:    |.|....|.
  Rat   534 CTCDIMGLKDWTEH-ANSPVII---NEVTC------------ESPAKHAGEI----LKFLGREAI 578

  Fly  1029 CTD--YYSGGSML--QHGI---------PESY------IPLLAAALALLFLLVVIAMVFAFRESL 1074
            |.|  ..|.|::|  .|..         |.||      :||   ::.:|.||||..:...|...|
  Rat   579 CPDNPNLSDGTVLSMNHNTDTPRSLSVSPSSYPELHTEVPL---SVLILGLLVVFILSVCFGAGL 640

  Fly  1075 RIWL 1078
            .:::
  Rat   641 FVFV 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380
		LRR_RI	247..501	CDD:238064	28/81 (35%)
		LRR_8	247..308	CDD:290566
		leucine-rich repeat	249..273	CDD:275380
		leucine-rich repeat	274..297	CDD:275380
		LRR_8	297..356	CDD:290566
		leucine-rich repeat	298..321	CDD:275380
		leucine-rich repeat	322..345	CDD:275380
		LRR_8	345..406	CDD:290566
		leucine-rich repeat	346..371	CDD:275380
		leucine-rich repeat	372..395	CDD:275380
		leucine-rich repeat	396..419	CDD:275380
		LRR_8	419..478	CDD:290566	19/57 (33%)
		leucine-rich repeat	420..443	CDD:275380	6/22 (27%)
		leucine-rich repeat	444..467	CDD:275380	8/22 (36%)
		LRR_RI	466..622	CDD:238064	46/167 (28%)
		leucine-rich repeat	468..488	CDD:275380	7/20 (35%)
		LRR_8	491..549	CDD:290566	19/57 (33%)
		leucine-rich repeat	491..514	CDD:275380	6/22 (27%)
		leucine-rich repeat	515..536	CDD:275380	7/20 (35%)
		leucine-rich repeat	539..562	CDD:275380	7/22 (32%)
		leucine-rich repeat	563..585	CDD:275380	5/24 (21%)
		leucine-rich repeat	586..626	CDD:275380	10/47 (21%)
		leucine-rich repeat	627..653	CDD:275380	5/26 (19%)
		LRRCT	716..772	CDD:214507	8/58 (14%)
		LRRNT	796..830	CDD:214470	9/33 (27%)
		leucine-rich repeat	812..829	CDD:275380	3/16 (19%)
		leucine-rich repeat	833..854	CDD:275380	4/20 (20%)
		LRR_8	853..913	CDD:290566	21/59 (36%)
		leucine-rich repeat	855..878	CDD:275380	7/22 (32%)
		LRR_4	878..918	CDD:289563	15/39 (38%)
		leucine-rich repeat	879..902	CDD:275380	8/22 (36%)
		leucine-rich repeat	903..926	CDD:275380	8/22 (36%)
		leucine-rich repeat	927..953	CDD:275380	8/38 (21%)
		TIR	1098..1235	CDD:214587
Slitrk2	NP_001101057.1	leucine-rich repeat	67..87	CDD:275378	8/19 (42%)
		LRR_8	86..146	CDD:404697	18/59 (31%)
		leucine-rich repeat	90..111	CDD:275380	8/20 (40%)
		leucine-rich repeat	112..135	CDD:275380	6/22 (27%)
		LRR_8	135..193	CDD:404697	18/59 (31%)
		leucine-rich repeat	136..159	CDD:275380	8/22 (36%)
		leucine-rich repeat	160..182	CDD:275380	8/23 (35%)
		leucine-rich repeat	183..207	CDD:275380	4/23 (17%)
		leucine-rich repeat	208..370	CDD:275380	43/250 (17%)
		TPKR_C2	216..>252	CDD:417692	12/55 (22%)
		PPP1R42	358..531	CDD:411060	43/172 (25%)
		leucine-rich repeat	371..401	CDD:275380	6/29 (21%)
		LRR_8	400..460	CDD:404697	21/59 (36%)
		leucine-rich repeat	402..425	CDD:275380	7/22 (32%)
		leucine-rich repeat	426..449	CDD:275380	8/22 (36%)
		leucine-rich repeat	450..469	CDD:275380	7/18 (39%)
		leucine-rich repeat	474..492	CDD:275380	6/17 (35%)
		leucine-rich repeat	497..510	CDD:275378	1/12 (8%)
		leucine-rich repeat	522..534	CDD:275378	4/11 (36%)
		LRRCT	530..580	CDD:214507	14/69 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3875
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.050