DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and Tlr1

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	XP_038947853.1	Gene:	Tlr1 / 305354	RGDID:	1309975	Length:	808	Species:	Rattus norvegicus

Alignment Length:	833	Identity:	164/833 - (19%)
Similarity:	301/833 - (36%)	Gaps:	239/833 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 PTRTLELFPDSLGGLKQLTDLDLGDNNLRQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFADMNC 238
            |...|...|..|.  .|.|.||:..||:.:|.:..:..:..|:|..::.||::......|
  Rat    48 PNANLTRVPKDLP--LQTTTLDVSQNNISELQTSDILLLSKLRVFIMSYNRLQYLNISVF----- 105

  Fly   239 GAGSGSAGSELQVLDASHNELRSISESWGISRLRRLQHLNLAYN------------NLSELSGEA 291
                 ...:||:.||.||||||.||    ......|:||:|::|            |||:|....
  Rat   106 -----KFNTELEYLDLSHNELRLIS----CHATADLKHLDLSFNAFDALPICKEFGNLSQLQFLG 161

  Fly   292 LAGL----ASLRIVNLSNNHLETLPEGLFAGSKE----LREIHLQQNELYELPKGLFHRLEQLLV 348
            |:|.    :|::::...|.....|..|...|.||    |:.|..:...:....|..||.|..:.|
  Rat   162 LSGSQIQNSSVQLIAHLNISKVLLVLGDTYGEKEDPKCLQHISTETLHIVFPSKREFHFLLDMSV 226

  Fly   349 -----VDLSG--------------------------NQLTSNHVDNT--TFAGLIRLI----VLN 376
                 ::||.                          :.||.|:||.|  :|..:::|:    |.:
  Rat   227 STAISLELSNIKCVLEDKNCSYFLGTLERLRKTQRLSNLTLNNVDTTWNSFINILQLVWHTPVKS 291

  Fly   377 LAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAF-LPLYNLHTLNLAENRLHTLDDKLFNG 440
            .:.:.:....:..|:..::.. .:||..||..:..:.| .|..|:::              :|:.
  Rat   292 FSISNVKLKGHFNFRRFHYSD-TSLRALSIHQVVTDVFSFPQSNIYS--------------IFSN 341

  Fly   441 LYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVP-RALQDLAMLRTLDLGENQIRTF 504
            :.:.|.......::.::.|   ...|....||.:.|.|.::. ...::|..|:||.|.:||::|.
  Rat   342 MNIQSFTVSGTRMVHMLCP---DQISPFLYLDFTDNLLTDIVFEDCRNLIRLKTLSLQKNQLKTL 403

  Fly   505 DNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLD 569
            :|                      .:.|..::..|..|::::|.::..:.||
  Rat   404 EN----------------------IILMSMEMTSLQKLDISQNSLRYSDAGS------------- 433

  Fly   570 RNFLADINGVFATLVSLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALG----NYYKLQEE 630
                     ..:...|||.||||.|.|....:..:|..:|.||:|.|.|.::.    :...|||
  Rat   434 ---------PCSWTQSLLVLNLSSNMLTDSVFRCLPPKVKVLDLHNNRIVSISKDVTHLQALQE- 488

  Fly   631 IRVKTLDASHNRITEIGPMSIPNTIELLFINNNLIGNVQPNAFVDKANLARVDLYANQLSKLQLQ 695
                 |:.:.|.:|::......:::.:|.|::|.:.:...:.|....|:..:.
  Rat   489 -----LNVASNFLTDLPGCGAFSSLSVLVIDHNSVSHPSSDFFQSCQNIRSIT------------ 536

  Fly   696 QLRVAPVVAPKPLPEFYLGGNPFECDCTM-DWLQRINNLTTRQHPRVMDMANIECVMPHARGAAV 759
                             .|.|||.|.|.: ::::.|...:........|  :..|..|.:
  Rat   537 -----------------AGNNPFRCTCELREFVKNIGQASREVVEGWPD--SYRCDYPDS----- 577

  Fly   760 RPLSGLRPQDFLCRYESHCFALCHCCDFDACDCEM-------------TCPSNCTCYHDQIWSTN 811
              :.|...|||      |...|       :||..:             ...::...|.|..|...
  Rat   578 --IKGTPLQDF------HMSPL-------SCDTILLTVTIGATLLLLAAIGASLCLYFDLPWYLR 627

  Fly   812 VVDCGGQQTTELPRRVPMDSSVVYLDGNNFPVLKNHAFIGRKNLRALYVNGSQV---------AA 867
            :: ....||....|.:|::.    |..|    |:.|||:......:.:|....:         ..
  Rat   628 ML-WQWTQTRHRARNIPLEE----LQRN----LQFHAFVSYSGHDSAWVKNELLPNLEKDDIRVC 683

  Fly   868 IQNRTFASLASL--QLLHLADNKLRTL-----HGYEFEQLSALRELYLQNNQL 913
            :..|.|....|:  .::|..:...:::     |..:.|...  .|||..::.|
  Rat   684 LHERNFVPGKSIVENIIHFIEKSYKSIFVLSPHFIQSEWCH--YELYFAHHNL 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	9/26 (35%)
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380	4/15 (27%)
		LRR_8	189..259	CDD:290566	19/69 (28%)
		leucine-rich repeat	191..214	CDD:275380	6/22 (27%)
		leucine-rich repeat	215..248	CDD:275380	5/32 (16%)
		LRR_RI	247..501	CDD:238064	70/312 (22%)
		LRR_8	247..308	CDD:290566	25/76 (33%)
		leucine-rich repeat	249..273	CDD:275380	11/23 (48%)
		leucine-rich repeat	274..297	CDD:275380	11/38 (29%)
		LRR_8	297..356	CDD:290566	16/93 (17%)
		leucine-rich repeat	298..321	CDD:275380	4/22 (18%)
		leucine-rich repeat	322..345	CDD:275380	6/22 (27%)
		LRR_8	345..406	CDD:290566	15/97 (15%)
		leucine-rich repeat	346..371	CDD:275380	10/57 (18%)
		leucine-rich repeat	372..395	CDD:275380	3/26 (12%)
		leucine-rich repeat	396..419	CDD:275380	6/23 (26%)
		LRR_8	419..478	CDD:290566	8/58 (14%)
		leucine-rich repeat	420..443	CDD:275380	1/22 (5%)
		leucine-rich repeat	444..467	CDD:275380	2/22 (9%)
		LRR_RI	466..622	CDD:238064	36/156 (23%)
		leucine-rich repeat	468..488	CDD:275380	4/20 (20%)
		LRR_8	491..549	CDD:290566	12/57 (21%)
		leucine-rich repeat	491..514	CDD:275380	8/22 (36%)
		leucine-rich repeat	515..536	CDD:275380	1/20 (5%)
		leucine-rich repeat	539..562	CDD:275380	5/22 (23%)
		leucine-rich repeat	563..585	CDD:275380	0/21 (0%)
		leucine-rich repeat	586..626	CDD:275380	15/43 (35%)
		leucine-rich repeat	627..653	CDD:275380	6/25 (24%)
		LRRCT	716..772	CDD:214507	13/56 (23%)
		LRRNT	796..830	CDD:214470	7/33 (21%)
		leucine-rich repeat	812..829	CDD:275380	3/16 (19%)
		leucine-rich repeat	833..854	CDD:275380	6/20 (30%)
		LRR_8	853..913	CDD:290566	10/75 (13%)
		leucine-rich repeat	855..878	CDD:275380	3/31 (10%)
		LRR_4	878..918	CDD:289563	8/43 (19%)
		leucine-rich repeat	879..902	CDD:275380	3/29 (10%)
		leucine-rich repeat	903..926	CDD:275380	4/11 (36%)
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
Tlr1	XP_038947853.1	PRK15370	<51..>146	CDD:185268	32/110 (29%)
		leucine-rich repeat	63..86	CDD:275378	6/22 (27%)
		leucine-rich repeat	87..110	CDD:275378	5/32 (16%)
		leucine-rich repeat	111..125	CDD:275378	9/13 (69%)
		leucine-rich repeat	132..156	CDD:275378	7/23 (30%)
		leucine-rich repeat	157..169	CDD:275378	3/11 (27%)
		PRK15370	<313..>500	CDD:185268	52/253 (21%)
		leucine-rich repeat	368..389	CDD:275380	5/20 (25%)
		leucine-rich repeat	390..415	CDD:275380	9/46 (20%)
		leucine-rich repeat	416..440	CDD:275380	5/45 (11%)
		leucine-rich repeat	441..462	CDD:275380	9/20 (45%)
		leucine-rich repeat	463..485	CDD:275380	6/21 (29%)
		leucine-rich repeat	486..507	CDD:275380	6/26 (23%)
		leucine-rich repeat	508..531	CDD:275380	4/22 (18%)
		LRRCT	540..594	CDD:214507	15/75 (20%)
		TIR	652..795	CDD:214587	14/85 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920