DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-7 and Tsku

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001009965.2	Gene:	Tsku / 308843	RGDID:	1359311	Length:	353	Species:	Rattus norvegicus

Alignment Length:	286	Identity:	83/286 - (29%)
Similarity:	125/286 - (43%)	Gaps:	39/286 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 LNLTRNRIRTAEQMGFADMNCGAGSGSAGSELQVLDASHNELRSISESWGISRLRRLQHLNLAYN 282
            |:|:.||:.|        :|.....|...:.|..||.|||.|.||:.: ..||||.|:.|:|::|
  Rat    64 LDLSSNRLET--------VNESVLGGPGYTTLAGLDLSHNLLTSITPT-AFSRLRYLESLDLSHN 119

  Fly   283 NLSELSGEALAGLASLRIVNLSNNHLETLPEGLFAGSKELREIHLQQNELYELPKGLFHRLEQLL 347
            .|:.|..|.... :.|..:|||:|.|..:....|....:.|.:|:      :|...|.|||....
  Rat   120 GLAALPAEVFTS-SPLSDINLSHNRLREVSISAFTTHSQGRALHV------DLSHNLIHRLLPYP 177

  Fly   348 V-VDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIED 411
            . ..||...:.|                |||:.|.|..:.  ..::|. |:.|:|..|.:..|..
  Rat   178 ARASLSAPTIQS----------------LNLSWNRLRAVP--NLRDLP-LRYLSLDGNPLATINP 223

  Fly   412 NAFLPLYNLHTLNLAE-NRLHTLDDKLFNGLYVLSKLTLNNN-LISVVEPAVFKNCSDLKELDLS 474
            .||:.|..|..|:||. ..:..|....|..|..|..|.|:.| .:......||.....|:|||||
  Rat   224 GAFMGLAGLTHLSLASLQGILQLPPHGFRELPGLQVLDLSGNPKLKWAGAEVFSGLGLLQELDLS 288

  Fly   475 SNQLNEVPRA-LQDLAMLRTLDLGEN 499
            .:.|..:|.. |..|..|:::.:|::
  Rat   289 GSSLVPLPETLLHHLPALQSVSVGQD 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566	13/40 (33%)
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380	7/29 (24%)
		LRR_RI	247..501	CDD:238064	76/257 (30%)
		LRR_8	247..308	CDD:290566	25/60 (42%)
		leucine-rich repeat	249..273	CDD:275380	12/23 (52%)
		leucine-rich repeat	274..297	CDD:275380	7/22 (32%)
		LRR_8	297..356	CDD:290566	16/59 (27%)
		leucine-rich repeat	298..321	CDD:275380	7/22 (32%)
		leucine-rich repeat	322..345	CDD:275380	7/22 (32%)
		LRR_8	345..406	CDD:290566	13/61 (21%)
		leucine-rich repeat	346..371	CDD:275380	3/25 (12%)
		leucine-rich repeat	372..395	CDD:275380	6/22 (27%)
		leucine-rich repeat	396..419	CDD:275380	8/22 (36%)
		LRR_8	419..478	CDD:290566	19/60 (32%)
		leucine-rich repeat	420..443	CDD:275380	7/23 (30%)
		leucine-rich repeat	444..467	CDD:275380	6/23 (26%)
		LRR_RI	466..622	CDD:238064	12/35 (34%)
		leucine-rich repeat	468..488	CDD:275380	9/20 (45%)
		LRR_8	491..549	CDD:290566	2/9 (22%)
		leucine-rich repeat	491..514	CDD:275380	2/9 (22%)
		leucine-rich repeat	515..536	CDD:275380
		leucine-rich repeat	539..562	CDD:275380
		leucine-rich repeat	563..585	CDD:275380
		leucine-rich repeat	586..626	CDD:275380
		leucine-rich repeat	627..653	CDD:275380
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
Tsku	NP_001009965.2	LRR	<39..286	CDD:227223	73/256 (29%)
		LRR 1	60..80		6/23 (26%)
		leucine-rich repeat	63..86	CDD:275380	7/29 (24%)
		LRR 2	86..107		9/21 (43%)
		leucine-rich repeat	90..110	CDD:275380	11/20 (55%)
		LRR 3	110..131		7/20 (35%)
		leucine-rich repeat	111..133	CDD:275380	7/22 (32%)
		LRR 4	133..154		7/20 (35%)
		leucine-rich repeat	134..159	CDD:275380	7/24 (29%)
		leucine-rich repeat	160..186	CDD:275380	8/31 (26%)
		LRR 5	160..180		6/25 (24%)
		LRR 6	186..207		6/38 (16%)
		leucine-rich repeat	187..205	CDD:275380	6/35 (17%)
		leucine-rich repeat	208..231	CDD:275380	8/22 (36%)
		LRR 7	208..228		7/19 (37%)
		LRR 8	231..253		6/21 (29%)
		leucine-rich repeat	232..256	CDD:275380	7/23 (30%)
		LRR 9	256..277		5/20 (25%)
		leucine-rich repeat	257..281	CDD:275380	6/23 (26%)
		LRR 10	281..302		9/20 (45%)
		leucine-rich repeat	282..305	CDD:275380	10/22 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100