DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and Slitrk5

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001100754.1	Gene:	Slitrk5 / 306152	RGDID:	1310957	Length:	958	Species:	Rattus norvegicus

Alignment Length:	1110	Identity:	220/1110 - (19%)
Similarity:	359/1110 - (32%)	Gaps:	381/1110 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   375 LNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKLFN 439
            |.|:.|.|.|:....|.......||:|.:|.|..||..||..|..|..|:|..|:|..|.|..|.
  Rat    86 LLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFL 150

  Fly   440 GLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRALQDLAMLRTLDLGENQIRTF 504
            ||..|..|.::.|.|||:||..|.....|:.|.|:.|.|:.:|..|.....|..|||..|:::..
  Rat   151 GLENLEYLQVDYNYISVIEPNAFGKLHMLQVLILNDNLLSGLPNNLFRFVPLTHLDLRGNRLKLL 215

  Fly   505 DNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLD 569
            .                       .||:.|.:.::..|.|.:|          ..|...|.|.|.
  Rat   216 P-----------------------YVGLLQHMDKVVELQLEEN----------PWNCSCELISLK 247

  Fly   570 RNFLADINGVFATLVSLLWL-NLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNY--------- 624
            .                 || ::|.:.||.......|..|     ||..::.:...
  Rat   248 D-----------------WLDSISYSALVGDVVCETPFRL-----HGRDLDEVSKQELCPRKLIS 290

  Fly   625 -YKLQEEIRVKTLDASHNRITEIGPMSIPNTIELLFINNNLI---------GNVQPNAFVDKANL 679
             |:::.:..:.|....|         :.|.::..:..:::.:         |..|||.
  Rat   291 DYEMRPQTPLSTTGYLH---------TTPASVNSVATSSSAVYKPPLKPPKGTRQPNK------- 339

  Fly   680 ARVDLYANQLSKLQLQQLRVAPVVA-----PKPLPEFYLGGNPFECDCTMDWLQRINNLTTRQHP 739
            .||...:.|.|| .|......|.:|     |.||.      .|..|.|.:
  Rat   340 PRVRPTSRQPSK-DLGYSNYGPSIAYQTKSPVPLE------CPTACTCNL--------------- 382

  Fly   740 RVMDMA-NIECVMPHARGAAVRPLSGLRPQDFLCRYESHCFALCHCCDFDACDCEMTCPSNCTCY 803
            ::.|:. |:.|     :...:..::.|:|:.:..:                   :|....|   |
  Rat   383 QISDLGLNVNC-----QERKIESIAELQPKPYNPK-------------------KMYLTEN---Y 420

  Fly   804 HDQIWSTNVVDCGGQQTTELPRRVPMDSSVVYLDGNNFPVLKNHAFIGRKNLRALYVNGSQVAAI 868
            ...:..|:.::..|           :|  :::|..|...::::.||....|||.||:||:::..:
  Rat   421 ITVVRRTDFLEATG-----------LD--LLHLGNNRISMIQDRAFGDLGNLRRLYLNGNRIERL 472

  Fly   869 QNRTFASLASLQLLHLADNKLRTLHGYEFEQLSALRELYLQNNQLTTIENATLAPLAALELIRID 933
            ....|..|.|||.|.|..|.:|.:....|:.:..|:.|:|.||||..:.:...:.|..|.| .:.
  Rat   473 SPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNQLQAMPSGVFSGLTLLRL-NLR 536

  Fly   934 GNRLVTLPIW----QMHATHFGTRLKSISLGRNQWSCRCQFL-------QALTSYVAD------- 980
            .|...:||:.    |:      |.|..|.|..|.|.|.|:.:       |.....:.|
  Rat   537 SNSFTSLPVSGVLDQL------TSLIQIDLHDNPWDCTCEVVGMKLWIEQLKVGVLVDEVICKAP 595

  Fly   981 ------------NALIVQDAQDIYCMAASSGTGSAALEDSSSNSGSLEKRELDFNATGAACTDYY 1033
                        :.|:..|..|:   ..|:.|.|:....|.:|:.:....:|:...|.|.
  Rat   596 KKFAETYMRSIKSELLCPDYSDV---VVSTPTPSSIQLPSRTNAAATPAVKLNSTGTPAG----- 652

  Fly  1034 SGGSMLQHGIPESYIPLLAAALALLFLLVVIAMVFAFRESLRIWLFAHYGVRVFGPRCEESEKLY 1098
                 |..|...|.:||  :.|.|..|||.|..||.                        :..|:
  Rat   653 -----LGAGTGASSVPL--SVLILSLLLVFIMSVFV------------------------AAGLF 686

  Fly  1099 DAVLLHSAKDSEFVCQHLAAQLETGRPPLRVCLQHRDLAHDATHYQLLEATRVSRRVVILLTRNF 1163
            ..|:....|:..                          .|.:|:
  Rat   687 VLVMKRRKKNQS--------------------------DHTSTN--------------------- 704

  Fly  1164 LQTEWARCELRRSVH----DALRGRPQKLVIIEEPEVAFEAESDIELLPYLKTSAVHRIRRSDRH 1224
             .::.:...::.||:    ....|.|...|                   :.:.||:.:::....|
  Rat   705 -NSDVSSFNMQYSVYGGGGGGGGGHPHAHV-------------------HHRGSALPKVKTPAGH 749

  Fly  1225 FWEKLRYAL------PV----------DYPTFRGNNYTLELDHHNHERVKQPASPGLLYRQAPPP 1273
            .:|.:.:.|      |:          ||........|...:||             |.:|.|||
  Rat   750 VYEYIPHPLGHMCKNPIYRSREGNSVEDYKDLHELKVTYSSNHH-------------LQQQQPPP 801

  Fly  1274 AYCGPADAVGIGAVPQVVPVNASVPAEQNYSTATTATPSPRPQRRGEQPGSGS-GGNHHLHAQYY 1337
                          ||       .|.:|         |.|:.|.   |||... ..:|||.:..|
  Rat   802 --------------PQ-------QPQQQ---------PPPQLQL---QPGEEERRESHHLRSPAY 833

  Fly  1338 QHHGMRPPSEHIYSSIDSD---YSTLDNEQHMLMMPGA---PGGLAMEAAQRAQTWRPK------ 1390
            ....:.|..:.:....|:|   ...|:.::|....|..   |.......:..|.|:.|.
  Rat   834 SVSTIEPREDLLSPVQDADRFYRGILEPDKHCSTTPAGSSLPEYPKFPCSPAAYTFSPNYDLRRP 898

  Fly  1391 REQLH 1395
            .:.||
  Rat   899 HQYLH 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380
		LRR_RI	247..501	CDD:238064	47/125 (38%)
		LRR_8	247..308	CDD:290566
		leucine-rich repeat	249..273	CDD:275380
		leucine-rich repeat	274..297	CDD:275380
		LRR_8	297..356	CDD:290566
		leucine-rich repeat	298..321	CDD:275380
		leucine-rich repeat	322..345	CDD:275380
		LRR_8	345..406	CDD:290566	10/30 (33%)
		leucine-rich repeat	346..371	CDD:275380
		leucine-rich repeat	372..395	CDD:275380	6/19 (32%)
		leucine-rich repeat	396..419	CDD:275380	10/22 (45%)
		LRR_8	419..478	CDD:290566	23/58 (40%)
		leucine-rich repeat	420..443	CDD:275380	10/22 (45%)
		leucine-rich repeat	444..467	CDD:275380	9/22 (41%)
		LRR_RI	466..622	CDD:238064	31/156 (20%)
		leucine-rich repeat	468..488	CDD:275380	7/19 (37%)
		LRR_8	491..549	CDD:290566	11/57 (19%)
		leucine-rich repeat	491..514	CDD:275380	5/22 (23%)
		leucine-rich repeat	515..536	CDD:275380	3/20 (15%)
		leucine-rich repeat	539..562	CDD:275380	4/22 (18%)
		leucine-rich repeat	563..585	CDD:275380	3/21 (14%)
		leucine-rich repeat	586..626	CDD:275380	9/50 (18%)
		leucine-rich repeat	627..653	CDD:275380	2/25 (8%)
		LRRCT	716..772	CDD:214507	8/56 (14%)
		LRRNT	796..830	CDD:214470	4/33 (12%)
		leucine-rich repeat	812..829	CDD:275380	1/16 (6%)
		leucine-rich repeat	833..854	CDD:275380	4/20 (20%)
		LRR_8	853..913	CDD:290566	22/59 (37%)
		leucine-rich repeat	855..878	CDD:275380	8/22 (36%)
		LRR_4	878..918	CDD:289563	15/39 (38%)
		leucine-rich repeat	879..902	CDD:275380	7/22 (32%)
		leucine-rich repeat	903..926	CDD:275380	8/22 (36%)
		leucine-rich repeat	927..953	CDD:275380	6/29 (21%)
		TIR	1098..1235	CDD:214587	14/146 (10%)
Slitrk5	NP_001100754.1	leucine-rich repeat	62..79	CDD:275380
		leucine-rich repeat	83..106	CDD:275380	6/19 (32%)
		LRR_8	84..141	CDD:290566	20/54 (37%)
		leucine-rich repeat	107..130	CDD:275380	10/22 (45%)
		LRR_8	129..189	CDD:290566	23/59 (39%)
		leucine-rich repeat	131..154	CDD:275380	10/22 (45%)
		leucine-rich repeat	155..178	CDD:275380	9/22 (41%)
		LRR_8	179..236	CDD:290566	18/89 (20%)
		leucine-rich repeat	179..200	CDD:275380	7/20 (35%)
		leucine-rich repeat	202..226	CDD:275380	8/46 (17%)
		LRRCT	235..>273	CDD:214507	13/69 (19%)
		LRR_8	433..493	CDD:290566	21/72 (29%)
		LRR_4	433..474	CDD:289563	13/53 (25%)
		leucine-rich repeat	435..458	CDD:275380	5/24 (21%)
		LRR_4	458..498	CDD:289563	16/39 (41%)
		leucine-rich repeat	459..482	CDD:275380	8/22 (36%)
		leucine-rich repeat	483..528	CDD:275380	14/44 (32%)
		leucine-rich repeat	530..554	CDD:275380	6/30 (20%)
		TPKR_C2	563..>599	CDD:301599	6/35 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3875
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050