DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and Tlr6

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_997487.1	Gene:	Tlr6 / 305353	RGDID:	1303030	Length:	806	Species:	Rattus norvegicus

Alignment Length:	892	Identity:	189/892 - (21%)
Similarity:	332/892 - (37%)	Gaps:	235/892 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   441 LYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRALQDLAMLRTLDLGENQIRTFD 505
            |.|.|....::.|.|||              |.|:..|..||:.|.  ...::|.|.:|.|.
  Rat    31 LIVGSMTQFSDELESVV--------------DYSNKNLTHVPKDLS--PSTKSLSLSQNSIS--- 76

  Fly   506 NQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDR 570
                            |.|:.:|:.     |..|.||.|:.|||:.::.|.|..|.:||.:.:..
  Rat    77 ----------------DLQMSDISF-----LSELRVLRLSHNRIRRLDFGVFLLNRDLEYLDVSH 120

  Fly   571 NFLADINGVFATLVSLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQ----EEI 631
            |.|.:|:  ...:|:|..|:||.|     |:..:|           ..:..||..||.    ...
  Rat   121 NQLQNIS--CCPMVNLKHLDLSFN-----DFEVLP-----------VYKEFGNLRKLSFLGLSAA 167

  Fly   632 RVKTLD---ASHNRIT--------------EIGPMSIPNT--IELLFINNNLIG---NVQPNAF- 673
            :.:.||   .||..::              |...:.:|||  :.|:|..|:|..   |:..||.
  Rat   168 KFRQLDLLPISHLHLSCVLLDLVNYQIKDGETESLQVPNTNVLHLVFHPNSLFSVQVNISVNALG 232

  Fly   674 --------VDKANLARVDLYANQLSK------LQLQQL--------RVAPVVAPKPLPEFYLGGN 716
                    ::..|...:.::.::|::      |.||.:        |:...:.|:|:.  ||
  Rat   233 CLQLSNIKLNDENCQSLIIFLSELTRGPTLLNLTLQHIETNWKCFVRLLQFLWPRPVE--YL--- 292

  Fly   717 PFECDCTMDWLQRINNLTTRQHPRVMDMANIECVMPHARGAAVRPLSGLRPQDFLCRYES--HCF 779
                        .|.|||..:.........:|.|:...:      :..:..|.||...::  ..|
  Rat   293 ------------NIYNLTITESISRETFIYVETVLKSLK------IEHVTNQVFLFVKDALYSVF 339

  Fly   780 ALCHCCDFDACD---CEMTCPSNCTCYHDQIWSTNV-VDCGGQQTTELPRRVPMDSSVVYLDGNN 840
            |..:.......|   ..|.||...:.:....::.|| .|...|..:.|.|   :::.::..:|
  Rat   340 AEMNIRMLTLSDTPFIHMVCPEFPSTFAFLNFTQNVFTDSIFQGCSTLKR---LETLILQRNG-- 399

  Fly   841 FPVLKNHAFIG-----RKNLRALYVN-GSQVAAIQNRTFASLASLQLLHLADN------------ 887
               |||...:.     ..:|..|.|: .|..:.:.:||.|...|:::|:|:.|
  Rat   400 ---LKNLFKVALMTKTMSSLETLDVSLNSLNSHVYDRTCAWAESIRVLNLSSNVLSDSVFRCLPP 461

  Fly   888 --KLRTLHG-------YEFEQLSALRELYLQNNQLTTIENATLAPLAALELIRIDGNRLVTLPIW 943
              |:..||.       .:...|.||:||.:.:|.||.:...  ...::|.::.||.|. |:.|
  Rat   462 KVKVLDLHNNRIVSIPKDVTHLQALQELNVASNFLTDLPGC--GAFSSLSVLVIDHNS-VSHP-- 521

  Fly   944 QMHATHFGT--RLKSISLGRNQWSCRCQFLQALTSYVADNALIVQDAQDIY-CMAASSGTGSAAL 1005
              .:..|.:  .::||:.|.|.:.|.|:..:.:.:....:..:|:...|.| |....|..|:..
  Rat   522 --SSDFFQSCQNIRSITAGNNPFRCTCELREFVKNIGQASREVVEGWPDSYRCDYPDSIKGTPL- 583

  Fly  1006 EDSSSNSGSLEKRELDFNATGAACTDYYSGGSMLQHGIPESYIPLLAAALALLFLLVV---IAMV 1067
                          .||:.:..:|               ::.:..:.....||.|..:   :.:.
  Rat   584 --------------QDFHMSPLSC---------------DTILLTVTIGATLLLLAAIGASLCLY 619

  Fly  1068 FAFRESLR-IWLFAHYGVRVFGPRCEESEK--LYDAVLLHSAKDSEFVCQHLAAQLETGRPPLRV 1129
            |.....|| :|.:.....|......||.::  .:.|.:.:|..||.:|...|...||  :..:||
  Rat   620 FDLPWYLRMLWQWTQTRHRARNIPLEELQRNLQFHAFVSYSEHDSAWVKNELLPNLE--KDDIRV 682

  Fly  1130 CLQHRD------LAHDATHYQLLEATRVSRRVVILLTRNFLQTEWARCELRRSVHDAL-RGRPQK 1187
            ||..|:      :..:..|:     ...|.:.:.:|:.:|:|:||...||..:.|:.. .|....
  Rat   683 CLHERNFVPGKSIVENIIHF-----IEKSYKSIFVLSPHFIQSEWCHYELYFAHHNLFHEGSDNL 742

  Fly  1188 LVIIEEPEVAFEAESDIELLPYL---KTSAVHRIRRSDRH-FWEKLR 1230
            ::|:.||.......|....|..|   :|.....|.:..|. ||..||
  Rat   743 ILILLEPIQQNNIPSRYHKLRALMAQRTYLEWPIEKGKRGLFWANLR 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380
		LRR_RI	247..501	CDD:238064	16/59 (27%)
		LRR_8	247..308	CDD:290566
		leucine-rich repeat	249..273	CDD:275380
		leucine-rich repeat	274..297	CDD:275380
		LRR_8	297..356	CDD:290566
		leucine-rich repeat	298..321	CDD:275380
		leucine-rich repeat	322..345	CDD:275380
		LRR_8	345..406	CDD:290566
		leucine-rich repeat	346..371	CDD:275380
		leucine-rich repeat	372..395	CDD:275380
		leucine-rich repeat	396..419	CDD:275380
		LRR_8	419..478	CDD:290566	9/36 (25%)
		leucine-rich repeat	420..443	CDD:275380	1/1 (100%)
		leucine-rich repeat	444..467	CDD:275380	5/22 (23%)
		LRR_RI	466..622	CDD:238064	37/155 (24%)
		leucine-rich repeat	468..488	CDD:275380	6/19 (32%)
		LRR_8	491..549	CDD:290566	13/57 (23%)
		leucine-rich repeat	491..514	CDD:275380	4/22 (18%)
		leucine-rich repeat	515..536	CDD:275380	3/20 (15%)
		leucine-rich repeat	539..562	CDD:275380	10/22 (45%)
		leucine-rich repeat	563..585	CDD:275380	5/21 (24%)
		leucine-rich repeat	586..626	CDD:275380	9/39 (23%)
		leucine-rich repeat	627..653	CDD:275380	6/46 (13%)
		LRRCT	716..772	CDD:214507	8/55 (15%)
		LRRNT	796..830	CDD:214470	8/34 (24%)
		leucine-rich repeat	812..829	CDD:275380	5/17 (29%)
		leucine-rich repeat	833..854	CDD:275380	4/25 (16%)
		LRR_8	853..913	CDD:290566	20/81 (25%)
		leucine-rich repeat	855..878	CDD:275380	7/23 (30%)
		LRR_4	878..918	CDD:289563	15/60 (25%)
		leucine-rich repeat	879..902	CDD:275380	7/43 (16%)
		leucine-rich repeat	903..926	CDD:275380	6/22 (27%)
		leucine-rich repeat	927..953	CDD:275380	7/27 (26%)
		TIR	1098..1235	CDD:214587	37/144 (26%)
Tlr6	NP_997487.1	leucine-rich repeat	46..64	CDD:275380	8/33 (24%)
		leucine-rich repeat	65..88	CDD:275378	8/46 (17%)
		LRR_8	87..144	CDD:290566	21/63 (33%)
		leucine-rich repeat	89..112	CDD:275378	10/22 (45%)
		leucine-rich repeat	113..133	CDD:275378	5/21 (24%)
		leucine-rich repeat	134..158	CDD:275378	9/39 (23%)
		leucine-rich repeat	369..385	CDD:275380	4/15 (27%)
		LRR_RI	<380..>500	CDD:238064	29/127 (23%)
		LRR_8	388..451	CDD:290566	16/70 (23%)
		leucine-rich repeat	390..415	CDD:275380	4/29 (14%)
		leucine-rich repeat	416..440	CDD:275380	7/23 (30%)
		leucine-rich repeat	441..462	CDD:275380	3/20 (15%)
		LRR_8	461..516	CDD:290566	14/56 (25%)
		leucine-rich repeat	463..485	CDD:275380	4/21 (19%)
		leucine-rich repeat	486..508	CDD:275380	6/23 (26%)
		leucine-rich repeat	510..531	CDD:275380	6/25 (24%)
		LRRCT	540..594	CDD:214507	12/83 (14%)
		TIR	652..791	CDD:214587	37/145 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820